Person: ŞİMŞEK, ABDURRAHMAN
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ŞİMŞEK
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ABDURRAHMAN
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Publication Phenotypes and functions of low(er)-density neutrophils (LDNs) in early childhood and children(Wiley, 2021-08-01) Dombaz, Fatma; Karaçay, Mehmet; Etgü, Onur; Kızmaz, Muhammed Ali; Şimşek, Abdurrahman; Çağan, Eren; Pınar, İbrahim Ethem; Bal, Salih Haldun; Özkocaman, Vildan; Özkalemkaş, Fahir; Budak, Ferah; Oral, Halük Barbaros; Ermiş, Diğdem Yöyen; Dombaz, Fatma; Karaçay, Mehmet; Etgü, Onur; Kızmaz, Muhammed Ali; ŞİMŞEK, ABDURRAHMAN; PINAR, İBRAHİM ETHEM; BAL, SALİH HALDUN; ÖZKOCAMAN, VİLDAN; ÖZKALEMKAŞ, FAHİR; BUDAK, FERAH; ORAL, HALUK BARBAROS; YÖYEN ERMİŞ, DİĞDEM; Sağlık Bilimleri Yüksekokulu; İmmünoloji Ana Bilim Dalı; Hematoloji Bilim Dalı; 0000-0001-7625-9148 ; 0000-0001-9907-1498 ; 0000-0001-8850-0269 ; 0000-0001-5334-7911 ; DWR-5356-2022; JHB-7829-2023; JIJ-1849-2023; HKN-2347-2023; AAG-7381-2021; KBR-5535-2024; FQG-8981-2022; JIW-1248-2023; IZP-9398-2023; K-7285-2012; GYL-2038-2022Publication Evaluation of the roles of regulatory B (Breg) cells and B cell exhaustion in COVID-19(Wiley, 2021-08-01) Budak, Ferah; Çağan, Eren; Kızmaz, Muhammed Ali; Şimşek, Abdurrahman; Dombaz, Fatma; Tezcan, Gülçin; Asan, Ali; Bal, S. Haldun; Ermiş, Diğdem Yöyen; Demir, H. İbrahim; Ediger, Dane; Yılmaz, Emel; Oral, Haluk Barbaros; Akalın, E. Halis; BUDAK, FERAH; Kızmaz, Muhammed Ali; ŞİMŞEK, ABDURRAHMAN; Dombaz, Fatma; TEZCAN, GÜLÇİN; BAL, SALİH HALDUN; YÖYEN ERMİŞ, DİĞDEM; Demir, H. İbrahim; EDİGER, DANE; YILMAZ, EMEL; ORAL, HALUK BARBAROS; AKALIN, EMİN HALİS; Tıp Fakültesi; Temel Bilimler Bölümü; 0000-0001-7625-9148; 0000-0001-5334-7911; 0000-0001-8850-0269; 0000-0001-7288-3250; 0000-0002-5956-8755; 0000-0002-8856-7356; 0000-0001-7585-7971; 0000-0002-2954-4293; 0000-0003-1785-3539; 0000-0003-0463-6818; 0000-0001-7530-1279; AAG-7381-2021; AAH-3843-2020; K-7285-2012; F-4657-2014; IZP-9398-2023; AAU-8952-2020; HKN-2347-2023; DWR-5356-2022; KBR-5535-2024; GYL-2038-2022; GPN-1473-2022; AAE-9142-2019; GDP-0005-2022Publication Association of cytotoxic T lymphocyte subsets with disease severity in Covid-19(Wiley, 2021-08-01) Kızmaz, Muhammed Ali; Çağan, Eren; Şimşek, Abdurrahman; Dombaz, Fatma; Tezcan, Gülçin; Aşan, Ali; Demir, H. İbrahim; Bal, S. Haldun; Ermiş, Diğdem Yöyen; Coşkun, Necmiye Funda; Akalın, E. Halis; Oral, Haluk Barbaros; Budak, Ferah; Kızmaz, Muhammed Ali; ŞİMŞEK, ABDURRAHMAN; Dombaz, Fatma; TEZCAN, GÜLÇİN; Demir, H. İbrahim; BAL, SALİH HALDUN; YÖYEN ERMİŞ, DİĞDEM; COŞKUN, NECMİYE FUNDA; AKALIN, EMİN HALİS; ORAL, HALUK BARBAROS; BUDAK, FERAH; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; 0000-0001-5334-7911; 0000-0001-8850-0269; 0000-0001-7288-3250; 0000-0002-5956-8755; 0000-0002-8856-7356; 0000-0001-7585-7971; 0000-0003-3604-8826; 0000-0001-7530-1279; 0000-0003-0463-6818; 0000-0001-7625-9148; 0000-0003-3604-8826; HKN-2347-2023; IZP-9398-2023; AAH-3843-2020; F-4657-2014; AAG-7381-2021; K-7285-2012; AAU-8952-2020; DWR-5356-2022; GPN-1473-2022; KBR-5535-2024; GYL-2038-2022; AAD-1271-2019Publication The age-dependent role of Th22, Tc22, and Tc17 cells in the severity of pneumonia in COVID-19 immunopathogenesis(Wiley, 2021-08) Şimşek, Abdurrahman; Çağan, Eren; Kızmaz, Muhammed Ali; Dombaz, Fatma; Tezcan, Gülçin; Asan, Ali; Demir, H. İbrahim; Bal, S. Haldun; Ermiş, Diğdem Yoyen; Demirdöğen, Ezgi; Heper, Yasemin; Akalın, E. Halis; Oral, Haluk Barbaros; Budak, Ferah; ŞİMŞEK, ABDURRAHMAN; TEZCAN, GÜLÇİN; BAL, SALİH HALDUN; DEMİRDÖĞEN, EZGİ; BUDAK, FERAH; HEPER, YASEMİN; AKALIN, EMİN HALİS; Kızmaz, Muhammed Ali; Dombaz, Fatma; YÖYEN ERMİŞ, DİĞDEM; ORAL, HALUK BARBAROS; Tıp Fakültesi; 0000-0001-8850-0269; 0000-0001-5334-7911; 0000-0001-7288-3250; 0000-0002-5956-8755; 0000-0002-7400-9089; 0000-0001-7625-9148; AAG-7381-2021; HKN-2347-2023; DWR-5356-2022; KBR-5535-2024; GYL-2038-2022; AAH-9812-2021; CTY-9474-2022; AAU-8952-2020; IZP-9398-2023; K-7285-2012; AAH-3843-2020Publication Peripheral CD39-expressing regulatory T cell subsets play an age-dependent role in the severity of COVID-19(Wiley, 2021-08-01) Çağan, Eren; Şimşek, Abdurrahman; Kızmaz, Muhammed Ali; Dombaz, Fatma; Tezcan, Gülçin; Asan, Ali; Demir, H. İbrahim; Bal, S. Haldun; Ermiş, Diğdem Yöyen; Dilektaşlı, Aslı Görek; Kazak, Esra; Akalın, E. Halis; Oral, Halük Barbaros; Budak, Ferah; ŞİMŞEK, ABDURRAHMAN; Kızmaz, Muhammed Ali; Dombaz, Fatma; TEZCAN, GÜLÇİN; Demir, H. İbrahim; BAL, SALİH HALDUN; YÖYEN ERMİŞ, DİĞDEM; GÖREK DİLEKTAŞLI, ASLI; KAZAK, ESRA; AKALIN, EMİN HALİS; ORAL, HALUK BARBAROS; BUDAK, FERAH; Diş Hekimliği Fakültesi; Temel Bilimler Bölümü; 0000-0001-7625-9148 ; 0000-0002-5956-8755 ; 0000-0001-5334-7911 ; 0000-0001-8850-0269 ; AAG-7381-2021; HKN-2347-2023; DWR-5356-2022; AAH-3843-2020; GPN-1473-2022; KBR-5535-2024; GYL-2038-2022; DTT-7416-2022; AAG-8459-2021; AAU-8952-2020; K-7285-2012; IZP-9398-2023European Federat Immunol SocPublication The distribution of mature and/or immature myeloid cells and their role in effective anti-viral immune responses in COVID-19 positive patients(Wiley, 2021-08-01) Ermiş, Diğdem Yöyen; Dömbaz, Fatma; Karaçay, Mehmet; Etgü, Onur; Kızmaz, Muhammed Ali; Şimşek, Abdurrahman; Çağan, Eren; Aşan, Ali; Yılmaz, Emel; Kazak, Esra; Pınar, İbrahim Ethem; Bal, Salih Haldun; Arslan, Gözde; Karaca, Mert; Özkocaman, Vildan; Özkalemtaş, Fahir; Akalın, Emin Halis; Budak, Ferah; Oral, Haluk Barbaros; YÖYEN ERMİŞ, DİĞDEM; Dombaz, Fatma; Karaçay, Mehmet; Etgü, Onur; Kızmaz, Muhammed Ali; ŞİMŞEK, ABDURRAHMAN; YILMAZ, EMEL; KAZAK, ESRA; PINAR, İBRAHİM ETHEM; BAL, SALİH HALDUN; Arslan, Gözde; KARACA, MERT; ÖZKOCAMAN, VİLDAN; Özkalemtaş, Fahir; AKALIN, EMİN HALİS; BUDAK, FERAH; ORAL, HALUK BARBAROS; Tıp Fakültesi; Hemotoloji Ana Bilim Dalı; 0000-0001-7288-3250; 0000-0001-5334-7911; 0000-0001-8850-0269; 0000-0002-8856-7356; 0000-0003-1785-3539; 0000-0001-7530-1279; 0000-0001-7625-9148; 0000-0003-0463-6818; KHE-5423-2024; AAU-8952-2020; HKN-2347-2023; JGM-6601-2023; JFS-2013-2023; AAG-7381-2021; K-7285-2012; IZP-9398-2023; F-4657-2014; JWP-2738-2024; GYL-2038-2022; DWR-5356-2022; CXY-4200-2022; CPT-2053-2022; GDP-0005-2022; AAG-8459-2021; FQJ-3657-2022; FQG-8981-2022Publication Macrophage polarization capacity of peripheral blood monocytes and monocytic cell line THP-1 in response to secreted factors from COVID-19 patients(Wiley, 2021-08-01) Etgü, Onur; Karaçay, Mehmet; Dombaz, Fatma; Kızmaz, Muhammed Ali; Şimsek, Abdurrahman; Asan, Ali; Yılmaz, Emel; Kazak, Esra; Pınar, İbrahim Ethem; Bal, Salih Haldün; Özkocaman, Vildan; Özkalemkaş, Fahir; Akalın, Emin Halis; Budak, Ferah; Oral, Haluk Barbaros; Ermiş, Diğdem Yöyen; Etgü, Onur; Karaçay, Mehmet; Dombaz, Fatma; Kızmaz, Muhammed Ali; ŞİMŞEK, ABDURRAHMAN; YILMAZ, EMEL; KAZAK, ESRA; PINAR, İBRAHİM ETHEM; BAL, SALİH HALDUN; ÖZKOCAMAN, VİLDAN; ÖZKALEMKAŞ, FAHİR; AKALIN, EMİN HALİS; BUDAK, FERAH; ORAL, HALUK BARBAROS; YÖYEN ERMİŞ, DİĞDEM; Tıp Fakültesi; İmmünoloji Ana Bilim Dalı; 0000-0001-7288-3250; 0000-0001-5334-7911; 0000-0001-8850-0269; 0000-0002-8856-7356; 0000-0003-1785-3539; 0000-0001-9907-1498; 0000-0001-7530-1279; 0000-0001-7625-9148; 0000-0003-0463-6818; JIJ-1849-2023; JHB-7829-2023; DWR-5356-2022; HKN-2347-2023; AAG-7381-2021; GDP-0005-2022; AAG-8459-2021; JGM-6601-2023; KBR-5535-2024; FQG-8981-2022; JIW-1248-2023; AAU-8952-2020; IZP-9398-2023; K-7285-2012; GYL-2038-2022Publication Effector memory T cell subset CD45RA-CCR7-CD27-CD28- EM3 increases in direct proportion to the disease severity of COVID-19(Wiley, 2022-10-21) Kızmaz, Muhammed Ali; Şimşek, Abdurrahman; Bozkurt, Tuğçe; Çağan, Eren; Dombaz, Fatma; Tezcan, Gülçin; Asan, Ali; Demir, Halil Ibrahim; Bal, Salih Haldün; Ermiş, Diğdem Yöyen; Coşkun, Funda; Yılmaz, Emel; Oral, Haluk Barbaros; Budak, Ferah; Akalın, Emin Halis; Kızmaz, Muhammed Ali; ŞİMŞEK, ABDURRAHMAN; Bozkurt, Tuğçe; Dombaz, Fatma; TEZCAN, GÜLÇİN; Demir, Halil İbrahim; BAL, SALİH HALDUN; YÖYEN ERMİŞ, DİĞDEM; COŞKUN, NECMİYE FUNDA; YILMAZ, EMEL; ORAL, HALUK BARBAROS; BUDAK, FERAH; AKALIN, EMİN HALİS; Diş Hekimliği Fakültesi; Temel Bilimler Bölümü; 0000-0001-7625-9148 ; 0000-0003-3604-8826 ; 0000-0001-5871-8769 ; 0000-0002-5956-8755 ; 0000-0001-8850-0269 ; 0000-0001-5334-7911 ; HKN-2347-2023; AAG-7381-2021; KLE-8588-2024; DWR-5356-2022; AAH-3843-2020; ILG-9986-2023; HJY-9001-2023; AAH-3888-2021; AAD-1271-2019; GDP-0005-2022; K-7285-2012; IZP-9398-2023; IAT-2552-2023COVID-19, which emerged in December 2019 and continues to wreak havoc, has led to the death of many people around the world. In this study, we aimed to uncover the variables underlying the exacerbation of the disease by considering the changes in T cell subsets in adults and juveniles with different disease severity of COVID-19. Peripheral blood samples of 193 patients (128 adults and 65 juveniles) diagnosed with COVID-19 were evaluated in a flow cytometer, and a broad T cell profile was revealed by examining T cell subsets in terms of exhaustion and senescence. We found remarkable differences in the effector memory (EM; CD45RA(-)CCR7(-)) cell subsets of severe pneumonia cases. The frequencies of EM2 CD4(+) T, EM3 CD4(+) T, EM3 CD8(+) T, EM2 DN T and EM3 DN T cells were found to increase in severe pneumonia cases. Consistently, these cells were found in juveniles and uncomplicated adults in similar or lower proportions to healthy controls. The findings of our study provide a view of the T cell profile that may underlie differences in the course of COVID-19 cases in juveniles and adults and may provide new insights into the development of effective treatment strategies.Publication New biological markers in the diagnosis and follow-up of brucellosis(Wiley, 2021-08-01) Çagan, Eren; Kızmaz, Muhammed Ali; Şimşek, Abdurrahman; Akalın, Halis; Oral, Haluk Barbaros; Budak, Ferah; Çagan, Eren; Kızmaz, Muhammed Ali; ŞİMŞEK, ABDURRAHMAN; AKALIN, EMİN HALİS; ORAL, HALUK BARBAROS; BUDAK, FERAH; Tıp Fakültesi; Mikrobiyoloji ve Enfeksiyon Ana Bilim Dalı; 0000-0001-5334-7911; 0000-0001-8850-0269; 0000-0001-7530-1279; 0000-0003-0463-6818; 0000-0001-7625-9148; HJI-2036-2023; HKN-2347-2023; K-7285-2012; F-4657-2014; IZP-9398-2023; AAG-7381-2021; AAU-8952-2020Publication Investigation of IL-35 and IL-39, new members of the IL-12 family, in different clinical presentations of brucellosis(Taylor & Francis Inc, 2023-01-15) Ellergezen, Pınar Hız; Kızmaz, Muhammed Ali; Şimşek, Abdurrahman; Demir, Nesrin; Çağan, Eren; Bal, S. Haldun; Akalın, E. Halis; Oral, H. Barbaros; Budak, Ferah; Ellergezen, Pınar Hiz; Kızmaz, Muhammed Ali; ŞİMŞEK, ABDURRAHMAN; BAL, SALİH HALDUN; AKALIN, EMİN HALİS; ORAL, HALUK BARBAROS; BUDAK, FERAH; Sağlık Bilimleri Enstitüsü; İmmünoloji Bilim Dalı; 0000-0001-7625-9148; 0000-0001-5334-7911; 0000-0001-8850-0269; JFJ-7690-2023; HKN-2347-2023; AAG-7381-2021; HJY-9001-2023; AAU-8952-2020; K-7285-2012; IZP-9398-2023Brucellosis is significantly influenced by the interactions between the causative Brucella bacteria and host immunity. Recently identified cytokines have been described for their immunomodulatory effects in numerous inflammatory, autoimmune and infectious diseases. Some of them are new members of cytokine superfamilies, including several members of the IL-12 superfamily (IL-35, IL-39). The major purpose of the present study was to investigate the role of these new immunomodulatory cytokines in Brucella infections. The levels of IL-35 and IL-39 in the serum of 40 acute and 40 chronic brucellosis patients and 40 healthy controls were measured by ELISA. The mRNA levels of IL-35 and IL-39 in PBMCs were detected by RT-qPCR. Both IL-35 and IL-39 serum concentrations were significantly higher in healthy control subjects than in brucellosis patients, and IL-35 and IL-39 serum levels of chronic brucellosis patients were higher than those of acute cases. It was also found that the expression of Ebi3/IL-12A (IL-35 genes) and Ebi3/IL-23A (IL-39 genes) was upregulated in chronic brucellosis patients compared to healthy controls. Moreover, the expression of the Ebi3/IL-12A and Ebi3/IL-23A genes was lower in patients with acute brucellosis than in patients with chronic brucellosis. Overall, this study showed that IL-35 and IL-39 are positively correlated in brucellosis and significantly decreased during the disease. Significantly lower levels of IL-35 and IL-39 in acute brucellosis than in chronic brucellosis and healthy controls suggest that these cytokines may play a key role in suppressing the immune response to brucellosis and its progression to chronicity.