Person: TURAN, SERKAN
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TURAN
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SERKAN
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Publication Reduced cortical thicknesses of adolescents with bipolar disorder and relationship with brain-derived neurotrophic factor(Sciendo, 2023-01-01) İnal, Neslihan; Cavuşoğlu, Berrin; Ermis, Çağatay; Görmez, Vahdet; Karabay, Nuri; Turan, Serkan; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; AFO-6356-2022Background: Cortical thickness (CT) and brain-derived neurotrophic factor (BDNF) were widely investigated in bipolar disorder (BD). Previous studies focused on the association between the volume of subcortical regions and neurotrophic factor levels.Objective: In this study, we aimed to evaluate the association of the CT in youth with early-onset BD with BDNF levels as a potential peripheral marker of neuronal integrity.Method: Twenty-three euthymic patients having a clinical diagnosis of BD and 17 healthy subjects as an age-matched control group with neuroimaging and blood BDNF levels were found eligible for CT measurement. A structural magnetic resonance scan (MRI) and timely blood samples were drawn.Results: Youth with BD exhibited lower cortical thickness in caudal part of left (L) middle frontal gyrus, right (R) paracentral gyrus, triangular part of R inferior frontal gyrus, R pericalcarine region, R precentral gyrus, L precentral gyrus, R superior frontal gyrus and L superior frontal gyrus when compared to healthy controls. The effect sizes of these differences were moderate to large (d=0.67-0.98) There was a significant correlation between BDNF levels with caudal part of the R anterior cingulate gyrus (CPRACG) in adolescents with BD (r=0.49, p=0.023).Conclusion: As a special region for mood regulation, the CT of the caudal part of the R anterior cingulate gyrus had a positive correlation with BDNF. Regarding the key role of CPRACG for affective regulation skills, our results should be replicated in future follow-up studies, investigating a predictive neuroimaging biomarker for the early-onset BD.Publication Violence against the doctor in the developing countries during covid-19 pandemic. mental health linkages(Medicinska Naklada, 2021-01-01) Shoib, Sheikh; Arafat, S. M. Yasir; Gupta, Anoop Krishana; Ullah, Irfan; Turan, Serkan; Turan, Serkan; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-6548-0629; HKE-9636-2023Publication Correlates of psychotic like experiences (PLEs) during Pandemic: An online study investigating a possible link between the SARS-CoV-2 infection and PLEs among adolescents(Elsevier, 2022-01-21) Kafalı, Helin Yılmaz; Turan, Serkan; Akpınar, Serap; Mutlu, Müge; Parlakay, Aslınur Özkaya; Cop, Esra; Toulopoulou, Timothea; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk ve Ergen Psikiyatrisi Anabilim Dalı.; 0000-0002-6548-0629 ; AFO-6356-2022Background: This study investigated whether SARS-CoV-2 infection, depression, anxiety, sleep problems, cigarette, alcohol, drug usage contribute to psychotic-like experiences (PLEs) among adolescents during the pandemic. We also aimed to explore whether baseline inflammatory markers or the number of SARS-CoV-2related symptoms are associated with PLEs, and the latter is mediated by internalizing symptoms. Methods: Altogether, 684 adolescents aged 12-18 (SARS-CoV-2 group n = 361, control group (CG) n = 323) were recruited. The Community Assessment of Psychic Experiences-42-Positive Dimension (CAPE-Pos), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Pittsburg Sleep Quality Index (PSQI) questionnaires were completed by all volunteers using an online survey. C-reactive Protein and hemogram values, and SARS-CoV-2-related symptoms during the acute infection period were recorded in the SARS-CoV-2 group. Group comparisons, correlations, logistic regression, and bootstrapped mediation analyses were performed. Results: CAPE-Pos-Frequency/Stress scores were significantly higher, whereas GAD-7-Total and PSQI-Total scores were significantly lower in SARS-CoV-2 than CG. Among the SARS-CoV-2 group, monocyte count and the number of SARS-CoV-2-symptoms were positively correlated with CAPE-Pos-Frequency/Stress scores. Besides SARS-CoV2, cigarette use, GAD-7, and PHQ-9 scores significantly contributed to the presence of at least one CAPE-Pos "often" or "almost always". PHQ-9 and GAD-7 fully mediated the relationship between the number of SARSCoV-2 symptoms and CAPE-Pos-Frequency. Conclusions: This study is the first to show a possible relationship between SARS-CoV-2 infection and PLEs among adolescents. Depression, anxiety, and cigarette use also contributed to PLEs. The number of SARS-Cov-2symptoms and PLEs association was fully mediated by internalizing symptoms, but prospective studies will need to confirm this result.Publication Exposure to violence and the presence of suicidal and self-harm behaviour predominantly in asian females: Scoping review(Springernature, 2022-08-18) Shoib, Sheikh; Khan, Sonia; Baiou, Alaa; Chandradasa, Miyuru; Swed, Sarya; Armiya'u, Aishatu Yusha'u; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-3739-706X; 0000-0003-0870-9260; 0000-0002-1873-8228; 0000-0002-9983-2020; 0000-0002-6548-0629; 0000-0003-0881-1281; AFO-6356-2022; ABA-9762-2021; HKE-9636-2023; AAQ-5795-2020Background Exposure to violence is associated with psychological distress, mental disorders such as depression, and suicidal behaviour. Most of the studies are conducted in the West, with limited publications from Asia. Thus, we conducted a scoping review of studies investigating the association between experiences of violence and later suicidal ideation/attempts from Asia in the twenty-first century. Results Many studies focused on domestic violence toward women in the Southeast Asian region. Sociocultural factors such as family disputes, public shaming, dowry, lack of education opportunities, and marriage life perceptions mediated the association. Many women exposed to violence and attempted suicide suffered from mental disorders such as depression, anxiety, and post-traumatic stress. The small number of suitable studies and the possible effect of confounders on participants were limitations in the review. Future studies would have to focus on specific types of violence and ethnoreligious beliefs. Conclusion Women in Asia exposed to violence appear to have an increased risk of suicidal behaviour and mental disorders. The early screening of psychological distress with culturally validated tools is essential for preventing suicides in Asian victims of violence.Publication Public health literacy unsold during panic buying comment(Elsevier Sci Ltd, 2022-08-02) Shoib, Sheikh; Lodi, Aisha; Saleem, Amna; Armiya'u, Aishatu Yusha'u; Philip, Sharad; Turan, Serkan; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; AFO-6356-2022Publication Impaired theory of mind and emotion recognition in pediatric bipolar disorder: A systematic review and meta-analysis(Pergamon-Elsevier Science Ltd, 2021-04-15) Halac, Eren; Ciray, Remzi Ogulcan; Tuncturk, Mustafa; Agac, Nilay; Elmas, Fatma Nur; Rosson, Stella; Ermis, Cagatay; Turan, Serkan; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; 0000-0003-2864-613X; 0000-0002-6548-0629; 0000-0003-3928-3194; 0000-0002-8554-3519; HKE-9636-2023; AFO-6356-2022; GRY-0250-2022Background: Social cognition is impaired in patients with severe mental disorders. We aimed to investigate impairments in social cognition in youth with pediatric bipolar disorder (PBD) through a systematic review of the literature and the meta-analysis.Method: Following the PRISMA guidelines, we searched in PubMed, Scopus, and Cochrane CENTRAL for studies reporting on the theory of mind (ToM) and emotion recognition (ER) abilities of patients with PBD compared to healthy controls (HC). We conducted a random-effects model meta-analysis for the contrast between PBD and HC. Subgroup and meta-regression analyses were conducted for demographic and clinical variables as appropriate.Results: A total of thirteen studies involving 429 patients with PBD and 394 HC were included. Patients with PBD had significantly poorer social cognitive abilities (Hedges' g for ER, g = -0.74, CI = -0.91, -0.57; and for ToM, g = -0.98, CI = -1.41 to -0.55). Subgroup analysis also revealed significant impairment in ER for patients in a euthymic state (g = -0.75). Age, gender, sample size, the severity of mood symptoms, estimated IQ, the frequencies of bipolar-I disorder, attention-deficit hyperactivity disorder, medications, study quality and euthymia did not moderate the difference in meta-regression. Heterogeneity was low in all analyses and there was no evidence for publication bias.Conclusion: The results of this meta-analysis supported the notion that PBD is associated with a deficit in social cognitive abilities at a medium to a large level. Impairments in social cognition could be an illness-related trait of PBD. Meta-regression results did not find a moderator of the deficits in social cognition.Publication Electroconvulsive therapy or clozapine for adolescents with treatment-resistant schizophrenia: An explorative analysis on symptom dimensions(Taylor & Francis Ltd, 2022-12-27) Tunçtürk, Mustafa; Ermis, Çağatay; Büyüktaşkın, Dicle; Turan, Serkan; Sağlam, Yeşim; Alarslan, Sezen; Güler, Duru; Sut, Ekin; Unutmaz, Güldal; Güzel, Ayse Beste; Canbek, Ozge Atay; Inal, Neslihan; Karacetin, Gul; Hazell, Philip; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk ve Ergen Psikiyatrisi Anabilim Dalı.; 0000-0002-6548-0629 ; AFO-6356-2022ObjectiveThis study sought to compare pre-intervention patient characteristics and post-intervention outcomes in a naturalistic sample of adolescent inpatients with treatment-resistant psychotic symptoms who received either electroconvulsive therapy (ECT) or clozapine.MethodsData of adolescents with schizophrenia/schizoaffective disorder receiving ECT or clozapine were retrospectively collected from two tertiary-care psychiatry-teaching university hospitals. Subscale scores of the Positive and Negative Symptom Scale (PANSS) factors were calculated according to the five-factor solution. Baseline demographics, illness characteristics, and post-intervention outcomes were compared.ResultsThere was no significant difference between patients receiving ECT (n = 13) and clozapine (n = 66) in terms of age, sex, and the duration of hospital stay. The ECT group more commonly had higher overall illness and aggression severity. Smoking was less frequent in the clozapine group. Baseline resistance/excitement symptom severity was significantly higher in the ECT group, while positive, negative, affect, disorganisation, and total symptom scores were not. Both interventions provided a significant reduction in PANSS scores with large effect sizes.ConclusionBoth ECT and clozapine yielded high effectiveness rates in adolescents with treatment-resistant schizophrenia/schizoaffective disorder. Youth receiving ECT were generally more activated than those who received clozapine.Publication Selective serotonin reuptake inhibitors and manic switch: A pharmacovigilance and pharmacodynamical study(Elsevier, 2021-10-16) Çıray, R. Oğulcan; Halaç, Eren; Turan, Serkan; Tunçtürk, Mustafa; Özbek, Mutlu; Ermiş, Çağatay; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk ve Ergen Psikiyatrisi Anabilim Dalı.; 0000-0002-6548-0629; HKE-9636-2023; AFO-6356-2022Background: There is still no approved mechanism of manic switch in bipolar disorder, yet many selective serotonin reuptake inhibitors were accused for this important adverse event. Therefore, we aimed to investigate to estimate SSRI' s risk for reporting mania and elevated mood using FEARS database and investigate receptor mechanisms involved.Methods: Mania and relevant side effects approved by FDA were screened in this dataset from the first quarter of 2004 to the third quarter of 2020. Disproportionality analysis were performed to estimate reporting odds ratio (ROR) and linear regressions were conducted to investigate relationship between ROR and Ki values. Receptor occupancy ratios were calculated from in vitro receptor binding profiles. The pharmacodynamical profile was extracted from the International Union of Basic and Clinical Pharmacology and the British Pharmacology Society dataset. Child and adolescent population was also investigated separately.Results: The analysis showed that the odds of a spontaneous report of mania in the FAERS database involving an SSRI were higher than the odds that such a report involved other types of drugs (ROR: 5.324 [CI: 3.773; 7.514]). The largest effect size in this estimation was found in fluvoxamine (ROR: 13.957 [CI: 10.391; 18.747]). Significant effects were found in regression analysis for Ki values of H1 and M1 receptors on ROR. Receptor occupation was not found to have an effect on ROR.Conclusion: Lower degress of Ki values on M1 and H1 may be plausible pharmacological mechanism. Further pharmacological data and clinical assessments may be important to validate this safety signal.Publication Searching the underlying mechanisms of specific learning disorder: An emotion recognition and social cognition aspect for turkish clinical youth population(Routledge Journals, Taylor & Francis Ltd, 2022-12-12) Çıray, Remzi Oğulcan; Turan, Serkan; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0003-2864-613X; HKE-9636-2023This study aimed to investigate impairments in social cognition in youth with specific learning disorder (SLD) through a cross sectional study. Eighty six adolescents which include of 43 SLD and 43 typically developing (TD) children completed a battery of tests to analyze social cognition, emotional process and clinical psychopathological profile. SLD group performed significantly worse than healthy controls in facial ER total accuracy score (Cohen d = .77) and Stroop interference (Cohen d = .92). In individual emotion analyses, patients with SLD have a very high deficiency in recognition of angry faces (Cohen d = .89). Between-group difference was also significant for Stroop congruent and facilitation scores (Cohen d = .99). The Specific Learning Disorder Symptom Check List-Parent Form scores were significant -and only- predictor of the model which for total accuracy score of facial recognition. The results of this study supported an impairment in emotion recognition and executive functions in adolescents with SLD but causality seems still unclear.Publication Circulating c1q complement/tnf-related protein (ctrp)-13 levels in obese children and its relationship with metabolic disorders(Karger, 2021-09-01) Erbas, Ibrahim Mert; Paketci, Ahu; Sisman, Ali Riza; Demir, Korcan; Bober, Ece; Abaci, Ayhan; Turan, Serkan; TURAN, SERKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; 0000-0002-8334-2422; 0000-0001-8828-0892; 0000-0002-1812-0321; HKE-9636-2023