Person: YENİGÜL, ALİ ERKAN
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YENİGÜL
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ALİ ERKAN
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Publication Effect of bone morphogenic protein-2 and desferoxamine on distraction osteogenesis(Elsevier Sci Ltd, 2022-05-25) Kalay, Emre; ERMUTLU, CENK; YENİGÜL, ALİ ERKAN; Yenigül, Ali Erkan; Yalçınkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Sarısözen, Bartu; SARISÖZEN, MEHMET BARTU; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0003-4071-8052; ACP-2755-2022; AFH-1678-2022; ABI-7283-2020; AEQ-5464-2022Background: Angiogenesis is crucial for formation of a stable regenerate during distraction osteogenesis (DO). This experimental study evaluates if bone morphogenic protein-2 (BMP-2) and desferrioxamine (DFO), two agents which are known to induce neoangiogenesis in vivo , would increase angiogenesis and osteogenesis, and improve mechanical properties of bone regenerate in DO model. Methods: Twenty-four tibias of 24 New Zealand rabbits were osteotomized and fixed with semi-circular fixators. Three groups of 8 animals were formed. BMP-2 soaked scaffolds were used in the first group, whereas daily local DFO injections were made in the second group. Subjects in the control group did not receive any agents during the surgery or in the distraction period. The rabbits in all three groups underwent distraction at a rate of 0.6 mm/day for 15 days following the 7-day latent period. Animals were sacrificed on day 38, and the tibia were harvested for histological and mechanical examination of the regenerate. Results: All 24 rabbits survived the surgical procedure, and there were no side effects against the BMP-2 and local DFO. Three-point bending tests revealed a higher force (361 +/- 267 N.) required for fracture in Group 1 ( p : 0.018). Similarly, the bending moment in Group 1 (5.4 +/- 4.0 Nmm) was significantly higher than the other groups ( p : 0.021). There was no significant difference between the groups in terms of deflection and stiffness ( p > 0.05). Histologically, there was no statistical difference between the groups in terms of endochondral, periosteal, and intramembranous ossification and VEGF activity ( p > 0.05). Conclusion: BMP-2 and DFO stimulate angiogenesis by increasing VEGF activity. Angiogenesis is one of the most important mechanisms for the initiation and maintenance of new bone formation. Stimulation of angiogenesis in unfavorable biomechanical conditions may not be sufficient for ideal bone formation.Publication Treatment of locally aggressive benign bone tumors by means of extended intralesional curettage without chemical adjuvants(Sage Publications Inc, 2022-04-22) Yenigül, Ali Erkan; Sofulu, Ömer; Erol, Bülent; YENİGÜL, ALİ ERKAN; Tıp Fakültesi; Ortopedi ve Travmatoloji Ana Bilim Dalı; ACP-2755-2022Objectives: The aim of this study is to present the clinical, oncological, and functional results of locally aggressive benign bone tumors treated with extended intralesional curettage without the use of adjuvant in a tertiary orthopedic oncology center.Method: A total of 172 patients treated with surgical curettage and high-speed burrs for the diagnosis of aneurysmal bone cyst, giant cell tumor, osteoblastoma, chondroblastoma, and chondromyxoid fibroma were included in the study. Demographic, radiological, and clinical data of the patients were analyzed.Results: One-hundred seventy two patients (101 (59%) female and 71 (41 %) male) with a mean age of 23 years (6-84). The mean follow-up period was 48 months (18-108). In the study, a total of 8 (4.6%) patients had postoperative complications, 17 (9.9%) patients had recurrence in the postoperative period. Diameter greater than 5cm was found to be a risk factor for recurrence (p < 0.004). The probability of developing complications was found to be significantly higher in patients with recurrence (p < 0.001). There was no significant relationship between recurrence and age, tumor type, and tumor stage.Conclusion: Successful treatment results can be obtained with extended surgical curettage, high-speed burr, and cauterization without the use of chemical adjuvants in locally aggressive bone tumors.Publication Outcomes of cable fixation after vancouver type b1 periprosthetic femoral fractures(Turkish Assoc Trauma Emergency Surgery, 2023-11-01) Yenigül, Ali Erkan; Ermutlu, Cenk; Önder, Cem; Atıcı, Teoman; Durak, Kemal; YENİGÜL, ALİ ERKAN; ERMUTLU, CENK; ÖNDER, CEM; ATICI, TEOMAN; DURAK, KEMAL; Tıp Fakültesi; Ortopedi ve Travmatoloji Ana Bilim Dalı; 0000-0002-3396-3407; 0000-0002-8289-8867; AFH-1678-2022; A-5095-2018; AEQ-5464-2022; JKS-7654-2023; COU-4147-2022BACKGROUND: In this study, it was aimed to evaluate the patients who underwent cable plate fixation due to a Vancouver-type B1 periprosthetic femur fracture and their clinical results.METHODS: Vancouver-type B1 patients who were operated on for periprosthetic fractures between 2014 and 2019 were investigated. Age, gender, body mass index (BMI), follow-up time, operation time, bleeding amount, non-union fracture, last surgery before fracture, the time between previous surgery and fracture, implant survival, patient survival, and complications were recorded. In addition, the postoperative clinical functions of these patients were compared. RESULTS: 23 patients who met the study criteria (Vancouver type B1 fracture) were identified. The mean age of the patients was 60 (49-76) years, the mean BMI was 26.3 (17.5-40.7), and the postoperative mean follow-up period was 14 (6-36) months. Considering the gender distribution, there were 5 (22%) men and 18 (78%) women. The mean time between the last surgery before the fracture and the fracture was 6 months (0-30). While the mean operation time was 95 min (60-180), the average amount of bleeding was 310 mL (150-600). Functional evaluations of patients: In total, five patients had decreased ambulatory abilities after surgery. Nonunion was observed in 2 patients during the follow-ups, and these patients underwent open surgery for treatment.CONCLUSION: Cable and locking plate applications are successful in Vancouver type B1 fractures, which are one of the most common forms of periprosthetic fractures. In this technique, the duration of the operation can be shortened under ideal conditions, and the need for blood and blood products is reduced as blood loss is reduced. If there is a complication, you still have the chance to treat it with the option of revision arthroplasty.Publication Comparison of patients undergoing revision total hip arthroplasty and patients undergoing re-revision(Verduci Publisher, 2023-01-01) Yenigül, A. E.; Dikici, A. E.; Eken, G.; Bilgen, M. S.; YENİGÜL, ALİ ERKAN; DİKİCİ, ALPER EMRE; EKEN, GÖKAY; BİLGEN, MÜHAMMET SADIK; Tıp Fakültesi; Ortobedi ve Travmatoloji Ana Bilim Dalı; ABE-9918-2021; IXN-8544-2023; AFH-1678-2022; ACP-2755-2022- OBJECTIVE: The aim of this study is to compare the demographic, clini-cal, and surgical characteristics of patients who underwent revision hip replacement sur-gery and those who underwent re-revision sur-gery. The secondary outcome is the investiga-tion of the factors that play a role in estimating the time between primary arthroplasty surgery and revision surgery.PATIENTS AND METHODS: The patients who underwent revision hip arthroplasty in our clinic between 2010-2020, patients with at least 2 years of follow-up, and who underwent re-revision surgery if needed were included. Demographic and clinical data were investigated. RESULTS: Of the 153 patients who met the study criteria, 120 (78.5%) underwent revision (Group 1) and 33 (21.5%) underwent re -revi-sion (Group 2). The mean age of Group 1 was 53.5 (32-85), and of Group 2 was 67 (38-81) (p=0.003). In both groups, patients who un-derwent hip replacement due to fracture had more revisions and re-revisions (p=0.794). While 53.3 of the patients in Group 1 did not need additional implants, 72.7% of the pa-tients in Group 2 needed additional implants (p=0.010). Fracture-dislocation, fistula, and the need for debridement after the revision were statistically significantly higher in pa-tients who underwent re-revision. Harris hip scores (HHS) were statistically lower in pa-tients who went for re-revision. CONCLUSIONS: The need for reoperation in patients who have undergone revision total hip arthroplasty (THA) surgery is due to the fact that the patient's age is advanced and the indi- cation for surgery is a fracture. While the rate of fistula, fracture, dislocation, and debride- ment increases after re-revision surgeries, the HHS values that indicate clinical success also decrease. We believe that studies with larger participation and longer follow-up periods are needed to explain this issue better.