Person: MUTLU, CANER
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MUTLU
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CANER
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Publication Functional outcome in late adolescence/early adulthood of patients with autism spectrum disorderresand its relationships with parental burnout and depression: A preliminary multi-center, cross-sectional study(Cell Press, 2023-10-13) Kutük, Meryem Özlem; Tufan, Ali Evren; Kılıçaslan, Fethiye; Vural, Pınar; Gökçen, Cem; Güney, Sevay Alsen; Kütük, Bahtim; Özyurt, Gonca; Inal, Neslihan; Multer, Tuba; Acikalin, Eren Yavuz; Ozer, Fadime Hande; Pamuk, Esma Nur; Yesilmese, Seyma Celikcan; Karadag, Mehmet; Hangul, Zehra; Bilginer, Çilem; Şahin, Nilfer; Bilac, Öznur; Kandemir, Hasan; Ercan, Eyup Sabri; Soylemez, Tugba Eseroglu; Acikel, Sadettin Burak; Aksu, Gulen Guler; Dag, Pelin; Toros, Fevziye; Mutlu, Caner; Kardas, Ömer; Kardas, Burcu; Kizildag, Suleyman; Demirci, Esra; Özmen, Sevgi; Sevicin, Leyla; Karagoz, Yuksel Sumeyra; Isik, Ümit; Aktepe, Evrim; Altun, Hatice; Yektas, Çigdem; Tuysuz, Berna Polat; Buber, Ahmet; Cansiz, Mehmet Akif; Ogutlu, Hakan; Eray, Safak; Taner, Hande Ayraler; Altintas, Ebru; Kutuk, Özgur; VURAL, AYŞE PINAR; MUTLU, CANER; ERAY ÇAMLI, ŞAFAK; Tıp Fakültesi; Çocuk ve Ergen Psikiyatrisi Ana Bilim Dalı; 0000-0002-4847-7751 ; GIK-1690-2022; AFS-8432-2022; AAG-8101-2021The aim of this study is to determine the functioning of adults with autism spectrum disorders (ASDs) diagnosed in childhood and depression and burnout levels among their parents. A total of 261 adults with ASDs and their parents were recruited for the study. Both parents completed the Beck Depression and Maslach Burnout Inventories and reported the functioning of their adult offspring with ASDs. Only 5.4 % of our sample reported "good" or "very good" outcomes. The most common psychiatric comorbidities were intellectual disabilities and attention-deficit/ hyperactivity disorder. Maternal burnout and depression scores were significantly elevated compared to those of fathers. There is an undeniable urgent need for more research to identify the needs of adults and families suffering from ASD. Modifications for those with ASD may have to be made for support in workplaces, achieving driving licenses, using public transportation and attendance at tertiary education.Publication Aripiprazole used to treat capgras syndrome in an adolescent diagnosed with autism(Lippincott Williams & Wilkins, 2023-03-01) Baykal, Saliha; Mutlu, Caner; MUTLU, CANER; Tıp Fakültesi; Psikiyatri Ana Bilim Dalı; AFS-8432-2022; JXY-4529-2024ObjectivesThis report discusses the emergence, clinical appearance, and treatment of the rare entity Capgras syndrome (CS) in an adolescent diagnosed with autism.MethodsAfter a brief introduction to the CS, we conduct a detailed description of the case and review, after a search on the PubMed database, the known pathophysiology, psychiatric disorders associated with the onset of this syndrome, and the management of CS.ResultsCapgras syndrome generally emerges during the course of delusional disorder, schizophrenia, or mood disorders, and for reasons such as neurological, infectious, or endocrinological diseases, drug intoxications, or deprivation. We encountered no previous reports of CS developing during the course of autism. There are no prospective studies concerning the treatment of the syndrome. However, antipsychotic drug use is primarily recommended in treatment. Antipsychotic drug therapy was therefore planned for the treatment of delusion, a psychotic symptom, in this case. The atypical antipsychotic aripiprazole was used based on the presence of accompanying diagnosis of autism, and the patient's body mass index and age. A relatively high dose of aripiprazole was required for the first psychotic attack in our patient. However, a good level of response was achieved within the expected time frame. In addition, no marked adverse effects were observed.ConclusionsAripiprazole seems to be an effective and well-tolerated antipsychotic drug in the treatment of CS accompanying autism.Publication Psychomotor agitation and irritability in adolescents with manic episode: Clinical data from three inpatient units(Sage Publications Inc, 2022-09-02) Turan, Serkan; Ermis, Çağatay; Eray, Şafak; Ağaç, Nilay; Aksoy, Sena; Yüksel, Ayşe Sena; Karaca, Ayca Bezir; Güler, Duru; Tunctürk, Mustafa; Ciray, Remzi Ogulcan; Mutlu, Caner; Karaçetin, Gül; Youngstrom, Eric A.; İnal, Neslihan; TURAN, SERKAN; ERAY ÇAMLI, ŞAFAK; KARACA, AYÇA; MUTLU, CANER; Tıp Fakültesi; Çocuk ve Ergen Psikiyatrisi Ana Bilim Dalı; 0000-0002-4847-7751; AAG-8101-2021; AFO-6356-2022; GRL-4499-2022; AFS-8432-2022; AFS-8432-2022Objectives We aimed to investigate the characteristics of adolescents with Bipolar disorder-I with irritability and agitation (Mania+IA) compared to those without irritability and agitation (Mania-IA) in a multi-center representative sample. Methods Data of 145 patients from three tertiary-care inpatient units between 2016 and 2021 were obtained. Psychomotor agitation was defined as a score of >= 3 on the YMRS "Increased Motor Activity--Energy" item, irritability as a score of >= 4 on the YMRS 'irritability' item, and severity anchors of speech and thought disturbance on the YMRS '6 and 7' items. Results Previous manic episodes (p = 0.013), involuntary hospitalization (p = 0.006), psychotic features (p = 0.001), formal thought disorder (p = 0.010) and aggressive/disruptive behavior (p = 0.021) were more frequent in the Mania+IA group. Conversely, depressive episodes (p = 0.006) and family history of depression (p = 0.024) were more frequent in the Mania-IA group. The Mania+IA had poorer functioning at the time of discharge. Conclusions Irritability and agitation were closely related to complications, psychotic symptoms and thought disorder. Assessment and monitoring of psychomotor agitation and irritability may help child and adolescent psychiatrists to predict clinical difficulties and appropriate interventions.