Person: ORUÇ, AYŞEGÜL
Loading...
Email Address
Birth Date
Research Projects
Organizational Units
Job Title
Last Name
ORUÇ
First Name
AYŞEGÜL
Name
46 results
Search Results
Now showing 1 - 10 of 46
Publication The effect of smoking on endothelial dysfunction in autosomal dominant polycystic kidney disease patients with preserved renal function(Taylor & Francis, 2021-06-23) Gül, Cuma Bülent; Yıldız, Abdülmecit; Sağ, Saim; Oruç, Ayşegül; Ersoy, Alparslan; Güllülü, Sümeyye; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; ERSOY, ALPARSLAN; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-0342-9692; AAH-4002-2021; HIG-9032-2022; CPX-5894-2022; EXG-3181-2022Background In autosomal dominant polycystic kidney disease (ADPKD), endothelial dysfunction (ED) is common and occurs much earlier than kidney function impairment. The impact of smoking on ED in ADPKD patients has not been previously studied. The aim of this study was to investigate the potential contribution of smoking habits to ED and subclinical atherosclerosis in these patients. Methods This case-control study included 54 ADPKD patients with preserved renal function and 45 healthy control subjects. ED was assessed using ischemia-induced forearm flow-mediated dilatation (FMD). Carotid intima-media thickness (CIMT) was measured from 10 mm proximal to the right common carotid artery. Clinical demographic characteristics and laboratory data were recorded for the patients and control group. Regression analysis was used to determine independent associations of ED and CIMT. Results FMD was significantly lower in the ADPKD patients (19.5 +/- 5.63 vs. 16.56 +/- 6.41, p = .018). Compared with nonsmoker ADPKD patients, smoker patients had significantly lower FMD values (18.19 +/- 6.52 vs. 13.79 +/- 5.27, p = .013). In multiple regression analysis, age (beta = -0.294, 95% CI: -0.392: -1.96, p = .001) for FMD and smoking (beta = 1.328, 95% CI: 0.251, 2.404, p = .017) for CIMT were independent predictors. Conclusions Patients with ADPKD had more impaired endothelial function and subclinical atherosclerosis compared with control subjects. Smoking may increase the risk of subclinical atherosclerosis in ADPKD patients.Publication Effect of operation timeline on frequency of surgical complication in deceased donor kidney transplantation(Frontiers Media SA, 2019-10-01) Ersoy, Alparslan; Düger, Hakan; Dizdar, Oğuzhan Sıtkı; Yıldız, Abdülmecit; Akgür, Suat; Kaygısız, Onur; Oruç, Ayşegul; Ünsal, Oktay; Coşkun, Burhan; Kordan, Yakup; Türker, Gürkan; Vuruşkan, Hakan; ERSOY, ALPARSLAN; Düger, Hakan; Dizdar, Oğuzhan Sıtkı; YILDIZ, ABDULMECİT; AKGÜR, SUAT; KAYGISIZ, ONUR; ORUÇ, AYŞEGÜL; Ünsal, Oktay; COŞKUN, BURHAN; Kordan, Yakup; TÜRKER, YUNUS GÜRKAN; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Nefroloji Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimasyon Anabilim Dalı.; 0000-0001-5478-3192; 0000-0002-9790-7295; 0000-0002-0342-9692; 0000-0002-8242-9921; 0000-0002-9947-848X; 0000-0002-3019-581X; AAM-9726-2020; AAH-5054-2021; AAI-6642-2021; AAH-4002-2021; IZP-9361-2023; AAH-9704-2021; BBE-2157-2022; HIG-9032-2022; EJA-1761-2022; JJY-8484-2023; AAH-9704-2021; GAF-0095-2022; EFH-9523-2022Publication Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation(Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.Publication Correlation between arterial stiffness and inflammatory markers in autosomal dominant polycystic kidney disease patients with preserved renal function(Springer, 2015-07-01) Gül, Cuma Bülent; Yıldız, Abdülmecit; Ersoy, Alparslan; Kahvecioğlu, Serdar; Asiltaş, Burak; Yıldırım, Fatih; Ermurat, Selime; Sağ, Saim; Oruç, Ayşegül; Güllülü, Sumeyye; Güllülü, Mustafa; YILDIZ, ABDULMECİT; ERSOY, ALPARSLAN; Asıltaş, Burak; YILDIRIM, FATİH; Ermurat, Selime; Sağ, Saim; ORUÇ, AYŞEGÜL; GÜLLÜLÜ, NAZMİYE SÜMEYYE; GÜLLÜLÜ, MUSTAFA; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0003-2467-9356; 0000-0002-0342-9692; 0000-0002-3090-1585; 0000-0001-8404-8252; HIG-9032-2022; AAH-5054-2021; JCN-7114-2023; AAH-4002-2021; ABE-4424-2022; AAW-9185-2020; EKV-7386-2022; EXG-3181-2022; CTG-8811-2022To evaluate the association between arterial stiffness and inflammatory markers including C-reactive protein (CRP), pentraxin 3 (PTX3) and neutrophil-to-lymphocyte ratio (NLR) in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function.A total of 52 ADPKD patients [mean (SD) age 38.2 (12.8) years, 69.2 % were females] with preserved renal function and 25 healthy volunteers [mean (SD) age 35.5 (6.5) years, 48.0 % were females] were included. Data on patient characteristics, blood biochemistry, inflammatory markers [PTX3 (pg/mL), CRP (mg/dL) and NLR] and arterial stiffness [large artery elasticity index (LAEI) (mL/mmHg x 10) and small artery elasticity index (SAEI) (mL/mmHg x 100)] were recorded in patient and control groups. Correlation between inflammatory markers and arterial stiffness parameters was analysed in patients.Overall, 42.3 % of ADPKD patients were hypertensive and 44.4 % were receiving renin-angiotensin-aldosterone system (RAAS) blockade therapy. Median levels for PTX3 [442.0 (20.0-4140.0) pg/mL vs. 220.5 (14.7-393.0) pg/mL, p < 0.001] and SAEI [4.90 (1.60-11.80) mL/mmHg x 100 vs. 6.45 (2.80-15.70) mL/mmHg x 10, p = 0.013] were significantly higher in ADPKD patients than in controls. PTX3 and CRP were not correlated with arterial elasticity, while NLR was significantly correlated with LAEI negatively (Rho = -0.278, p = 0.042).In conclusion, our findings revealed increased PTX3 levels and reduced SAEI in patients as compared with controls, while no correlation between inflammatory markers studied and the small artery elasticity.Publication The effect of medical complications on early graft function after kidney transplantation(Frontiers Media Sa, 2019-10-01) Düger, Hakan; Ersoy, Alparslan; Oruç, Ayşegül; Yıldız, Abdülmecit; Ünsal, Oktay; Akgür, Suat; Ersoy, Canan; Aydın, Mehmet Fethullah; Düger, Hakan; ERSOY, ALPARSLAN; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; Ünsal, Oktay; AKGÜR, SUAT; ERSOY, CANAN; Aydın, Mehmet Fethullah; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.; 0000-0001-5478-3192; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-8861-2021; AAH-4002-2021; GPK-6118-2022; IZP-9361-2023; AAH-5054-2021; HIG-9032-2022; JJY-8484-2023; EJA-1761-2022Publication Pregnancy and kidney transplantation: A single-center experience(Aves, 2022-07-01) Ayar, Yavuz; Sayılar, Emel Işıktaş; Demir, Bilge Cetinkaya; ÇETİNKAYA DEMİR, BİLGE; ERSOY, ALPARSLAN; OCAKOĞLU, GÖKHAN; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Jinekoloji ve Doğum Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-1114-6051; 0000-0002-0342-9692; 0000-0001-6845-9991; AAH-5180-2021; AAH-4002-2021Objective: The possibility of pregnancy increases with kidney transplantation in patients with chronic kidney disease. However, graft dysfunction, risk of fetal growth retardation, and fetal anomaly should be monitored closely. In this study, renal and obstetric outcomes were analyzed in pregnant kidney recipients who were followed in our center.Methods: We analyzed 140 reproductive-aged patients who underwent renal transplantation between January 2009 and May 2015, and clinical and laboratory data were evaluated retrospectively.Results: Twenty-four patients became pregnant (17.1%). In pregnant group, median age was significantly lower than nonpregnant group (P =.014). The median age of pregnant group at the time of transplantation was also significantly lower than non-pregnant patients (P <.001). The rate of pregnant patients was 66.7% in 18-25 year age group (P =.008). The rate of urinary tract infection in non-pregnant group was higher than pregnant group (P =.03). Live birth rates were 83.3% and 45.8% of those whose birth weight was higher than 2500 g. The increased level of daily urinary proteinuria and the time from diagnosis of renal failure to transplantation had significant effect on pregnancy (odds ratio = 13.81;95% CI: 2.06-92.45; P =.007 and odds ratio = 3.25;95% CI: 1.11-9.48; P =.031, respectively). Low serum creatinine level had significant protective effect (odds ratio = 0.001; 95% CI: 0-0.30, P =.018). The patients in 18-25 age group were 48.39 times more eligible for pregnancy compared to those in >35 age group (odds ratio = 48.39; 95% CI: 1.26-1860.72; P =.037). Rejection episodes were observed in 1 of pregnant women and 11 of non-pregnant women (P >.05).Conclusion: Pregnancy is possible in kidney transplant recipients of reproductive age. Calcineurin inhibitors and azathioprine seem to be safe. Maternal age, low-serum creatinine, and urinary proteinuria affect pregnancy. The close monitoring of renal function and fetal parameters is very important.Publication Investigation of the tissue allele distribution of the deceased kidney donors between 2007 and 2017.(Lippincott Williams & Wilkins, 2019-11-01) Oflaz, Rafet; Elgin, Ersin; Yıldız, Abdülmecid; Oruç, Ayşegül; Akgür, Suat; Ünsal, Oktay; Karaca, Mert; Ersoy, Sahriye; Selimoğlu, Kerem; Arslan, İlknur; Karan, Elif; Çiçek, Mehmet Çağatay; Günseren, Kadir Ömür; Güllülü, Sümmeyye; Vuruşkan, Hakan; Oflaz, Rafet; Elgin, Ersin; Yıldız, Abdülmecid; ORUÇ, AYŞEGÜL; AKGÜR, SUAT; Ünsal, Oktay; KARACA, MERT; Ersoy, Sahriye; Selimoğlu, Kerem; Arslan, İlknur; Karan, Elif; ÇİÇEK, MEHMET ÇAĞATAY; GÜNSEREN, KADİR ÖMÜR; GÜLLÜLÜ, NAZMİYE SÜMEYYE; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-9509-5799; 0000-0002-0342-9692; 0000-0003-3635-7282; 0000-0002-3454-8483; 0000-0002-0471-5404; 0000-0001-6711-676X; AAG-7406-2021; AAH-4002-2021; DJU-5362-2022; DXA-2790-2022; EIF-8983-2022; JIX-1144-2023; JJY-8484-2023; AAG-7406-2021; EVS-9805-2022; CDS-3299-2022; CCH-8947-2022; FDB-4488-2022; HGM-5995-2022; EFH-9523-2022; CST-9838-2022; ITO-9188-2023Publication Association of morning blood pressure surge (mbps) with left ventricular hypertrophy in autosomal dominant polycystic kidney disease (ADPKD): Across sectional study(Oxford Univ Press, 2016-05-01) Sağ, Saim; Yıldız, Abdulmecit; Ersoy, Alparslan; Ocakoğlu, Gökhan; Oruç, Ayşegül; Güngören, Fatih; Ayar, Yavuz; Gül, Cuma Bülent; Güllülü, Sümeyye; Güllülü, Mustafa; Sağ, Saim; YILDIZ, ABDULMECİT; ERSOY, ALPARSLAN; OCAKOĞLU, GÖKHAN; ORUÇ, AYŞEGÜL; Güngören, Fatih; Ayar, Yavuz; GÜL, CUMA BÜLENT; GÜLLÜLÜ, NAZMİYE SÜMEYYE; GÜLLÜLÜ, MUSTAFA; Uludağ Üniversitesi/Tıp Fakültesi/Kardioloji Bölümü; 0000-0002-1114-6051; 0000-0002-0342-9692; 0000-0003-4607-9220; 0000-0003-2467-9356; AAH-5180-2021; AGF-0767-2022; AAW-9185-2020; AAH-5054-2021; O-9948-2015; AAA-3163-2021; HLG-6346-2023; AAH-4002-2021; A-7063-2018; GSE-0029-2022; HIG-9032-2022; JGR-6552-2023; CTG-8811-2022Publication Arterial function worsens faster than renal function in autosomal dominant polycystic kidney disease(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2018-01-01) Yıldız, Abdülmecit; Ersoy, Alparslan; Sağ, Saim; Oruç, Ayşegül; Çiğilli, Ercan; Ayar, Yavuz; Güllülü, Sümeyye; Gül, Cuma Bülent; YILDIZ, ABDULMECİT; ERSOY, ALPARSLAN; Sağ, Saim; ORUÇ, AYŞEGÜL; Çiğilli, Ercan; Ayar, Yavuz; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0003-4607-9220; AAH-4002-2021; O-9948-2015; HIG-9032-2022; AAH-5054-2021; GSE-0029-2022; AAW-9185-2020; AGF-0767-2022OBJECTIVE: Early arterial stiffness has been shown in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function. However, to our knowledge, no prospective study evaluated changes in arterial functions in patients with ADPKD. The study aimed to monitor the changes in renal and arterial functions in patients with ADPKD with preserved renal functions.MATERIAL and METHODS: A total of 25 ADPKD patients and 12 controls were included in the study. Data on patient characteristics, biochemical parameters and arterial stiffness were recorded at baseline and at the end of fourth year. Determination of independent correlates of the change in eGFR and arterial functions was performed by linear regression analyses.RESULTS: There was a similar decline in renal functions over the study period in both groups. However, arterial functions deteriorated more rapidly in the ADPKD group. Having ADPKD was the only independent factor associated with the decline in arterial functions.CONCLUSION: There were significant decreases in arterial elasticity characteristics in the ADPKD group compared with the control group despite a similar decline in renal functions. Monitoring of arterial stiffness may be as important as monitoring of renal functions in ADPKD patients.Publication The outcomes of kidney transplantation from elder deceased donors a single center experience(Lippincott Williams & Wilkins, 2019-11-01) Selimoğlu, Kerem; Elgin, Ersin; Yıldız, Abdülmecit; Oruç, Ayşegül; Akgür, Suat; Ünsal, Oktay; Keskin, Sahriye; Oflaz, Rafet; Arslan, İlknur; Karan, Elif; Çiçek, Mehmet Çağatay; Günseven, Kadir Ömür; Karaca, Mert; Güllülü, N. Sümeyye; Vuruşkan, Hakan; Ersoy, Alparslan; Selimoğlu, Kerem; Elgin, Ersin; Yıldız, Abdülmecit; ORUÇ, AYŞEGÜL; AKGÜR, SUAT; Ünsal, Oktay; Keskin, Sahriye; Oflaz, Rafet; Arslan, İlknur; Karan, Elif; ÇİÇEK, MEHMET ÇAĞATAY; Günseven, Kadir Ömür; KARACA, MERT; GÜLLÜLÜ, NAZMİYE SÜMEYYE; VURUŞKAN, HAKAN; ERSOY, ALPARSLAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0003-3635-7282; 0000-0002-9509-5799; 0000-0002-0342-9692; 0000-0002-3454-8483; 0000-0002-0471-5404; CDS-3299-2022; DXA-2790-2022; HIG-9032-2022; AAH-4002-2021; EJA-1761-2022; JJY-8484-2023; CZH-6714-2022; DJU-5362-2022; CCH-8947-2022; FDB-4488-2022; HGM-5995-2022; CUF-3990-2022; AAG-7406-2021; CTR-6558-2022; EFH-9523-2022; AAH-5054-2021