Person: OCAKOĞLU, GÖKHAN
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OCAKOĞLU
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GÖKHAN
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Publication Retrospective analysis of decompressive craniectomy performed in pediatric patients with subdural hematoma(Travma Acil Cerrahisi, 2019-07-01) Taşkapılıoğlu, Mevlüy Özgür; Özmarasalı, Ali İmran; Ocakoğlu, Gökhan; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; ÖZMARASALI, ALİ İMRAN; OCAKOĞLU, GÖKHAN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0001-5472-9065; 0000-0002-7529-2808; 0000-0002-1114-6051; HLG-6346-2023; AAW-5254-2020; CAI-5927-2022; AAH-5180-2021; ABB-8161-2020BACKGROUND: The impact of decompressive craniectomy (DC) on the overall outcome of pediatric acute subdural hematoma patients has not been fully determined to date. In this paper, we aimed to investigate the role of decompressive craniectomy performed to treat traumatic subdural hematoma in patients from the pediatric age group.METHODS: We described our experience with DC in pediatric acute subdural hematoma patients and analyzed the outcomes.RESULTS: Eleven (7 unilateral and 4 bilateral) DCs were performed. The patients' ages ranged from 8 months to 15 years. The mean GCS score at admission was 7.8. All patients underwent DC with duraplasty within 2 hours of injury. All the patients were admitted to the intensive care unit for 10 days postoperatively. The mean hospital stay was 22 days and the mean follow-up period was 3.7 years.CONCLUSION: Early DC for pediatric subdural hematoma patients, independent of their initial GCS, was recommended. Larger studies are needed to define the indications, surgical techniques, and timing of DC in the pediatric population.Publication Evaluation of the cases with non-cystic fibrosis bronchiectasis(Galenos Yayıncılık, 2018-01-01) Korkmaz, Serpil; Canıtez, Yakup; Çekiç, Şükrü; Efe, Hülya Poyraz; Ocakoğlu, Gökhan; Sapan, Nihat; Korkmaz, Serpil; CANITEZ, YAKUP; ÇEKİÇ, ŞÜKRÜ; Efe, Hülya Poyraz; OCAKOĞLU, GÖKHAN; SAPAN, NİHAT; Tıp Fakültesi; Çocuk Alerji Ana Bilim Dalı; 0000-0002-9574-1842; 0000-0002-1114-6051; HLG-6346-2023; L-1933-2017; CJQ-2060-2022; CPN-6371-2022; FFE-8839-2022; FUI-8766-2022INTRODUCTION: Bronchiectasis is a chronic inflammatory disease characterized by a permanent dilation of the bronchial wall. We aimed to evaluate pediatric cases diagnosed with non-cystic fibrosis bronchiectasis.METHODS: A total of 98 cases who were diagnosed with non-cystic fibrosis bronchiectasis and were being followed-up between January 2010 and January 2015 at our clinic were included. Clinical, laboratory and radiological evaluations were recorded from patients electronic files.RESULTS: Female to male ratio of the cases was 1.3 (56/42). The median age of the cases was 12.2 years (1-18), the median age of diagnosis was 6 years (1-17 years), and the median duration of follow-up was 38 months (3-140 months).The most common symptom of the cases was cough (n: 91, 93%) followed by sputum expectoration (n: 56, 57%). In the pulmonary function tests performed during the initial phase of diagnosis; restrictive pattern was seen in 29.1% (n = 21) of patients and obstructive pattern was seen in 23.2% (n = 17). Furthermore, in last control visit, restrictive pattern was seen in 17.3% (n=9) of them and obstructive pattern was seen in 44.2% (n = 23). The most frequent etiological cause was infectious diseases (n: 41, 42%). Bronchiectasis was seen most commonly in the left lower lobe of the lung (n: 52, 53%), followed by the right lower lobe (n=32, 33.7%).DISCUSSION and CONCLUSION: Bronchiectasis is still a major health problem in developing countries and causes irreversible damage to the lung when untreated. Postinfectious lung diseases are one of the most important causes of bronchiectasis in children. Early diagnosis improves treatment success.Publication The efficacy of new oral contrast mixture for computed tomography enterography(Int Scientific Information Inc, 2019-10-15) Eyrimler, Sehnaz; Algın, Oktay; Ocakoğlu, Gökhan; OCAKOĞLU, GÖKHAN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-1114-6051; HLG-6346-2023; AAH-5180-2021Purpose: To show the reliabilities of the new mixture (composed of water, methylcellulose, lactulose, locust bean gum, and sorbitol) and to compare the luminal distension and radiological confidence scores of this solution with water-lactulose mixture.Material and methods: Computed tomography enterography (CTE) images in a three-year period were included randomly in our institutional review board-approved and retrospective study. Ninety-one patients drank a lactulose and water mixture (Group 1), and 54 patients drank the new mixture (Group 2). Patients who drank the oral contrast agent were taken to a 64-detector row multiple detector computed tomography machine. Coronal and sagittal reformatted images were also formed. The gastrointestinal tract was divided into 11 segments for scoring. Each segment was graded for distensional and radiological confidence. CTE images were evaluated by two radiologists.Results: Inter- and intra-reader reliabilities were good or excellent for all gastrointestinal segments in both groups (p < 0.001). The best. values were obtained in sigmoid colon assessments. Lower agreement values were detected in duodenum and jejunum scores. The new mixture group (Group 2) showed better results than Group 1 for ileum and colonic segments according to distension and confidence scorings.Conclusions: Inter- and intra-reader reliabilities of the new mixture were good or excellent for CTE. The new mixture seems to be more efficient and reliable for ileum and colon. The new mixture can increase bowel distention, radiological confidence, and quality in CTE evaluations.Publication Association of morning blood pressure surge (mbps) with left ventricular hypertrophy in autosomal dominant polycystic kidney disease (ADPKD): Across sectional study(Oxford Univ Press, 2016-05-01) Sağ, Saim; Yıldız, Abdulmecit; Ersoy, Alparslan; Ocakoğlu, Gökhan; Oruç, Ayşegül; Güngören, Fatih; Ayar, Yavuz; Gül, Cuma Bülent; Güllülü, Sümeyye; Güllülü, Mustafa; Sağ, Saim; YILDIZ, ABDULMECİT; ERSOY, ALPARSLAN; OCAKOĞLU, GÖKHAN; ORUÇ, AYŞEGÜL; Güngören, Fatih; Ayar, Yavuz; GÜL, CUMA BÜLENT; GÜLLÜLÜ, NAZMİYE SÜMEYYE; GÜLLÜLÜ, MUSTAFA; Tıp Fakültesi; Kardioloji Bölümü; 0000-0002-1114-6051; 0000-0002-0342-9692; 0000-0003-4607-9220; 0000-0003-2467-9356; AAH-5180-2021; AGF-0767-2022; AAW-9185-2020; AAH-5054-2021; O-9948-2015; AAA-3163-2021; HLG-6346-2023; AAH-4002-2021; A-7063-2018; GSE-0029-2022; HIG-9032-2022; JGR-6552-2023; CTG-8811-2022Publication Statistical shape analysis of cerebellum in patients with chiari malformation I(Lippincott, 2019-09-01) Ocakoğlu, Gökhan; Baykal, Duygu; Altunyuva, Oğuz; Taşkapılıoğlu, Mevlüt Özgür; Yılmazlar, Selçuk; OCAKOĞLU, GÖKHAN; ALTUNYUVA, OĞUZ; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; YILMAZLAR, SELÇUK; Tıp Fakültesi; Beyin Cerrahi Ana Bilim Dalı; 0000-0003-3633-7919; 0000-0002-3450-0471; 0000-0001-5472-9065; ABB-8161-2020; AAW-5254-2020; HLG-6346-2023; AAH-5180-2021; AAK-9899-2020; AAH-5070-2021The surgical procedure is viewed as a typical treatment choice for patients with Chiari malformation (CM). Decompression is the preferred method for surgery, but it is not always possible to understand whether decompression has been successful especially in an early period. The present study focuses on investigating the shape differences in the cerebellums of Chiari patients compared with healthy controls, and to assess the clinical application of this situation whether if present. The MRI scans were reviewed retrospectively. Cerebellar data were obtained from the digital images and 9 anthropometric landmarks were marked on each image. Shape difference was assessed by performing Generalized Procrustes analysis. The cerebellar shape deformation from control to the patient was evaluated performing the Thin Plate Spline approach. There is a statistically significant cerebellar shape difference between groups. Highest deformation was determined at the cerebellar tonsillar inferior area, posterior of the uvula, and anterior of inferior medullary velum. The present study demonstrated cerebellar shape differences in CM I patients using a landmark-based geometric morphometric approach, considering the topographic distribution of cerebellum for the first time.Publication A demographic and polysomnographic investigation of fatigue and sleep disorders in patients with multiple sclerosis(Galenos Yayınevi, 2018-09-01) Sıvacı, Ali Özhan; Demir, Aylin Bican; Turan, Ömer Faruk; Taşkapılıoğlu, Özlem; Bora, İbrahim; Ocakoğlu, Gökhan; Sıvacı, Ali Özhan; BİCAN DEMİR, AYLİN; TURAN, ÖMER FARUK; Taşkapılıoğlu, Özlem; BORA, İBRAHİM HAKKI; OCAKOĞLU, GÖKHAN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-9697-9510; 0000-0001-6739-8605; 0000-0003-4436-3797; 0000-0002-1114-6051; AAK-6623-2020; V-7170-2017; JCE-6657-2023; AAH-5180-2021; HLG-6346-2023; X-4479-2018Objective: To investigate fatigue and sleep disorders based on demographic, clinical and polysomnographic data and show their effects on the quality of life in multiple sclerosis (MS) patients.Materials and Methods: Thirty MS patients were enrolled in the study depending on the results of the polysomnography (PSG), Fatigue Severity scale, Epworth Sleepiness scale (ESS), Pittsburgh Sleep Quality lindex, Beck Depression and Anxiety inventories. Patients, using (n=16) and non-using (n=14) interferon, were compared with each other in all parameters; ESS and PSG data were compared with a control group consisting of 19 healthy people. Short form-36 (SF-36) data were also compared with the society norms.Results: Central fatigue was observed in 86.7% of the patients. PSG data revealed that stage N2 sleep duration of those who did not use interferon was significantly longer than those who used it (p<0.001). According to the PSG, total sleep time, sleep efficiency, stage N3 and rapid eye movement time, mean respiratory disturbance index, sleep latency and the mean value of total leg movements were significantly higher in the patient group than in the control group (p<0.001). All parameters of SF-36 were significantly lower in patient group (p<0.001). The stage N3 sleep time length was found related with physical component summary of SF-36 (p<0.001).Conclusion: MS patients have high level of fatigue and additionally there are weighty disturbances in objective and subjective sleep parameters. Our findings were revealed that all the components of quality of life decreased significantly in these patients. Furthermore, our study showed that deep sleep duration was related with physical activity and emphasized the importance of sleep evaluation in MS patients.Publication Pregnancy and kidney transplantation: A single-center experience(Aves, 2022-07-01) Ayar, Yavuz; Sayılar, Emel Işıktaş; Demir, Bilge Cetinkaya; ÇETİNKAYA DEMİR, BİLGE; ERSOY, ALPARSLAN; OCAKOĞLU, GÖKHAN; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; Tıp Fakültesi; Jinekoloji ve Doğum Ana Bilim Dalı; 0000-0003-4607-9220; 0000-0002-1114-6051; 0000-0002-0342-9692; 0000-0001-6845-9991; AAH-5180-2021; AAH-4002-2021Objective: The possibility of pregnancy increases with kidney transplantation in patients with chronic kidney disease. However, graft dysfunction, risk of fetal growth retardation, and fetal anomaly should be monitored closely. In this study, renal and obstetric outcomes were analyzed in pregnant kidney recipients who were followed in our center.Methods: We analyzed 140 reproductive-aged patients who underwent renal transplantation between January 2009 and May 2015, and clinical and laboratory data were evaluated retrospectively.Results: Twenty-four patients became pregnant (17.1%). In pregnant group, median age was significantly lower than nonpregnant group (P =.014). The median age of pregnant group at the time of transplantation was also significantly lower than non-pregnant patients (P <.001). The rate of pregnant patients was 66.7% in 18-25 year age group (P =.008). The rate of urinary tract infection in non-pregnant group was higher than pregnant group (P =.03). Live birth rates were 83.3% and 45.8% of those whose birth weight was higher than 2500 g. The increased level of daily urinary proteinuria and the time from diagnosis of renal failure to transplantation had significant effect on pregnancy (odds ratio = 13.81;95% CI: 2.06-92.45; P =.007 and odds ratio = 3.25;95% CI: 1.11-9.48; P =.031, respectively). Low serum creatinine level had significant protective effect (odds ratio = 0.001; 95% CI: 0-0.30, P =.018). The patients in 18-25 age group were 48.39 times more eligible for pregnancy compared to those in >35 age group (odds ratio = 48.39; 95% CI: 1.26-1860.72; P =.037). Rejection episodes were observed in 1 of pregnant women and 11 of non-pregnant women (P >.05).Conclusion: Pregnancy is possible in kidney transplant recipients of reproductive age. Calcineurin inhibitors and azathioprine seem to be safe. Maternal age, low-serum creatinine, and urinary proteinuria affect pregnancy. The close monitoring of renal function and fetal parameters is very important.Publication Is there a relationship between the diameter of the inferior vena cava and hemodynamic parameters in critically ill patients?(Medknow Publications, 2015-11-01) Aydın, Şule A.; Özdemir, Fatma; Taşkın, G.; Ocakoğlu, Gökhan; Yıldırım, H.; Köksal, Özlem; AYDIN, ŞULE; ÖZDEMİR, FATMA; Taşkın, G.; OCAKOĞLU, GÖKHAN; KÖKSAL, ÖZLEM; Tıp Fakültesi; Acil Servis Bölümü; 0000-0002-1114-6051; AAH-5180-2021; AAK-8332-2020; HLG-6346-2023; AAI-2164-2021; IOY-2055-2023; GHW-4797-2022Introduction: The early detection of critically ill patients together with the rapid initiation of effective treatment in emergency departments(ED) increase the survival rates.Aim: This study investigated whether a correlation exists between haemodynamic parameters of critically ill patients and the diameter of the inferior vena cava (IVC).Materials and Methods: A cross-sectional study was performed included patients aged >= 18 years with an unstable haemodynamic and/or respiratory status who were referred to the ED for non-traumatic issues. IVC diameters were measured by ultrasound (US) and then central venous pressures (CVP) were measured. Anteroposterior (AP) and mediolateral (ML) diameters of the IVC, both in the inspirium (IAP, IML) and expirium (EAP, EML), were measured by US.Results: 102 patients were evaluated with a median age of 59. The relationship between the diameters of IVC and CVP was evaluated and significant correlation was found in IAP, EAP according to CVP values (p<0.001). ROC analyses were performed and significant relationship was found between the EAP diameter with haemoglobin (Hmg), haemotocrit (Hct), and central venous oxygen saturation (ScvO2) and also significant correlation was detected between the IAP diameter and white blood cell (WBC).Discussion: We detected significant correlation between the CVP and the IVC diameter in our study compatible with recent studies besides, significant correlation was found between the diameter of the IVC and CVP values as well as between the EAP diameter and Hmg, Hct, ScvO2 levels.Conclusion: Measurement of IVC diameters, especially EAP may be useful at the monitoring of critically ill patients in ED.Publication Prognostic value of estrogen receptors in patients who underwent prostatectomy for non-metastatic prostate cancer(Spandidos Publ Ltd, 2023-02-01) Aydın, Yavuz Mert; Şahin, Ahmet Bilgehan; Dölek, Rabia; Vuruşkan, Berna Aytaç; Ocakoğlu, Gökhan; Vuruşkan, Hakan; Yavaşçaoğlu, İsmet; Coşkun, Burhan; AYDIN, YAVUZ MERT; ŞAHİN, AHMET BİLGEHAN; DÖLEK, RABİA; AYTAÇ VURUŞKAN, BERNA; OCAKOĞLU, GÖKHAN; VURUŞKAN, HAKAN; YAVAŞCAOĞLU, İSMET; COŞKUN, BURHAN; Tıp Fakültesi; Tıbbi Onkoloji Ana Bilim Dalı; 0000-0002-6287-6767; 0000-0002-7846-0870; 0000-0002-1114-6051; 0000-0002-8242-9921; AAH-9704-2021; AFP-3055-2022; HSH-9815-2023; JCO-5169-2023; AAH-5180-2021; AAM-4927-2020; EEJ-1452-2022; EFH-9523-2022; EIN-0828-2022Estrogen receptors in prostate cancer (PCa) are a subject of debate. The aim of the present study was to investigate whether estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) impact the biochemical recurrence (BCR) of non-metastatic PCa after surgery. Following the application of the exclusion criteria, data from 108 patients who underwent laparoscopic radical prostatectomy between January 2011 and December 2019 were retrospectively evaluated. A total of 36 patients with BCR constituted the BCR group. The control group was formed using the Propensity Score Matching (PSM) method with a 1:2 ratio, including parameters with well-studied effects on BCR. The median follow-up time was 74.3 (range, 30-127.5) months in the BCR group and 66.6 (range, 31.5-130) months in the control group. Pathology specimens from the two groups were immunohistochemically stained with ER alpha and ER beta antibodies. Logistic regression analysis and survival analysis were performed. No differences in clinicopathological characteristics were detected between the two groups. The patients with ER alpha(-)/ER beta(+) staining results had a significantly fewer BCRs than other patients (P=0.024). In the logistic regression analysis, patients with ER alpha(-)/ER beta(+) PCa also had a significantly lower risk of recurrence (P=0.048). In the survival analysis, the 5-year BCR-free survival rate of patients with ER alpha(-)/ER beta(+) PCa was higher than that of other patients (85.7 vs. 66.1%; P=0.031). Excluding the effects of well-studied risk factors for recurrence by the PSM method, the present study showed that ER alpha and ER beta have prognostic value for non-metastatic PCa. The 5-year BCR-free survival rate is significantly higher in patients whose PCa tissue has ER alpha(-)/ER beta(+) staining results.Publication Epidemiological comparison between two decades of pediatric head injury hospitalization in Turkey in 2000-2010 and 2011-2020(Turkish Neurosurgical Soc, 2023-01-01) Taşkapılıoğlu, Mevlüt O.; TAŞKAPILIOĞLU, MEVLÜT ÖZGÜR; Özmaraşali, Ali, I; ÖZMARASALI, ALİ İMRAN; Balcı, Mustafa; Ocakoğlu, Gökhan; OCAKOĞLU, GÖKHAN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-7529-2808; 0000-0001-9912-3948; 0000-0002-1114-6051; JKH-6642-2023; AAH-5180-2021; CAI-5927-2022AIM: To understand the changing trends in pediatric head injury in a university hospital comparing two decades.MATERIAL and METHODS: The medical records of pediatric patients hospitalized for head injuries were evaluated retrospectively between 2000 and 2020 to investigate the epidemiological differences between decades. The patient files were evaluated in terms of age, sex, mechanism of trauma, whether there was additional trauma, radiological findings, Glasgow coma score (GCS), and Rankin scores.RESULTS: A difference was found between the ages of the patients who were hospitalized for head trauma in 2000-2010 (first decade) and 2011-2020 (second decade) (p<0.001). The admission rate of children in the preschool age group was higher in the second decade (p<0.05), whereas the admission rate of school-age children and adolescents was higher in the first decade (p<0.05). The admission rate of patients who had head trauma due to traffic accidents was higher in the first decade (p<0.05). The rate of linear fracture was higher in the second decade (29.90% vs. 55.60%, p<0.05). The incidence of epidural hemorrhage was higher in patients admitted in the first decade (18.50% vs. 7.90%, p<0.05).CONCLUSION: Some classical information has changed over the years. Multicenter studies with a higher number of patients will correct the changing knowledge about pediatric head trauma.