Person: ÖZDEMİR, BÜLENT
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ÖZDEMİR
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BÜLENT
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Publication A family with IgA nephropathy and hereditary lymphoedema praecox(Wiley, 2002-05-01) Usta, M; Dilek, Kamil; Ersoy, Ahmet; Alper, E; Özbek, Serhat; Özdemir, Bülent; Filiz, G; Yavuz, M; Güllülü, Mustafa; Yurtkuran, Merih; Usta, M; DİLEK, KAMİL; Ersoy, Ahmet; Alper, E; ÖZBEK, SERHAT; ÖZDEMİR, BÜLENT; Filiz, G; Yavuz, M; GÜLLÜLÜ, MUSTAFA; Yurtkuran, Merih; Uludağ Üniversitesi Tıp Fakültesi; Nefroloji Bölümü; 0000-0003-3427-8337; 0009-0001-9179-9107; HYD-3798-2023; CNY-9323-2022; GXG-1656-2022; CCY-8570-2022; FTG-3544-2022; JHE-3353-2023; EVQ-8652-2022; HJG-9929-2022; JGS-9425-2023; GLB-5791-2022Immunoglobulin A (IgA) nephropathy is the most common primary glomerulonephritis worldwide. The pathogenesis is still unknown and treatment has not yet been established. Rarely it can be associated with other disorders. Its association with hereditary lymphoedema is not reported before. We report four patients, a 60-year-old father, his two sons and his daughter, with hereditary lymphoedema. The family had nine members and in four of them lymphoedema was evident. The other members had neither lymphoedema nor IgA nephropathy. This is the first report of IgA nephropathy in association with hereditary lymphoedema.Publication Association of aortic diameters with coronary artery disease severity and albumin excretion(Hindawi, 2015-04-08) Özdemir, Bülent; Emul, Ali; Özdemir, Levent; Sağ, Saim; Biçer, Murat; Aydınlar, Ali; ÖZDEMİR, BÜLENT; Sağ, Saim; BİÇER, MURAT; AYDINLAR, ALİ; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; 0000-0002-8974-8837; 0000-0001-8404-8252; AAW-9185-2020; ABC-2231-2020; AAI-6632-2021; JHE-3353-2023Introduction. Aortic diameters, aortic distensibility, microalbuminuria, coronary artery disease which are all together related to vascular aging are investigated in this paper. Methods. Eighty consecutive nondiabetic patients undergoing elective coronary angiography were enrolled into the study. Systolic and diastolic aortic diameters, aortic distensibility, CAD severity by angiogram with the use of Gensini scoring, and albumin excretion rates were determined. Results. Cases with CAD had significantly larger systolic (30,72 +/- 3,21mm versus 34,19 +/- 4,03 mm for cases without and with CAD, resp.) and diastolic aortic diameters measured 3 cm above aortic valve compared to patients without CAD (33,56 +/- 4,07 mm versus 29,75 +/- 3,12 mm). The systolic and diastolic diameters were significantly higher in albuminuria positive patients compared to albuminuria negative patients (p = 0.017 and 0.008, resp., for systolic and diastolic diameters). Conclusion. In conclusion aortic diameters are increased in patients with coronary artery disease and in patients with microalbuminuria. In CAD patients, systolic blood pressure, pulse pressure, aortic systolic and diastolic pressure, and albumin excretion rate were higher and aortic distensibility was lower.Publication Coronary risk factors and coronary angiography results of 12.257 patients(Elsevier, 2013-10-29) Günay, Şeyda; Serdar, Osman Akın; Özyılmaz, Sinem Özbay; Dereli, Seçkin; Aydınlar, Ali; Baran, İbrahim; Özdemir, Bülent; Yeşilbursa, Dilek; Güllülü, Sümeyye; GÜNAY POLATKAN, ŞEYDA; SERDAR, OSMAN AKIN; Özyılmaz, Sinem Özbay; Dereli, Seçkin; AYDINLAR, ALİ; Baran, İbrahim; ÖZDEMİR, BÜLENT; YEŞİLBURSA, DİLEK; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; 0000-0003-1744-8883; 0000-0002-7788-9739; 0000-0003-0090-3835; AAF-5116-2019; AAG-8709-2020; AAI-5350-2021; AAI-6632-2021; AAJ-3962-2020; AAB-5861-2021; CDA-1396-2022; JHE-3353-2023; EHA-0046-2022; JGR-6552-2023Publication Effects of origanum onites on endothelial function and serum biochemical markers in hyperlipidaemic patients(Sage Publications Ltd, 2008-11-01) Özdemir, Bülent; Ekbul, Adem; Topal, N. B.; Sarandöl, E.; Sağ, S.; Başer, K. H. C.; Cordan, J.; Güllülü, S.; Tuncel, E.; Baran, I.; Aydınlar, A.; ÖZDEMİR, BÜLENT; Ekbul, Adem; Topal, N. B.; SARANDÖL, EMRE; Sağ, S.; Cordan, J.; Güllülü, S.; Tuncel, E.; Baran, I.; Aydınlar, A.; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; 0000-0003-2710-0231; 0000-0002-2593-7196; 0000-0002-8974-8837; ABE-1716-2020; AAI-6632-2021; JGV-9775-2023; COV-8886-2022; ECS-3439-2022; FVJ-4207-2022; CMF-6002-2022; JGR-6552-2023; EBN-7188-2022; CDA-1396-2022The effects of Origanum onites on endothelial function and antioxidative status were investigated in 48 patients with mild hyperlipidaemia who required no drug therapy. All participants were given lifestyle and low-fat dietary advice, however 32 of the patients (study group) were also prescribed 25 ml of aqueous distillate of Origanum onites to be taken after each meal for 3 months. The remaining 16 patients were the control group. Various biochemical markers and endothelial function parameters were measured at baseline and after 3 months. A significantly greater increase in high density lipoprotein-cholesterol and significantly greater decreases in low density lipoprotein-cholesterol, apolipoprotein B, lipoprotein(a) and high-sensitivity C-reactive protein occurred in the study group compared with the control group over the 3-month study period. Paraoxonase and arylesterase activities, and flow- and nitroglycerine-mediated dilatation of the brachial artery showed significantly greater increases in the study group compared with the changes in the control group. In conclusion, consumption of Origanum onites distillate had beneficial effects on lipid profiles, antioxidant status and endothelial function in patients with mild hyperlipidaemia.Publication Dislodgement of a sirolimus-eluting stent in the circumflex artery and its successful deployment with a small-balloon technique(Turkish Soc Cardiology, 2011-07-01) Şentürk, Tunay; YEŞİLBURSA, DİLEK; ŞENTÜRK, TUNAY; ÖZDEMİR, BÜLENT; Özdemir, Bülent; Serdar, Osman Akın; SERDAR, OSMAN AKIN; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; 0000-0003-1744-8883; AAF-5116-2019; C-1517-2017Coronary stent dislodgement or embolization before deployment is a rare but serious complication in interventional cardiology. A 60-year-old male presented with unstable angina five years after coronary artery bypass surgery. There was a stenosis (70%) in the obtuse marginal branch of the circumflex artery. During percutaneous coronary intervention, a sirolimus-eluting stent was stripped from its balloon mainly because of significant proximal angulation and incarcerated within the proximal circumflex artery. A smaller balloon dilatation catheter was advanced and pushed through the inside of the slipped stent. Using this technique, the stent could be advanced into the lesion and was successfully deployed. To our knowledge, this is the first case report on sirolimus-eluting stent dislodgement.Publication A comparison of percutaneous and mini-open techniques of Achilles tenotomy: An experimental study in rats(British Editorial Soc Bone Joint Surgery, 2009-12-01) Doğan, Ahmet; Uzumcugil, Onat; Sarısözen, Bartu; Özdemir, Bülent; Akman, Y. Emre; Bozdağ, Ergün; Sunbuloğlu, Emin; Bozkurt, Erol; SARISÖZEN, MEHMET BARTU; ÖZDEMİR, BÜLENT; Tıp Fakültesi; Ortopedi ve Travmatoloji Kliniği; 0000-0003-4071-8052; FVC-9695-2022; ABI-7283-2020Purpose To investigate the effect of Achilles tenotomy performed percutaneously and by mini-open methods on tendon healing and final strength.Materials and methods In two groups, each consisting of 14 rats, percutaneous and mini-open techniques in Achilles tenotomy were compared in terms of biomechanical, histological and gross properties.Results In the gross evaluation, it was observed that an obvious thickening and adhesion to the subcutaneous tissue of the healing tendon were observed in nearly all rats in which the mini-open technique was performed. In the biomechanical analysis, there was no significant difference between percutaneous and mini-open groups and between operated and intact Achilles tendons in both groups, in terms of tendon strength (P > 0.05). In the histological evaluation, irregularity in the parallel pattern of the collagen fibres, emergence of a non-specific collagenous tissue formation and infiltration of mild mononuclear inflammatory cells were reported. These changes were more marked in the rats in which the percutaneous technique was performed.Conclusion Mini-open technique for Achilles tenotomy may be considered as an alternative method of treatment to apply the tenotomy technique in a secure way. Clinical relevance There are two basic advantages of Achilles tenotomy performed by the mini-incision open technique: (1) a complete tenotomy is guaranteed, as it has to be in the original Ponseti technique, (2) iatrogenic neuro-vascular injury risk is nearly completely avoided due to the subparatenon exploration of the tendon and direct visual observation during the transection. The mini-open technique may only be used in cases in which a vascular compromise is clinically suspected or confirmed by Doppler ultrasonography and/or arteriography. On the other hand, the technique may be performed in all cases routinely by the choice of the surgeon.Publication Serum fetuin-a levels for the detection and evaluation of the left ventricular systolic heart failure(Elsevier, 2013-10-29) Keçebaş, Mesut; Güllülü, Sümeyye; Sağ, Saim; Açıkgöz, Ebru; Besli, Feyzullah; Şentürk, Tunay; Kaderli, Aysel Aydın; Özdemir, Bülent; Baran, İbrahim; Sarandöl, Emre; Aydınlar, Ali; Keçebaş, Mesut; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Sağ, Saim; Açıkgöz, Ebru; Besli, Feyzullah; ŞENTÜRK, TUNAY; Kaderli, Aysel Aydın; ÖZDEMİR, BÜLENT; Baran, İbrahim; SARANDÖL, EMRE; AYDINLAR, ALİ; Tıp Fakültesi; Biyokimya Ana Bilim Dalı; 0000-0002-6206-8700; C-1517-2017; ABE-1716-2020; AAW-9185-2020; AAI-6632-2021; JKQ-3658-2023; JGR-6552-2023; CBS-6076-2022; DXE-4816-2022; CXL-7581-2022; JHE-3353-2023; CDA-1396-2022Publication Attitudes of smoking and knowledge about substances in cigarette smoke in university students(Scibulcom, 2015-01-01) Özdemir, A.; Utkualp, N.; Özdemir, B.; Özdemir, L.; ÖZDEMİR, AYSEL; UTKUALP, NEVİN; ÖZDEMİR, BÜLENT; ÖZDEMİR, LEVENT; Tıp Fakültesi; Halk Sağlığı Hemşireliği Bölümü; 0000-0002-0815-9505; 0000-0002-4330-8334; AAJ-1202-2021; C-7487-2018; AAC-9352-2021; FRF-3343-2022Smoking is a worldwide problem causing significant mortality. Due to the complications occurring later in life giving up is not intended for many users. Media, environment, family, friends, and cultural factors are effective in the onset and prolongation of this habit.In this study we aimed to determine the knowledge level of 188 students of the Institute of Health Sciences who gave informed consent and participated in the study. We gathered data with a questionnaire form and asked questions related to the diseases proven to be caused by smoking and the substances in the cigarette smoke. We used the Fagerstrom Nicotine Dependence Test to evaluate the nicotine dependence status of smoking students. The mean age of the students was 20.49 +/- 1.19 and the number of females was 144 (76.6%). The mean age of onset of smoking and alcohol consumption was 17.04 +/- 2.13 and 17.06 +/- 2.34, respectively. Overall rate of smoking was 11.7% (n = 22) and in females and males 7.6 and 25.0%, respectively (p < 0.003).It was concluded that the smoking rate in students of the Institute of Health Sciences is high, particularly in male students. The knowledge of substances in cigarette smoke did not affect the smoking pattern of students.Publication Association between blood pressure, inflammation and spirometry parameters in chronic obstructive pulmonary disease(Korean Assoc Internal Medicine, 2019-01-01) Arslan, Sülhattin; Yıldız, Gürsel; Özdemir, Levent; Kaysoydu, Erdal; Özdemir, Bülent; ÖZDEMİR, BÜLENT; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; JHE-3353-2023Background/Aims: Many systems including the cardiovascular system (ischemic heart diseases, heart failure, and hypertension) may act as comorbidities that can be seen during the course of chronic obstructive pulmonary disease (COPD). Comorbidities affect the severity and prognosis of COPD negatively. Nearly 25% of patients with COPD die due to cardiovascular diseases. In this study, we aimed to evaluate the relationship between the blood pressure, inflammation, hypoxia, hypercapnia, and the severity of airway obstruction.Methods: We included 75 COPD patients in the study with 45 control cases. We evaluated age, sex, body mass index, smoking history, C-reactive protein levels, 24-hour ambulatory blood pressure Holter monitoring, arterial blood gas, and respiratory function tests of the patient and the control groups.Results: In COPD patients, the night time systolic, diastolic blood pressures and pulse per minute and the mean blood pressures readings were significantly elevated compared to the control group (p < 0.05). In the correlation analysis, night time systolic pressure was associated with all the parameters except forced expiratory volume in 1 second (FEV1%). Diastolic blood pressure was associated with pH and HCO3 levels. The mean night time, day time pulse pressures and 24-hour pulse per minute values were also associated with all the parameters except FEV1%.Conclusions: In this study we found that parameters of systolic and diastolic blood pressures and pulse pressures were significantly elevated in COPD patients compared to the control groups. Blood pressure was associated blood gas parameters and inflammation parameters in COPD patients. This, in turn, may cause understanding of the pathophysiology of COPD and its complications.Publication Use of tolvaptan in patients hospitalized for worsening chronic heart failure with severe hyponatremia: The initial experience at a single-center in Turkey(Kare Yayınevi, 2017-07-01) Sağ, Saim; Kaderli, Aysel Aydın; Yıldız, Abdülmecit; Gül, Bülent Cuma; Özdemir, Bülent; Baran, İbrahim; Güllülü, Sümeyye; Aydınlar, Ali; Çavuşoğlu, Yüksel; Sağ, Saim; Kaderli, Aysel Aydın; YILDIZ, ABDULMECİT; GÜL, CUMA BÜLENT; ÖZDEMİR, BÜLENT; Baran, İbrahim; GÜLLÜLÜ, NAZMİYE SÜMEYYE; AYDINLAR, ALİ; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; AAI-6632-2021; AAW-9185-2020; A-7063-2018; CXL-7581-2022; HIG-9032-2022; JHE-3353-2023; CDA-1396-2022; JGR-6552-2023Objective: The aim of the present study was to assess the efficacy and safety of tolvaptan for severe hyponatremia (SH) in hypervolemic heart failure (HF) patients within daily clinical practice.Methods: We restrospectively reviewed our database on tolvaptan as an add-on treatment in hypervolemic patients admitted to our clinic due to deterioration of HF and having hyponatremia resistant to standard therapy. Severe hyponatremia was defined as serum sodium concentration <= 125 mEq/L. The database included demographic, clinical, laboratory, and echocardiographic findings on admission, and numerous outcome measures for oral tolvaptan treatment were used to assess its efficacy and safety.Results: The study group consisted of 56 hypervolemic HF patients with severe hyponatremia (25 female and 31 male) with mean age of 66 years. All patients received a single dose of tolvaptan 15 mg daily for an average of 3.2 days due to severe hyponatremia. Sodium and potassium concentrations, fluid intake, and urine volume increased (p<0.0001, p=0.037, p<0.0001, and p<0.0001, respectively), whereas furosemide dosage, body weight, heart rate, systolic and diastolic blood pressure, and New York Heart Association class decreased significantly in response to tolvaptan treatment, without a rise in serum creatinine or urea concentrations (p<0.0001, p<0.0001, p=0.001, p<0.049, p<0.009 ve p=0.001, respectively).Conclusion: In this retrospective, single-centered study conducted in a small group of Turkish patients, short-term treatment with low-dose tolvaptan added to standard therapy of hypervolemic HF patients with severe hyponatremia was well tolerated with a low rate of major side effects and was effective in correcting severe hyponatremia.