Person: YAVUZ, MAHMUT
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YAVUZ
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MAHMUT
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Publication Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation(Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.Publication Retrospective evaluation of the factors affecting etiology and prognosis of adult acute kidney injury(Galenos Yayıncılık, 2020-06-01) Göçken, Abdulkadir; Ayar, Yavuz; Yavuz, Mahmut; Yabacı, Ayşegül; YAVUZ, MAHMUT; Yabacı, Ayşegül; Tıp Fakültesi; Biyoistatistik Bilim Dalı; CAJ-5024-2022; EHM-7377-2022Aim: Acute kidney injury (AKI) is still an important cause of morbidity and mortality. Several factors are effective in its frequency, etiology, prognosis and mortality. In our study, we aimed to demonstrate the etiology and prognostic factors of AKI.Methods: A total of 272 patients diagnosed with AKI, who were hospitalized in the nephrology department between January 2011 and December 2015, were included in the study. In addition to the demographic characteristics of patients, clinical and laboratory findings were evaluated retrospectively.Results: Forty-seven point four percent of patients were female and 52.6% were male. The mean age of the patients was 61.6 years, the mean length of hospital stay was 13.3 days, the number of hemodialysis sessions was 1.24 and the mortality rate was 4.8%. The need and number of hemodialysis sessions were significantly higher in older patients (>65 years). The need and number of hemodialysis sessions were higher in the renal AKI group (48.7%, 1.9). The length of hospital-stay was longer and mortality rate was higher in patients with renal AKI compared to the other groups (16.4 days, 8.8%). Mortality rate, length of hospital-stay, and number of hemodialysis sessions were found to be increased significantly in patients with infection (42%).Conclusion: Etiology and accompanying infection in AKI are the most important factors affecting mortality. In addition, anemia and advanced age increase the length of hospital stay and the need for hemodialysis.Publication Efficacy of tacrolimus in patients with primary focal segmental glomerulosclerosis resistant to immunosuppressive treatments(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2011-01-01) Usta, Mehmet; Ersoy, Alparslan; Gül, Cuma Bülent; Kahvecioğlu, Serdar; Akdağ, İbrahim; Güllülü, Mustafa; Yavuz, Mahmut; Dilek, Kamil; Yurtkuran, Mustafa; ERSOY, ALPARSLAN; GÜL, CUMA BÜLENT; GÜLLÜLÜ, MUSTAFA; YAVUZ, MAHMUT; DİLEK, KAMİL; Yurtkuran, Mustafa; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; 0000-0002-0710-0923 ; 0000-0003-2467-9356; AAH-5054-2021; A-7063-2018; JGS-9425-2023; EHM-7377-2022; EUF-5229-2022; EGT-2006-2022OBJECTIVE: We investigated the efficacy and safety of tacrolimus in patients with primary focal segmental glomerulosclerosis (FSGS) resistant to treatment in this study.MATERIAL and METHODS: This prospective study included 9 patients (5 female/4 male) with FSGS resistant to steroids. Their immunosuppressive treatments except corticosteroids were stopped at least six months previously. Tacrolimus (4 mg/day) treatment was administered. The daily urinary protein excretion, serum creatinine, albumin and total cholesterol values were measured before and after treatment.RESULTS: The mean level of daily urinary protein excretion, serum creatinine and serum albumin at the baseline was 4.7 +/- 3.3 g/day, 1.2 +/- 0.6 mg/dL, and 3.5 +/- 0.7 g/dL, respectively. The daily urinary protein excretion significantly reduced from the 1st month of the treatment. At the 6th month, complete remission was achieved in 3 patients (33%) and partial remission in 2 patients (22%). 3 patients were resistant to the treatment. There was no difference in serum albumin, creatinine and cholesterol levels after the treatment when compared to the baseline levels.CONCLU SION: Tacrolimus is a safe and effective treatment in patients with FSGS resistant to treatment. However, the tendency to relapse in all patients who have complete or partial remission when the treatment was withdrawn demonstrates dependence on treatment.Publication Paricalcitol protects peritoneal membrane function in encapsulating peritoneal sclerosis(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2016-01-01) Gül, Cuma Bülent; Yıldız, Abdülmecit; Vuruşkan, Berna; Gül, Özen Öz; Oruç, Ayşegül; Aktaş, Nimet; Ersoy, Alparslan; Güllülü, Mustafa; Dilek, Kamil; Yavuz, Mahmut; Yurtkuran, Mustafa Abbas; YILDIZ, ABDULMECİT; AYTAÇ VURUŞKAN, BERNA; ÖZ GÜL, ÖZEN; ORUÇ, AYŞEGÜL; ERSOY, ALPARSLAN; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; YAVUZ, MAHMUT; Yurtkuran, Mustafa Abbas; Tıp Fakültesi; Endokrinoloji ve Metabolizma Ana Bilim Dalı; 0000-0002-0710-0923 ; 0000-0002-0342-9692; HIG-9032-2022; AAH-9746-2021; AAI-1005-2021; AAH-4002-2021; AAH-5054-2021; JGS-9425-2023; EUF-5229-2022; EHM-7377-2022; IPP-3337-2023OBJECTIVE: The most lethal complication of peritoneal dialysis is encapsulating peritoneal sclerosis (EPS), which develops as a result of epithelio-mesenchymal transformation (EMT) and known fibrotic processes. Paricalcitol has previously been shown to inhibit both EMT and fibrosis. We investigated the effect of paricalcitol on EPS.MATERIAL and METHODS: Forty non-uremic albino Wistar rats divided into four groups of equal numbers. The first group was administered 2 mL saline intraperitoneally (IP) and the second group was administered 2 mL of 200 gram chlorhexidine gluconate (CG) (0.1%) dissolved in saline and ethanol (15%) IP. The treatment groups received CG for three weeks in addition to subcutaneous paricalcitol at a dose of 0.2 mcg/kg/day to the third group and 0.4 mcg/kg/day to the fourth group. A one-hour peritoneal equilibration test was performed with 25 mL 3.86% PD solution at the end of the study. Peritoneal membrane and intracardiac blood samples were obtained.RESULTS: D/P urea was significantly low in both treatment groups when compared to group 2 (p<0.05). Paricalcitol co-treatment recovered ultrafitration failure and peritoneal membrane thickness was better paricalcitol groups but there was no statistically significant difference between the groups. Serum calcium, phosphorus and parathyroid hormone levels were similar in all groups.CONCLUSION: Paricalcitol can be effective in the protection of peritoneal functions.Publication The relationship between visfatin and carotid atherosclerosis in patients with advanced chronic kidney disease(Oxford Univ Press, 2015-05-01) Ayar, Yavuz; Ersoy, Alparslan; Sayılar, Emel Işıktaş; Yıldız, Abdülmecit; Pektaş, Fatih; Tüysüz, Özlem; Yavuz, Mahmut; Topal, Naile Bolca; Dirican, Melahat; Arslan, Ismail; Ateş, Çiğdem Aksu Coşkun; Ayar, Yavuz; ERSOY, ALPARSLAN; Sayılar, Emel Işıktaş; YILDIZ, ABDULMECİT; Pektaş, Fatih; Tüysüz, Özlem; YAVUZ, MAHMUT; BOLCA TOPAL, NAİLE; Dirican, Melahat; Arslan, İsmail; Ateş, Çiğdem Aksu Coşkun; Tıp Fakültesi; Radyoloji Ana Bilim Dalı; 0000-0003-4607-9220; 0000-0002-1539-9216; HIG-9032-2022 ; O-9948-2015; AAI-2327-2021; W-2575-2017; GSE-0029-2022; AGF-0767-2022; AAH-5054-2021; JDU-0150-2023; ECR-6289-2022; EHM-7377-2022; ESK-6562-2022; JML-0742-2023; IIU-0465-2023Publication Arm circumference: Its importance for dialysis patients in the obesity era(Springer, 2013-08-01) Akpolat, Tekin; Kaya, Coskun; Utaş, Cengiz; Arınsoy, Turgay; Taskapan, Hulya; Erdem, Emre; Yılmaz, M. Emin; Ataman, Rezzan; Bozfakioglu, Semra; Özener, Cetin; Karayaylalı, İbrahim; Kazancıoğlu, Rumeyza; Camsarı, Taner; Ersoy, Fevzi; Duman, Soner; Ateş, Kenan; Yavuz, Mahmut; YAVUZ, MAHMUT; Tıp Fakültesi; Nefroloji Ana Bilim DalıThe purposes of this study were to investigate the association between arm circumference and body mass index (BMI) and to discuss problems, mainly arm circumference and cuff size mismatch, that could affect the reliability of home blood pressure monitoring (HBPM) among peritoneal dialysis (PD) and hemodialysis (HD) patients.525 PD and 502 HD patients from 16 centers were included in the study. A two-part questionnaire was used to gather information from the participants. Arm circumferences were categorized into four groups according to the British Hypertension Society cuff size recommendations.Mean BMI and arm circumference of all participants were 25.0 kg/m(2) and 27.6 cm, respectively. There was a significant correlation between BMI and arm circumference. The mean BMI and arm circumference values were higher in PD patients than in HD patients. Requirement of a large-sized adult cuff was more common among PD patients compared to HD patients (14 % vs 8 %, p = 0.002).Since HBPM is a useful tool for clinicians to improve BP control, nephrologists should be aware of the problems related to HBPM in dialysis patients and take an active role to increase the reliability of HBPM.Publication Lessons learned from the Marmara disaster: Time period under the rubble(Lippincott Williams & Wilkins, 2002-11-01) Sever, Mehmet; Erek, Ekrem; Vanholder, R; Özener, Çetin; Kayacan, Seyit; Ergin, Hülya; Apaydın, Süheyla; Çobanoğlu, M; Erdem, Yunus; Lameire, Norbert; Yavuz, Mahmut; YAVUZ, MAHMUT; Dönmez, Osman; DÖNMEZ, OSMAN; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; CCS-5304-2022; EHM-7377-2022Objective. To investigate the effect of the time period under the rubble on morbidity and mortality of the crush-syndrome patients after the catastrophic Marmara earthquake that struck northwestern Turkey in August 1999.Design: Observational study.Setting. Consecutive admissions to emergency and intensive care units of 35 reference hospitals that treated the renal victims.Method & Analysis of questionnaires obtained from these hospitals.Patients: A total of 539 of 639 crush-syndrome patients whose time under the rubble was identified in the questionnaires.Results. Mean time under the rubble was 11.7 +/- 14.3 hrs (median, 8 hrs; interquartile range, 6 hrs; range, 0.5-135 hrs). The highest number of patients was entrapped within the 5-8 hrs time stratum, and by the end of 48 hrs, 97% of the victims had been rescued. Nondialyzed victims spent a longer duration under the rubble than dialyzed ones (15.9 +/- 23.1 hrs [median, 7 hrs; interquartile range, 8.5 hrs] vs. 10.3 +/- 9.5 hrs [median, 8 hrs; interquartile range, 6 hrs), p <.001)]. Likewise, in the strata of longer time under the rubble, the percentage of survivors was higher (p =.07). Time under the rubble correlated positively with the number of amputated extremities (p <.001) and admission platelet count (p <.001), and it correlated negatively with admission serum albumin (p <.001). The victims entrapped for >50 hrs (n = 6) were characterized by lower figures of admission blood urea nitrogen (p =.04), serum creatinine (p =.003), hemodialysis sessions, and duration of hemodialysis support (p =.005, for both analyses) compared with victims whose time under the rubble was shorter.Conclusion. Rescue efforts should continue at least for 5 days after the disaster. Time under the rubble is not an adverse prognostic indicator of survival or renal dysfunction for the patients of crush syndrome, probably because only the victims with mild or moderate injuries can survive under the rubble for longer durations.Publication Modified histopathological classification with age-related glomerulosclerosis for predicting kidney survival in ANCA-associated glomerulonephritis(Springer, 2022-09-25) Aydın, Mehmet Fethullah; Yıldız, Abdülmecit; Oruç, Ayşegül; Vuruşkan, Berna Aytaç; Akgür, Suat; Ayar, Yavuz; Güllülü, Mustafa; Dilek, Kamil; Yavuz, Mahmut; Ortaç, Hatice; Ersoy, Alparslan; Aydın, Mehmet Fethullah; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; AYTAÇ VURUŞKAN, BERNA; Ortaç, Hatice; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0002-0342-9692 ; 0000-0002-5665-7402 ; AAJ-8220-2020; HIG-9032-2022; AAH-4002-2021; EEJ-1452-2022; JGS-9425-2023; EUF-5229-2022; EHM-7377-2022; HJF-9598-2022; CPX-5894-2022Background The histopathological classification of ANCA-GN divides patients into four groups based on signs of glomerular injury. However, this classification did not consider age-related glomerulosclerosis. In this study, we aimed to compare the prediction of renal survival between Berden's ANCA-GN histopathological classification and ANCA-GN histopathological classification modified with age-related glomerulosclerosis. Methods Between January 2004 and December 2019, 65 patients diagnosed with ANCA-GN were enrolled. Demographic, laboratory, and histopathologic findings were retrospectively analyzed. Renal survival analyses were compared according to classical and modified ANCA-GN histopathological classifications. Multivariate Cox regression analysis for the factors affecting renal survival was performed. Results In Berden's ANCA-GN histopathological classification, 15 patients were in the focal group, 21 in the crescentic, 21 in the sclerotic, and 8 in the mixed group. The ANCA-GN histopathological classification model generated statistically significant predictions for renal survival (p = 0.022). When the histopathological classification was modified with age-related glomerulosclerosis, eight of the nine patients previously classified in the sclerotic group were classified in the mixed and one in the crescentic groups. Modification of histopathological classification with age-related glomerulosclerosis increases the statistical significance in renal survival analysis (p = 0.009). The multivariate Cox regression analysis showed that the disease-related global sclerotic glomeruli percentage and serum creatinine level were significant independent factors. Conclusion Modification of Berden's ANCA-GN histopathological classification model with age-related glomerulosclerosis may increase the statistical significance of the histopathological classification model.Publication Demographic and clinical characteristics of patients with autosomal dominant polycystic kidney disease: A single center experience(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2016-01-01) Yıldız, Abdulmecit; Sağ, Saim; Oruç, Ayşegül; Ayar, Yavuz; Gül, Bülent; Aktaş, Nimet; Aydın, Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Güllülü, Mustafa; Dilek, Kamil; YILDIZ, ABDULMECİT; Sağ, Saim; ORUÇ, AYŞEGÜL; Ayar, Yavuz; Aydın, Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0002-0342-9692; 0000-0003-4607-9220; 0000-0002-5665-7402; AAJ-8220-2020; AGF-0767-2022; AAW-9185-2020; AAH-5054-2021; O-9948-2015; GSE-0029-2022; AAH-4002-2021OBJECTIVE: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common hereditary kidney disease. We presented the ADPKD patients who were not undergoing replacement therapy.MATERIAL and METHODS: According to the Turkish Nephrology Society Cystic Kidney Disease Working Group online database, patients with ADPKD were questioned for age, sex, smoking, level of education, hypertension (HT), hematuria, history of urinary stones, urinary infections, and extrarenal history of any cysts. Patients who had undergone kidney replacement therapy and who had a glomerular filtration rate (GFR) less than 30 ml/min were excluded.RESULTS: A total of 93 patients (41 +/- 13 years, 44 female, 49 male) were included. 47% of the patients were current smokers and 72% were on at least one antihypertensive drug. The average GFR was 92 +/- 29 ml/min, and the microalbumin-to-creatinine ratio on spot urine was 18 mg/g. Apart from patients who had kidney cysts, 35% had a history of a liver cyst, 25% had kidney stones and 14% had macroscopic hematuria.CONCLUSION: HT and smoking are frequently seen in early phase of ADPKD. These risk factors have a negative effect on the development of cardiovascular disease and renal prognosis in these patients. Overall, this study showed that aggressive care must be ensured to control these risk factors.Publication An enflammatory marker in chronic renal failure patients: Visfatin(Galenos Yayıncılık, 2015-09-01) Ayar, Yavuz; Sayılar, Emel Işıktaş; Yavuz, Mahmut; Arslan, İsmail; Aksu, Çiğdem; Ateş, Coşkun; Pektaş, Fatih; Tüysüz, Özlem; Topal, Naile Bolca; Dirican, Melahat; Ayar, Yavuz; Sayılar, Emel Işıktaş; YAVUZ, MAHMUT; Arslan, İsmail; Aksu, Çiğdem; ATEŞ, COŞKUN; Pektas, Fatih; Tüysüz, Özlem; BOLCA TOPAL, NAİLE; Dirican, Melahat; Tıp Fakültesi; Radyoloji Ana Bilim Dalı; 0000-0003-4607-9220; 0000-0002-1539-9216; 0000-0003-4565-9848; AGF-0767-2022; W-2575-2017; EHM-7377-2022; JML-0742-2023; HPQ-6488-2023; CDO-0747-2022; JDU-0150-2023; ECR-6289-2022; AAI-2327-2021; ESK-6562-2022Aim: Visfatin is a cytokine released from adipose tissue, especially in enflammation. In our study, we tried to show the relationship of visfatin levels with chronic renal failure (CRF) as an enflammatory marker.Methods: We included 50 CRF patients (28 male, 22 female) who attended Uludag University Nephrology Clinic and 31 healthy volunteers (13 male, 18 female). Visfatin levels and biochemical parameters, such as parathyroid hormone (PTH), lipid parameters, albumin, C-reactive protein (CRP), creatinine, urea, immunoglobulins, etc. were examined.Results: In CRF patients, visfatin levels were found to be significantly increased (p<0.001) and albumin, hemoglobin, body mass index (BMI) and high density lipoprotein (HDL) cholesterol levels were decreased (p<0.001). Triglycerides (p=0.003), CPR (p=0.005), procalcitonin (p<0.001), IgG3 (p=0.003), and ferritin (p<0.001) levels were significantly higher in patient group than in control group as an enflammatory marker.Conclusion: CRF is an independent enflammatory process. Visfatin levels in patients with chronic renal failure patients are determined to be high as an indicator of enflammation.