Person: TÜRKMEN İNANIR, NURSEL
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TÜRKMEN İNANIR
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NURSEL
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Publication The importance of hemosiderin deposition in the infant brain: An autopsy study(Lithographia, 2015-01-01) İnanır, Türkmen N.; Eren, F.; Akgöz, S.; Eren, B.; Çetin, S.; Gündoğmuş, U. N.; Çomunoğlu, N.; Çomunoğlu, C.; TÜRKMEN İNANIR, NURSEL; Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.; ACP-5545-2022Background/aim: Iron is an essential element involved in many metabolic processes. Presence and accumulation of iron in various body systems can result in different outcomes. Its accumulation in the central nervous system (CNS) cannot be detected routinely by application of hematoxylin-eosin staining. Detection of the presence of hemosiderin in the brain and cerebellum by application of Perls' dye is of importance in cases of infant deaths.Material and Methods: In this study, brain and cerebellar specimens obtained from 52 eligible infants (aged 0-1 years) autopsied in our institute between the years 2010 and 2013, independent of the cause of death, were analyzed in order to detect possible presence of hemosiderin. Perls' dye was used to detect histopathological staining intensity and distribution of hemosiderin in the brain and cerebellum.Results: Cases did not differ significantly as for the patients' age and gender (p = 0.473), type of the culprit trauma (p = 0.414), death/crime scene (p = 0.587), and diagnosis groups (p = 0.550). In this autopsy study blue colored hemosiderin granulations, stained with Perls' dye were detected in the brain (n: 39, 75%), and cerebellum (n: 35, 67.3%). A weakly negative, but significant correlation was detected between the postmortem interval and intensity values of cerebellar hemosiderin (Spearman's correlation coefficient: -0.381, p = 0.024). A statistically significant difference was found between the distribution scores of cerebral hemosiderin in cases with and without trauma history (p = 0.03). Median cerebral hemosiderin distribution scores were 2.5 and 2, respectively.Conclusions: The detection of a correlation between the presence of cerebral and cerebellar hemosiderin, and post-mortem interval in the age group of 0-1 years, should be interpreted as an important finding in the analysis of cerebral iron. The presence of hemosiderin in the CNS may be a significant finding in the elucidation of infant deaths and this procedure should be carried out on a routine basis.Publication Glial fibrillary acidic protein (GFAP) and CD34 expression in the human optic nerve and brain in methanol toxicity(Springer, 2008-02-01) Türkmen, Nursel; Eren, Bülent; Fedakar, Recep; Akgöz, Semra; Comunoglu, Nil; TÜRKMEN İNANIR, NURSEL; Eren, Bülent; FEDAKAR, RECEP; Akgöz, Semra; Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-2319-1757; JGZ-0807-2023; AAH-6287-2021; ACP-5545-2022; AAK-8096-2021Introduction: The toxicity of methanol is as a result of its metabolites, formaldehyde and formic acid. Formic acid induces severe metabolic acidosis causing death, and is the primary agent responsible for ocular toxicity. Glial fibrillary acidic protein ( GFAP) immunostaining is the most commonly used method for examining astrocyte proliferation and hypertrophy after various central nervous system injuries. The antigen CD34 is expressed widely on vascular endothelium, including that of the central nervous system and high endothelial venules.Methods: In this study, GFAP and CD34 were immunohistochemically localised in the post-mortem optic nerve head, and brain tissue ( basal ganglia putamen) samples were collected from methanol-exposed and non-methanol-exposed ( control) subjects.Results: There was a positive correlation between the GFAP and CD34 intensity of staining scores in the methanol-exposed group ( P=0.711, P=0.010). Furthermore, there was also a positive correlation between the brain putamen and optic nerve head GFAP extent of staining in the methanol-exposed group ( P=0.720, P=0.008). A statistically significant difference was found between the methanol-exposed group and the control group optic nerve CD34 intensity scores ( P=0.014), but no significant difference was found between optic nerve CD34 and GFAP extent scores ( P=0.05).Conclusion: The study revealed that methanol affects brain putamen and the optic nerve selectively. We detected a positive significant correlation between brain and optic nerve GFAP expression. CD34 expression was markedly decreased by the toxic effects of methanol.Publication Road traffic collisions in Bursa, Turkey, during 2003, 2004 and 2005(Elsevier Sci Ltd, 2008-05-01) Durak, Dilek; Fedakar, Recep; Türkmen, Nursel; Akgöz, Semra; Baduroğlu, Erol; DURAK, DİLEK; FEDAKAR, RECEP; TÜRKMEN İNANIR, NURSEL; Akgöz, Semra; Baduroğlu, Erol; Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-3469-340X; AAH-6587-2021; AAH-6287-2021; ACP-5545-2022; JGZ-0807-2023; ENO-6380-2022Aim: To highlight the demographic pattern of road traffic injuries in Bursa and to improve emergency care and health facility-based treatment.Methods: Records of all registered road traffic collisions maintained by the Uludag University Emergency Department in Bursa for the period 2003 to 2005 and trauma files of 1307 road traffic collision victims were examined in this study. A form was designed to document patients' age, gender, type of trauma, time of trauma (hour, day, month and year), type and time to hospital of transport, presence of safety devices, presence of alcohol and blood alcohol concentration, localisations of wounds, trauma scores and outcomes.Results: Of the 1307 cases, 418 (32%) were female and 889 (68%) were mate. Ages ranged from 3 months to 87 years; mean age (+/-S.D.) was 34.8 (+/-17.3) years. The mean (+/-S.D.) ages of women and men were 35 +/- 17.6 and 34.7 +/- 17.2 years, respectively. Trauma was most commonly sustained within the motor vehicle (72.2%), followed by pedestrian injuries (21.7%), motorcycle injuries (5.5%) and bicycle injuries (0.6%). Collisions were most frequent in summer (34.7%) and on Fridays and weekends (48.5%). Seat belts were used in only 1.8% of incidents. In 90 cases (6.9%) alcohol was found in the blood; mean blood alcohol concentration was 139.2 +/- 88.3 mg/dl.Conclusions: The identification of RTC characteristics may contribute to the development of injury prevention measures. Road travel requires extra attentiveness at peak accident times. Seat-belt use should increase, as well as use of other safety equipment such as collision helmets. Shorter transportation time of casualties to hospital would improve outcome. (C) 2007 Elsevier Ltd. All rights reserved.