Person: KIRLI, SELÇUK
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KIRLI
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SELÇUK
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Publication A pilot study: Is belonging one of the effective factors for perception of cities?(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2020-06-01) Kirli Özer, Gözde; KIRLI ÖZER, GÖZDE; Cahantimur, Arzu; ÇAHANTİMUR, ARZU; Kırlı, Selçuk; KIRLI, SELÇUK; Bursa Uludağ Üniversitesi/Tıp Fakültesi; Bursa Uludağ Üniversitesi/Mimarlık Fakültesi; AAI-4727-2021; AAH-2742-2021Objective: The identification of the person develops when he/she can distinguish between himself/herself and other relevant persons, and it includes objects, some areas and places that he/she considers his/her own. Thus, place identity is a substructure of self-definition and consists mostly of what one perceives about the physical world in which she lives. In this sense, belonging can be considered as a common field of study psychology, psychiatry and architecture. This study is planned as the first pilot study of a multidisciplinary research series to determine; reflections of the human-place relationship on the selection process and behavior, the perceptions of people about the homeworlds and how changes and/or distortions in perceptions affect people's psychology, and the importance of these effects in terms of psychiatric disorders and what preventive/preventive practices may be. Methods: In order to determine whether the sense of belonging is effective in the perception of a city or not, to measure the current perception of the city, a field study was conducted with the secondary school and undergraduate students who lived in Bursa but had never seen the Iznik before. On a day trip with two groups of students, the city of Iznik was visited by foot on a specific route. At the end of the trip, mental (cognitive) maps were obtained from students about their perception of the city, and then a 12-item General Belonging Scale was applied. Afterwards, the structures which were drawn on the maps and other symbolic elements were grouped as Ottoman, and Roman/Byzantine structures and the dominant preferences were determined for each subject. Conclusion: By comparing the characteristics of these preferences in terms of high and low belonging students' groups, it is concluded that belongingness is an essential factor in the perception of the city.Publication Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features(Sage Publications Ltd, 2012-04-01) Kotan, Zeynep; Sarandöl, Emre; Kırhan, Emine; Özkaya, Güven; Kırlı, Selçuk; SARANDÖL, EMRE; Kırhan, Emine; ÖZKAYA, GÜVEN; KIRLI, SELÇUK; Uludağ Üniversite/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversite/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversite/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; 0000-0003-0297-846X; A-4421-2016; ABE-1716-2020; DBC-8927-2022; CZU-1387-2022Objective: Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and leptin have been hypothesized to be involved in the neurobiology of depression. The aim of this study was to investigate BDNF, VEGF and leptin levels in patients with severe melancholic depression. Methods: A total of 40 drug-free patients with major depressive disorder (MDD) with melancholic features and 40 healthy controls were included in the study. Demographic information, psychiatric evaluation and physical examination were documented for both groups. Serum BDNF, VEGF levels were determined by enzyme-linked immunosorbent assay and leptin with radioimmunoassay methods. The Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were applied to the patients. Results: There were no significant differences in serum BDNF, VEGF and leptin levels between the patient and control groups. There was a negative correlation between BDNF levels and the number of depressive episodes. It was noted that VEGF levels decreased with increasing severity of depression. Conclusions: These findings suggest that BDNF levels might be associated with the recurrence of depression and VEGF levels might be a determinant of the severity of depression.Publication Illicit drug related crime profile in Bursa between the years 1974-2003(Yare Yayınevi, 2006-01-01) Akkaya, Cengiz; Akgöz, Semra; Kotan, Zeynep; Kaya, Berrin; Kırlı, Selçuk; AKKAYA, CENGİZ; Akgöz, Semra; Kotan, Zeynep; Kaya, Berrin; KIRLI, SELÇUK; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; EKJ-8427-2022; EKV-4953-2022; FGI-0597-2022; IDX-3542-2023; CZU-1387-2022Objective: It was aimed in this study to draw the illicit drug profile of our region by collecting the data of the last 30 years regarding the illicit drug related crimes in Bursa and its vicinity.Method: The universe of the study comprised of drug related crime facts (crime fact is the drug related crime committed by a criminal who is arrested by the narcotic bureau) in the archives of Narcotic Bureau of Bursa Police Department between the years 1974-2003. A special form was prepared for the study and this form was completed for each registered drugs crime fact.Results: In the result of criminal record screening, 3.664 drug related crime facts were analyzed. The average age of drug production crime was significantly higher than the average age of dealing, possession and using drug crimes. Ratio of males was higher in the total of each crime type. 53,5% of drug related crimes committed by females and 35,1% of drug related crimes committed by males was associated with dealing crimes. A statistically significant difference was found between the distribution of the type of drugs and the type of crime.Discussion and Conclusion: It was found out that the majority of drug related crimes are committed by males with a lower socio-cultural and economical level, who are young or in their mids, born and living in Bursa, and that the committed drug related crimes are to a very great extent associated with cannabis.Publication The efficacy of flupenthixol decanoate in bipolar disorder patients who have no sufficient remission with existing treatments(Cumhuriyet Üniversitesi Tıp Fak Psikiyatri Anabilim Dalı, 2015-10-01) Eker, Salih Saygın; Akkaya, Cengiz; Pirinçci, Erdal; Cangür, Şengül; Kırlı, Selçuk; EKER, SALİH SAYGIN; AKKAYA, CENGİZ; Pirinçci, Erdal; KIRLI, SELÇUK; Uludağ Üniversitesi/Tıp Fakültesi/Ruh Sağlığı ve Hastalıkları Anabilim Dalı; Q-9477-2019; EKJ-8427-2022; FVU-0359-2022; CZU-1387-2022Objective: It is aimed to evaluate the prophylactic effect of flupenthixol decanoate in remitted BD patients. Methods: Remitted patients with bipolar disorder (BD), who had at least one mood episode each year in the last five years in spite of adequate pharmacotherapy, were included. Flupenthixol decanoate 20 mg/ml was administered in every two weeks. Hamilton Depression Rating Scale (HDRS), Young Mania Rating Scale (YMRS), Bipolar Disorder Functioning Questionnaire (BDFQ), General Assessment of Functionality (GAF) and Side Effect Rating Scale (UKU) were applied. Patients were followed up for 12 months. Results: Eight patients with a mean age of 34.7 +/- 7.5 were enrolled to the study. None of the patients were under monotherapy before the study enrollment. Three (37.5%) of the three patients were dropped out. The data of remaining 5 patients' were evaluated. At the end of the study mean number of mood episodes declined to 0.2 +/- 0.4 per year indicating a statistical significance and the mean score of BDFQ declined to 119.6 +/- 2.7. Conclusions: Flupenthixol decanoate significantly improved functionality and decreased the number of mood episodes allowing an alternative treatment even in remitted BD patients.Publication The burden of urinary incontinence on caregivers and evaluation of its impact on their emotional status(Aves, 2021-01-01) Kırlı, Elif Altınay; Türk, Şeyda; Kırlı, Selçuk; TÜRK, ŞEYDA; KIRLI, SELÇUK; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı; GFL-4528-2022; CZU-1387-2022Objective: This study aimed to evaluate caregivers of children with urinary incontinence in terms of the caregiving burden and its associated manifestations.Methods: Caregivers of children who are being treated for urinary incontinence secondary to neurogenic and non-neurogenic lower urinary tract dysfunction (LUTD) were evaluated for caregiver burden (Zarit score), depression (Beck Depression Inventory [BDI]), and anxiety (Beck Anxiety Inventory [BAI]). Additionally, children were evaluated for dysfunctional voiding score. All scores were statistically analyzed for correlation with and relation to the caregiver's emotional status.Results: Zarit score was equal in caregivers of children with neurogenic and non-neurogenic LUTD. BDI score was higher in caregivers of patients with neurogenic LUTD, whereas BAI score was higher in caregivers of patients with non-neurogenic LUTD. In the evaluation performed, considering the etiological difference, Zarit score in the group with non-neurogenic LUTD correlated positively with BAI and BDI scores. In the neurogenic bladder group, Zarit score correlated with BDI score.Conclusion: It is important not only in psychiatric patients, but also in those with other chronic disease processes, to evaluate the mental status of caregivers and to support them in dealing with the problem.Publication Epworth sleepiness scale and polysomnographic evaluation of dysthymic women with chronic insomnia(Turkish Neurological Soc, 2010-01-01) BİCAN DEMİR, AYLİN; Bican, Aylin; Kotan, Ozan Vahap; Bora, Ibrahim; BORA, İBRAHİM HAKKI; Akkaya, Cengiz; AKKAYA, CENGİZ; Carkungöz, Ender; UZABACI, ENDER; Kırlı, Selçuk; KIRLI, SELÇUK; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pskiyatri Anabilim Dalı.Objective: In patients with dysthymic disorder (DD), sleep problems are assessed as a part of their depressive state, and different treatable conditions, such as other primary sleep disorders, are often skipped. We aimed to determine symptoms related to daytime sleepiness and polysomnographic findings in dysthymic women with chronic insomnia and to find out whether or not there is an accompanying sleep disorder. We suggest that pathologies that can lead to sleep problems in dysthymic patients should be searched, and to this end, application of the Epworth sleepiness scale (ESS) and polysomnography examination should be used much more frequently.Patients and Methods: We included 20 female dysthymic patients with complaints of chronic sleep problems who had been under follow-up at Uludag University Hospital Psychiatry Outpatient Clinic for at least the last two years. Twenty healthy female volunteers, aged 18-65 years, were included in the study as the control group. ESS and polysomnography examination were applied in all patients.Results: When patients with DD and healthy controls were compared, significant differences in ESS scores and ratios of sleep phases were determined between groups. DD patients had higher ESS scores and higher ratios of rapid eye movements (REM), non-REM-1 (Stage 1), non-REM-2 (Stage 2) phases and lower ratios of slow wave sleep (Stage 3 + Stage 4).Conclusion: The findings of our study suggest that there are structural sleep changes in dysthymic patients, but no direct connection between sleep variables and depressive states is evident.Publication Comparison of effects of sertraline and reboxetine on the loss of social functioning in major depressive disorder: A randomized, open-labeled study(Kare Yayınevi, 2006-01-01) Akkaya, Cengiz; Sivrioğlu, E. Yusuf; Sarandöl, Aslı; Eker, S. Saygın; Kırlı, Selçuk; AKKAYA, CENGİZ; SİVRİOĞLU, ENVER YUSUF; SARANDÖL, ASLI; EKER, SALİH SAYGIN; KIRLI, SELÇUK; Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; Q-9477-2019; EKJ-8427-2022; GBQ-8020-2022; FTX-6743-2022; CZU-1387-2022Objective: In this study we aimed to compare the effects of sertraline and reboxetine, which are influential on two different neurotransmitters, on social functioning.Method: 41 patients conforming to the study protocol and who met DSM-IV MDD diagnostic criteria were recruited for the study. These subjects were distributed randomly into two groups, sertraline and reboxetine. The subjects were assessed six times during the study which lasted 11 weeks. At each assessment the subjects were asked to complete "Hamilton Depression Rating Scale" (HDRS), "Montgomery-Asberg Depression Rating Scale" (MADRS) and "Social Adaptation Self-evaluation Scale (SASS).Results: In both groups, the decrease in HDRS and MADRS scores was found to be statistically significant starting from the 2nd visit, compared to the values prior to medication. The decrease in SASS scores, on the other hand, was significant starting from the 3rd visit. In comparison of reboxetine and sertraline groups, HDRS scores were found to be significantly higher in the reboxetine group in visits 2, 3, and 4. However, no significant difference was found in MADRS and SASS scores.Discussion and Conclusion: In this study two antidepressants which create a selective effect via serotonin and noradrenalin were compared and it was found that clinically an earlier response and remission was provided with reboxetine. Nevertheless, it is notable that there was no statistically significant difference on their social functioning levels.Publication Bipolar disorder with thrombophilia: A case report of possible association(Universitatsverlag Ulm Gmbh, 2008-01-01) Akkaya, Cengiz; AKKAYA, CENGİZ; Taşkapılıoğlu, Özlem; Gündüz, Cem; Seferoğlu, Meral; Hakyemez, Bahattin; HAKYEMEZ, BAHATTİN; Kırlı, Selcuk; KIRLI, SELÇUK; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0003-4436-3797; 0000-0003-3858-0306; AAI-2318-2021; AAK-6623-2020A 26-year-old female who had an 8-year history of BD was hospitalized due to manic episode. Because of the ischemic lesions on the cranial resonance imaging and pyramidal tractus signs in the neurological examination, a comprehensive etiologic diagnostic work-up including consultation of the patient by the Rheumatology Department for the differential diagnosis of vasculitis was suggested by the consultant neurologist. Abnormal findings were heterozygotic fVL and MTHFR mutations and decreased Protein S level. Because of positive test results for thrombophilia factors, the Hematology Department consulted the patient and put her on acetylsalicylic acid 100 mg/day treatment. To our knowledge, this is a singular report of a case which suggests an association between thrombophilia, stroke, and BD. But answers to questions "Is BD caused by silent stroke?" and "Does silent stroke complicate the clinical picture of this patient?" in this case are not straightforward and confusing. It should be kept in mind that human being is a biopsychosocial entity. The patients should be evaluated globally not to stick on their signs only. This will result in the exact diagnosis of the patients providing them with accurate treatment that improves their quality of life.Publication Metabolic, endocrinologic and cardiac effects of amisulpride: A 24-week follow-up study(Sage Publications Ltd, 2011-12-01) Kotan, Zeynep; Ertepe, Berrin; Akkaya, Cengiz; SARANDÖL, EMRE; AKKAYA, CENGİZ; Sarandöl, Emre; Özkaya, Güven; ÖZKAYA, GÜVEN; Kirli, Selçuk; KIRLI, SELÇUK; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-0297-846X; A-4421-2016; ABE-1716-2020Background: Amisulpride is a second-generation antipsychotic which has been proved to be effective in the control of both positive and negative symptoms of schizophrenia. In this study we aimed to determine metabolic, endocrinologic and cardiac effects of amisulpride commonly used in our clinical practice.Methods: A total of 18 patients (11 males, 7 females) diagnosed with schizophrenia received amisulpride at the dosage of 800 mg/day and were followed up for 24 weeks. Positive and negative psychotic symptoms, extrapyramidal and sexual side effects, metabolic, endocrinologic and cardiac parameters were evaluated at regular intervals.Results: Significant improvement in both positive and negative symptoms was observed in patients starting from the second week of treatment. Prolactin levels increased significantly both in men and women starting from the measurement on day 4. Prolactin elevation was significantly higher in women than in men. Increase in total cholesterol level became significant at week 24. No other significant difference was observed between weeks 1 and 24 regarding the other parameters.Conclusions: The clinical data from the present study supports the fact that amisulpride is an effective and safe antipsychotic drug, but elevates prolactin levels in both sexes.