Person: ASLIER, MUSTAFA
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ASLIER
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MUSTAFA
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Publication The prognostic value of thyroid gland invasion in locally advanced laryngeal cancers(Taylor, 2021-08-16) Aslıer, Mustafa; Uçurum, Bahar Ezgi; Kaya, Hilmi Cem; Coşkun, Hakan; ASLIER, MUSTAFA; UÇURUM KANTARCI, BAHAR EZGİ; KAYA, HİLMİ CEM; COŞKUN, HAMDİ HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz-Baş Boyun Cerrahisi Anabilim Dalı; 0000-0001-8257-0979; 0000-0003-0786-4453; 0000-0003-3670-4651; 0000-0002-0881-1444; ABH-1328-2021; KHB-5653-2024; GDF-8132-2022; GEH-1871-2022; DVC-7511-2022Background Locally advanced laryngeal cancers can spread to the thyroid gland by direct invasion of cricothyroid membrane. The prevalence of thyroid gland invasion (TGI) and the predictive factors of TGI were well described in literature. However, the association of TGI with survival was undetermined yet. Objectives The aim of this study is to analyze the effects of TGI on survival rates in patients with locally advanced laryngeal cancer. Materials and methods Medical records of 91 patients who underwent total laryngectomy with thyroidectomy were retrospectively reviewed. Demographical, clinical, and histopathological characteristics of the patients were noted. Kaplan-Meier test was used for survival analysis. Results Histopathology reports revealed the prevalence of TGI as 14.3% (13/91). Survival analyses showed that TGI did not affect recurrence free (p = .078) and overall (p = .080) survival rates. Conclusions Thyroid gland invasion is one of the characteristic features of locally aggressive laryngeal tumors. In this study, TGI is not a statistically significant prognostic factor that has impact on survival of the patients with locally advanced laryngeal cancer.Publication The bibliometric aspects of case report/series in science citation index otorhinolaryngology journals(Galenos Yayıncılık, 2021-08-29) Aslıer, Nesibe Gül Yüksel; Aslıer, Mustafa; ASLIER, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; 0000-0001-8257-0979; KHB-5653-2024Objective: The rate of case report/series (CR/S) acceptance by the high impact journals is steadily declining mainly due to low citations. The aim of this study is primarily to investigate the bibliometric aspects of CR/S in the field of otorhinolaryngology (ORL) and secondarily to guide prospective authors as to which type of CR/S have better chances of acceptance and citation in the current publication climate.Methods: Bibliometric and citation analysis of CR/S published in Science Citation Index (SCI) journals of ORL covering the years of 2012-2016 was conducted.Results: There were 1332 (8.9%) CR/S among 14900 publications in 11 SCI ORL journals published between January 1st, 2012 and December 31st, 2016. The most common published field and subject were the 'pediatric ORL' (33.2%) and 'rare cases/conditions' (47.1%) respectively. 'General ORL' (5.13) and 'treatment' (4.93) categories had the highest citations. Only 10% of CR/S had >= 10 citations. The mean citation counts were positively correlated with impact factors of journals (r=0.131, p<0.001), mean number of authors (r=0.151, p<0.001), mean number of cases (r=0.192, p<0.001), mean number of references (r=0.315, p<0.001) and mean number of Web of Science visits (r=0.291, p<0.001).Conclusion: Although CR/S provides low citation rates in ORL SCI journals, they may serve important topics in terms of diagnosis, treatment, or complications. The findings and the main discussions of this study may direct the rationale for the consistent publication of CR/S in the evidence-based medicine era.Publication The influence of age and language on developmental trajectory of theory of mind in children with cochlear implants(Elsevier Ireland, 2020-08-01) Aslıer, Mustafa; Aslıer, Nesibe Gül Yüksel; Kırkım, Günay; Güneri, Enis Alpin; ASLIER, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; KHB-5653-2024Objective: The present study investigates if children with cochlear implants (CI) are associated with delayed development of Theory of Mind (ToM) and the differences in gain of ToM ability with respect to age, language and other aspects of CI.Methods: One-hundred-eleven children with participation of their hearing parents, aged between 36 months and 132 months, who had congenital profound bilateral deafness and were unilateral CI users; plus 99 healthy children underwent 'Peabody Picture Vocabulary' and 'Sally-Anne' tests. A total of 77 children with CI (mean age: 76.51 months, 31 girls and 46 boys) and 82 healthy children (mean age: 72.41 months, 47 girls and 35 boys) were included in the analyses. Analytic comparisons were created between the controls and children with CI and between subgroups of CI users by univariate and multivariate analysis. The effects of age of hearing aid use, age of CI surgery, duration of CI use, language scores and the presence of risk factors, early rehabilitation with hearing aid and CI on the ToM development were analyzed.Results: The Sally-Anne test success rates of 67.1% were significantly higher in controls than that of children with CI (49.4%) (p < 0.05). The mean age difference of the children, who were successful in Sally-Anne test was 5.33 months in favor of healthy controls. The ToM task success rates were 57.1% (24/42) and 40% (14/35) in children with early CI and late CI respectively. The children, who were good at language, were also better in Sally-Anne tests, but the mean Peabody Picture Vocabulary test scores were indifferent in the same age group with respect to the presence of CI use (p > 0.05). However, multivariate analysis presented the higher language scores as the only significant independent variable that has impact on the success in Sally-Anne test (p < 0.05).Conclusion: The results revealed that among all children, who did better in ToM were older in age and better in language skills. Children with CI also performed better in false-belief test depending on their language scores. Early CI surgery, older age, and hence longer CI use can provide a well-developed ToM for children with CI.Publication Treatment results and postoperative complications of single-stage tracheal resection in adolescent patients with post-intubation tracheal stenosis, compared to adults(Galenos Yayıncılık, 2022-03-01) Aslıer, Mustafa; Yıldırım, Muhammed Furkan; Coşkun, Hakan; ASLIER, MUSTAFA; YILDIRIM, MUHAMMED FURKAN; COŞKUN, HAMDİ HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz, Baş Boyun Cerrahisi Anabilim Dalı.; 0000-0002-6117-9345; 0000-0002-0881-1444; 0000-0001-8257-0979; CCA-0193-2022; IRY-6058-2023; DVC-7511-2022Objective: The purpose of this study was to analyze the treatment outcomes and postoperative complications of tracheal resection in patients under the age of 19 years with post-intubation tracheal stenosis, and to compare the results with those of adults.Methods: Data were retrospectively retrieved from the medical records, including demographic characteristics. perioperative features, any postoperative complications and follow-up statuses of the patients. Treatment results and postoperative complications were compared between adolescent and adult groups.Results: Overall, anastomotic and non-anastomotic complication rates in the adolescent group and the adult group were 40%, 40%, 10% and 63%, 44.4%, 33.3%, respectively. Overall treatment success rates based on tracheostomy tube and tracheal stent free status were 90% and 92.6% in adolescent and adults, respectively.Conclusion: Treatment success rates and incidence of anastomotic complications were found similar in patients under the age of 19 years and adult patients who underwent single-stage tracheal resection and end to end anastomosis for treatment of post-intubation tracheal stenosis.Publication Role of the neck dissection in early-stage lower lip cancers(Wolters Kluwer Medknow Publications, 2023-09-01) İNAN, HAKKI CANER; İnan, Caner; Yanaşma, H. O.; ÖZTÜRK YANAŞMA, HALİDE; Saraydaroğlu, O.; SARAYDAROĞLU, ÖZLEM; Aslier, Mustafa; ASLIER, MUSTAFA; Şahin, İ.; Basut, O.; BASUT, OĞUZ İBRAHİM; Kasapoğlu, F.; Özmen, A. O.; Demir, U. L.; Coşkun, H.; KASAPOĞLU, FİKRET; ÖZMEN, ÖMER AFŞIN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0001-6254-372X; O-2907-2018Background: In early-stage lip cancer, spread to cervical lymph nodes is extremely rare. Elective neck treatment options include suprahyoid or supraomohyoid neck dissection, sentinel lymph node biopsy, or close follow-up. Aim: In this study, our aim was to investigate the effect of elective surgery on survival in patients operated for early-stage lip cancer. Methods: Patients who underwent surgical treatment for lower lip squamous cell carcinoma between 2005 and 2020 were retrospectively analyzed. Age, gender, neck dissection status (yes/no), clinical and pathological T stage of the tumor, grade, and perineural invasion were recorded and 3-year and 5-year overall (OS) and disease-free survival (DFS) rates were estimated. Results: Thirty patients were included: 20 patients had pT1 and 10 patients had pT2 tumors. Neck dissection was performed in 13 patients. The 5-year OS rate was 90.9% and 87.8% with and without dissection, respectively. Neck dissection did not appear to affect OS (P = 0.534) in these patients. The 5-year DFS rate was 96.4% in the overall group, while it was 91.7% and 100% in patients who did or did not undergo neck dissection, respectively (P = 0.756). Discussion: Patients with or without neck dissection did not differ significantly in terms of OS and DFS. Watchful waiting with regular ultrasound imaging of the neck in patients with T1 and T2 lip tumors may be an appropriate therapeutic option.Publication The incidence of thyroid gland invasion in advanced stage laryngeal cancers with emphasis on risk factors and its impact on survival(Elsevier, 2021-07-01) Aslıer, Mustafa; Uçurum, Bahar Ezgi; Kaya, Hilmi Cem; Coşkun, Hakan; ASLIER, MUSTAFA; KAYA, HİLMİ CEM; UÇURUM KANTARCI, BAHAR EZGİ; COŞKUN, HAMDİ HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Hastalıkları Anabilim Dalı.; 0000-0003-3670-4651; 0000-0002-0881-1444; CCA-0193-2022; JJJ-8575-2023; GEH-1871-2022; DVC-7511-2022Publication Clustering upper airway physicals, otitis media with effusion and auditory functions in children(Elsevier Sci Ltd, 2022-03-12) Aslıer, Nesibe Gül Yüksel; Keskin, Serhan; Ercan, İlker; ERCAN, İLKER; Aslıer, Mustafa; ASLIER, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/ Kulak, Burun ve Boğaz Hastalıkları Anabilim Dalı.; 0000-0002-2382-290X; HHN-7050-2022Objective: Adenoid hypertrophy (AH) has been identified as a cause of otitis media with effusion (OME), which is the most common cause of childhood hearing loss. Indeed, there may be other upper airway-related predisposing factors such as, location of the adenoid, accompanying tonsillar hypertrophy (TH) and nasal septal deviation (NSD) for the development of OME. In this study, we aimed to evaluate the associations between the upper airway physicals and OME with auditory functions. Methods: Eighty-six ears of 43 children, aged 3-11 years were included in this prospective clinical study. Findings of otolaryngologic examinations were noted. Data of pure tone audiometry (PTA), traditional tympanometry (TT) and wideband tympanometry (WBT) parameters were collected. Cluster analysis was performed to the following variables: age, sex; the adenoid choana percentage (ACP), the presences of adenoid around torus tubarius (AATT), TH, NSD and OME; peak pressure (PP) values on TT, resonance frequencies (RF) on WBT, ambient pressure absorbance ratios (APAR) and PTA hearing thresholds. Results: Two groups of ears revealed by clustering; cluster-1 (n = 46) and cluster-2 (n = 40), at the similarity level of 0.662. The presences of AH, AATT, OME and the medians of ACP, PP, RF, WBT APARs at all frequencies except 5656 Hz and 8000 Hz, all PTA thresholds were significantly different between two clusters (p < 0.05). The lower WBT APARs and higher PTA thresholds were associated with higher levels of ACP and higher frequencies of the presence of AATT and OME in cluster-1. Conclusion: There are associations between AH, AATT and OME together with decline in hearing and SEA. Whereas, TH and NSD are not related to the formation of clusters and they are insignificant factors.Publication Successful treatment of central nervous system involvement in posttransplant EBV-related lymphoproliferative disease with intrathecal rituximab therapy(Lippincott Williams & Wilkins, 2023-07-01) Aslan, Fatma; Güler, Salih; Evim, Melike Sezgin; Aslıer, Mustafa; Yazıcı, Zeynep; Nazlıoğlu, Hülya Öztürk; Güneş, Adalet Meral; ASLAN, FATMA; GÜLER, SALİH; SEZGİN EVİM, MELİKE; ASLIER, MUSTAFA; YAZICI, ZEYNEP; ÖZTÜRK NAZLIOĞLU, HÜLYA; MERAL GÜNEŞ, ADALET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Radyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz-Baş Boyun Cerrahisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Hematoloji Anabilim Dalı.; 0000-0003-1577-8109; 0000-0002-6180-901X; GBG-1533-2022; AAA-2856-2021; IRI-7023-2023; CCA-0193-2022; AAI-2303-2021; JIO-9152-2023; JGX-6145-2023The posttransplant lymphoproliferative disease is a severe cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation. Central Nervous System involvement in EBV-related PTLD is rare, and there is no standard treatment recommendation. We present our patient and discuss other previously reported cases of EBV-associated PTLD with CNS involvement.Publication Disease and quality of life aspects of cat allergy in non-pet owners with allergic rhinitis(Karger, 2023-03-29) Aslıer, Nesibe Gül Yüksel; Saatçi, Özlem; Aslıer, Mustafa; ASLIER, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Hastalıkları Anabilim Dalı.; IYJ-7551-2023Introduction: The severity of cat allergy-related symptoms varies widely. The rising prevalence of cat owning makes it a significant human health problem. The aim of this study was to evaluate disease severity and quality of life (QoL) aspects of cat sensitization and allergy in non-pet owners with allergic rhinitis (AR). Methods: In this study, 231 out of 596 patients with AR were enrolled. The disease severity and QoL measures of the non-pet owner patients were evaluated according to their demographics and allergen sensitizations. The data were re-gathered after cat exposure for cat-sensitized patients (n = 53). Results: The median age of the patients (174 females, 57 males) was 33 (18-70). The overall frequency of cat sensitization was 12.6% (75/596). The frequency of cat allergy in this cohort was 13.9% (32/231). Family history of atopy and multi-allergen sensitization were more common in the cat-sensitized patients. Disease severity and QoL scores were higher in the cat allergy group after cat exposure. Cat allergy was the major independent risk factor for the severity of AR and QoL measures. Conclusion: Due to the fact that indirect exposure to cat dander allergens can occur anywhere, even where cats are not present, cat-sensitized people should be aware of cat allergy. Cat allergy appears to be an independent risk factor for disease severity and QoL effects for non-pet owner patients with AR.