Person: MELEK, HÜSEYİN
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MELEK
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HÜSEYİN
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Publication Diagnostic value of cervical mediastinoscopy: Report of 506 cases(European Respiratory, 2013-09-01) Erol, Mehmet; Melek, Hüseyin; Bayram, Ahmet; Kermenli, Tayfun; Coşkun, Funda; Akyıldız, Elif; Gebitekin, Cengiz; Erol, Mehmet; MELEK, HÜSEYİN; BAYRAM, AHMET SAMİ; Kermenli, Tayfun; COŞKUN, NECMİYE FUNDA; AKYILDIZ, ELİF ÜLKER; GEBİTEKİN, CENGİZ; Tıp Fakültesi; Göğüs Hastalıkları Bölümü; 0000-0003-0684-0900; 0000-0002-7371-4026; 0000-0003-3604-8826; AAE-1069-2022; AAD-1271-2019; AAI-5039-2021; JCE-0097-2023; ABB-7580-2020; KHO-7454-2024; A-6612-2019; IAV-7890-2023Publication Lung cancer surgery in patients with a history of coronary artery bypass graft: A multicentre study(Elsevier Science, 2021-02-17) Akçam, Tevfik İlker; Samancılar, Özgür; Yazgan, Serkan; Ceylan, Kenan Can; Kocatürk, Celalettin İbrahim; Sezen, Celal Buğra; Tezel, Cağatay Salim; Gürer, Deniz; Bayram, Ahmet Sami; Melek, Hüseyin; Özkan, Berker; Ülker, Melike Güler; Kaba, Erkan; Toker, Alper; BAYRAM, AHMET SAMİ; MELEK, HÜSEYİN; Tıp Fakültesi; Göğüs Cerrahisi Ana Bilim Dalı; 0000-0003-1822-8153 ; 0000-0003-0684-0900 ; AAI-5039-2021 ; ABB-7580-2020Background Lung cancer surgery may be required for patients with a history of coronary artery bypass graft (CABG). In this study, we evaluated the general characteristics of patients, the difficulties experienced during and after lung cancer surgery and complications and mortality rates.Method Patients who were operated on for primary lung cancer between January 2012 and July 2017 in the participating centres were analysed retrospectively (n=7,530). Patients with a history of CABG (n=220) were examined in detail. This special group was analysed and compared with other patients operated on for lung cancer who did not have CABG (n=7,310) in terms of 30-day mortality and revision for haemorrhage.Results Of the 7,530 patients operated on for primary lung cancer, 2.9% were found to have undergone CABG. Surgical revision was required in the early postoperative period for 6.8% of those who had CABG and 3.5% in those who did not have CABG (p=0.009). Thirty-day (30-day) mortality was 4.5% in those who had CABG and 2.9% in those who did not have CABG (p=0.143). Further analysis of patients who had undergone CABG demonstrated that video-assisted thoracoscopic surgery (VATS) resulted in fewer complications (p=0.015). Patients with a left-sided left internal mammary artery (LIMA) graft had a higher number of postoperative complications (p=0.30).Conclusions Patients who had CABG suffered postoperative haemorrhage requiring a revision twice as often, and a tendency towards higher mortality (non-statistically significant). In patients with a history of CABG, VATS was demonstrated to have fewer complications. Patients with a LIMA graft who had a left-sided resection had more postoperative complications.Publication Comparison of survival results of patients with t0 and t1-2-3 in pathological t staging in patients with non-small cell lung cancer who underwent surgery after neoadjuvant treatment(Termedia Publishing House, 2020-01-01) Kermenli, Tayfun; Melek, Hüseyin; Bayram, Ahmet Sami; Gebitekin, Cengiz; MELEK, HÜSEYİN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Tıp Fakültesi; 0000-0003-0684-0900; 0000-0003-1822-8153; AAE-1069-2022; AAI-5039-2021; JCE-0097-2023; ABB-7580-2020Aim: In this study, we aimed to compare the survival results of patients who underwent neoadjuvant treatment with NSCLC between March 1997 and August 2014 and were found to have T0N0 and T1-2-3/N0.Material and methods: A hundred ninety-five patients who had complete neoadjuvant therapy, complete lung resection and lymph node dissection, and pathologically diagnosed as T0 or T1-2-3/N0, M0 were included in the study.Results: Of the 195 patients included in the study, 181 were male, 14 were female and the mean age of the patients was 57.9. The mean age of the groups was as follows: group 1: 58.1, group 2: 57.7, group 3: 59.7 and group 4: 56.8. In our series the most common complication was atelectasis (n = 19). Others were prolonged air leak (n = 16), pneumonia (n = 12), apical pleural space (n = 6), wound infection (n = 3), cardiac problems (n = 3), hematoma (n = 3), bronchopleural fistula (n = 3), empyema (n = 2), chylothorax (n = 1). The 5-year survival rate for patients in the T0N0 group was 76.3%. This rate was 71.8% in group 2, 63.6% in group 3 and 44.1% in group 4.Conclusions: Survival was found to be better in patients who underwent surgery after neoadjuvant therapy and had a complete pathological response. We believe that we can provide better results with the increase in the number of cases detected as TxN0 after the neoadjuvant treatment and prolongation of the follow-up period.Publication Gastrointestinal stromal tumor of the esophagus: Report of a case(Derman Medical Publ, 2016-01-01) GEBİTEKİN, CENGİZ; Erol, M. Muharrem; Melek, Huseyin; MELEK, HÜSEYİN; BAYRAM, AHMET SAMİ; Akyıldız, Elif Ülker; AKYILDIZ, ELİF ÜLKER; Tıp Fakültesi; Göğüs Cerrahisi Ana Bilim Dalı; 0000-0003-0684-0900; ABB-7580-2020; AAI-5039-2021; JCE-0097-2023; AAE-1069-2022Gastrointestinal stromal tumors are rare neoplasms to be thought to arise from mesenchymal cells of the gastrointestinal tract. Gastrointestinal stromal tumors (GIST) of the esophagus am weIl documented but are very much rarer than gastrointestinal stronmI tumors of the stomach and small [voted, We describe a case of GIST of the esophagus that was resected With wide surgical resection.Publication Platin-based chemotherapy does not improve survival in patients with non-metastatic resected typical carcinoid tumors(Spandidos Publ Ltd, 2022-10-01) Şahin, Ahmet Bilgehan; Melek, Hüseyin; Ocak, Birol; Oyucu Orhan, Sibel; Erkan, Buket; Caner, Burcu; Deligönül, Adem; Çubukcu, Erdem; Bayram, Ahmet Sami; Akyıldız, Elif Ülker; Evrensel, Türkkan; ŞAHİN, AHMET BİLGEHAN; MELEK, HÜSEYİN; OCAK, BİROL; OYUCU ORHAN, SİBEL; ERKAN ÖZMARASALI, BUKET; CANER, BURCU; DELİGÖNÜL, ADEM; ÇUBUKÇU, ERDEM; BAYRAM, AHMET SAMİ; AKYILDIZ, ELİF ÜLKER; EVRENSEL, TÜRKKAN; Tıp Fakültesi; Tıbbi Onkoloji Ana Bilim Dalı; 0000-0002-7846-0870; 0000-0003-0684-0900; 0000-0003-1822-8153; 0000-0001-8217-3471; 0000-0003-1591-3323; AAM-4927-2020; AAI-5039-2021; AEC-2238-2022; AAJ-8314-2021; CPN-8681-2022; HJH-6371-2023; ESM-4544-2022; ETP-1691-2022; ABB-7580-2020; ELN-4128-2022; EXZ-0745-2022Chemotherapy is controversial in non-metastatic typical carcinoid (TC) tumors. Therefore, it was aimed to evaluate the impact of platin-based chemotherapy on the survival of patients with lung TC. The medical records of patients who underwent surgical resection for non-metastatic TC from 2002 to 2020 at our institution were retrospectively reviewed. Multivariate regression analysis was performed for chemotherapy and prognostic factors in disease-free survival (DFS) in 72 patients. The pathological stages of patients were as follows: 73.6% of the patients were in stage I, 15.3% in stage II and 11.1% in stage III. A total of 5 patients (6.9%) received platin-based chemotherapy and 6 patients (8.3%) had recurrences. The DFS rates at 12, 36 and 60 months were 98.5, 95.1 and 92.5%, respectively. Log-rank testing showed that patients who received chemotherapy and had stage III disease had shorter DFS (P=0.021 for chemotherapy and P<0.001 for stage). However, multivariate analysis revealed that the pathological stage was the only statistically significant factor affecting DFS (P=0.016). Platin-based chemotherapy did not improve DFS, and the eighth edition of TNM (tumor, nodes, metastases) staging did have prognostic value for patients with non-metastatic TC. Although resection has satisfying long-term outcomes, studies on new agents are needed to decrease the recurrence rate, particularly in patients with stage III disease.Publication Can thoracic sympathetic nerve damage be reversed?(Georg Thieme Verlag, 2015-12-01) Erol, M. Muharrem; Salcı, Hakan; Melek, Hüseyin; İlhan, Tuncay; Özfiliz, Nesrin; Bayram, Ahmet Sami; Gebitekin, Cengiz; Erol, M. Muharrem; SALCI, HAKAN; MELEK, HÜSEYİN; İLHAN, TUNCAY; ÖZFİLİZ, NESRİN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Veteriner Fakültesi; Cerrahi Ana Bilim Dalı; 0000-0003-0684-0900; 0000-0003-1822-8153; AAI-5039-2021; AAE-1069-2022; AAH-2756-2021; JCE-0097-2023; AAH-8859-2021; ABB-7580-2020; T-4623-2019; KHE-8874-2024Background Function of the thoracic sympathetic chain (TSC) reportedly recovers after surgical clips are removed. Hence, this study was designed to study nerve regeneration after unclipping the TSC.Methods The bilateral TSCs of six goats were studied; the goats were separated into three groups (groups I, II, and III) during excision, clipping, and unclipping. During surgery, the TSCs were excised with a scalpel in group I and clipped in groups II and III. In group III, the clips were removed 1 month postoperatively and observed for possible nerve healing for 1 month. All TSCs were examined histologically following en block resection at 1 month postoperatively in groups I and II and at 2 months postoperatively in group III.Results Inflammation in nerve sections was noted following clip removal. Furthermore, there was significant degeneration and cell infiltration in the nerve fibers of the clipped regions. The Schwann cells around the peripheral nerve endings in the unclipped regions facilitated nerve transmission by reconstitution of myelin.Conclusion Clipping the TSC can cause histologic degeneration; however, histologic nerve regeneration occurs after unclipping.Publication Vats lobectomy and chest wall resection for NSCLC(Elsevier, 2019-10-01) Melek, Hüseyin; Özkan, B.; Kara, H.; Kaba, E.; Bayram, A.; Ülker, M.; Ersen, E.; Turna, A.; Toker, A.; Gebitekin, Cengiz; MELEK, HÜSEYİN; GEBİTEKİN, CENGİZ; Tıp Fakültesi; Göğüs Cerrahisi Ana Bilim Dalı; AAI-5039-2021; AAE-1069-2022Publication Minimally invasive approaches for en-bloc anatomical lung and chest wall resection(Baycinar Medical Publ-Bayçınar Tıbbı Yayıncılık, 2023-07-01) Melek, Hüseyin; Özkan, Berker; Kara, Hasan Volkan; Sevinc, Tolga Evrim; Kaba, Erkan; Turna, Akif; Toker, Alper; Gebitekin, Cengiz; MELEK, HÜSEYİN; SEVİNÇ, TOLGA EVRİM; GEBİTEKİN, CENGİZ; Tıp Fakültesi; Göğüs Cerrahisi Ana Bilim Dalı; 0000-0003-1822-8153 ; AAI-5039-2021; IGQ-1108-2023; JCE-0097-2023Background: The aim of this study was to evaluate the feasibility of en-bloc anatomical lung and chest wall resection via minimally invasive surgery.Methods: Between January 2013 and December 2021, a total of 22 patients (18 males, 4 females; mean age: 63 & PLUSMN;6.9 years; range, 48 to 78 years) who underwent anatomical lung and chest wall resection using minimally invasive surgery for non-small cell lung cancer were retrospectively analyzed. Demographic, clinical, intra-and postoperative data of the patients, recurrence, metastasis, mortality, and overall survival rates were recorded.Results: The surgical technique was robot-assisted thoracic surgery in two, multiport video-assisted thoracoscopic surgery in 18, and uniport video-assisted thoracoscopic surgery in two patients. Upper lobectomy was performed in 17 (77.3%) patients, lower lobectomy in three (13.6%) patients, and upper lobe segmentectomy in two (9.1%) patients. Five different techniques were used for chest wall resection. Nine (40.9%) patients had one, eight (36.4%) patients had two, four (18.2%) patients had three, and one (4.5%) patient had four rib resections. Chest wall reconstruction was necessary for only one of the patients. The mean operation time was 114 & PLUSMN;36.8 min. Complete resection was achieved in all patients. Complications were observed in seven (31.8%) patients without mortality. The mean follow-up was 24.4 & PLUSMN;17.9 months. The five-year overall survival rate was 55.3%. Conclusion: Segmentectomy/lobectomy and chest wall resection with minimally invasive surgery are safe and feasible in patients with non -small cell lung cancer. In addition, the localization of the area where chest wall resection would be performed should be considered the most crucial criterion in selecting the ideal technique.Publication Comparison of survival results of patients with t0 and t1-2-3 in pathological t staging in patients with non-small cell lung cancer who underwent surgery after neoadjuvant treatment(Termedia Publishing House Ltd, 2020-01-01) Kermenli, Tayfun; Melek, Huseyin; MELEK, HÜSEYİN; Bayram, Ahmet Sami; BAYRAM, AHMET SAMİ; Gebitekin, Cengiz; GEBİTEKİN, CENGİZ; Tıp Fakültesi; Göğüs Cerrahisi Ana Bilim Dalı; 0000-0003-0684-0900; JCE-0097-2023; ABB-7580-2020; AAE-1069-2022; AAI-5039-2021Aim: In this study, we aimed to compare the survival results of patients who underwent neoadjuvant treatment with NSCLC between March 1997 and August 2014 and were found to have T0N0 and T1-2-3/N0.Material and methods: A hundred ninety-five patients who had complete neoadjuvant therapy, complete lung resection and lymph node dissection, and pathologically diagnosed as T0 or T1-2-3/N0, M0 were included in the study.Results: Of the 195 patients included in the study, 181 were male, 14 were female and the mean age of the patients was 57.9. The mean age of the groups was as follows: group 1: 58.1, group 2: 57.7, group 3: 59.7 and group 4: 56.8. In our series the most common complication was atelectasis (n = 19). Others were prolonged air leak (n = 16), pneumonia (n = 12), apical pleural space (n = 6), wound infection (n = 3), cardiac problems (n = 3), hematoma (n = 3), bronchopleural fistula (n = 3), empyema (n = 2), chylothorax (n = 1). The 5-year survival rate for patients in the T0N0 group was 76.3%. This rate was 71.8% in group 2, 63.6% in group 3 and 44.1% in group 4.Conclusions: Survival was found to be better in patients who underwent surgery after neoadjuvant therapy and had a complete pathological response. We believe that we can provide better results with the increase in the number of cases detected as TxN0 after the neoadjuvant treatment and prolongation of the follow-up period.Publication The importance of lymphatic and vascular invasion in stage 1 non-small cell lung cancer and definition of a totally curable tumors(Elsevier Science Inc, 2019-10-01) Turna, Akif; Sarbay, İsmail; Kara, H.; Kaynak, Kamil; Melek, Hüseyin; MELEK, HÜSEYİN; Gebitekin, Cengiz; GEBİTEKİN, CENGİZ; Tıp Fakültesi; Göğüs Cerrahisi Ana Bilim Dalı; AAI-5039-2021; AAE-1069-2022
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