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CENGİZ, MURAT

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CENGİZ

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20202
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    Impact of pH on the activity of co-used antimicrobials against resistant Escherichia coli strains of animal origin
    (TÜBİTAK, 2020-01-01) Cengiz, Murat; Hepbostancı, Gülce; CENGİZ, MURAT; Hepbostancı, Gülce; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Farmakoloji ve Toksikoloji Anabilim Dalı/Moleküler Farmakoloji Laboratuvarı.; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü.; ABE-5935-2020; FAV-5978-2022
    In this study, combination antimicrobial therapy, due to its higher potential against resistant bacteria, was evaluated for the inhibition of multidrug-resistant E. coli strains. The influence of pH as an environmental variable on the activity of antimicrobial combinations was evaluated by calculating the factional concentration indexes at pH values 5.0, 6.0, 7.3, and 8.0.The highest synergistic activity rates of ceftriaxone + colistin, danofloxacin + colistin, danofloxacin + ceftiofur, and ceftiofur + gentamicin combinations were 50%, 33%, 100%, and 50%, respectively measured at >7.3 pH. The lowest synergistic activity rates for all combinations were observed at the acidic pH values of 5.0 and 6.0. The results of this study clearly demonstrated that acidic pH of the medium impaired the activity of the antimicrobial combinations. Although ceftriaxone and ceftiofur exert optimal activity at acidic pH values, the synergistic activity of the co-used drugs reached its highest level at pH >= 7.3.
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    A novel β-lactam-aminoglycoside combination in veterinary medicine: The couse of ceftiofur and gentamicin to combat resistant Escherichia coli
    (Hellenic Veterinary Medical Society, 2020-04-01) Cengiz, M.; Şahintürk, P.; Hepbostancı, G.; Akalın, H.; Sonal, S.; CENGİZ, MURAT; ŞAHİNTÜRK, SERDAR; AKALIN, EMİN HALİS; SONAL, SONGÜL; HEPBOSTANCI, G.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; Bursa Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü.; 0000-0001-7530-1279; AAU-8952-2020; ABE-5935-2020
    The focus of this study was to evaluate the efficacy of ceftiofur+gentamicin combination to increase the success of antimicrobial inhibition against resistant Escherichia coli (E.coli) strains isolated from animals. Interaction between drugs was determined using checkerboard method and the fractional inhibitory concentration index was interpreted as synergism, antagonism and indifference. The combination was defined as bactericidal or bacteriostatic based on the minimum bactericidal test results. Mutant prevention concentration test was used to evaluate the resistance tendency suppression potential of the combination. The synergistic effect was detected for all E. coli strains by the checkerboard method; even the strains that were resistant to the individual compounds in the combination. Based on the results of minimum bactericidal concentration test, the combination exhibited bactericidal effect against all E. coli strains. In addition, the individual mutant prevention concentrations of ceftiofur and gentamicin decreased up to 125-fold by using the combination for the inhibition of resistant E. coli strains. The results indicated that killing potential of co-use of the compounds is much stronger than their individual use. The combination achieved to decrease the mutant prevention concentrations and this can reduce the risk of emergence of single mutations during treatment done with suggested doses.