Person: UĞRAŞ, NESRİN
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UĞRAŞ
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NESRİN
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Publication Prognostic value of p53 protein expression in giant cell tumor of bone(Vesalius Univ Medical Publ, 2015-12-01) Yalçınkaya, Ulviye; Uğraş, Nesrin; Kabul, Selva; Ocakoğlu, Gökhan; Bilgen, Muhammed S.; YALÇINKAYA, ÜLVİYE; UĞRAŞ, NESRİN; KABUL, SELVA; Bilgen, Muhammed S.; Ocakoğlu, Gökhan; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji ve Pediatrik Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi Anabilim Dalı.; 0000-0002-1114-6051; AAH-2716-2021; AAH-8924-2021; HLG-6346-2023; AAH-5180-2021; CAH-9737-2022; ELH-9133-2022Giant cell tumor of bone (GCTB) is a benign tumor with a tendency for local recurrence. GCTB may cause lung metastases, and secondary malignant GCTB is rare. Its histological appearance does not predict local aggressiveness and/or the metastatic potential of the tumor. We aimed to investigate the prognostic value of the Ki-67 proliferative index and p53 protein expression in GCTB in predicting local recurrence, lung metastasis, and malignant transformation. We retrospectively reviewed 42 cases of GCTB. The p53 expression was positive in 20 cases. We used 10% as a cut-off value for p53 expression. In 10 cases, there were local recurrences. Lung metastases were found in three cases and malignant transformation was found in one case with classical GCTB located in the sacrum three years following diagnosis. The Ki-67 index was higher in cases with recurrence, but this difference was not statistically significant. Of the recurrent cases, two had no p53 staining while eight had moderate-to-strong staining. The staining was usually weakly positive in the non-recurrent cases. In conclusion, we believe that p53 may be used as a marker for the biological behavior of GCTB.Publication Malignant glomus tumor with oncocytic features: An unusual presentation of dysphagia(Wiley, 2015-07-01) Uğras, Nesrin; Yerci, Ömer, I.; Yalçınkaya, Ulviye; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; UĞRAŞ, NESRİN; YERCİ, ÖMER; YALÇINKAYA, ÜLVİYE; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; 0000-0002-9600-9418; AAH-8924-2021; AAH-2716-2021; JIO-2609-2023; JII-0241-2023; JGW-0566-2023; GCS-6830-2022; JIV-8745-2023Glomus tumors in the gastrointestinal tract are unusual, as the previous series in the literature have been mainly limited to the stomach. Less than 10 cases of esophageal glomus tumors have been described in the literature. Oncocytic glomus tumors are a recently identified, rare variant of the glomus tumor. We report a 47-year-old female who presented with an approximately 3-month history of dysphagia and weight loss. Upper gastrointestinal endoscopy showed a black-purple, hypervascular, protruding lesion measuring approximately 65mm at the 37th cm of the esophagus. The patient underwent an Ivor Lewis operation via open thoracotomy. The resected specimen had a protuberant, ulcerated mass measuring 80x35mm in the posterior wall of the esophagus. Based on the histopathological, immunohistochemical and electron microscope findings, the final diagnosis was a malignant glomus tumor with oncocytic features. To our knowledge, this is the first report of a malignant glomus tumor with oncocytic features in an esophageal location.Publication Histopathological changes of neoadjuvant chemoradiation and relation with the pre-treatment tumor stage in rectal carcinoma(Gazi Univ, Fac Med, 2017-01-01) Özgün, Gonca; ÖZ ATALAY, FATMA; Ugraş, Nesrin; UĞRAŞ, NESRİN; Yerci, Ömer; YERCİ, ÖMER; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-7188-6115; AAH-2716-2021Objective: Neoadjuvant chemoradiotherapy has considered one of the standard treatment modalities for locally advanced rectal cancers. Chemoradiotherapy has a variety of different effects and responses on tumor, tumor bed and peritumoral tissues. The purpose of the present study was to evaluate the stromal responses in tumor bed between the different treatment modalities and different clinical T stages.Methods: Fifty-seven consecutive patients with median age of 62.4 years were treated for rectal adenocarcinoma between January 2005 and July 2012 in Uludag University Medical Faculty. Twenty-three of the patients were treated with neoadjuvant chemoradiation therapy and following surgery, 34 patients treated with surgery only.Results: When we compared the stromal responses in the tumor bed between the two different treatment modalities, the amount of fibrosis and intensity of inflammatory cell infiltration were found considerably marked. The existence of calcification, hemosiderin-laden macrophages and mucin lakes were found also significant marked. There was no difference found in between the patients with different clinical stages which were received neoadjuvant CRT.Conclusion: The stromal response in the tumor bed increases with the neoadjuvant chemoradiotherapy but the excess of the response doesn't have any relation with the clinical T stage.Publication An incidental unique mediastinal mass in an asymptomatic young patient: Thymolipoma(Turkish Assoc Tuberculosis & Thorax, 2013-01-01) Uğraş, Nesrin; Akyıldız, Elif Ülker; Ünal, Nermin; Bayram, Ahmet Sami; UĞRAŞ, NESRİN; AKYILDIZ, ELİF ÜLKER; Ünal, Nermin; BAYRAM, AHMET SAMİ; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0003-0684-0900; ABB-7580-2020; AAH-2716-2021; JHY-9777-2023; CDS-3138-2022Publication The expression and relationship of adipo R1/R2 in gastric intestinal metaplasia(Wolters Kluwer Medknow Publications, 2021-04-01) Ayyildiz, T.; Erturk, B.; Dolar, E.; DOLAR, MAHMUT ENVER; Ugras, N.; UĞRAŞ, NESRİN; Dizdar, O. S.; Adim, S. B.; Yerci, O.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Gastroentoloji Anabilim Dalı.; D-6213-2013; AAG-9177-2021Background: Adiponectin (ApN) is a 244-amino acid protein mainly secreted from the adipose tissue and involved in various physiological functions. ApN exerts its metabolic effects by binding to two major receptors: adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Recent studies have reported ApN's involvement in the progression of cancer. However, there are no studies evaluating the relationship between Adipo-R1/R2 expression and gastric intestinal metaplasia (IM), which is a predisposing factor in gastric cancer (GC) development, and Helicobacter pylori H. pylori infection. Aims: In this study we aimed to investigate the relationship between the Adipo-R1/-R2 expression and H. pylori infection in patients with GC and gastric IM. Materials and Methods: Forty patients that underwent gastric resection and 56 patients that developed gastric IM were included in the study. The Adipo-R1/-R2 expression and the presence of H. pylori were examined immunohistochemically. The univariate analyses showed that the expression of Adipo-R1/-R2 in GC patients was significantly lower compared to both complete metaplasia (CM) and incomplete metaplasia (ICM) patients (p <0.0001 for both). Results: According to multiple multinomial logistic regression analysis, Adipo-R1/-R2 expression in the CM group was significantly higher than in the GC group (p = 0.05, p = 0.014, respectively). Moreover, Adipo-R1/-R2 expression was significantly higher in ICM group compared to the GC group (p=0.012, p=0.045, respectively). However, in both analyses no significant difference was determined in terms of H. pylori positivity between the groups.Conclusion: The resulting data suggests that ApN plays a role in GC processes via Adipo-R1/-R2 receptors.Publication Perforation of the small intestine caused by enteropathy-associated t cell lymphoma(Aves, 2018-09-01) Kabul, Selva; KABUL, SELVA; Uğras, Nesrin; UĞRAŞ, NESRİN; Yerci, Ömer; YERCİ, ÖMER; Öztürk, Ersin; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; AAH-2716-2021; CAF-3650-2022Enteropathy-associated T cell lymphoma is a rare lymphoma specific to the gastrointestinal system, arising from intraepithelial T lymphocytes, that is often associated with celiac disease. We report a 53-year-old female patient with no previous disease who presented with severe abdominal pain. Physical examination revealed diffuse abdominal tenderness and abdominal guarding and the patient underwent emergency surgery with a diagnosis of acute abdomen. During the operation, a 20-cm mass was found located on Treitz ligament, invading the duodenum and pancreatic head and perforating the jejunum. Histologically, medium-sized monomorphic atypical lymphocyte infiltration with dark nucleus and narrow cytoplasm was seen in the layers of mucosa, submucosa, muscular wall, and serosa of the duodenum. The final pathological diagnosis was "enteropathy-associated T cell lymphoma type 2" based on immunohistochemical and serological findings. Based on the World Health Organization 2008 criteria, enteropathy-associated T cell lymphoma has two subtypes. Type 1 enteropathy-associated T cell lymphoma is associated with celiac disease and has HLA DQ2 and HLA DQ8 genotype. Enteropathy-associated T cell lymphoma 2 enteropathy-associated T cell lymphoma seldom occurs and is not associated with celiac disease.Publication Liver metastasis of breast carcinoma: An unusual presentation and growth pattern(Wolters Kluwer Medknow Publications, 2023-10-01) Özsen, Mine; ÖZŞEN, MİNE; Ugraş, Nesrin; UĞRAŞ, NESRİN; Deligönül, Adem; DELİGÖNÜL, ADEM; Yerci, Ömer; YERCİ, ÖMER; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.Breast carcinoma is one of the tumors that frequently metastasize to the liver. Extramedullary hematopoiesis (EMH) usually occurs due to insufficient medullary hematopoiesis. In this case report, we present a female patient with sinusoidal breast carcinoma metastasis and extramedullary hematopoiesis in liver biopsy. A 63-year-old female patient with history of breast carcinoma was admitted to our center with respiratory distress. Pleural effusion was detected and thoracentesis was planned. Treatment was given after detection of non-mycobacterial tuberculosis bacillus in the thoracentesis fluid. Antibiotherapy was terminated due to elevation of liver enzymes and bilirubin. The patient's clinical status was evaluated and treatment was re-initiated. The patient did not have any mass lesion in the liver. Tru-cut biopsy was performed to evaluate a possible tuberculosis involvement in the liver. The diagnosis of metastatic breast carcinoma located in the sinusoidal area and cholestatic liver with extramedullary hematopoiesis foci was given using the histomorphological, immunohistochemical and histochemical findings. Radiological evaluation has an important role in staging of malignancies. However, it should be kept in mind that hepatic metastases may present without formation of a mass lesion, and unexpected laboratory results of cases without abnormal radiological features should raise the suspicion of a metastasis. Such materials should be evaluated in detail by making multiple serial sections in the pathology laboratory. Rare metastatic tumor growth patterns not causing a mass lesion such as sinusoidal or portal pattern, should also be kept in mind.Publication Thermal welding surgery in benign neoplasm cases with oral cavity localized(Derman Tıp Yayınları, 2013-11-01) Atar, Yavuz; Demirgüneş, Nadir; Uğraş, Nesrin; UĞRAŞ, NESRİN; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı; 0000-0003-4496-6408; AAH-2716-2021Aim: We aimed to analyze data obtained from cases operated by thermal welding method to evaluate data from the oral cavity of patients who underwent surgery for the masses, and this method was to share relevant clinical experience. Material and Method: 20 cases who were operated by thermal welding between November 2010 and April 201 1 were included in to study. Age, gender, size, period of operation, complication, histopathology and recurrence were the parameters evaluated. Results: Mean age of the patients was 42.3 +/- 18.7, female to male ratio was 14/6 while the cases age between 6 to 79. The mean age of male patients was 42.6 +/- 20.7 and female was 40.8 +/- 15.1 he most common localization was buccal mucousa with 8 cases (40%) whereas retromolar trigon was the least common with 1 lesion (545). The longest operation period was 20 minutes during excision of capillary hemangioma on tounge and the shortest period was 3 minutes measured during papillom excision from buccal mucousa. The most common histopathological diagnosis were squamous papilloma (n=8 cases) 40%. There was one recurrence of mucocele at the first month. Discussion: Thermal welding method appropriately selected benign neoplasms in the oral cavity may be an alternative to surgery to the cold knife technique.Publication Recurrent hepatocellular carcinoma after liver transplantation: Identifying the high-risk patient using the expression profiles of emt-associated lncrnas(Frontiers Media Sa, 2019-10-01) Aksoy, Seçil Ak; Aksoy, Fuat; Dündar, Haliz Ziya; Tunca, Berrin; Taşar, Pınar; Uğraş, Nesrin; Egeli, Ünal; Çeçener, Gülşah; Yerci, Ömer; Kaya, Ekrem; Aksoy, Seçil Ak; AKSOY, FUAT; Dündar, Haliz Ziya; TUNCA, BERRİN; TAŞAR, PINAR; UĞRAŞ, NESRİN; EGELİ, ÜNAL; ÇEÇENER, GÜLŞAH; YERCİ, ÖMER; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0001-7904-883X; 0000-0002-3820-424X; AAH-8540-2021; AAG-7319-2021; AAP-9988-2020; ABI-6078-2020; AAH-1420-2021; AAH-2716-2021; HII-8895-2022; EGD-8703-2022; IIC-9825-2023Publication Incidentally discovered extensive squamous metaplasia within borderline phyllodes tumor: Presentation of a rare tumor(Federation Turkish Pathology Soc, 2016-01-01) ÖZ ATALAY, FATMA; UĞRAŞ, NESRİN; Uğraş, Nesrin; Tolunay, Sahsine; TOLUNAY, ŞAHSİNE; Gökgöz, Sehsuvar; GÖKGÖZ, MUSTAFA ŞEHSUVAR; Bursa Uludağ Üniversitesi/Tıp Fakültesi/PatolojicAnabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 0000-0002-7188-6115; AAH-2716-2021; AAI-1612-2021Phyllodes tumors are uncommon biphasic fibroepithelial neoplasms of breast, comprising less than 1% of all breast neoplasms. We therefore aimed to present the case with its microscopic findings. In this article, we report a 59-year-old female admitted to the general surgery department with a rapidly, enlarging, palpable mass in right breast. After histopathological examination, it was diagnosed as borderline phyllodes tumor with extensive squamous metaplasia. Metaplastic changes are infrequent in the stromal and epithelial component of these tumors. Extensive squamous metaplasia within phyllodes tumor is rare and may occur in benign, borderline and malign subtypes.