Person: AKSOY, FUAT
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AKSOY
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FUAT
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Publication Does liver transplant improve neurological symptoms in wilson disease? report of 24 cases(Başkent Üniversitresi, 2022-11-01) Aksoy, Fuat; Arslan, İbrahim Ethem; Özgür, Taner; Dündar, Halit Ziya; Çelik, Fatih; Demir, Aylin Bican; Özbek, Sevda Erer; Kıyıcı, Murat; Özkan, Tanju Başarır; Kaya, Ekrem; AKSOY, FUAT; Arslan, İbrahim Ethem; ÖZGÜR, TANER; DÜNDAR, HALİT ZİYA; ÇELİK, FATİH; BİCAN DEMİR, AYLİN; ERER ÖZBEK, ÇİĞDEM SEVDA; KIYICI, MURAT; Özkan, Tanju Başarır; KAYA, EKREM; Tıp Fakültesi; Organ Nakli Merkezi; 0000-0001-5808-9384; 0000-0002-9245-1241; 0000-0001-6739-8605; HII-8895-2022; ABD-3885-2020; AAG-7319-2021; FPE-9941-2022; EWI-3634-2022; JKN-9078-2023; KHB-9765-2024; DLN-1836-2022; FHW-0015-2022; JKL-3648-2023Objectives: Wilson disease is an inherited disorder that results in copper accumulation in the tissues with liver injury and failure. Orthotopic liver transplant is one of the treatments of choice for this disease. The aim of this study was to compare the neurological symptoms, before and after orthotopic liver transplant, of patients with liver cirrhosis due to Wilson disease, who represent a special group of patients with liver failure. Materials and Methods: Between 2007 and 2020, there were 24 patients with Wilson disease resistant to medical treatment who underwent deceased donor orthotopic liver transplant and were followed up for 1 year, 5 years, and 10 years for evaluation with neurological scoring systems. Patients were also evaluated for postoperative complications and survival. Results: Of the 24 patients evaluated, there were 13 (54.2%) female patients and 11 (45.8%) male patients, and the mean age was 34 years (range, 14-57 years). One of the patients died from early postoperative sepsis. After orthotopic liver transplant, disease scores returned to normal in 16 patients and improved in the remaining patients. Before transplant, all patients required help in their daily activities. After transplant, there were significant improvements in some symptoms, and the patients became more independent in their daily lives. Conclusions: Our study shows that orthotopic liver transplant provides significant improvement in neurological symptoms and quality of life in patients with Wilson disease.Publication Long non-coding rna hulc overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation(Wiley, 2021-08-01) Aksoy, Fuat; Kaya, Ekrem; Aksoy, Seçil Ak; Dündar, Halit Ziya; Tunca, Berrin; AKSOY, FUAT; KAYA, EKREM; Aksoy, Seçil Ak; DÜNDAR, HALİT ZİYA; TUNCA, BERRİN; Bursa Uludağ Üniversitesi; 0000-0001-5808-9384; 0000-0002-1619-6680; HII-8895-2022; ADM-8457-2022; AAG-7319-2021; EWI-3634-2022; ABI-6078-2020Publication Outcome of split liver transplantation vs living donor liver transplantation: A systematic review and meta-analysis(Baishideng Publishing Group Inc, 2023-07-27) Garzali, İbrahim Umar; Akbulut, Sami; Aloun, Ali; Naffa, Motaz; Aksoy, Fuat; AKSOY, FUAT; Tıp Fakültesi; Genel Cerrahi Ana Bilim Dalı; 0000-0001-5808-9384; HII-8895-2022BACKGROUNDThe outcomes of liver transplantation (LT) from different grafts have been studied individually and in combination, but the reports were conflicting with some researchers finding no difference in both short-term and long-term outcomes between the deceased donor split LT (DD-SLT) and living donor LT (LDLT).AIMTo compare the outcomes of DD-SLT and LDLT we performed this systematic review and meta-analysis.METHODSThis systematic review was performed in compliance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. The following databases were searched for articles comparing outcomes of DD-SLT and LDLT: PubMed; Google Scholar; Embase; Cochrane Central Register of Controlled Trials; the Cochrane Database of Systematic Reviews; and Reference Citation Analysis (https://www.referencecitationanalysis.com/). The search terms used were: "liver transplantation;" "liver transplant;" "split liver transplant;" "living donor liver transplant;" "partial liver transplant;" "partial liver graft;" "ex vivo splitting;" and "in vivo splitting."RESULTSTen studies were included for the data synthesis and meta-analysis. There were a total of 4836 patients. The overall survival rate at 1 year, 3 years and 5 years was superior in patients that received LDLT compared to DD-SLT. At 1 year, the hazard ratios was 1.44 (95% confidence interval: 1.16-1.78; P = 0.001). The graft survival rate at 3 years and 5 years was superior in the LDLT group (3 year hazard ratio: 1.28; 95% confidence interval: 1.01-1.63; P = 0.04).CONCLUSIONThis meta-analysis showed that LDLT has better graft survival and overall survival when compared to DD-SLT.Publication Blood-based biomarkers in Afp normal/stable hepatocellular carcinoma: Diagnostic and prognostic relevance of Mir-10b for patients on liver transplant list(Elsevier Science Inc, 2022-09-01) Aksoy, Fuat; Aksoy, Seçil Ak; Dündar, Halit Ziya; Tunca, Berrin; Erçelik, Melis; Tekin, Çağla; Kıyıcı, Murat; Selimoğlu, Kerem; Kaya, Ekrem; AKSOY, FUAT; Aksoy, Seçil Ak; DÜNDAR, HALİT ZİYA; TUNCA, BERRİN; Erçelik, Melis; Tekin, Çağla; KIYICI, MURAT; Selimoğlu, Kerem; KAYA, EKREM; İnegöl Meslek Yüksekokulu; Organ Nakli Merkezi; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0003-3635-7282; 0000-0002-3760-9755; 0000-0002-9562-4195; HII-8895-2022; ADM-8457-2022; EWI-3634-2022; ABI-6078-2020; EUG-3329-2022; JIT-9986-2023; FHW-0015-2022; CDS-3299-2022; AAG-7319-2021Background. As a diagnostic criteria of hepatocellular carcinoma (HCC), the exact threshold of alpha-fetoprotein (AFP) is controversial. In additional, not all HCC tumors are AFP positive or secrete elevated amounts of AFP into the serum. However, the diagnosis of HCC is quite important on the liver transplant list. Therefore, the purpose of this study was to investigate the expression of circulating micro RNAs (miRNAs) in AFP-stable HCC patients. Thus, we aimed to determine a diagnostic biomarker in these patients.Methods. Sixteen miRNAs were evaluated using a real-time quantitative reverse transcription polymerase chain reaction system in AFP-stable HCC and AFP-trending HCC patients.Results. In our study, 46.7% (n = 28) of the patients diagnosed with HCC had stable/normal AFP levels. We detected that high expression of miR-24, miR-10b and the low expression of miR-143 were independently and significantly associated with HCC in AFP-stable compared with AFP trending (P <.05). Additionally, we demonstrated that the overexpression of miR-10b was associated with poor disease-free survival in HCC (P = 0.001).Conclusions. Although more clinical validations are needed for the diagnosis of HCC, our current results indicate that the coexistence of high expression of miR-10b and miR-24 may help clinicians adjust in the diagnosis of HCC in patients who are on the liver transplant list but awaiting biopsy for the diagnosis of HCC.Publication Comparison of severity and complication rates of acute cholecystitis during pandemic and pre-pandemic periods?(Sage Publications Ltd, 2022-11-22) Candan, Selman; Dündar, Halit Ziya; Öngen, Gökhan; AKSOY, FUAT; Özpar, Rıfat; ERDEMLİ GÜRSEL, BAŞAK; ÖZPAR, RİFAT; NAS, ÖMER FATİH; İNECİKLİ, MEHMET FATİH; Gürsel, Başak Erdemli; TAŞAR, PINAR; Savcı, Gürsel; SAVCI, GÜRSEL; Nas, Ömer Fatih; Tıp Fakültesi; Genel Cerrahi Ana Bilim Dalı; AAG-8561-2021; AAH-6568-2021; AAK-5124-2020Background Cancellations of surgeries for elective cases and late admissions of symptomatic cases during the pandemic period might have increased the number of cases of acute cholecystitis and its complications. Purpose To compare the severity of acute cholecystitis and complication rates during the pandemic and pre-pandemic periods. Material and Methods We evaluated the computed tomography (CT) findings observed for the diagnosis of complications for both acute simple and acute complicated cholecystitis during both the pandemic and pre-pandemic periods. Patients admitted to the hospital between March 2020 and December 2020 made up the study group and the corresponding appropriate patients from one year earlier were studied as the control group. In addition to the CT findings, clinical and laboratory findings, co-morbidities such as diabetes, as well as the admission time to hospital from the onset of the initial symptoms to hospital admission were also evaluated. Results A total of 88 patients were evaluated (54 in the study group, 34 in the control group; mean age = 64.3 +/- 16.3 years). The male-to-female ratio was 51/37. The number of patients diagnosed with complicated cholecystitis were significantly higher in the study group (P = 0.03). Murphy finding and diabetes status were similar between the two groups (P = 0.086 and P = 0.308, respectively). Admission time to the hospital was significantly different for study and control groups in simple cholecystitis patients (P = 0.045); with no significant difference in cases of complicated cholecystitis (P = 0.499). Conclusion Our study reveals the course of acute cholecystitis during the pandemic period was much more serious with higher complications.Publication Effect of locoregional treatments in hepatocellular carcinoma: What are the pathologic/radiologic Milan Criteria?(Başkent Üniversitesi, 2023-10-01) Aksoy, Fuat; Dündar, Halit Ziya; Çelik, Fatih; Öngen, Gökhan; Nas, Ömer Fatih; Sağlam, Kutay; Gürlüler, Ercüment; Kıyıcı, Murat; Kaya, Ekrem; AKSOY, FUAT; DÜNDAR, HALİT ZİYA; ÇELİK, FATİH; ÖNGEN, GÖKHAN; NAS, ÖMER FATİH; SAĞLAM, KUTAY; GÜRLÜLER, ERCÜMENT; KIYICI, MURAT; KAYA, EKREM; Tıp Fakültesi; Organ Nakli Merkezi; 0000-0001-5808-9384; 0000-0003-2728-9521; HII-8895-2022; X-7425-2018; EWI-3634-2022; JYY-5340-2024; FQR-8472-2022; JJS-3965-2023; JSD-3843-2023; FHW-0015-2022; JSF-3184-2023Objectives: Milan criteria is the most commonly used criteria for patients with hepatocellular carcinoma awaiting liver transplant. The effects of locoregional therapy on downstaging or bridging before liver transplant on survival remain controversial. Considering that the tumor size may change with locoregional therapy and formalin fixation after explantation, we aimed to evaluate the effects of locoregional therapy on radiological and pathological Milan criteria and survival.Materials and Methods: Demographic data, etiology, preoperative alpha-fetoprotein value, Child-Pugh and Model for End-Stage Liver Disease-Na scores, status of being inside or outside of radiological Milan criteria, status of being inside or outside of Milan criteria in explant (pathological Milan criteria), and the locoregional therapy types and combinations were evaluated for their effects on inclusion in Milan criteria and survival.Results: During the study period, 396 patients underwent liver transplant at our center, with 97 because of cirrhosis and hepatocellular carcinoma. When we viewed patients according to preoperative radiologic evaluations, 67.9% were within Milan criteria and 32.1% were outside. When we viewed according to explant (pathological) evaluations, 80.7% of patients were within Milan criteria. Among 97 patients, 71 (73.2%) had locoregional therapy (22 [30.9%] for downstaging, 49 [69.0%] for bridging to transplant), and 12 patients (12.3%) were within Milan criteria on explant examination while outside of Milan criteria before LT. One-year, 3-year, and 5-year survival rates were 80.7%, 76.1%, and 71.6%, respectively. Conclusions: As a result of radiological evaluations, in patients who were outside of Milan criteria and underwent locoregional therapy, explant pathology within Milan criteria had a positive effect on survival; however, after locoregional therapy, there was no significant effect on survival in patients who were still outside of Milan criteria.Publication Recurrent hepatocellular carcinoma after liver transplantation: Identifying the high-risk patient using the expression profiles of emt-associated lncrnas(Frontiers Media Sa, 2019-10-01) Aksoy, Seçil Ak; Aksoy, Fuat; Dündar, Haliz Ziya; Tunca, Berrin; Taşar, Pınar; Uğraş, Nesrin; Egeli, Ünal; Çeçener, Gülşah; Yerci, Ömer; Kaya, Ekrem; Aksoy, Seçil Ak; AKSOY, FUAT; Dündar, Haliz Ziya; TUNCA, BERRİN; TAŞAR, PINAR; UĞRAŞ, NESRİN; EGELİ, ÜNAL; ÇEÇENER, GÜLŞAH; YERCİ, ÖMER; KAYA, EKREM; Tıp Fakültesi; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0001-7904-883X; 0000-0002-3820-424X; AAH-8540-2021; AAG-7319-2021; AAP-9988-2020; ABI-6078-2020; AAH-1420-2021; AAH-2716-2021; HII-8895-2022; EGD-8703-2022; IIC-9825-2023Publication Identification of CHEK2 germline mutations in BRCA1/2- and PALB2-negative breast and ovarian cancer patients(Karger, 2022-08-01) Aksoy, Fuat; Tezcan Ünlü, Havva; Çeçener, Gülşah; Güney Eskiler, Gamze; Egeli, Ünal; Tunca, Berrin; Efendi Erdem, Ecem; Şenol, Kazım; Gökgöz, Mustafa Şehsuvar; AKSOY, FUAT; Tezcan Ünlü, Havva; ÇEÇENER, GÜLŞAH; EGELİ, ÜNAL; TUNCA, BERRİN; Efendi Erdem, Ecem; ŞENOL, KAZIM; GÖKGÖZ, MUSTAFA ŞEHSUVAR; Tıp Fakültesi; Genel Cerrahi Ana Bilim Dalı; 0000-0001-5808-9384; 0000-0002-0910-4258; 0000-0002-3820-424X; 0000-0001-7904-883X; 0000-0002-1619-6680; 0000-0001-6273-0664; HII-8895-2022; AAP-9988-2020; GYU-0252-2022; AAH-1420-2021; ABI-6078-2020; GWP-6104-2022; KGQ-4411-2024; EWY-5692-2022Introduction: The CHEK2 gene is known to be an important signal transducer involved in DNA repair, apoptosis, or cell cycle arrest in response to DNA damage. The mutations in this gene have been associated with a wide range of cancers, both sporadic and hereditary. Germline CHEK2 mutations are linked to an increased risk of breast cancer. Therefore, the aim of this study was to identify the prevalence of CHEK2 variants in BRCA1/2- and PALB2-negative early-onset patients with breast cancer and/or ovarian cancer in a Turkish population for the first time. Methods: The study included 95 patients with BRCA1/2- and PALB2-negative early-onset breast cancer and/or ovarian cancer and also 60 unaffected women. All the intron/exon boundaries and coding exons of CHEK2 were subjected to mutational analysis by heteroduplex analysis and DNA sequencing. Results: A total of 16 CHEK2 variants were found in breast cancer patients within the Turkish population. CHEK2 c.1100delC mutation most frequently studied in the CHEK2 gene was not detected in our study. The prevalence of variants of uncertain significance in CHEK2 was found to be 7.3% (n = 7) in BRCA1/2 and PALB2 mutation-negative Turkish patients with early-onset breast and/or ovarian cancer. Conclusion: The present study may shed light on alternative variations that could be significant for understanding the prevalence and clinical suitability of the CHEK2 gene.Publication Evaluation of the trend of biochemical functions in the early period after cadaveric liver transplantation(Elsevier Science Inc, 2023-06-28) Aksoy, Fuat; Gürlüler, Ercüment; Çelik, Fatih; Şen, Murat; Balkan, Eyüp Anıl; Dündar, Halit Ziya; Kaya, Ekrem; AKSOY, FUAT; GÜRLÜLER, ERCÜMENT; ÇELİK, FATİH; ŞEN, MURAT; BALKAN, EYÜP ANIL; DÜNDAR, HALİT ZİYA; KAYA, EKREM; Tıp Fakültesi; Organ Nakli Merkezi; 0000-0001-5808-9384; 0000-0003-2728-9521; HII-8895-2022; X-7425-2018; AAG-7319-2021; JYY-5340-2024; JEX-7100-2023; IZR-9309-2023; EWI-3634-2022Background. Monitoring biochemical parameters to detect early complications after liver transplantation (LT) is important. Thus, we aimed to investigate parameter trends indicating liver function in patients who did not develop complications after cadaveric LT. Methods. A total of 266 cadaveric LT operations performed by a single center between 2007-2022 were included in the study. Patients with any early complications were excluded from the study. During the first 15 days, the parameters reflecting the patients' liver integrity and synthesis functions were evaluated. All parameters studied were evaluated at the same time of day and by a single laboratory. Results. Regarding synthesis functions, the coagulation parameters (prothrombin time and international normalized ratio) peaked on the first day and then decreased. Regarding tissue hypoxia, there was no significant change in lactate values. Total and direct bilirubin values also decreased after peaking on the first day. No significant change was observed in albumin, another liver synthesis value. Conclusions. Although an increase in aspartate aminotransferase, alanine aminotransferase, total and direct bilirubin, prothrombin time, and international normalized ratio, which was especially seen on the first day, is considered normal, values that do not decrease after the second day or lactate values that increase gradually should be a warning in terms of possible early complications.Publication Liver-derived exosomes in liquid biopsies: Advantage before liver transplantation - a pilot study(Lippincott Williams & Wilkins, 2021-08-01) ; Aksoy, F.; AKSOY, FUAT; Aksoy, Seçil Ak; Tunca, B.; TUNCA, BERRİN; Kıyıcı, M.; Kaya, E.; Bursa Uludağ Üniversitesi; 0000-0001-5808-9384; 0000-0002-1619-6680; HII-8895-2022; ADM-8457-2022