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YAVUZ, MAHMUT

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YAVUZ

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MAHMUT

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    Retrospective evaluation of the factors affecting etiology and prognosis of adult acute kidney injury
    (Galenos Yayıncılık, 2020-06-01) Göçken, Abdulkadir; Ayar, Yavuz; Yavuz, Mahmut; Yabacı, Ayşegül; YAVUZ, MAHMUT; Yabacı, Ayşegül; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Bilim Dalı.; CAJ-5024-2022; EHM-7377-2022
    Aim: Acute kidney injury (AKI) is still an important cause of morbidity and mortality. Several factors are effective in its frequency, etiology, prognosis and mortality. In our study, we aimed to demonstrate the etiology and prognostic factors of AKI.Methods: A total of 272 patients diagnosed with AKI, who were hospitalized in the nephrology department between January 2011 and December 2015, were included in the study. In addition to the demographic characteristics of patients, clinical and laboratory findings were evaluated retrospectively.Results: Forty-seven point four percent of patients were female and 52.6% were male. The mean age of the patients was 61.6 years, the mean length of hospital stay was 13.3 days, the number of hemodialysis sessions was 1.24 and the mortality rate was 4.8%. The need and number of hemodialysis sessions were significantly higher in older patients (>65 years). The need and number of hemodialysis sessions were higher in the renal AKI group (48.7%, 1.9). The length of hospital-stay was longer and mortality rate was higher in patients with renal AKI compared to the other groups (16.4 days, 8.8%). Mortality rate, length of hospital-stay, and number of hemodialysis sessions were found to be increased significantly in patients with infection (42%).Conclusion: Etiology and accompanying infection in AKI are the most important factors affecting mortality. In addition, anemia and advanced age increase the length of hospital stay and the need for hemodialysis.
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    Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation
    (Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023
    Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.
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    Publication
    The relationship between severity of interstitial fibrosis and anemia in patient with primary glomerulonephritis: The data from TSN-gold working group
    (Oxford Univ Press, 2020-06-01) Cebeci, Egemen; Turgutalp, Kenan; Öztürk, Savaş; Özlük, Yasemin; Bek, Sibel Gökçay; Şumnu, Abdullah; Seyahi, Nurhan; Yavuz, Mahmut; Pişkinpaşa, Serhan Vahit; Akçay, Ömer Faruk; Sakaci, Tamer; Şahin, Garip; Tokgöz, Bülent; Şahin, Gülizar Manga; Bozacı, Ilter; Dursun, Belda; Sipahi, Savaş; Kayalar, Arzu Özdemir; Süleymanlar, Gültekin; Ulu, Memnune Sena; Güzel, Fatma Betül; Kutlay, Sim; Parmaksız, Ergün; Koz, Süleyman; Kurultak, İlhan; Selçuk, Nedim Yılmaz; Yildırım, Yaşar; Gürsu, Meltem; Çavdar, Caner; Timuçin, Meryem; Aydın, Zeki; Oygar, Deren; Kahvecioğlu, Serdar; Kibar, Müge Uzerk; Torun, Dilek; Taymez, Dilek Güven; Küçük, Mehmet; Demir, Serap; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altintepe, Lüftullah; Koç, Mehmet; Azak, Alper; Odabaş, Ali Rıza; Yılmaz, Zülfikar; Paydaş, Saime; YAVUZ, MAHMUT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; EHM-7377-2022