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TAYFUN ŞENTÜRK, EBRU

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TAYFUN ŞENTÜRK

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    Publication
    Qt dispersion in epileptic children and effect of antiepileptic drugs on QT dispersion
    (Erciyes Üniversitesi Tıp Fakültesi, 2010-09-01) Şentürk, Ebru Tayfun; Semizel, Evren; Bostan, Özlem Mehtap; Okan, Mehmet; Çil, Ergün; TAYFUN ŞENTÜRK, EBRU; Semizel, Evren; BOSTAN, ÖZLEM MEHTAP; OKAN, MEHMET SAİT; ÇİL, ERGÜN; Tıp Fakültesi; Pediatri Ana Bilim Dalı; 0000-0001-7707-2174; 0000-0003-3516-0082; JMN-6038-2023; DQX-9595-2022; AAG-8558-2021; IMZ-1723-2023; AAG-9324-2021
    Purpose: Sudden death in epileptic patients may due to epilepsia or drug induced arrhythmia. The aim of this study is to identify changes of QT dispersion, as a predictive marker for arrhythmias, in children treated with antiepileptic drugs.Material and Methods: Ninety children treated with antiepileptic drugs and 30 healthy children as controls were involved in the study. Standard 12-lead surface electrocardiograms (ECG) of the study groups were evaluated before antiepileptic drug therapy and after 3 months. ECG of the control group was also reviewed at the beginning of the study and after 3 months. QT, JT and RR intervals were measured in both groups. The corrected QT (QTc) and JT (JTc) intervals were determined and QTc and JTc dispersions were measured.Results: QTc and JTc dispersion were found to be 85.8+/-16.5 ms and 79.8+/-15.6 ms respectively in patients group before the therapy and 43.3+/-8.2 ms and 40.8+/-5.6 ms in control group at the beginning (p<0.05). Even QTc dispersion were found to be significantly decreased after 3 months of therapy (80.5+/-12.9 ms), it was still significantly higher than the QTc dispersion in control group after 3 months.Conclusion: Determination of QTcd and JTcd values may be useful to predict the risk of sudden death in epileptic patients.