Person: ÖZBEK, SERHAT
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ÖZBEK
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SERHAT
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Publication A family with IgA nephropathy and hereditary lymphoedema praecox(Wiley, 2002-05-01) Usta, M; Dilek, Kamil; Ersoy, Ahmet; Alper, E; Özbek, Serhat; Özdemir, Bülent; Filiz, G; Yavuz, M; Güllülü, Mustafa; Yurtkuran, Merih; Usta, M; DİLEK, KAMİL; Ersoy, Ahmet; Alper, E; ÖZBEK, SERHAT; ÖZDEMİR, BÜLENT; Filiz, G; Yavuz, M; GÜLLÜLÜ, MUSTAFA; Yurtkuran, Merih; Uludağ Üniversitesi Tıp Fakültesi; Nefroloji Bölümü; 0000-0003-3427-8337; 0009-0001-9179-9107; HYD-3798-2023; CNY-9323-2022; GXG-1656-2022; CCY-8570-2022; FTG-3544-2022; JHE-3353-2023; EVQ-8652-2022; HJG-9929-2022; JGS-9425-2023; GLB-5791-2022Immunoglobulin A (IgA) nephropathy is the most common primary glomerulonephritis worldwide. The pathogenesis is still unknown and treatment has not yet been established. Rarely it can be associated with other disorders. Its association with hereditary lymphoedema is not reported before. We report four patients, a 60-year-old father, his two sons and his daughter, with hereditary lymphoedema. The family had nine members and in four of them lymphoedema was evident. The other members had neither lymphoedema nor IgA nephropathy. This is the first report of IgA nephropathy in association with hereditary lymphoedema.Publication A retrospective epidemiological study of 385 burn patients hospitalized during 6 years in bursa(Springer, 2005-09-01) Özbek, Serhat; KAHVECİ, RAMAZAN; ÖZGENEL, GÜZİN YEŞİM; ÖZBEK, SERHAT; Özcan, Mesut; AKIN, SELÇUK; Akın, Selçuk; ERCAN, İLKER; Ercan, İlker; Karaca, Kemal; Tıp Fakültesi; Plastik ve Rekonstruktif Cerrahi Ana Bilim Dalı; 0000-0002-2382-290X; AAG-4626-2019; AAH-5064-2021; AAH-5441-2021A retrospective analysis of 385 consecutive admissions to a regional burns unit in a period of 6 years is presented. The majority were flame burns, followed by scalds. The male to female ratio was 3: 1. More than half of the patients were adults (more than the age of 16 years) and most of the injuries occurred at home. In the group of patients under 2 years of age, scalds were the leading cause of burns and among them hot tea spill was the most common reason. Many of the electrical burns occurred at the workplace and at home were resulted from inappropriate close location of high voltage lines to constructions and houses, and inappropriate use of paint thinner was found to be an important cause for flame burns occurred at the work place. The mean hospitalization time was 27.1 days and the overall mortality rate was 14% (n=54). In this paper, regional characteristics of some etiologic factors, together with some descriptive analysis in burn injury and some preventive measures are presented.Publication Outcomes of elderly burn patients requiring hospitalization(Taylor ve Francis, 2015-06-01) Şimşek, Muhammed Eren; Özgenel, G. Yeşim; Kahveci, Ramazan; Akın, Selçuk; Özbek, Serhat; Tufan, Fatih; ÖZGENEL, GÜZİN YEŞİM; KAHVECİ, RAMAZAN; AKIN, SELÇUK; ÖZBEK, SERHAT; Tıp Fakültesi; Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı; 0000-0003-3245-1618; 0000-0003-1683-0722; 0000-0003-0000-8355; AAH-5064-2021; AAH-5441-2021; AAH-4233-2021; AAG-4626-2019Background: The elderly population is more likely to be affected by accidents, such as burns, compared to younger populations because of their diminished host defense. There is limited data about the outcomes of elderly burn patients requiring hospitalization.Methods: In this retrospective study, we assessed the epidemiology and outcomes of burn injuries in elderly patients (>60 years old) admitted to a burn unit of a tertiary medical center based on patient characteristics, type and extent of burns, treatment, hospital stay and mortality rates.Results: Forty-eight elderly burn patients among 870 burn patients during the study period were evaluated. Fire was the most common cause of burns (77.1%). Most of the burns involved more than 20% of total body surface area. Twenty-six (54.2%) patients died during hospitalization. Although burn surface area slightly and non-significantly increased in patients over 75 years, there was a significantly increased mortality rate in these patients. Multivariate linear regression analysis revealed burn area and age as independent associates of mortality.Conclusion: Our data show a high mortality rate in elderly burn patients. Extensive burns and increased age seem to increase the mortality risk.Publication Identification of mast cells and immunophenotypic subtypes in peripheral nerve damage caused by epineurotomy and systemic inflammation(Wolters Kluwer Medknow Publications, 2023-01-01) Yavaş, Özkan; YAVAŞ, ÖZKAN; Yavaş, Senem Esin; Kavruk, Kaan; KAVRUK, KAAN; Özbek, Serhat; ÖZBEK, SERHAT; Ersoy, Semiha; ERSOY, SEMİHA; Tıp Fakültesi; Histoloji ve Embriyoloji Ana Bilim Dalı; KHD-4075-2024Purpose: This study aims to investigate the numerical increase, localization, granulation status, and immunophenotypic properties of mast cells (MCs) in epineurectomy-induced nerve damage and lipopolysaccharide (LPS)-induced systemic infection models. Materials and Methods: In this study, the animals were divided into three groups of 6 each. One of the groups was determined as the control group, epineurectomy was applied to one group, and systemic inflammation was created by regular LPS injections in the other group. Then, the obtained nerve tissues were stained histochemically with Hematoxylin and Eosin toluidine blue, and the increase, localization, and granulation status of MCs were examined. Immunohistochemically, antitryptase and antichymase staining were performed to determine the immunophenotypes of MCs. Results: As a result, while the number of MCs increased in both groups compared to the control group, MCs in the LPS group were in the epineurium, and MCs in the epineurotomy group were located between the nerve fibers. While MCs in the LPS group showed very severe degranulation, mild degranulation was observed in the epineurotomy group, and almost no degranulated MCs were observed in the control group. Conclusion: This study is critical because it is one of the first studies to compare MCs in different nerve damage types and examine the expression of chymase and tryptase.Publication In vivo use of n-butyl-2-cyanoacrylate in cleft palate surgery and a comparison of its efficacy with suture material(İstanbul Üniversitesi, 2021-01-03) Karabulut, Furkan; Özbek, Serhat; ÖZBEK, SERHAT; Tıp Fakültesi; Plastik ve Rekonstrüktif Cerrahi Ana Bilim Dalı; JKS-6969-2023Objective: In this experimental work, we aimed to compare the efficacy of two different methods of combining the mucoperiosteal flaps in an animal model: using a tissue adhesive material N-butyl-2-cyanoacrylate (Glubran (R) 2) and the classical suturing technique in cleft palate surgery.Methods: Rats were separated into group A and B. In group A (n=12) mucoperiosteal flaps were brought together with absorbable suturing material, while in group B (n=12), adhesive material was used for the same purpose. Palatal mucosa healing was evaluated histologically in terms of inflammatory cell infiltration, fibroblastic activity and vascularization on the postoperative 8th and 16th days.Results: As a result of this experimental study, there were no differences macroscopically in palatal mucosa healing in both groups. Histologically, on day 8, the inflammation severity was higher in the suture material group and the difference was statistically significant. On day 16, fibroblastic activity was significantly lower in the suture material group. There was no significant difference between the groups in terms of vascularity.Conclusion: As a result of these findings, Glubran (R) 2 was found to be easily usable and effective with low complication rates, moreover, it was a practical tissue adhesive material for merging mucosal flaps in the midline of the palate.Publication Treatment of recurrent temporomandibular joint dislocation(Springer India, 2013-12-01) Kahveci, Ramazan; Şimşek, M. Eren; Akın, Selçuk; Özbek, Serhat; Özgenel, Güzin Yeşim; Gökmen, Zeynep Gül; KAHVECİ, RAMAZAN; Şimşek, M. Eren; AKIN, SELÇUK; ÖZBEK, SERHAT; ÖZGENEL, GÜZİN YEŞİM; Gökmen, Zeynep Gül; Tıp Fakültesi; Plastik, Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı; AAH-5441-2021; AAH-4233-2021; AAH-5064-2021; AAG-4626-2019; IHE-7148-2023; IEB-8849-2023Temporomandibular joint dislocation is defined as the movement of condyle out of the fossa and the advancement of the posterior surface of the condyle in front of the articular eminence. If this condition becomes chronic, surgical treatment is the only option. The goal of surgical treatment is to reposition the condyle and prevent further recurrences. In this study, a retrospective analysis is presented examining 73 patients and 83 joints that were treated with hook-shaped miniplates and miniscrews fixed to otolog bone grafts. Records were obtained from archives of the Uludag University Medical Faculty, Plastic, Reconstructive and Aesthetic Surgery Department. The duration of postoperative follow-up was 3-30 months. In one case, the miniplate was fractured, and in two cases, abscesses existed. This study aims to emphasize that using miniplates and otolog bone grafts is more cost effective.Publication Odontogenic keratocyst seen in three generations(Medknow Publications & Media Pvt Ltd, 2010-09-01) Özgenel, Güzin Yeşim; Özbek, Serhat; Akın, Selçuk; Kahveci, Ramazan; ÖZGENEL, GÜZİN YEŞİM; ÖZBEK, SERHAT; AKIN, SELÇUK; KAHVECİ, RAMAZAN; Tıp Fakültesi; Plastik Rekonstrüktif ve Estetik Cerrahi Ana Bilim Dalı; AAG-4626-2019; AAH-5064-2021; AAH-5441-2021; AAH-4233-2021Odontogenic keratocyst, being most commonly seen in the jaws, is an epithelial developmental odontogenic cyst which has a high recurrence rate and a rapid growth potential. It is a bening interosseous pathology of the jaw. Most commonly seen clinical signs are swelling and pain at the localization of the cyst. The classic treatment of this pathology is surgical enucleation and curettage being performed through an intraoral approach. Multiple odontogenic cysts are sometimes seen with nevoid basal cell carcinoma syndrome. In this article, cases of odontogenic keratocysts with multiple basal cell carcinoma lesions in the different generations of the same family were presented.