Person: KASAPOĞLU, IŞIL
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KASAPOĞLU
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IŞIL
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Publication Preliminary results of the DINE study (Dienogest vs. norethindrone acetate in endometriosis treatment)(Oxford Univ Press, 2023-06-01) Gürbüz, Tansu Bahar; Uncu, Gürkan; Aslan, K.; Gadirli, Z.; Kasapoğlu, Işıl; GÜRBÜZ, TANSU BAHAR; UNCU, GÜRKAN; Aslan, K.; Gadirli, Z.; KASAPOĞLU, IŞIL; Uludağ Üniversitesi/Tıp Fakültesi/Doğum ve Jinekoloji Bilim Dalı; GXB-3440-2022; GER-9626-2022; GLW-2086-2022; JDO-9798-2023; CXJ-7203-2022Publication Fertility and breast cancer: Recommendations of the 2019 izmir consensus conference(Turkish Surgical Assoc, 2020-03-01) Koçdor, Mehmet Ali; Doğan, Erbil; Güllüoğlu, Bahadır; Güven, Davut; Cantürk, Nuh Zafer; Isik, Ahmet Zeki; Altıntas, Sevilay; Emiroglu, Mustafa; Atahan, Kemal; Gode, Funda; Posacı, Cemal; Mentes, Öner; Saatli, Bahadır; Sancı, Muzaffer; Kurt, Sefa; Özeren, Mehmet; Kebudi, Abut; Uncu, Gürkan; Celiloğlu, Murat; Kasapoğlu, Işıl; KASAPOĞLU, IŞIL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; CXJ-7203-2022Publication Mesh complications on youtube(Elsevier, 2020-09-01) Orhan, Adnan; ORHAN, ADNAN; Göktürk, Gözde Güner; Özerkan, Kemal; ÖZERKAN, KEMAL; Kasapoglu, Işıl; KASAPOĞLU, IŞIL; Aslan, Kiper; ASLAN, MÜNİR KİPER; Uncu, Gurkan; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-7558-8166; 0000-0002-9277-7735; K-2269-2016; AAH-9791-2021; AER-7173-2022; AAH-9694-2021; AAT-3479-2021; V-5292-2019Objective: There has been a heated discussion about mesh materials in urogynecology in recent years. The role of social media in this discussion is critical. This study aims to make a systematic analysis of videos uploaded to YouTube about mesh complications in urogynecology.Study Design: YouTube was searched using specific terms about mesh materials. The primary outcome was the relationship between the video characteristics-which were publisher identity, attitude, the main focus of the video country, and year- and the mesh debate in urogynecology.Results: We analyzed 1128 YouTube videos about mesh complications. There was no distinction between stress urinary incontinence and pelvic organ prolapse when referring to the mesh material in 79 % of the videos. 35.2 % of the videos were in the News group, 31.2 % were in the Patients group, 19.6 % were in the Doctors group, and 14.0 % were in the Lawyers group. Videos in the News (75.7 %), Patients (92.6 %), and Lawyers (99.4 %) groups mostly had a negative attitude, while videos in the Doctors (48.9 %) group mostly had an informative attitude. News (43.2 %) and Patients (51.2 %) group videos were predominantly from the United Kingdom. However, Lawyers (81.0 %) and Doctors (44.3 %) videos were predominantly from the USA. In the last three years, the news and patients videos have increased by an average of 40 % each year.Conclusion: YouTube has influenced the mesh dilemma with a negative attitude. As long as social media is at the center of this discussion, a healthy outcome cannot be achieved.Publication Does the presence of endometriosis cause a challenge for transvaginal oocyte retrieval? A comparison between patients with and without endometriosis(Galenos Yayıncılık, 2018-03-12) Kasapoğlu, Işıl; Türk, Pınar; Dayan, Aylin; Uncu, Gürkan; KASAPOĞLU, IŞIL; Türk, Pınar; Dayan, Aylin; UNCU, GÜRKAN; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; AAT-3479-2021; CXJ-7203-2022; JJP-1980-2023; ETO-8465-2022Objective: The aim of the study was to compare patients with and without endometriosis regarding performance rates, difficulties, and complications associated with transvaginal oocyte retrieval (TVOR) procedures.Material and Methods: A prospective cohort study was conducted at the In Vitro Fertilization Unit of the Division of Reproductive Endocrinology and Infertility Department of a university hospital. Fifty-eight patients with endometriosis and 61 patients without endometriosis underwent TVOR procedures consecutively. Primary outcome measures were; number of needle entries per patient and performance rating defined as the total number of oocytes retrieved per vaginal needle entry. The requirement for manual compression of the abdominal wall (assistance) to reach the ovaries, procedure-related pain, and procedural complications were also evaluated.Results: The median number of needle entries through the vaginal wall per patient was comparable between the two groups (p=0.45). Performance rates were higher in the control group (p=0.001). Performance rates and total number of the needle entries through the vaginal wall were not significantly correlated with ovarian endometrioma (OMA) diameter (r=0.28; p=0.68; r=0.275, p=0.068, respectively) in the endometriosis group. Body mass index (BMI) scores were found to be correlated with the number of the needle entries and higher BMI scores were associated with higher numbers of vaginal wall punctures (p< 0.001). The requirement for manual compression of the abdominal wall was significantly higher in the control group (57.4% vs 27.6%, p=0.001). A similar proportion of women needed analgesic medications after the TVOR procedure in both groups (10.3% vs 16.9%, p=0.33). Hospital readmissions for any symptoms were also comparable between the two groups (p=0.22). Three women were treated for pelvic infection, all of whom were in the endometriosis group.Conclusion: Endometriosis seems to cause a challenge for TVOR that may have reflection on individual surgeon's performance rates for the procedure, independently from the diameter of a pre-existing OMA or ovarian adhesions. Obesity is another factor that may present a challenge for the procedure.Publication Fertilisation and early embryonic development of immature and rescue in vitro-matured sibling oocytes(Taylor & Francis, 2020-01-16) Avcı, Berrin; Kasapoğlu, Işıl; Çakir, Cihan; Özbay, Aysun; Ata, Barış; Uncu, Gürkan; AVCI, BERRİN; KASAPOĞLU, IŞIL; ÇAKIR, CİHAN; Özbay, Aysun; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-8332-7353; 0000-0001-8135-5468; AAT-3479-2021; GQR-0770-2022; AAH-5249-2021; CXJ-7203-2022 ; ABE-6685-2020The objective of this study was to assess the effect of rescue in vitro maturation and immediate intracytoplasmic sperm injection (ICSI) application on fertilisation success and early embryonic development of metaphase I (MI) oocytes. This was a retrospective cohort study including 2425 sibling oocytes in 259 ICSI cycles. ICSI was performed on 104 GV (germinal vesicle) oocytes which had reached the metaphase II (MII) stage (Group 1) and 231 MI oocytes which had reached the MII stage (Group 2) following IVM (in vitro maturation). Immediate ICSI was applied following oocyte aspiration on 292 MI stage (Group 3) and 1798 MII stage oocytes (Group 4). Normal fertilisation rates in Groups 1, 2, 3 and 4 were 51.9%, 39%, 30.1% and 59.5%, respectively. The rates of blastocyst development per oocyte and per zygote were calculated as 3.8%, 3.0%, 6.8%, 14.1% and 7.4%, 7.7%, 22.7%, 23.6% for Groups 1, 2, 3 and 4, respectively. The blastocyst development rate was significantly higher in the MI-ICSI group compared with other immature oocytes. Even though performing ICSI on the oocytes at the MI stage on the day of oocyte aspiration resulted in lower fertilisation rates, it was associated with significantly higher rates of blastocyst development.Publication Effect of embryo morphology on maternal serum β-hCG level in pregnancies resulting from a fresh single cleavage embryo and a fresh single blastocyst(Oxford Univ Press, 2018-07-01) Kuşpınar, Göktan; Kasapoğlu, Işıl; Sarıbal, Seda; Uncu, Gürkan; Avcı, Berrin; KUŞPINAR, GÖKTAN; KASAPOĞLU, IŞIL; Sarıbal, Seda; UNCU, GÜRKAN; AVCI, BERRİN; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Kadın Hastalıkları ve Doğum Anabilim Dalı; 0000-0002-0338-8368; AAH-5119-2021; HTQ-5866-2023; AAT-3479-2021; ABE-6685-2020; CXJ-7203-2022; FTW-2214-2022Publication Amh levels may predict for mullerian anomalies and pregnancy outcomes patients with pcos.(Elsevier, 2020-09-01) Aslan, Kiper; ASLAN, MÜNİR KİPER; Albayrak, Özge; Bilgiç, Kübra Özlem; BİLGİÇ, KÜBRA ÖZLEM; Kasapoglu, Işıl; KASAPOĞLU, IŞIL; Avci, Berrin; AVCI, BERRİN; Uncu, Gurkan; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-9277-7735; AAH-9694-2021; AER-7173-2022; AAT-3479-2021Publication Does gonadotropin dose adjustment in inadequate ovarian response during controlled ovarian hyperstimulation improve the live birth rates of patients with diminished ovarian reserve?(Oxford Univ Press, 2022-07-01) Mesut, O. C.; MESUT, ÖMER ÇAĞATAY; Gürbüz, T. B.; GÜRBÜZ, TANSU BAHAR; Aslan, K.; ASLAN, MÜNİR KİPER; Uncu, G.; UNCU, GÜRKAN; Kasapoğlu,; KASAPOĞLU, IŞIL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.Publication Evaluation of endometrioma pathophysiology and related ovarian damage by PTEN / AKT apoptosis signaling pathway(Elsevier Science, 2020-09-01) Şen, Furkan; Aslan, Kiper; Kuşpınar, Göktan; Çakır, Cihan; Kasapoglu, Işıl; Avcı, Berrin; Uncu, Gürkan; ŞEN, HAMZA FURKAN; ASLAN, MÜNİR KİPER; KUŞPINAR, GÖKTAN; ÇAKIR, CİHAN; KASAPOĞLU, IŞIL; AVCI, BERRİN; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-9277-7735; 0000-0002-8332-7353; AAH-5119-2021; AAT-3479-2021; HTQ-5866-2023; AER-7173-2022; AAH-9694-2021; AAH-5249-2021; KEU-2073-2024; CXJ-7203-2022; ELU-2357-2022Publication EROSS study: Effect of ovarian reserve on sexual satisfaction(Taylor & Francis Inc, 2022-06-03) Aslan, Elif Kulahçı; Aslan, Kiper; Gürlüler, Jale; Uyanıklar, Özlem; Kılık, Tuğba; Türk, Pınar; Özden, Okan; Kasapoğlu, Işıl; Uncu, Gürkan; ASLAN, MÜNİR KİPER; KASAPOĞLU, IŞIL; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-9277-7735 ; AER-7173-2022; CXJ-7203-2022; AAT-3479-2021The population of this multicenter prospective cohort study comprised 180 women. Women who were admitted to the gynaecology department with any symptoms aged 18-40 years, whose ovarian reserve was tested, were prospectively enrolled in the study. The Female Sexual Function Index (FSFI) survey was administered to all patients. Demographic parameters (age, body mass index), ovarian reserve tests and FSFI scores were analysed. FSFI scores were compared between the patients with diminished ovarian reserve (DOR) and normal ovarian reserve (NOR). Mean women age was 30.8 +/- 5.1 years. Median (with quartiles) AFC was 15 (10-20) and anti-mullerian hormone (AMH) was 2.6 (1.3-4.3) ng/mL. Mean FSFI score was 27 +/- 4.7. The FSFI score was positively correlated with AMH and AFC and negatively correlated with women age. FSFI score depending on ovarian reserve were; 24.7 +/- 5.2 vs. 27.4 +/- 4.3, p < .01 (Respectively; DOR group (n = 43) vs. NOR group (n = 132)). Threshold value for AMH to predict sexual hypofunction was 2.32 with 67% sensitivity - 62% specificity (AUC: 0.68 p < .01) and for AFC to predict sexual hypofunction was 15 with 65% sensitivity - 60% specificity (AUC: 0.67 p < .01). In conclusion, the ovarian reserve should be considered in reproductive aged women while assessing the exact aetiology of female sexual dysfunction. IMPACT STATEMENT What is already known on this subject? Sexual dysfunction is a common disorder and negatively affects the life quality of women. Its estimated prevalence is 40% in women worldwide. There are still unknown aetiologies for sexual dysfunction. What do the results of this study add? The female sexual function index is positively correlated with ovarian reserve. Decreasing sexual functions is related to decreased ovarian reserve. Lower AMH than 2.32 ng/dl and lower antral follicle count than 15 are associated with sexual hypofunction. What are the implications of these findings for clinical practice and/or further research? This pilot study showed the relationship between sexual functions and ovarian reserve. In daily practice, the ovarian reserve should be considered in reproductive-aged women while assessing the exact aetiology of the sexual dysfunction.