Person: ORUÇ, AYŞEGÜL
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
ORUÇ
First Name
AYŞEGÜL
Name
55 results
Search Results
Now showing 1 - 10 of 55
Publication Association of morning blood pressure surge (mbps) with left ventricular hypertrophy in autosomal dominant polycystic kidney disease (ADPKD): Across sectional study(Oxford Univ Press, 2016-05-01) Sağ, Saim; Yıldız, Abdulmecit; Ersoy, Alparslan; Ocakoğlu, Gökhan; Oruç, Ayşegül; Güngören, Fatih; Ayar, Yavuz; Gül, Cuma Bülent; Güllülü, Sümeyye; Güllülü, Mustafa; Sağ, Saim; YILDIZ, ABDULMECİT; ERSOY, ALPARSLAN; OCAKOĞLU, GÖKHAN; ORUÇ, AYŞEGÜL; Güngören, Fatih; Ayar, Yavuz; GÜL, CUMA BÜLENT; GÜLLÜLÜ, NAZMİYE SÜMEYYE; GÜLLÜLÜ, MUSTAFA; Tıp Fakültesi; Kardioloji Bölümü; 0000-0002-1114-6051; 0000-0002-0342-9692; 0000-0003-4607-9220; 0000-0003-2467-9356; AAH-5180-2021; AGF-0767-2022; AAW-9185-2020; AAH-5054-2021; O-9948-2015; AAA-3163-2021; HLG-6346-2023; AAH-4002-2021; A-7063-2018; GSE-0029-2022; HIG-9032-2022; JGR-6552-2023; CTG-8811-2022Publication Investigation of the tissue allele distribution of the deceased kidney donors between 2007 and 2017.(Lippincott Williams & Wilkins, 2019-11-01) Oflaz, Rafet; Elgin, Ersin; Yıldız, Abdülmecid; Oruç, Ayşegül; Akgür, Suat; Ünsal, Oktay; Karaca, Mert; Ersoy, Sahriye; Selimoğlu, Kerem; Arslan, İlknur; Karan, Elif; Çiçek, Mehmet Çağatay; Günseren, Kadir Ömür; Güllülü, Sümmeyye; Vuruşkan, Hakan; Oflaz, Rafet; Elgin, Ersin; Yıldız, Abdülmecid; ORUÇ, AYŞEGÜL; AKGÜR, SUAT; Ünsal, Oktay; KARACA, MERT; Ersoy, Sahriye; Selimoğlu, Kerem; Arslan, İlknur; Karan, Elif; ÇİÇEK, MEHMET ÇAĞATAY; GÜNSEREN, KADİR ÖMÜR; GÜLLÜLÜ, NAZMİYE SÜMEYYE; VURUŞKAN, HAKAN; Tıp Fakültesi; Organ Nakli Merkezi; 0000-0002-9509-5799; 0000-0002-0342-9692; 0000-0003-3635-7282; 0000-0002-3454-8483; 0000-0002-0471-5404; 0000-0001-6711-676X; AAG-7406-2021; AAH-4002-2021; DJU-5362-2022; DXA-2790-2022; EIF-8983-2022; JIX-1144-2023; JJY-8484-2023; AAG-7406-2021; EVS-9805-2022; CDS-3299-2022; CCH-8947-2022; FDB-4488-2022; HGM-5995-2022; EFH-9523-2022; CST-9838-2022; ITO-9188-2023Publication Irritable bowel syndrome in patients on renal replacement treatment(Oxford Univ Press, 2015-05-01) Aktaş, Nimet; Oruç, Ayşegül; Ersoy, Alparslan; Coşkun, Belkıs Nihan; Gül, Bülent; Yıldız, Abdulmecit; Ayar, Yavuz; Sayılar, Emel Işıktaş; Aktaş, Nimet; ORUÇ, AYŞEGÜL; ERSOY, ALPARSLAN; COŞKUN, BELKIS NİHAN; GÜL, CUMA BÜLENT; YILDIZ, ABDULMECİT; Ayar, Yavuz; Sayılar, Emel Işıktaş; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; 0000-0002-0342-9692; 0000-0003-4607-9220; 0000-0002-0710-0923; 0000-0003-0298-4157; AGF-0767-2022; AAH-4002-2021; AAH-5054-2021; O-9948-2015; AAG-7155-2021; GSE-0029-2022; W-2575-2017Publication Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation(Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.Publication Assessment of cognitive dysfunction in hemodialysis patients by the mini mental test and the clock drawing test(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2018-01-01) Yıldız, Demet; Seferoğlu, Meral; Güneş, Aygül; Büyükkoyuncu, Nilüfer; Yıldız, Abdulmecit; Kılıç, Kasım; Gül, C. Bülent; Kahvecioglu, Serdar; Oruç, Ayşegül; Siığrlı, Deniz; YILDIZ, ABDULMECİT; SIĞIRLI, DENİZ; ORUÇ, AYŞEGÜL; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; HIG-9032-2022; AAA-7472-2021; AAH-4002-2021OBJECTIVE: Our aim was to assess cognitive dysfunction, which is common in hemodialysis patients and difficult to diagnose, by an easily applicable test, the Mini Mental State Examination and Clock Drawing Test.MATERIAL and METHODS: Two hundred and sixty six (266, 88.37%) dialysis patients that were followed-up at the Nephrology Clinic of Bursa Specialty Training and Research I lospital and private dialysis centers, and 35 (11.63%) healthy control individuals were involved in our study. Mini Mental State Examination and Clock Drawing Test were applied by a neurologist to the subjects. MMSE and CIA' scores of the patients were compared with the control group.RESULTS: Patient and control groups were similar in terms of age, gender, diabetes, and smoking. The rate of hypertension was significantly higher in the dialysis group. Mini Mental State Examination and Clock Drawing Test success rates were significantly higher in the control group. Orientation, attention and language modalities evaluated in the MMSE were observed to be significantly lower in the hemodialysis group. A statistically significant inverse correlation was found between registration memory and recall scores in MMSE, and urea.CONCLUSION: Cognitive performances of hemodialysis patients must be monitored closely. The relationship between record memory and recall scores and urea suggests that uremic toxins may affect memory functions negatively. In addition, cognitive performance can be monitored by Clock Drawing Test in these patients.Publication Pregnancy and kidney transplantation: A single-center experience(Aves, 2022-07-01) Ayar, Yavuz; Sayılar, Emel Işıktaş; Demir, Bilge Cetinkaya; ÇETİNKAYA DEMİR, BİLGE; ERSOY, ALPARSLAN; OCAKOĞLU, GÖKHAN; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; Tıp Fakültesi; Jinekoloji ve Doğum Ana Bilim Dalı; 0000-0003-4607-9220; 0000-0002-1114-6051; 0000-0002-0342-9692; 0000-0001-6845-9991; AAH-5180-2021; AAH-4002-2021Objective: The possibility of pregnancy increases with kidney transplantation in patients with chronic kidney disease. However, graft dysfunction, risk of fetal growth retardation, and fetal anomaly should be monitored closely. In this study, renal and obstetric outcomes were analyzed in pregnant kidney recipients who were followed in our center.Methods: We analyzed 140 reproductive-aged patients who underwent renal transplantation between January 2009 and May 2015, and clinical and laboratory data were evaluated retrospectively.Results: Twenty-four patients became pregnant (17.1%). In pregnant group, median age was significantly lower than nonpregnant group (P =.014). The median age of pregnant group at the time of transplantation was also significantly lower than non-pregnant patients (P <.001). The rate of pregnant patients was 66.7% in 18-25 year age group (P =.008). The rate of urinary tract infection in non-pregnant group was higher than pregnant group (P =.03). Live birth rates were 83.3% and 45.8% of those whose birth weight was higher than 2500 g. The increased level of daily urinary proteinuria and the time from diagnosis of renal failure to transplantation had significant effect on pregnancy (odds ratio = 13.81;95% CI: 2.06-92.45; P =.007 and odds ratio = 3.25;95% CI: 1.11-9.48; P =.031, respectively). Low serum creatinine level had significant protective effect (odds ratio = 0.001; 95% CI: 0-0.30, P =.018). The patients in 18-25 age group were 48.39 times more eligible for pregnancy compared to those in >35 age group (odds ratio = 48.39; 95% CI: 1.26-1860.72; P =.037). Rejection episodes were observed in 1 of pregnant women and 11 of non-pregnant women (P >.05).Conclusion: Pregnancy is possible in kidney transplant recipients of reproductive age. Calcineurin inhibitors and azathioprine seem to be safe. Maternal age, low-serum creatinine, and urinary proteinuria affect pregnancy. The close monitoring of renal function and fetal parameters is very important.Publication Immunosuppressive treatment results in patients with primary iga nephropathy in Turkiye: A nationwide study(Oxford Univ Press, 2023-06-01) Sümnü, Abdullah; Türkmen, Aydın; Baştürk, Taner; Cebeci, Egemen; Turgutalp, Kenan; Çetinkaya, Hakkı; Kibar, Müge Üzerk; Seyahi, Nurhan; Tatar, Erhan; Ergül, Metin; Derici, Ülver; Aylı, Deniz; Pınar, Musa; Bakar, Betül; Kazancıoğlu, Rümeyza; Dirim, Ahmet Burak; Yılmaz, Zülfikar; Türkmen, Kültiğin; Tunca, Onur; Koç, Mehmet; Kutlay, Sim; Mlicozkadioğlu, Hasan; Azak, Alper; Boztepe, Burcu; Ustundağ, Sedat; Öztürk, Seda Şafak; Ünsal, Abdülkadir; Karadağ, Serhat; Şahin, Gülizar Manga; Yenigün, Ezgi Coşkun; Eren, Necmi; Güllülü, Mustafa; GÜLLÜLÜ, MUSTAFA; Oruç, Ayşegül; ORUÇ, AYŞEGÜL; Yıldız, Abdülmecit; YILDIZ, ABDULMECİT; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; 0000-0002-0342-9692; AAH-4002-2021; HIG-9032-2022; JCR-8518-2023Publication Clinical and pathologic features of primary membranous nephropathy in turkey: A multicenter study by the turkish society of nephrology glomerular diseases working group(Taylor, 2022-12-31) Yildiz, Abdulmecit; Ulu, Sena; Oruc, Aysegul; Ucar, Ali Riza; Ozturk, Savas; Alagoz, Selma; Eren, Necmi; Kocyigit, Ismail; Cevher, Simal Koksal; Haras, Ali Burak; Sumnu, Abdullah; Arinsoy, Turgay; Sahin, Garip; Suleymanlar, Gultekin; Cavdar, Caner; Sahin, Gizem Kumru; Kurultak, Ilhan; Unsal, Abdulkadir; Sahin, Gulizar; Kazan, Sinan; Tatar, Erhan; Dikec, Mehmet; Dursun, Belda; Sayarlioglu, Hayriye; Turkmen, Kultigin; Artan, Ayse Serra; Aktas, Nimet; Yilmaz, Zulfikar; Behlul, Ahmet; Dheir, Hamad; Kutlay, Sim; Seyahi, Nurhan; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; HIG-9032-2022; AAH-4002-2021Background We aimed to evaluate the features of primary membranous nephropathy (MNP) in Turkish people. Methods This is a retrospective analysis of patients with biopsy-proven primary MNP. We obtained the data collected between 2009 and 2019 in the primary glomerulonephritis registry of the Turkish Society of Nephrology Glomerular Diseases Study Group (TSN-GOLD). Patients with a secondary cause for MNP were excluded. Clinical, demographic, laboratory, and histopathological findings were analyzed. Results A total of 995 patients with primary MNP were included in the analyses. Males constituted the majority (58.8%). The mean age was 48.4 +/- 13.9 years. The most common presentation was the presence of nephrotic syndrome (81.7%) and sub nephrotic proteinuria (10.3%). Microscopic hematuria was detected in one-third of patients. The median estimated glomerular filtration rate (eGFR) was 100.6 mL/min/1.73 m(2) (IQR, 75.4-116.3), and median proteinuria was 6000 mg/d (IQR, 3656-9457). Serum C3 and C4 complement levels were decreased in 3.7 and 1.7% of patients, respectively. Twenty-four (2.4%) patients had glomerular crescents in their kidney biopsy samples. Basal membrane thickening was detected in 93.8% of cases under light microscopy. Mesangial proliferation and interstitial inflammation were evident in 32.8 and 55.9% of the patients, respectively. The most commonly detected depositions were IgG (93%), C3 complement (68.8%), and kappa and lambda immunoglobulin light chains (70%). Although renal functions were normal at presentation, vascular, interstitial, and glomerular findings were more prominent on biopsy in hypertensive patients. No significant effect of BMI on biopsy findings was observed. Conclusions Despite some atypical findings, the main features of primary MNP in Turkey were similar to the published literature. This is the largest MNP study to date conducted in Turkish people.Publication The outcomes of kidney transplantation from elder deceased donors a single center experience(Lippincott Williams & Wilkins, 2019-11-01) Selimoğlu, Kerem; Elgin, Ersin; Yıldız, Abdülmecit; Oruç, Ayşegül; Akgür, Suat; Ünsal, Oktay; Keskin, Sahriye; Oflaz, Rafet; Arslan, İlknur; Karan, Elif; Çiçek, Mehmet Çağatay; Günseven, Kadir Ömür; Karaca, Mert; Güllülü, N. Sümeyye; Vuruşkan, Hakan; Ersoy, Alparslan; Selimoğlu, Kerem; Elgin, Ersin; Yıldız, Abdülmecit; ORUÇ, AYŞEGÜL; AKGÜR, SUAT; Ünsal, Oktay; Keskin, Sahriye; Oflaz, Rafet; Arslan, İlknur; Karan, Elif; ÇİÇEK, MEHMET ÇAĞATAY; Günseven, Kadir Ömür; KARACA, MERT; GÜLLÜLÜ, NAZMİYE SÜMEYYE; VURUŞKAN, HAKAN; ERSOY, ALPARSLAN; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; 0000-0003-3635-7282; 0000-0002-9509-5799; 0000-0002-0342-9692; 0000-0002-3454-8483; 0000-0002-0471-5404; CDS-3299-2022; DXA-2790-2022; HIG-9032-2022; AAH-4002-2021; EJA-1761-2022; JJY-8484-2023; CZH-6714-2022; DJU-5362-2022; CCH-8947-2022; FDB-4488-2022; HGM-5995-2022; CUF-3990-2022; AAG-7406-2021; CTR-6558-2022; EFH-9523-2022; AAH-5054-2021Publication Arterial function worsens faster than renal function in autosomal dominant polycystic kidney disease(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2018-01-01) Yıldız, Abdülmecit; Ersoy, Alparslan; Sağ, Saim; Oruç, Ayşegül; Çiğilli, Ercan; Ayar, Yavuz; Güllülü, Sümeyye; Gül, Cuma Bülent; YILDIZ, ABDULMECİT; ERSOY, ALPARSLAN; Sağ, Saim; ORUÇ, AYŞEGÜL; Çiğilli, Ercan; Ayar, Yavuz; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; 0000-0002-0342-9692; 0000-0003-4607-9220; AAH-4002-2021; O-9948-2015; HIG-9032-2022; AAH-5054-2021; GSE-0029-2022; AAW-9185-2020; AGF-0767-2022OBJECTIVE: Early arterial stiffness has been shown in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function. However, to our knowledge, no prospective study evaluated changes in arterial functions in patients with ADPKD. The study aimed to monitor the changes in renal and arterial functions in patients with ADPKD with preserved renal functions.MATERIAL and METHODS: A total of 25 ADPKD patients and 12 controls were included in the study. Data on patient characteristics, biochemical parameters and arterial stiffness were recorded at baseline and at the end of fourth year. Determination of independent correlates of the change in eGFR and arterial functions was performed by linear regression analyses.RESULTS: There was a similar decline in renal functions over the study period in both groups. However, arterial functions deteriorated more rapidly in the ADPKD group. Having ADPKD was the only independent factor associated with the decline in arterial functions.CONCLUSION: There were significant decreases in arterial elasticity characteristics in the ADPKD group compared with the control group despite a similar decline in renal functions. Monitoring of arterial stiffness may be as important as monitoring of renal functions in ADPKD patients.