Person: YALÇINKAYA, ÜLVİYE
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YALÇINKAYA
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ÜLVİYE
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Publication The effect of transforming growth factor -β on regulation of intimal hyperplasia in a rabbit carotid anastomosis model(Excerpta Medica Inc-elsevier Science Inc, 2014-04-01) Sürer, S.; Toktaş, F.; Yavuz, S.; Türk, T.; Ata, Y.; Vural, A. H.; Goncu, M. T.; Yaşar, N. G.; Yalçınkaya, Ülviye; Yaşar, N. G.; YALÇINKAYA, ÜLVİYE; Veteriner Fakültesi; Patoloji Bölümü; JFV-7973-2023; JJV-5073-2023Publication The effect of HIF stabilizer on distraction osteogenesis(Turkish Assoc Orthopaedics Traumatology, 2015-01-01) Özdel, Ahmet; Sarısozen, Bartu; Yalçınkaya, Ulviye; Demirağ, Burak; Özdel, Ahmet; SARISÖZEN, MEHMET BARTU; YALÇINKAYA, ÜLVİYE; Demirağ, Burak; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0003-4071-8052; ABI-7283-2020; AAH-8924-2021; DLP-2668-2022; EVT-6166-2022Objective: The aim of this study was to investigate the effect of an orally applicable hypoxia-inducible factor (HIF) stabilizer on distraction osteogenesis (DO) in a rat model.Methods: The study included 24 Wistar albino rats undergoing osteotomy of the left tibia diaphysis. Rats were divided equally into experiment and control groups. Tibias were fixed using an external fixator. HIF stabilizer was administered to the experiment group. On the 5th postoperative day, distraction with increased rate (0.4 mm twice a day) was commenced and continued for 10 days. Histological and immunohistochemical evaluation was performed.Results: Vascular endothelial growth factor levels of the experiment group were higher than those of the control group (p<0.05). The experiment group had slightly better intramembranous ossification quality than the control group on both Day 16 and 30. Endochondral ossification rates were better in the experiment group on Day 16.Conclusion: Vascular endothelial growth factor levels increased and stimulated angiogenesis in the presence of HIF pathway activation by oral administration of HIF stabilizer during DO. The biomechanical features of the distraction and angiogenesis should be coupled to achieve adequate bone homeostasis.Publication Malignant transformation of monostotic fibrous dysplasia into angiosarcoma in the proximal tibia(Wolters Kluwer Medknow Publications, 2021-04-01) Yalçınkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Narter, Selin; NARTER, SELİN; Bilgen, Muhammet S.; BİLGEN, MÜHAMMET SADIK; Yazıcı, Zeynep; YAZICI, ZEYNEP; Tıp Fakültesi; Ortopedi Ana Bilim DalıThe majority of bone angiosarcomas are primary tumors while secondary angiosarcomas arise after radiation therapy or bone infarctus. This article presents a case of malignant transformation of monostotic fibrous dysplasia into angiosarcoma. An 80-year-old female presented with pain on right cruris. Radiological examination revealed a lesion with lytic areas and destruction of cortical bone on right tibia. Gross and histopathological examination showed two areas with an abrupt transition. The solid component was composed of curved, immature bony trabeculae in a fibroblastic stroma. The other component involved epitheloid cells forming slit-like vascular spaces. The diagnosis of angiosarcoma and fibrous dysplasia was given. Malignant transformation of fibrous dysplasia into angiosarcoma is extremely rare; as this is the sixth case in the existing literature. Prognosis of fibrous dysplasia is generally good and less than 1% of the patients develop a malignant tumor. Therefore, patients with fibrous dysplasia should be offered a life-long follow-up.Publication Craniofacial fibroosseous lesions(Türk Patoloji Derneği, 2006-01-01) Yalçınkaya, Ulviye; Doğanavşargil, Başak; Sezak, Murat; Öztop, Fikri; YALÇINKAYA, ÜLVİYE; Tıp Fakültesi; Patoloji Ana Bilim Dalı; AAH-8924-2021Fibroosseous lesions of the cranial and facial bones are usually benign and tend to grow slowly, yet act aggressively clinically. If not totally excised, recurrence is common in these locally destructive and deforming lesions. Degeneration into sarcoma has been reported in recurred lesions, as well. Diagnosis, classification and treatment of these lesions have exposed various difficulties in the past. Predilection sites are maxillae and mandibles. They are often seen in children and young adults.In this study 43 cases from Ege University Medical School Surgical Pathology Department between 1976 and 2004, and 12 cases from Uludag University Medical School Surgical Pathology Department between 2003 and 2006 were reviewed. Cases were noted as for age, gender, lesion site, lesion type, histological properties, recurrence, and degeneration into sarcoma.In conclusion we suggest that specific diagnosis of fibroosseous lesions of cranial and facial bony regions should rely on clinicopathological correlation and radiological findings along with pathological criteria.Publication Preoperative endovascular embolization of orbital solitary fibrous tumor with 500-700 micron tris-acryl gelatin microspheres(Galenos Publ House, 2022-10-01) Muz, Ömer Ersin; Yazıcı, Bülent; Hakyemez, Bahattin; HAKYEMEZ, BAHATTİN; Yazıcı, Zeynep; YAZICI, ZEYNEP; Yalcinkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0001-8889-1933; AAA-5384-2020; AAI-2318-2021; AAH-8924-2021; AAA-5384-2020; AAI-2303-2021The reported experience with preoperative embolization of solid orbital tumors is scarce. Herein, we present a case of a large and hypervascular orbital solitary fibrous tumor (SFT) in which 500-700 mu m tris-acryl gelatin microspheres (TAGM) were used for preoperative embolization. A 41-year-old man presented with severe proptosis, palpable mass, restrictive myopathy, exposure keratopathy, and compressive optic neuropathy in the right orbit. Magnetic resonance imaging showed a 65x35x35 mm, diffusely contrast-enhanced tumor in the superior orbit, extending to the apex, and multiple intratumoral vascular flow voids. A diagnosis of SFT was made by incisional biopsy. Endovascular tumor embolization was performed with 500-700 mu m TAGM. Two days later, the tumor was entirely removed with minimal bleeding. No embolization-or surgery-related complications and tumor recurrence or metastasis developed during the 42-month postoperative follow-up.Publication Malignant glomus tumor with oncocytic features: An unusual presentation of dysphagia(Wiley, 2015-07-01) Uğras, Nesrin; Yerci, Ömer, I.; Yalçınkaya, Ulviye; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; UĞRAŞ, NESRİN; YERCİ, ÖMER; YALÇINKAYA, ÜLVİYE; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; Tıp Fakültesi; Histoloji ve Embriyoloji Ana Bilim Dalı; 0000-0002-9600-9418; AAH-8924-2021; AAH-2716-2021; JIO-2609-2023; JII-0241-2023; JGW-0566-2023; GCS-6830-2022; JIV-8745-2023Glomus tumors in the gastrointestinal tract are unusual, as the previous series in the literature have been mainly limited to the stomach. Less than 10 cases of esophageal glomus tumors have been described in the literature. Oncocytic glomus tumors are a recently identified, rare variant of the glomus tumor. We report a 47-year-old female who presented with an approximately 3-month history of dysphagia and weight loss. Upper gastrointestinal endoscopy showed a black-purple, hypervascular, protruding lesion measuring approximately 65mm at the 37th cm of the esophagus. The patient underwent an Ivor Lewis operation via open thoracotomy. The resected specimen had a protuberant, ulcerated mass measuring 80x35mm in the posterior wall of the esophagus. Based on the histopathological, immunohistochemical and electron microscope findings, the final diagnosis was a malignant glomus tumor with oncocytic features. To our knowledge, this is the first report of a malignant glomus tumor with oncocytic features in an esophageal location.Publication The effects of phytoestrogens on fracture healing:: experimental research in New Zealand white rabbits(Turkish Assoc Trauma Emergency Surgery, 2008-01-01) Öztürk, Alpaslan; Ilman, Aysu Altıkardeşler; Sağlam, Hüsniye; Yalçınkaya, Ulviye; Aykut, Serkan; Akgöz, Semra; Özkan, Yüksel; Yanık, Kemal; Kivcak, Bijen; Yalçın, Nazan; Özdemir, Recai Mehmet; Ilman, Aysu Altıkardeşler; YALÇINKAYA, ÜLVİYE; Akgöz, Semra; Yanık, Kemal; Veteriner Fakültesi; Cerrahi Ana Bilim Dalı; FAM-4675-2022; AAH-8924-2021; JGZ-0807-2023; GIV-6327-2022BACKGROUNDPhytoestrogens are plant-derived natural molecules having some bone forming and bone substituting effects. In the present study, the role of phytoestrogens on bone healing was investigated in a rabbit fracture model.METHODSTwenty-two New Zealand white rabbits with right tibia fracture were divided into two groups randomly. The plant derived extract of Vitex agnus-castus L. (Verbenaceae) prepared before the study was administered intramuscularly in group 1 and group 2 was chosen as control. Fracture healing was monitored in weekly basis with blood alkaline phosphatase level, radiographs of extremities and 99m-Tc MDP bone scintigraphy. The study was finished at the end of the 3rd week. The extremities including tibial fractures were collected for histological examination.RESULTSRadiographic evidence of fracture healing obtained on postoperative day seven was superior in group 1 than control group (p < 0.01). The 99m-Tc MP bone scintigraphy uptake ratios on postoperative seventh day showed higher uptake in group I than in group 2 (p < 0.05). The differences of scintigraphic uptakes in fractured tibias calculated on postoperative seventh day and postoperative 14th in group I were higher than group 2 (p=0.04). The histopathologic evaluation performed after sacrification of all rabbits on postoperative 25th day showed no significant difference between both groups. No statistical difference was determined related to the other variables.CONCLUSIONFlavonoids affected positively the early periods of fracture healing mechanism in New Zealand white rabbits. We suggest further studies with phytoestrogens to determine the effects of various dosages and administration ways.Publication Discoid lupus erythematosus of the eyelid: Case report(Turkish Ophthalmological Soc, 2006-11-01) Yıldız, Meral; YILDIZ, MERAL; Yazıcı, Bülent; Filiz, Gülaydan; Yalçınkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0001-8889-1933; AAH-1885-2021; AAA-5384-2020; AAH-8924-2021Discoid lupus erythematosus is a chronic, autoimmune disease of the skin. Localized OLE involving the eyelid is seen rarely. In this report, a 28 year-old male who had a localized OLE involving the eyelid has been presented. The examination findings of the patient were a welldefined, slight elevated erythema through the right lower eyelid, scaling on the lesion and madarosis. The diagnosis was made by observing the typical histopatological changes such as hyperkeratosis, lymphoid infiltration at the dermoepidermal junction and telangiectasis in the substantia propria. The eyelid lesion totally disappeared with the treatment of 3 months-systemic hydorxychloroquine (200 mg/day). However, it recurred in the same region 14 months later. Discoid lupus did not recur after the second-systemic hydorxychloroquine treatment. Systemic lupus erythematosus did not develope in the patient followed-up for 40 months.Publication Efficacy of single-dose radiotherapy in preventing posttraumatic tendon adhesion(Springernature, 2020-06-02) Ermutlu, Cenk; ERMUTLU, CENK; Kaleli, Tufan; KALELİ, HÜSEYİN TUFAN; Yalçınkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Çetintaş, Sibel; ÇETİNTAŞ, SİBEL; Atıcı, Teoman; ATICI, TEOMAN; Tıp Fakültesi; Ortopedi Ana Bilim Dalı; 0000-0001-8259-3695; 0000-0003-1109-8958; 0000-0002-3396-3407; AAH-8924-2021; AAB-6136-2022; A-5095-2018; AAB-2795-2021Background and AimPosttraumatic peritendinous adhesion is the greatest obstacle to achieve normal tendon function following lacerations of extrinsic flexor tendons of the hand. In this study, we aimed to evaluate whether single-dose radiotherapy (RT) has the potential to modulate intrasynovial tendon adhesions.Materials and MethodsA total of 80 tendons from the third to fourth flexor profundus of both hind paws of 20 adult New Zealand rabbits were used in this study. Rabbits in the RT group received 3 Gy of X-irradiation in a single fraction. Histopathological evaluation of longitudinal sections of tendons was made using the Tang grading system for peritendinous adhesions. Intratendinous quality of the healing tissue in the laceration zone was assessed using a modified Movin scale.ResultsAdhesion and inflammatory response were greater in the RT group (p(<)0.001). Tendon healing in the radiation group was found to he more uniform and organized compared with the control group. However, this difference was not statistically significant. The nuclei of the tenocytes in the radiation group showed a closer resemblance to normal tendon tissue when compared with the control group (p=0.007).ConclusionsDespite RT's certain advantages such as extracorporeal use, anti-inflammatory effect, and homogenous tissue penetration, 3-Gy X-irradiation resulted in increased peritendinous posttraumatic adhesion, possibly due to dose imbalance. Increased roundness in the tenocyte nuclei was present in the RT group. Studies with different dosing regimens and a higher number of subjects are necessary to establish an ideal dose suppressing the synovial response without compromising tendon healing.Publication The ki-67 proliferation index predicts recurrence-free survival in patients with dermatofibrosarcoma protuberans(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2021-01-01) Tanriverdi, Ozgur; Ozsen, Mine; ÖZŞEN, MİNE; Deligonul, Adem; DELİGÖNÜL, ADEM; Yazici, Serkan; YAZİCİ, SERKAN; Cetintas, Sibel Kahraman; Yalcinkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Sahin, Ahmet Bilgehan; ŞAHİN, AHMET BİLGEHAN; Orhan, Sibel Oyucu; OYUCU ORHAN, SİBEL; Ocak, Birol; OCAK, BİROL; Evrensel, Turkkan; EVRENSEL, TÜRKKAN; Kahveci, Ramazan; KAHVECİ, RAMAZAN; Cubukcu, Erdem; ÇUBUKÇU, ERDEM; Tıp Fakültesi; Onkoloji Ana Bilim Dalı; 0000-0001-6407-0962; 0000-0002-5771-7649; 0000-0002-7846-0870; 0000-0002-0598-7284; 0000-0001-7537-1699; AAJ-8314-2021; AEC-2238-2022; AAM-4927-2020; M-2172-2015Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma that originates from the dermis or subcutaneous tissue in the skin. While its prognosis is generally favorable, disease recurrence is relatively frequent. Since morbidity after repeated surgery may be significant, an optimized prediction of recurrence-free survival (RFS) has the potential to improve current management strategies. The purpose of this study was to investigate the prognostic value of the Ki-67 proliferation index with respect to RFS in patients with DFSP We retrospectively analyzed data from 45 patients with DFSP. We calculated the Ki-67 proliferation index as the percentage of immunostained nuclei among the total number of tumor cell nuclei regardless of the intensity of immunostaining. We constructed univariate and multivariate Cox proportional hazards regression models to identify predictors of RFS. Among the 45 patients included in the study, 8 developed local recurrences and 2 had lung metastases (median follow-up: 95.o months; range: 5.2-412.4 months). The RFS rates at 60, 120, and 240 months of follow-up were 83.8%, 76.2%, and 65.3%, respectively. The median Ki-67 proliferation index was 14%. Notably, we identified the Ki-67 proliferation index as the only independent predictor for RFS in multivariate Cox proportional hazards regression analysis (hazard ratio = 1.106, 95% confidence interval = 1.019-1.200, p = 0.016). In summary, our results highlight the potential usefulness of the Ki-67 proliferation index for facilitating the identification of patients with DFSP at a higher risk of developing disease recurrences.
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