Person: ÇIKRIKLAR, HALİL İBRAHİM
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ÇIKRIKLAR
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HALİL İBRAHİM
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Publication Rhinocerebral mucormycosis case in the emergency room(Acil Tıp Hekimleri Derneği Türkiye, 2021-12-01) Aslan, Şahin; Omar, Issa; Durak, Vahide Aslıhan; Cıkrıklar, Halil İbrahim; Özdemir, Fatma; ASLAN, ŞAHİN; OMAR, ISSA MALONGO; DURAK, VAHİDE ASLIHAN; ÇIKRIKLAR, HALİL İBRAHİM; ÖZDEMİR, FATMA; Tıp Fakültesi; Acil Tıp Ana Bilim Dalı; 0000-0003-0836-7862; 0000-0002-6665-7166; EMD-3139-2022; GXT-8042-2022; AAE-9483-2021; AAH-8714-2021; JRF-5591-2023Introduction: Rhinocerebral mucormycosis is a rare disease, which causes serious and life-threatening fungal infections.The disease usually develops in immunocompromised individuals and usually begins by mimicking cellulite, especially in the face area, and shows a very rapid course.Case Report: A 75-year-old male patient previously admitted to an external center with 3-4 days complaints of headache, numbness in the right half of his face and closure of his left eye was brought to our emergency department for further investigation.The cranial magnetic resonance imaging (MRI) revealed suspected opportunistic fungal infection or malignancy in the ethmoidal and sphenoidal sinuses.The patient was hospitalized with the diagnosis of opportunistic fungal infection after consultations to relevant clinics. Biopsy revealed polypes and mucocele like cystic tissues. The patient, followed-up and treated with rhinocerebral mucormicosis, was transferred to intensive care unit after deterioration of his general condition.After approximately 45 days of follow-up and treatment, the patient was lost due to multiple organ failure.Conclusion: Rhinocerebral mucormycosis is an emergency that requires a multidisciplinary approach. Presence of one or more of the non-traumatic orbital apex syndrome findings should alert emergency physicians. In this and similar infections with high mortality rates, early diagnosis and treatment may lead to good results.Publication Serum pNF-H levels in the first six hours after experimental mild traumatic brain injury in rats(Verduci Publisher, 2022-01-01) Karesioğlu, E.; Çıkrıklar, H. I.; Durak, V. A.; Aydın, B.; Ardıç, A.; Armağan, E.; KARESİOĞLU, EMİNE; ÇIKRIKLAR, HALİL İBRAHİM; DURAK, VAHİDE ASLIHAN; AYDİN, BİRNUR; Ardıç, Aslıgül; Armağan, Ersin; Tıp Fakültesi; Acil Tıp Bölümü; 0000-0003-0836-7862; 0000-0002-8193-474X; HEI-9103-2022; AAH-8714-2021; AAE-9483-2021; ADT-6417-2022; EKH-5913-2022; CBW-8706-2022OBJECTIVE: Mild traumatic brain injury (mTBI) cases with a normal CT scanning account for the vast majority of all TBI patients. The aim of this study was to investigate the course of serum Phosphorylated Neurofilament Heavy Chain (pNF-H) levels in the first six hours after trauma in rats in experimental mTBI.MATERIALS AND METHODS: In this experi-mental animal study, 32 female Sprague-Dawley rats were enrolled equally (n=8) into 3 experimen-tal groups and 1 control group. In experimental groups, animals were exposed to a mTBI with a free fall of 50-gram metal disc from a height of 80 cm. We compared serum pNF-H levels at the 2nd, 4th, and 6th hours after traumatic brain injury in the experimental groups with the control group.RESULTS: Serum pNF-H levels at the 2nd and 4th hours after traumatic brain injury were sta-tistically significantly higher than the control group. Serum pNF-H levels gradually decreased at the 4th and 6th hours compared to the 2nd hour and decreased to a similar level to the control group at the 6th hour after injury.CONCLUSIONS: A high serum pNF-H value, could be used in the diagnosis and management of mTBI patients.Publication Investigation of early diagnostic value of glial fibrillary acidic protein and ubiquitin c-terminal hydrolase blood levels in minor head trauma in Turkey(Clin Lab Publ, 2021-12-06) Polat, Zeynep M.; Yücel, Murat; Yürümez, Yusuf; Çıkrıklar, Halil I.; ÇIKRIKLAR, HALİL İBRAHİM; Tıp Fakültesi; Acil Tıp Ana Bilim Dalı; AAH-8714-2021Background: The aim was to investigate the early diagnostic value of serum glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) levels in adults with minor head trauma (MHT) and whether it could be an alternative diagnostic method to computed tomography (CT). This is the first study with the combination of GFAP and UCH-L1 in the first 3 hours of MHT. Methods: The study comprised 88 patients, 60 patients and 28 controls, who were evaluated as having MHT, were admitted to the emergency department of our hospital within the first 3 hours of the trauma and met the inclusion criteria. CT was performed on all patients. Serum GFAP and UCH-L1 levels were measured within the first 3 hours of the trauma. Results: The median serum GFAP level was 1.07 ng/mL in the group with pathology on CT and 0.42 ng/mL in the group with no pathology on CT. The median serum UCH-L1 level was 0.40 ng/mL in the group with pathology on CT and 0.39 ng/mL in the group with no pathology on CT. A statistically significant difference was found between the serum GFAP levels of the CT (+) group and the CT (-) group (p = 0.021). GFAP levels were compared according to the CT (+) and CT (-) groups with a cutoff value of ??? 1.56 ng/mL for GFAP, which had 50% sensitivity and 97.5% specificity. This was statistically significant (p = 0.008). It was found that the UCH-L1 level of the control group was lower than the UCH-L1 levels of the CT (+) and CT (-) groups, and this difference was found to be statistically significant (p = 0.003 and p = 0.018, respectively). Conclusions: GFAP was found to be more specific than UCH-L1 in demonstrating the presence of intracranial pathology in patients with head trauma who were admitted to the emergency department in the first 3 hours after trauma.Publication Rhinocerebral mucormycosis case in the emergency room(Acil Tıp Hekimleri, 2021-12-01) Aslan, Şahin; Omar, Issa; Durak, Vahide Aslıhan; Çıkrıklar, Halil Ibrahim; Özdemir, Fatma; ASLAN, ŞAHİN; OMAR, ISSA MALONGO; DURAK, VAHİDE ASLIHAN; ÇIKRIKLAR, HALİL İBRAHİM; ÖZDEMİR, FATMA; Tıp Fakültesi; Acil Tıp Bölümü; 0000-0003-0836-7862; EMD-3139-2022; JRF-5591-2023Introduction: Rhinocerebral mucormycosis is a rare disease, which causes serious and life-threatening fungal infections.The disease usually develops in immunocompromised individuals and usually begins by mimicking cellulite, especially in the face area, and shows a very rapid course.Case Report: A 75-year-old male patient previously admitted to an external center with 3-4 days complaints of headache, numbness in the right half of his face and closure of his left eye was brought to our emergency department for further investigation.The cranial magnetic resonance imaging (MRI) revealed suspected opportunistic fungal infection or malignancy in the ethmoidal and sphenoidal sinuses.The patient was hospitalized with the diagnosis of opportunistic fungal infection after consultations to relevant clinics. Biopsy revealed polypes and mucocele like cystic tissues. The patient, followed-up and treated with rhinocerebral mucormicosis, was transferred to intensive care unit after deterioration of his general condition.After approximately 45 days of follow-up and treatment, the patient was lost due to multiple organ failure.Conclusion: Rhinocerebral mucormycosis is an emergency that requires a multidisciplinary approach. Presence of one or more of the non-traumatic orbital apex syndrome findings should alert emergency physicians. In this and similar infections with high mortality rates, early diagnosis and treatment may lead to good results.