Person: MALYER, HULUSİ
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Publication Allergenic airborne pollen concentrations of Chenopodiaceae/Amaranthaceae (Goosefoot/pigweed families) in Turkey(Bilimsel Tıp Yayınevi, 2010-01-01) Bıçakçı, Adem; Altunoğlu, Mustafa Kemal; Tosunoğlu, Aycan; Akkaya, Ahmet; Malyer, Hulusi; Sapan, Nihat; BIÇAKÇI, ADEM; Altunoğlu, Mustafa Kemal; TOSUNOĞLU, AYCAN; MALYER, HULUSİ; SAPAN, NİHAT; Tıp Fakültesi; Pediatri Alerji Bölümü, Çocuk Sağlığı ve Hastalıkları Bölümü; 0000-0002-6333-3123; 0000-0001-6906-3403; O-1244-2018; LKK-4133-2024; GGP-2094-2022; DDS-8738-2022; FUI-8766-2022Pollen grains of Chenopodiaceae/Amaranthaceae family members belonging to weed taxa are one of the main causes of allergic respiratory system diseases. In this study, airborne pollen studies were carried out in Turkey, and the monthly changes in Chenopodiacea/Amaranthaceae pollen rates for 58 regions were evaluated. Within the studies, the highest Chenopodiaceae/Amaranthaceae pollen grains were recorded on august-september, around year.Publication Airborne pollen grains of Gemlik (Bursa)(Bilimsel Tıp Yayınevi, 2011-01-01) Saatcioğlu, Gülşah; Tosunoğlu, Aycan; Malyer, Hulusi; Bıçakcı, Adem; Saatcioğlu, Gülşah; TOSUNOĞLU, AYCAN; MALYER, HULUSİ; BIÇAKÇI, ADEM; Fen Edebiyat Fakültesi; Biyoloji Bölümü; 0000-0002-6333-3123; 0000-0001-5124-7239; O-1244-2018; HLH-0776-2023; GGP-2094-2022; DDS-8738-2022Objective: Pollen calendars, which exposes by determinig airborne pollen, help the allergologists and the people that sensitive to allergenic pollen. The goal of this study to identify the airborne pollen grains to establish the pollen calendar of Gemlik (Bursa) in the year 2008.Materials and Methods: Airborne pollen grains in Gemlik (Bursa) were collected between 1st January and 31st December 2008 by using Durham sampler. Weekly pollen grains per cm2 were calculated.Results: During the period 6957 pollen grains/cm(2) belonging to 43 taxa (excluding unidentified pollen grains) were recorded. Eleven plant taxa take a place, which encountered up to 1% of the total and it can be reported that pollen season durations and total percentages for the dominaing pollen grains in Gemlik were; 5-32nd week for Pinus spp. (22.14%), 19-37th week for Olea europaea L. (18.19%), 9-43rd week for Gramineae (10.62%), 1224th week for Platanus spp. (10.58%), 4-27th week for Cupressaceae/Taxaceae (10.19%), 13-23rd week for Fagus spp. (6.09%), 9-21st week for Quercus spp. (5.33%), 5-19th week for Fraxinus spp. (2.41%), 423rd week for Betula spp. (1.81%), 27-44th week for Xanthium spp. (1.53%) and 14-22nd week for Jug-lans spp. (1.35%). 40.46% of total pollen grains were recorded during the month of april with a prevalence of arboreal pollen grains.Conclusion: This preliminary study performed to determine pollen calendar for Gemlik region (Bursa) may be useful for allergologists to establish an exact diagnosis of the people that has pollen allergy.Publication The anticancer effect of inula viscosa methanol extract by miRNSs' re-regulation: An in vitro study on human malignant melanoma cells(Taylor, 2021-02-04) Çolak, Dilara Kamer; Egeli, Ünal; Eryılmaz, Işıl Ezgi; Aybastıer, Önder; Malyer, Hulusi; Çeçener, Gülşah; Tunca, Berrin; Çolak, Dilara Kamer; EGELİ, ÜNAL; ERYILMAZ, IŞIL EZGİ; AYBASTIER, ÖNDER; MALYER, HULUSİ; ÇEÇENER, GÜLŞAH; TUNCA, BERRİN; Fen Edebiyat Fakültesi; Analitik Kimya Bölümü; 0000-0001-7904-883X; 0000-0002-0380-1992; 0000-0002-3820-424X; 0000-0002-1619-6680; 0000-0002-3316-316X; GWV-3548-2022; AAH-1420-2021; HXB-1173-2023; X-4621-2018; DDS-8738-2022; AAP-9988-2020; ABI-6078-2020Alternative and natural therapies are needed for malignant melanoma (MM), the most deadly skin cancer type due to chemotherapy's limited effect. In the present study, we evaluated the anticancer potentials of Inula viscosa methanol and water extracts (IVM and IVW) on MM cells, A2058 and MeWo, and normal fibroblasts. After the chromatographic and antioxidant activity analysis, their antiproliferative effects were determined with the increasing doses for 24-72 h. IVM induced more cell death in a dose and time-dependent manner in MM cells compared to IVW. This effect was probably due to the higher amount of phenolics in it. IVM significantly induced more apoptotic death in MM cells than fibroblasts (p < 0.01), which was also supported morphologically. IVM also caused cell cycle arrest at G0/G1 and G2/M phases in A2058 and MeWo, respectively, and suppressed the migration ability of MM cells (p < 0.01). Additionally, IVM was found to have significant potential in regulating MM-related miRNAs, upregulating miR-579 and miR-524, and downregulating miR-191 and miR-193, in MM cells (p < 0.05, p < 0.01). As a result, the anticancer effect of IVM via regulating miRNAs' expression has been demonstrated for the first time. Thus, IVM, with these potentials, may be a promising candidate for MM treatment.Publication Allergenic Cupressaceae (cypress family) pollen concentrations in Turkey(Bilimsel Tip Yayinevi, 2010-01-01) Bıçakçı, Adem; BIÇAKÇI, ADEM; Tosunoğlu, Aycan; TOSUNOĞLU, AYCAN; Altunoğlu, Mustafa Kemal; Çelenk, Sevcan; ÇELENK, SEVCAN; Erkan, Perihan; ERKAN ALKAN, PERİHAN; Canıtez, Yakup; CANITEZ, YAKUP; Malyer, Hulusi; MALYER, HULUSİ; Sapan, Nihat; SAPAN, NİHAT; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0002-6333-3123; 0000-0003-4925-8902; 0000-0002-8837-3375; K-2981-2012; AAK-4004-2021; O-1244-2018Cupressus and Juniperus airborne pollen grains, belonging to the Cupressaceae family and causing respiratory system allergy by inhalation, have an important place among aeroallergens. In this study, airborne pollen studies were carried out in Turkey, and the monthly changes in Cupressaceae pollens rates in 57 regions were evaluated. Results of the studies showed that the highest numbers of Cupressaceae pollen grains were recorded between march and may.Publication Airborne pollen grains of Turkey(Bilimsel Tip Yayinevi, 2009-01-01) Bıçakçı, Adem; BIÇAKÇI, ADEM; CANITEZ, YAKUP; Altunoğlu, Mustafa Kemal; Bilişik, Aycan; Çelenk, Sevcan; ÇELENK, SEVCAN; SAPAN, NİHAT; Sapan, Nihat; Malyer, Hulusi; MALYER, HULUSİ; Fen Edebiyat Fakültesi; Biyoloji Bölümü; 0000-0002-6333-3123; 0000-0003-4925-8902; O-1244-2018; K-2981-2012In this evaluation, the results of aeropalynological studies carried out for 49 regions of Turkey have been assessed. The most common and greatest amounts of pollens in the atmosphere of Turkey were Cupressaceae, Pinus and Gramineae. The highest amount for pollen grains was recorded between March and June.Publication Allergenic pinus (pine) pollen concentrations in Turkey(Bilimsel Tip Yayinevi, 2011-01-01) Akkaya, Ahmet; BIÇAKÇI, ADEM; Tosunoglu, Aycan; TOSUNOĞLU, AYCAN; Altunoglu, Mustafa Kemal; MALYER, HULUSİ; Sapan, Nihat; SAPAN, NİHAT; Fen Edebiyat Fakültesi; Biyoloji Ana Bilim Dalı; 0000-0002-6333-3123; 0000-0001-6906-3403; O-1244-2018; LKK-4133-2024Objective: Pine tree is a wind pollinated plant which produces high amount of pollen and has a long-distance distribution of pollen grains although allergenic effects of pine pollen have been classified in low or non-allergenic level. In recent years, as well as the extensive amounts of pine pollen-sensitive individuals exposed to show some symptoms that have been reported.Materials and Methods: In this study, monthly variation and annual proportions of Pinus pollen investigated for 59 atmospheric pollen studies in Turkey, which carried out by using Lanzoni/Burkard sampler with volumetric method or by using Durham sampler with gravimetric method. Furthermore, researches evaluated about Pinus pollen sensitivities, performed in Europe and our country.Results: Pollen grains of this genus have been detected in quite high levels in almost all atmospheric pollen studies prepared in our country. According to results of the study, Pious pollen can be seen in the atmosphere throughout whole year but especially found in high amounts in april-may.Conclusion: Having a contribution over 50% of annual total pollen counts, pine pollens are important for sensitive patients living in Turkey.Publication Allergenic Plantago (plantain) pollen concentrations in Turkey(Bilimsel Tip Yayinevi, 2011-01-01) Altunoğlu, Mustafa Kemal; Akkaya, Ahmet; BIÇAKÇI, ADEM; Tosunoglu, Aycan; TOSUNOĞLU, AYCAN; Sapan, Nihat; MALYER, HULUSİ; SAPAN, NİHAT; Fen Edebiyat Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0002-6333-3123; O-1244-2018Objective: Pollen grains of the species belonging to Plantago genus cause some allergic diseases like allergic rhinitis, allergic conjunctivitis and allergic asthma on sensitive individuals.Materials and Methods: In this study, monthly variation and annual proportions of Plantago pollen investigated for 62 atmospheric pollen studies in Turkey, which carried out by using Lanzoni/Burkard sampler with volumetric method or by using Durham sampler with gravimetric method. Furthermore, researches evaluated about Plantago pollen sensitivities, performed in Europe and our country.Results: According to the atmospheric pollen studies, incidences of Plantago pollen grains are changing between 0.08 to 11.45% in respect of total pollen amount. Plantago pollen grains are seen in the atmosphere for a long period and present in high levels in may-june.Conclusion: In the regions, atmospheric pollen studies have been prepared, Plantago pollen grains detected in the air in small amounts but for a long period. It should be considered that, Plantago pollen, which have important allergic effects, may cause symptoms on sensitive individuals especially between may-june, also in the other months.Publication Olea europaea leaf extract improves the treatment response of GBM stem cells by modulating miRNA expression(E-century Publishing Corp, 2014-01-01) Tezcan, Gülçin; Tunca, Berrin; Bekar, Ahmet; Budak, Ferah; Şahin, Saliha; Çeçener, Gülşah; Egeli, Ünal; Taşkapılıoğlu, Mevlut Özgür; Kocaeli, Hasan; Tolunay, Şahsine; Malyer, Hulusi; Demir, Cevdet; Tümen, Gülendam; TEZCAN, GÜLÇİN; TUNCA, BERRİN; BEKAR, AHMET; BUDAK, FERAH; ŞAHİN, SALİHA; ÇEÇENER, GÜLŞAH; EGELİ, ÜNAL; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; KOCAELİ, HASAN; TOLUNAY, ŞAHSİNE; MALYER, HULUSİ; DEMİR, CEVDET; Tümen, Gülendam; Tıp Fakültesi; Beyin Cerrahi Kliniği; 0000-0002-5956-8755; 0000-0002-1619-6680; 0000-0001-7625-9148; 0000-0002-3820-424X; 0000-0001-7904-883X; 0000-0001-5472-9065; 0000-0002-9381-0410; ABA-2005-2020; F-8554-2017; ABX-9081-2022; AFR-1890-2022; F-4657-2014; AAH-3843-2020; AAI-1612-2021; ABI-6078-2020; IZP-9398-2023; AAW-5254-2020; AAP-9988-2020; AAH-2892-2021; ABB-8161-2020; AAH-1420-2021; ABI-6078-2020The stem-like cells of Glioblastoma multiforme (GBM) tumors (GSCs) are one of the important determinants of recurrence and drug resistance. The aims of the current study were to evaluate the anticancer effect of Olea europaea leaf extract (OLE) on GBM cell lines, the association between OLE and TMZ responses, and the effect of OLE and the OLE-TMZ combination in GSCs and to clarify the molecular mechanism of this effect on the expression of miRNAs related to cell death. The anti-proliferative activity of OLE and the effect of the OLE-TMZ combination were tested in the T98G, U-138MG and U-87MG GBM cell lines using WST-1 assay. The mechanism of cell death was analyzed with Annexin V/FITC and TUNEL assays. The effects of OLE on the expression levels of miR-181b, miR-153, miR-145 and miR-137 and potential mRNA targets were analyzed in GSCs using RT-qPCR. OLE exhibited anti-proliferative effects via apoptosis and necrosis in the GBM cell lines. In addition, OLE significantly induced the expression of miR-153, miR-145, and miR-137 and decreased the expression of the target genes of these miRNAs in GSCs (p < 0.05). OLE causes cell death in GBM cells with different TMZ responses, and this effect is synergistically increased when the cells are treated with a combination of OLE and TMZ. This is the first study to indicate that OLE may interfere with the pluripotency of GSCs by modulating miRNA expression. Further studies are required, but we suggest that OLE may have a potential for advanced therapeutic cancer drug studies in GBM.Publication Allergenic airborne olea (olive) and fraxinus (ash) pollen concentrations belonging to the oleaceae family in Turkey(Bilimsel Tip Yayinevi, 2009-01-01) Bıçakcı, Adem; TOSUNOĞLU, AYCAN; BIÇAKÇI, ADEM; Altunoğlu, Mustafa Kemal; SAPAN, NİHAT; ÇELENK, SEVCAN; Çelenk, Sevcan; Canıtez, Yakup; CANITEZ, YAKUP; Canıtez, Yakup; Malyer, Hulusi; MALYER, HULUSİ; Sapan, Nihat; TOSUNOĞLU, AYCAN; Tıp Fakültesi; Pediatri Ana Bilim Dalı; 0000-0002-6333-3123; 0000-0003-4925-8902; O-1244-2018; K-2981-2012One of the most important allergens causing allergic diseases of the respiratory system is airborne tree, grass and weed pollen grains. Oleaceae family members are very important in tree pollen grains. In this study, airborne pollen studies were carried out in Turkey, and the monthly changes in Olea and Fraxinus pollens rates for 55 regions were evaluated. In the studies carried out, the highest Fraxinus pollen grains were recorded in spring, and Olea pollen grains were recorded in late spring and early summer. According to atmospheric pollen studies, although Fraxinus pollen grains were found in more regions than Olea, more Olea pollen grains were recorded than of Fraxinus.Publication Daily pollen concentration of three allergenic families in the atmosphere of Bursa (NW Turkey), 2003-2004(Wiley, 2008-01-01) Çelenk, S.; Altunoğlu, M.; Canıtez, Y.; Bıçakcı, A.; Malyer, H.; Sapan, N.; ÇELENK, SEVCAN; Altunoğlu, Mustafa; CANITEZ, YAKUP; BIÇAKÇI, ADEM; MALYER, HULUSİ; SAPAN, NİHAT; Fen Edebiyat Fakültesi; Çocuk Alerji Ana Bilim Dalı; 0000-0001-6906-3403 ; 0000-0003-4925-8902 ; K-2981-2012; LKK-4133-2024; CJQ-2060-2022; O-1244-2018; DDS-8738-2022; FUI-8766-2022