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ALTUNYUVA, OĞUZ

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ALTUNYUVA

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OĞUZ

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2019 - 201912020 - 20211
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    Statistical shape analysis of cerebellum in patients with chiari malformation I
    (Lippincott, 2019-09-01) Ocakoğlu, Gökhan; Baykal, Duygu; Altunyuva, Oğuz; Taşkapılıoğlu, Mevlüt Özgür; Yılmazlar, Selçuk; OCAKOĞLU, GÖKHAN; ALTUNYUVA, OĞUZ; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; YILMAZLAR, SELÇUK; Tıp Fakültesi; Beyin Cerrahi Ana Bilim Dalı; 0000-0003-3633-7919; 0000-0002-3450-0471; 0000-0001-5472-9065; ABB-8161-2020; AAW-5254-2020; HLG-6346-2023; AAH-5180-2021; AAK-9899-2020; AAH-5070-2021
    The surgical procedure is viewed as a typical treatment choice for patients with Chiari malformation (CM). Decompression is the preferred method for surgery, but it is not always possible to understand whether decompression has been successful especially in an early period. The present study focuses on investigating the shape differences in the cerebellums of Chiari patients compared with healthy controls, and to assess the clinical application of this situation whether if present. The MRI scans were reviewed retrospectively. Cerebellar data were obtained from the digital images and 9 anthropometric landmarks were marked on each image. Shape difference was assessed by performing Generalized Procrustes analysis. The cerebellar shape deformation from control to the patient was evaluated performing the Thin Plate Spline approach. There is a statistically significant cerebellar shape difference between groups. Highest deformation was determined at the cerebellar tonsillar inferior area, posterior of the uvula, and anterior of inferior medullary velum. The present study demonstrated cerebellar shape differences in CM I patients using a landmark-based geometric morphometric approach, considering the topographic distribution of cerebellum for the first time.
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    Statistical shape analyses of the brainstem in chiari patients
    (Türk Nöroloji Derneği, 2021-01-01) Ocakoglu, Gokhan; OCAKOĞLU, GÖKHAN; Taskapilioglu, Mevlut Ozgur; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; Altunyuva, Oguz; ALTUNYUVA, OĞUZ; Yilmazlar, Selcuk; YILMAZLAR, SELÇUK; Tıp Fakültesi; Tıbbi Biyoloji Ana Bilim Dalı; 0000-0002-1114-6051; 0000-0001-5472-9065; 0000-0002-3450-0471; AAH-5180-2021; AAK-9899-2020
    AIM: To ascertain whether the brain stem's shape differs in patients with syrinx and without syrinx in cases with Chiari malformation Type I (CM-1), relative to healthy controls.MATERIAL and METHODS: Data on marked brainstem regions were obtained from 2D digital image files. Generalized Procrustes analysis was used to evaluate shape differences among patients with syrinx, patients without syrinx, and healthy controls. Shape deformations among groups were examined by Thin Plate Spline (TPS) analysis.RESULTS: According to the brain stem shape, there were differences between patients with syrinx and controls, and between patients without syrinx and controls. High-level deformations were also observed among the groups.CONCLUSION: In the present study, the presence of shape deformations in Chiari patients' brainstem was demonstrated. This is the first study using a landmark-based geometrical morphometric method to demonstrate the shape difference in Chiari patients' brainstem.