Person: TOPAL, AYŞE
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TOPAL
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AYŞE
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Publication Comparison of end-tidal CO2 and arterial oxygen saturation during halothane, isoflurane or sevoflurane anaesthesia in dogs(Indian Veterinary Journal, 2004-12-01) Topal, Ayşe; Gül, N; Görgül, OS; TOPAL, AYŞE; GÜL SATAR, NİHAL YAŞAR; Görgül, O. Sacit; Veteriner Fakültesi; Cerrahi Bölümü; CEV-2430-2022; ILB-7024-2023; CRG-1499-2022The effects of halothane, isoflurane and sevoflurane snaesthesia on end tidal CO2 (ETCO2) and arterial oxygen saturation (SpO(2)) were investigated in dogs. The anaesthesia was induced with propofol 2 mg/kg IV; maintained with halothane, isoflurane or sevoflurane in oxygen in the concentrations 1.5%, 2%, 3%, respectively. Intermittent positive pressure ventilation (tidal volume, 15 ml/kg; respiration rate, 12/min) was started immediately after intubation and the anaesthesia was continued for 60 minutes. The end-tidal carbon dioxide concentration was measured continuously at the proximal end of the tracheal tube using CO2 monitor. SpO(2) readings were obtained with a pulse oximeter whose probe was placed on the tongue. End-tidal CO2 during halothane anaesthesia was lower than isoflurane and sevoflurane anaesthesia. SpO(2) in dogs of the halothane group was less than in dogs of other two groups. Isoflurane or sevoflurane anaesthesia appear to be safer than halothane anaesthesia in dogs.Publication Ankaferd blood stopper accelerates deep second degree burn wound healing in rats(Veterinarni A Farmaceuticka Univerzita Brno, 2018-01-01) Topal, Ayşe; Satar, Nihal Yaşar Gül; Cangül, İbrahim Taci; Oktay, M. Ayberk; İnan, Kıvanç; Ceçen, Göksen; Akarsu, E. Pınar; Can, Hakcahan; TOPAL, AYŞE; GÜL SATAR, NİHAL YAŞAR; CANGÜL, İBRAHİM TACİ; Oktay, M. Ayberk; İnan, Kıvanç; Çeçen, Göksen; Akarsu, E. Pınar; Can, Hakcahan; Veteriner Fakültesi; Patoloji Bölümü; 0000-0001-8537-0761; 0000-0003-0537-2113; AAK-9543-2020; AAB-4360-2021; GGO-6894-2022; FTA-8490-2022; DLW-3934-2022; FDI-9072-2022; CCC-5151-2022; CHT-0705-2022In this study, the effects of Ankaferd Blood Stopper (ABS) and silver sulphadiazine (SSD) cream on burn wound healing were investigated in rats. A total of 24 outbred, male, Sprague-Dawley rats were randomly allocated to (1) ABS, (2) SSD, and (3) control groups. Bilateral burn wounds were created near the caudal border of the scapula. Wounds in each group were treated daily with sponges soaked in ABS solution, 1% SSD cream, or saline, respectively. On days 0, 7, 14, 21, and 28, unhealed wound area was measured and biopsy samples were taken for histopathological examination (except day 0). At the end of day 28, all rats in the ABS and SSD groups had complete coverage of the wounds with granulation tissue and epithelialization, whereas wounds in the control group were not completely epithelialized. On day 7, the mean unhealed wound areas and the mean percentages of wound contraction were not significantly different among the groups. However, the mean percentage of wound contraction in the ABS and SSD groups was significantly higher than in the control group on days 14, 21, and 28. Histopathologically, wound healing was characterized by a decrease in neutrophil counts and an increase in vessel counts. Our results suggest that ABS can be successfully used for burn wound healing besides SSD.Publication Comparison of the effects of ketamine-diazepam, tiletamine-zolazepam and propofol infusion anesthesia in rabbits(Kafkas Üniversitesi, 2023-02-14) Topal, Ayşe; Satar, Nihal Yaşar Gül; Ateş, Özge; Uçkan, Elyesa Melih; Yavaş, Özkan; Cangül, İbrahim Taci; TOPAL, AYŞE; GÜL SATAR, NİHAL YAŞAR; Ateş, Özge; Uçkan, Elyesa Melih; YAVAŞ, ÖZKAN; CANGÜL, İBRAHİM TACİ; Veteriner Fakültesi; Cerrahi Ana Bilim Dalı; KHD-4075-2024; AAB-4360-2021; GGO-6894-2022; FTA-8490-2022; CEC-2677-2022; HQA-9810-2023In this study we evaluated the anesthetic effects of ketamine-diazepam (K-D), tiletamine zolazepam (T-Z), and propofol (P) infusion for one h in rabbits, and also the impact of these anesthetics on physiological and biochemical parameters, and the tissue structure of the liver, kidney, and lungs. 18 New Zealand white rabbits were allocated to three administration groups. All groups were premedicated with xylazine. For induction, ketamine and diazepam were administered intravenously in group K-D, tiletamine-zolazepam combination was administered in group T-Z, and propofol was administered in group P. After induction, infusion anesthesia was continued for one h by intravenously ketamine and diazepam in group K-D, tiletamine-zolazepam combination in group T-Z, and propofol in group P. The respiratory rate significantly decreased in the P group at 30, 45, and 60 min compared to the initial values (P<0.05). End-tidal CO2 significantly increased in the P group at 30, 45, and 60 min compared to the initial values (P<0.05). All physiological and serum biochemical parameters were within the reference ranges. Infusions resulted in varying degrees of degenerative changes in the kidney, lung, and liver, but these changes did not affect the anesthesia status or biochemical parameters. We suggest that K-D, T-Z, and P can be applied safely as an infusion for one h anesthesia of rabbits as an alternative to traditional anesthesia regimens.Publication Interval between injection of contrast material and positive contrast cheliography affects accurate diagnosis of diaphragmatic hernia(Veterinarni A Farmaceuticka Univerzita Brno, 2015-01-01) Şen, İsmail A.; Akgül, M. Banş; Satar, Nihal Yaşar Gül; Topal, Ayşe; Şen, İsmail A.; Akgül, M. Banş; GÜL SATAR, NİHAL YAŞAR; TOPAL, AYŞE; Veteriner Fakültesi; Cerrahi Ana Bilim Dalı; JDD-9615-2023; EKW-0914-2022; FTA-8490-2022; GGO-6894-2022The aim of this study was to evaluate the clinical, surgical and diagnostic imaging findings in 11 cats and 3 dogs with suspected acute and chronic traumatic diaphragmatic hernia, and to compare the results of positive contrast cheliography (peritoneography) taken immediately and 5 min after the injection of contrast material. Thoracic and abdominal radiography, ultrasonography, and positive contrast cheliography of all animals were performed. Eight cases were considered as acute and six cases were considered chronic. The contrast images taken immediately after the injection of contrast material revealed the contrast material in the thoracic cavity in 8/8 acute trauma patients, but in none of the chronic cases. In 5/6 of these cases contrast material was seen in the thoracal cavity only in additional images taken after 5 min. One patient was diagnosed with PIP and excluded from the study. Twelve cases had complete resolution and one animal died during the early postoperative period. Our results suggest that positive contrast cheliography performed immediately after the injection of contrast material may not reveal chronic cases of diaphragmatic hernia and a second imaging (or imaging after 5 min) is indicated in order not to overlook chronic cases.Publication Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing(Springer, 2014-11-01) Bağdaş, Deniz; Gül, Nihal Yaşar; Topal, Ayşe; Taş, Sibel; Özyiğit, Musa Özgür; CinkIlıç, NilÜfer; Gül, Zülfiye; Etoz, Betül Cam; Ziyanok, Sedef; İnan, Sevda; Turacozen, Özge; Gürün, Mine Sibel; Bağdaş, Deniz; GÜL SATAR, NİHAL YAŞAR; TOPAL, AYŞE; TAŞ, SİBEL; ÖZYİĞİT, MUSA ÖZGÜR; CinkIlıç, Nilüfer; Gül, Zülfiye; Etoz, Betül Cam; ZİYANOK DEMİRTAŞ, SEDEF; İnan, Sevda; Turacözen, Özge; GÜRÜN, MİNE SİBEL; Fen Edebiyat Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0001-6225-774X; 0000-0002-3595-6286; 0000-0002-8872-0074; 0000-0003-3878-3808; 0000-0001-8138-5851; AAG-8716-2019; AAH-4272-2021; AAF-9939-2020; ABE-6873-2020; JBJ-7162-2023; AAH-5296-2021; AAR-6478-2021; AAH-2873-2021; E-3364-2018; EOB-5882-2022; GGO-6894-2022; AAH-5296-2021Chlorogenic acid (CGA) is a well-known natural antioxidant in human diet. To understand the effects of CGA on wound healing by enhancing antioxidant defense in the body, the present study sought to investigate the potential role of systemic CGA therapy on wound healing and oxidative stress markers of the skin. We also aimed to understand whether chronic CGA treatment has side effects on pivotal organs or rat bone marrow during therapy. Full-thickness experimental wounds were created on the backs of rats. CGA (25, 50, 100, 200 mg/kg) or vehicle was administered intraperitoneally for 15 days. All rats were sacrificed on the 16th day. Biochemical, histopathological, and immunohistochemical examinations were performed. Possible side effects were also investigated. The results suggested that CGA accelerated wound healing in a dose-dependent manner. CGA enhanced hydroxyproline content, decreased malondialdehyde and nitric oxide levels. and elevated reduced glutathione, superoxide dismutase, and catalase levels in wound tissues. Epithelialization, angiogenesis, fibroblast proliferation, and collagen formation increased by CGA while polymorph nuclear leukocytes infiltration decreased. CGA modulated matrix metalloproteinase-9 and tissue inhibitor-2 expression in biopsies. Otherwise, high dose of CGA increased lipid peroxidation of liver and kidney without affecting the heart and muscle samples. Chronic CGA increased micronuclei formation and induced cytotoxicity in the bone marrow. In conclusion, systemic CGA has beneficial effects in improving wound repair. Antioxidant, free radical scavenger, angiogenesis, and anti-inflammatory effects of CGA may ameliorate wound healing. High dose of CGA may induce side effects. In light of these observations, CGA supplementation or dietary CGA may have benefit on wound healing.