Person: ÖZGÜR, TANER
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ÖZGÜR
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Publication Liver involvement in congenital hypopituitarism(Springer India, 2019-05-01) Altay, Derya; Eren, Erdal; EREN, ERDAL; Özkan, Tanju Başarır; Özgür, Taner; ÖZGÜR, TANER; Tarım, Ömer; TARIM, ÖMER FARUK; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-1684-1053; 0000-0001-5740-9729; 0000-0002-5322-5508; AAG-8381-2021; AAG-8416-2021; JPK-3909-2023ObjectiveCholestatic jaundice in early infancy is a complex diagnostic challenge. Cholestasis caused by endocrine disease is rare and poorly recognized. The aim of this paper is to report patients with liver dysfunctions resulting from hypopituitarism.MethodsSix patients with liver dysfunction diagnosed as hypopituitarism were studied and followed up atUludag University Faculty of Medicine.ResultsThe median age of the patients at first presentation was 2.5 mo. Three patients were diagnosed with congenital hypopituitarism at the first visit, and the other three were diagnosed during follow-up. Serum aminotransferase levels were very high in two patients and only moderately elevated in the others. Combined adrenal, thyroid, and growth hormone deficiencies were diagnosed in two patients, while remaining 4 patients had various combinations of adrenal, thyroid, and growth hormone deficiencies. Liver function abnormalities resolved between 10 d and 2 mo follow-up after hormone replacement therapy.ConclusionsAbnormal liver biochemical test results due to hormonal deficiencies in infants should be considered in the differential diagnosis by pediatricians. Hormone replacement therapy is the basis of treatment.Publication Celiac disease and autoimmune hepatitis presenting with fulminant hepatic failure: A case report(Erciyes Üniversitesi, 2021-07-01) Kaptan, Kadriye Nil; Özgür, Taner; Turan, Enes; Özkan, Tanju Başarır; Özkan, Tanju Başarır; KAPTAN, KADRİYE NİL; ÖZGÜR, TANER; TURAN, ENES; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Gastroenteroloji Bölümü; CXV-7127-2022; JJX-2704-2023; JSJ-2135-2023; IGW-0111-2023Background: Fulminant hepatic failure (FHF) may be a rare presentation of autoimmune hepatitis (AIH) in previously asymptomatic adolescents. Celiac disease (CD) is a chronic immune disease that may be associated with severe forms of liver disease and coexists with AIH. We report a patient presenting with an FHF at the diagnosis of AIH and CD.Case Report: An 8-year-old female patient who had no known background or family history of liver disease was referred to our center with an FHF diagnosis. Her clinical and laboratory findings fulfilled the criteria of seronegative AIH and CD. After 7 days of starting the medical treatment, encephalopathy and liver function tests gradually improved.Conclusion: AIH and CD usually follow a chronic course and rarely coexist. However, they should be considered the etiologies of FHF and should be treated promptly.Publication The effectiveness of serum amyloid a for prediction of neonatal cholestasis associated with parenteral nutrition in premature infants(Turkish J Pediatrics, 2019-01-01) Özkan, Hilal; ÖZKAN, HİLAL; Köksal, Nilgun; Doğan, Pelin; Güney-Varal, İpek; Bağcı, Onur; Özgür, Taner; ÖZGÜR, TANER; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Pediatri Anabilim Dalı.; 0000-0002-3298-066X; 0000-0001-9308-9806; AAG-8393-2021; AAI-5981-2020; AAG-8381-2021Parenteral nutrition (PN) has been widely used in premature infants untill enteral feeding can be tolerated. Cholestasis is an important complication of PN. The objective of this study was to evaluate the role of serial measurements of serum amyloid A (SAA) during PN and compare its' effectiveness with C-reactive protein (CRP) and procalcitonin (PCT). We also aimed to determine the risk factors for PN associated cholestasis (PNAC).Premature infants (<34 weeks' gestational age) who were started on PN during hospitalization were included in this prospective study. SAA, CRP and PCT levels were measured on days 0, 3, 7, 14, and 21 of PN in all infants. Infants who had PN for less than 2 weeks, who developed sepsis and/or necrotizing enterocolitis were excluded.A total of 85 infants were included. The mean birth weight was 1226 +/- 329 g, and the mean gestational age was 29.4 +/- 1.8 weeks. The birth weight of infants who developed cholestasis were significantly lower. Enteral nutrition was started significantly later in infants with cholestasis. CRP and PCT did not correlate with conjugated bilirubin levels at any time point. SAA levels on days 7 and 14 showed a significant correlation with conjugated bilirubin levels. SAA levels on day 7 was found to have the highest sensitivity for prediction of PNAC.Low birth weight, late commencement of enteral feeding, and prolonged PN were the main risk factors for PNAC development. This is the first study that shows the predictive value of SAA for PNAC development. We suggest that SAA may be used as an accurate and useful biomarker for prediction of PNAC in high risk premature infants receiving PN.Publication The assessment of the quality of life in children with chronic liver disease(Aves, 2021-03-14) Demiral, Meliha; Özkan, Tanju Başarır; Özgür, Taner; Özkan, Bige; Eren, Gülin Erdemir; Altay, Derya; Özkan, Tanju Başarır; ÖZGÜR, TANER; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Gastroenteroloji ve Hepatoloji Anabilim Dalı.; DKU-2575-2022; JLC-5143-2023Background: improvement in the quality of life (QoL) of patients with chronic diseases is as important as medical care. This study aimed to evaluate the QoL of children with chronic liver diseases and to determine related factors.Methods: For this study, 101 children with chronic liver disease, 100 healthy controls, and their parents were included. The Pediatric Quality of Life Scale (PedsQL) was used to evaluate health-related QoL; higher scores indicate better QoL. Patients were evaluated before and after initiation of treatment and being educated about their illness.Results: The mean patient age was 12.9 +/- 3.9 years. Total PedsQL scores of the patients and the healthy control group were 38.6 +/- 18.9 and 55.4 +/- 14.3, respectively (P = .01). The scores of the parents of the patient and control groups were 35.4 +/- 14.2 and 54.0 +/- 16.9, respectively (P = .02). Patient and parent scores were positively correlated. Significantly higher scores were found in the 5-10 age group compared to the 10-15 and 15-18 age groups in the psychosocial score category. An increase in the QoL scores of patients who were started on medication other than steroid treatment was observed in the sixth month of treatment (35.8 +/- 13.4 vs. 33.6 +/- 8.9, P = .01, respectively).Conclusion: Both children with chronic liver diseases and their parents have a perceived lower QoL than healthy peers. The effect of chronic liver disease on psychosocial health is more pronounced in children older than 10 years. The quality of life is inversely proportional to the severity of the disease. It was observed that primary or symptomatic treatments have a positive impact on the perception of QoL, with the exception of steroid treatment.