Person: BOLCA TOPAL, NAİLE
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BOLCA TOPAL
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NAİLE
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Publication Castleman's disease: Unilateral cervical involvement and imaging findings a case report(Sage Publications Inc, 2007-06-01) Atahan, S.; Hakyemez, B.; Doğan, Nurullah; HAKYEMEZ, BAHATTİN; Topal, N. B.; BOLCA TOPAL, NAİLE; Parlak, M.; PARLAK, MÜFİT; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0003-1455-6918; AAI-2327-2021; AAI-2318-2021; AAG-8521-2021Castleman's disease is an idiopathic lymphoproliferative disorder characterized by massive enlargement of lymph nodes. It may have a unifocal or multifocal presentation; the mediastinum is the most common site (70%). Patients with cervical disease usually have unifocal involvement (90%). The main problem posed by cervical Castleman's disease is that it should be considered in the differential diagnosis of cervical tumors. This report describes a patient who had unifocal Castleman's disease on the left side of the neck, and discusses the differential diagnosis with findings on magnetic resonance imaging, computed tomography and ultrasonography.Publication Efficacy of 0.1% tacrolimus ointment in chronic plaque psoriasis: A randomized double-blind placebo-controlled study(Deri Zuhrevi Hastaliklar Dernegi, 2015-01-01) Kaçar, Seval Dogruk; Kaçar, Emre; Baskan, Emel Bulbul; BÜLBÜL BAŞKAN, EMEL; Bolca, Naile; BOLCA TOPAL, NAİLE; Adım, Sadiman Balaban; BALABAN ADIM, ŞADUMAN; Tunalı, Şükran; Sarıcaoğlu, Hayriye; SARICAOĞLU, HAYRİYE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Deri ve Zührevi Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; JLM-2426-2023; AAH-1388-2021Background and Design: Despite the development of effective systemic treatments and new biological agents for psoriasis nowadays, topical medications are still the mainstay of treatment. Topical calcineurin inhibitors are currently used in various skin diseases. We investigated the efficacy and safety of tacrolimus, which is an alternative in topical treatment, in comparison with the present medications in plaque psoriasis.Materials and Methods: This prospective double-blind placebo-controlled study was conducted in 24 patients with the diagnosis of plaque psoriasis who were seen in Uludag University Hospital dermatology outpatient clinic. 0.1% tacrolimus ointment, 0.1% mometasone furoate ointment, 0.005% calcipotriol ointment and placebo in encrypted bottles were randomly applied under occlusion to 27 psoriatic plaques in test chambers, every other day, for a period of 19 days. Clinic sum scores, side effects, and epidermal thickness measured by superficial ultrasound were noted before and after treatment in all microplaques. Besides, histopathologic scoring and epidermal thickness were measured in 9 patients at the end of the study.Results: The clinic sum scores and ultrasonographic epidermal thickness at the end were both significantly lower than the beginning values in all microplaques (p<0.05). The reduction in these two values with tacrolimus were significantly higher than that with placebo (p<0.001), but no difference was observed with calcipotriol (p=0.287, p=0.813, respectively). On the other hand, the reduction in these values with mometasone was significantly higher than with tacrolimus (p<0.05). Mometasone furoate was the most effective when the three ointments were compared with placebo in terms of total histopathological score and epidermal thickness.Conclusion: Tacrolimus ointment applied under occlusion is an alternative topical medication in the treatment of plaque psoriasis. Occlusion in practice requires patient compliance. Thus, studies to find a new formulation that will increase absorption of drug from thick psoriatic plaques are needed.Publication X-ray-evaluation(Aves Yayincilik, Ibrahim Kara, 2009-03-01) HACIMUSTAFAOĞLU, MUSTAFA KEMAL; ÇELEBİ, SOLMAZ; Çelebi, Solmaz; Bolca, Naile; BOLCA TOPAL, NAİLE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0003-4646-660XPublication Detection of vesico-ureteric reflux in renal transplant recipients by colour doppler urosonograpy(Aves, 2005-09-01) Vuruskan, Hakan; VURUŞKAN, HAKAN; Çift, Ali; Oktay, Bülent; Bolca, Naile; BOLCA TOPAL, NAİLE; Kordan, Yakup; Yavasçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0002-9947-848X; AAH-7103-2019Introduction: In this study, we evaluated the vesico-ureteric reflux (VUR) in renal transplant recipients by using color Doppler urosonography (CDU).Materials and Methods: Among 149 renal transplant recipients, 42 (27 men, 15 women) who accepted to take part were included to the study. The mean age and duration of post-transplant follow-up of the patients were 35.1+/-1.39 years (15-55) and 63.6+/-7.2 months (7-170), respectively. In all patients, ureterovesical anastomosis and antireflux submucosal tunnel were performed with Lich-Gregoir technique without using ureteral stent. Urinary system was assessed in all patients with CDU without any contrast enhancing agent by the same radiologist. During CDU, patients were asked to make Valsalva maneuver when their bladders were full with urine and were evaluated for reflux. The patients' ureteric jets were first investigated in transverse and then in longitudinal plane by observing distal ureteric segment and ureteral orifice. The flows coming towards the transducer were coded red in color while those moving away from the transducer were coded blue in color. During observation of the distal ureteric segment; detection of red color was regarded as reflux. The patients, in whom reflux was detected by CDU, were reassessed by voiding cystouretrography (VCUG).Results: Among 42 patients who underwent CDU, 7 patients (16.7%) were diagnosed to have VUR. In all patients, the diagnosis of CDU detected VUR was confirmed by VCUG. In 4 patients (57.2%) low grade and in 3 patients (42.9%) intermediate grade reflux was found by using CDU. None of the patients had high grade reflux. In 3 patients (42.9%) grade 2, in 3 patients (42.9%) grade 3, in 1 patient (14.2%) grade 4 reflux were observed during evaluation of these patients by VCUG. Since VCUG is an invasive procedure and the patients who were determined not to have VUR by CDU had no urinary tract infection history in the follow-up they did not undergo VCUG.Conclusion: CDU is a non-invasive and effective method for the diagnosis and follow-up of VUR in renal transplant recipients.Publication The relationship between visfatin and carotid atherosclerosis in patients with advanced chronic kidney disease(Oxford Univ Press, 2015-05-01) Ayar, Yavuz; Ersoy, Alparslan; Sayılar, Emel Işıktaş; Yıldız, Abdülmecit; Pektaş, Fatih; Tüysüz, Özlem; Yavuz, Mahmut; Topal, Naile Bolca; Dirican, Melahat; Arslan, Ismail; Ateş, Çiğdem Aksu Coşkun; Ayar, Yavuz; ERSOY, ALPARSLAN; Sayılar, Emel Işıktaş; YILDIZ, ABDULMECİT; Pektaş, Fatih; Tüysüz, Özlem; YAVUZ, MAHMUT; BOLCA TOPAL, NAİLE; Dirican, Melahat; Arslan, İsmail; Ateş, Çiğdem Aksu Coşkun; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-1539-9216; HIG-9032-2022 ; O-9948-2015; AAI-2327-2021; W-2575-2017; GSE-0029-2022; AGF-0767-2022; AAH-5054-2021; JDU-0150-2023; ECR-6289-2022; EHM-7377-2022; ESK-6562-2022; JML-0742-2023; IIU-0465-2023Publication Predictors for the risk and severity of post-thrombotic syndrome in vascular Behcet's disease(Elsevier, 2021-02-04) Aksoy, Aysun; Çolak, Seda; Yağız, Burcu; Coşkun, Belkıs Nihan; Omma, Ahmet; Yıldız, Yasin; Sarı, Alper; Ataş, Nuh; Ilgın, Can; Karadağ, Ömer; Erden, Abdulsamet; Dalkılıç, Ediz; Bolca, Naile; Ergelen, Rabia; Onur, Mehmet Ruhi; Direskeneli, Haner; Alibaz-Öner, Fatma; YAĞIZ, BURCU; COŞKUN, BELKIS NİHAN; BOLCA TOPAL, NAİLE; DALKILIÇ, HÜSEYİN EDİZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0003-0298-4157; JQW-5031-2023; AAG-7155-2021; CMF-4757-2022 ; EKW-9201-2022Objective: Deep vein thrombosis (DVT) of the lower extremities is the most common form of vascular involvement in Behcet disease (BD), frequently leading to post-thrombotic syndrome (PTS) as a disabling complication. We have described the clinical characteristics and predictors of PTS presence among patients with BD and lower extremity DVT. We also used venous Doppler ultrasound (US) examinations in our assessment. Methods: Patients with BD (n = 205; 166 men, 39 women; age 39 6 9.5 years) and a history of DVT were investigated. The Villalta scale was used to assess the presence and severity of PTS. Doppler US examinations were performed within 1 week of the clinical evaluation. The total number of vessels with reflux, thrombi, recanalization, and collateral vessels were calculated. Results: Of the 205 patients with BD, 62% had had PTS and 18% had had severe PTS. Patients with PTS had had greater reflux (P = .054) and thrombosis (P = .02) scores compared with patients without PTS. Treatment with anticoagulation (AC), immunosuppressive (IS) therapy, or AC combined with IS drugs did not affect the occurrence of PTS. However, patients treated with IS therapy, with or without AC drugs, had a decreased incidence of severe PTS compared with the AC-only group (P = .017). Patients treated with AC plus IS agents also had increased collateral scores compared with patients treated with only IS drugs. Interferon-a use seemed to provide better recanalization scores compared with azathioprine only (1.0 [range, 0-14] vs 2.5 [range, 0-10]; P = .010). Conclusions: Patients with BD and DVT have a high risk of developing severe PTS. IS treatment decreases the development of severe PTS. AC therapy might influence the course of PTS by increasing the collateral scores, and the use of interferon-a also increased recanalization scores. Routine assessment with Doppler US examinations could be helpful in the prediction of severe PTS.Publication Assessment of presence, severity and risk factors of post- thrombotic syndrome in vascular behcet disease: Muticentered retrospective study(Bmj Publishing Group, 2019-06-01) Aksoy, Aysun; Çolak, Seda; Omma, Ahmet; Yağız, Burcu; Seniz, Belkıs Nihan; Bolca, Naile; Ergelen, Rabia; Direskeneli, Haner; Alibaz-Öner, Fatma; YAĞIZ, BURCU; Seniz, Belkıs Nihan; BOLCA TOPAL, NAİLE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Ana Bilim Dalı/Romatoloji Bilim Dalı.; JQW-5031-2023; DPZ-9938-2022; EKW-9201-2022Publication Prenatal diagnosis of fetal umbilical cord teratoma(Walter De Gruyter Gmbh, 2014-08-01) Demir, Bilge Çetinkaya; Topal, Naile Bolca; Güneş, Esra Şahin; Yazıcı, Zeynep; Yalçınkaya, Ulviye; ÇETİNKAYA DEMİR, BİLGE; BOLCA TOPAL, NAİLE; Güneş, Esra Şahin; YAZICI, ZEYNEP; YALÇINKAYA, ÜLVİYE; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0001-6845-9991; AAH-9834-2021; AAH-8924-2021; AAI-2327-2021; AAI-2303-2021; IDE-0603-2023Umbilical cord teratomas are rare tumoral lesions of umbilical cord which have challenging antenatal diagnosis. The cord teratomas contain tissue from all three germ layers and have both cystic and solid components. This ultrasonographic appearance may help the clinician to clarify the correct diagnosis. We report a case of cord teratoma diagnosed prenatally by ultrasonography and magnetic resonance imaging. Since cord teratomas may lead to adverse fetal outcomes, close follow-up of the fetus is recommended.Publication Spontaneous remission of acromegaly due to apoplexy(Galenos Yayincilik, 2008-01-01) Duran, Cevdet; Ersoy, Canan; ERSOY, CANAN; Kıyıcı, Sinem; Bolca, Naile; BOLCA TOPAL, NAİLE; ERTÜRK, ERDİNÇ; İmamoğlu, Sazi; Tuncel, Ercan; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı.; ursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0001-9560-180X; AAJ-6536-2021; AAH-8861-2021Pituitary apoplexy is a rare clinical syndrome characterized by sudden onset of headache and vomiting, accompanied by visual disturbance or ocular motility impairment and pituitary insufficiency. Pituitary apoplexy presenting with these symptoms is seen in approximately 3% of patients with surgically treated pituitary adenomas. In acromegalic patients, apoplexy can be related to some provocating factors and rarely may be spontaneous. We present the case of an acromegalic patient with spontaneous remission after apoplexy. A 39-year-old male patient had transsphenoidal microsurgery for acromegaly in 1994 but remission was not achieved. After a 10-year period without follow-up, he experienced severe headache, nausea, vomiting, photophobia, and visual disturbance in July 2005 and scheduled an appointment with an ophthalmologist. His complaints ceased spontaneously within weeks. In October 2005, sellar MRI examination revealed a 3x2.5 cm mass of adenomatous tissue with necrosis. On admission to our clinic in November 2005, visual acuity, visual fields, and ocular motility, were normal; but results of laboratory tests revealed panhypopituitarism. He was thought to have apoplexy of a growth hormone secreting tumor, and hormone replacement therapy was initiated for panhypopituitarism. Because his symptoms had regressed, surgery was not considered. On rare occasions, acromegaly spontaneously remits after apoplexy, resulting in improved control of the functional adenoma without surgical intervention.Publication An enflammatory marker in chronic renal failure patients: Visfatin(Galenos Yayıncılık, 2015-09-01) Ayar, Yavuz; Sayılar, Emel Işıktaş; Yavuz, Mahmut; Arslan, İsmail; Aksu, Çiğdem; Ateş, Coşkun; Pektaş, Fatih; Tüysüz, Özlem; Topal, Naile Bolca; Dirican, Melahat; Ayar, Yavuz; Sayılar, Emel Işıktaş; YAVUZ, MAHMUT; Arslan, İsmail; Aksu, Çiğdem; ATEŞ, COŞKUN; Pektas, Fatih; Tüysüz, Özlem; BOLCA TOPAL, NAİLE; Dirican, Melahat; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biokimya Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-1539-9216; 0000-0003-4565-9848; AGF-0767-2022; W-2575-2017; EHM-7377-2022; JML-0742-2023; HPQ-6488-2023; CDO-0747-2022; JDU-0150-2023; ECR-6289-2022; AAI-2327-2021; ESK-6562-2022Aim: Visfatin is a cytokine released from adipose tissue, especially in enflammation. In our study, we tried to show the relationship of visfatin levels with chronic renal failure (CRF) as an enflammatory marker.Methods: We included 50 CRF patients (28 male, 22 female) who attended Uludag University Nephrology Clinic and 31 healthy volunteers (13 male, 18 female). Visfatin levels and biochemical parameters, such as parathyroid hormone (PTH), lipid parameters, albumin, C-reactive protein (CRP), creatinine, urea, immunoglobulins, etc. were examined.Results: In CRF patients, visfatin levels were found to be significantly increased (p<0.001) and albumin, hemoglobin, body mass index (BMI) and high density lipoprotein (HDL) cholesterol levels were decreased (p<0.001). Triglycerides (p=0.003), CPR (p=0.005), procalcitonin (p<0.001), IgG3 (p=0.003), and ferritin (p<0.001) levels were significantly higher in patient group than in control group as an enflammatory marker.Conclusion: CRF is an independent enflammatory process. Visfatin levels in patients with chronic renal failure patients are determined to be high as an indicator of enflammation.