Person: BORA, İBRAHİM HAKKI
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BORA
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İBRAHİM HAKKI
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Publication Long term video EEG monitorization(Kare, 2012-01-01) Bican, Aylin; Bilir, Erhan; Bora, İbrahim; BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; Tıp Fakültesi; Nöroloji Ana Bilim Dalı; CEN-7664-2022; ENI-7759-2022Long term video EEG monitorisation is an essential step in the evaluation of patients with intractable epilepsy before the decision of epilepsy surgery. Considerations for long term monitorisation in the evaluation of the onset zone of seizures will be discussed in this paper.Publication Two cases of lafora disease diagnosed by genetical tests(Kare Publ, 2021-04-06) Bican Demir, Aylin; Hakkı Bora, İbrahim; BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; Tıp Fakültesi; Nöroloji Ana Bilim Dalı; 0000-0001-6739-8605; KHB-9765-2024; ICC-2353-2023Epilepsy develops related to a complex genetic heredity as many diseases in society. Lafora disease (LD) is an autosomal recessive inheritance. It is localized at EPM2A gen 6q23-25 and encodes tyrosine phosphatase (Laforin protein). About 80% of the patients have mutations in this gene. In a case of LD, rapid and progressive dementia and frequent occipital seizures are clinical symptoms. For definitive diagnosis, through genetical study, EPM2A and EPM2B genes should be analyzed. A male at the age of 18, with a medical history of meningitis and seizures with high temperature. Starting from the age of 10, there have been symptoms such as generalized tonic-clonic (GTC) seizures, startles in the whole body, and forgetfulness. In genetical tests, homozygote deletion of adenine nucleotide in the position of 468 at codon 156 and guanine nucleotide in the position of 469 at codon 157 is found. In other words, there has been dinucleotide deletion which is compatible with LD. A 20-year-old male was examined because of such symptoms as forgetfulness, myoclonia, hallucinations, and GTC clonic seizures. He was diagnosed with LD because of the heterozygote transformation of CCC to CTC at codon 111. Even though genetic disorders have many different reasons, it is advised that every society should have their own advanced studies on gene mutation. In Turkish cases, both of these genes were found mutated, each in different various studies.Publication Our cases of secondary narcolepsy with three different etiology: Review of the literature(Galenos Yayınevi, 2015-09-01) Savrun, Yusuf; Demir, Aylin Bican; Sıvacı, Ali Özhan; Bora, İbrahim; Zarifoğlu, Mehmet; Savrun, Yusuf; BİCAN DEMİR, AYLİN; Sıvacı, Ali Özhan; ZARİFOĞLU, MEHMET; BORA, İBRAHİM HAKKI; Tıp Fakültesi; Nöroloji Ana Bilim Dalı; 0000-0001-6739-8605; 0000-0002-9697-9510; FUS-0738-2022; KHB-9765-2024; GCS-6691-2022; ENI-7759-2022; EHN-5825-2022Narcolepsy is neurological disorder classified among central hypersomnolences group and characterized by excessive daytime sleepiness, cataplexy, associated symptoms like hypnogogic/hypnopompic hallucinations and sleep paralysis. It is divided into two types on the basis of accompanying cataplexy. In the pathophysiology of this disorder, which is accused an autoimmune process, hypocretin deficiency in the hypothalamus was shown. Narcolepsy is often seen as a primary disease in young population but may also occur with other disorders like cerebrovascular diseases, intracranial tumors, encephalitis, sarcoidosis, multiple sclerosis or after head trauma, infections, and vaccines; in which the disease is accepted as secondary narcolepsy. In this case report, patients presenting with excessive daytime sleepiness and diagnosed as having secondary narcolepsy due to medical causes, and who have Parkinson's disease (PD), history of interferon use and hypothalamic involvement associated with Langerhans cell histiocytosis (LCH) were reported. Daytime sleepiness complaints should be well questioned in organic pathologies related with hypothalamus-pituitary system such as PD and similar diseases or in patients with history of drug use and secondary narcolepsy should be beared in mind.Publication A demographic and polysomnographic investigation of fatigue and sleep disorders in patients with multiple sclerosis(Galenos Yayınevi, 2018-09-01) Sıvacı, Ali Özhan; Demir, Aylin Bican; Turan, Ömer Faruk; Taşkapılıoğlu, Özlem; Bora, İbrahim; Ocakoğlu, Gökhan; Sıvacı, Ali Özhan; BİCAN DEMİR, AYLİN; TURAN, ÖMER FARUK; Taşkapılıoğlu, Özlem; BORA, İBRAHİM HAKKI; OCAKOĞLU, GÖKHAN; Tıp Fakültesi; Biyoistatistik Ana Bilim Dalı; 0000-0002-9697-9510; 0000-0001-6739-8605; 0000-0003-4436-3797; 0000-0002-1114-6051; AAK-6623-2020; V-7170-2017; JCE-6657-2023; AAH-5180-2021; HLG-6346-2023; X-4479-2018Objective: To investigate fatigue and sleep disorders based on demographic, clinical and polysomnographic data and show their effects on the quality of life in multiple sclerosis (MS) patients.Materials and Methods: Thirty MS patients were enrolled in the study depending on the results of the polysomnography (PSG), Fatigue Severity scale, Epworth Sleepiness scale (ESS), Pittsburgh Sleep Quality lindex, Beck Depression and Anxiety inventories. Patients, using (n=16) and non-using (n=14) interferon, were compared with each other in all parameters; ESS and PSG data were compared with a control group consisting of 19 healthy people. Short form-36 (SF-36) data were also compared with the society norms.Results: Central fatigue was observed in 86.7% of the patients. PSG data revealed that stage N2 sleep duration of those who did not use interferon was significantly longer than those who used it (p<0.001). According to the PSG, total sleep time, sleep efficiency, stage N3 and rapid eye movement time, mean respiratory disturbance index, sleep latency and the mean value of total leg movements were significantly higher in the patient group than in the control group (p<0.001). All parameters of SF-36 were significantly lower in patient group (p<0.001). The stage N3 sleep time length was found related with physical component summary of SF-36 (p<0.001).Conclusion: MS patients have high level of fatigue and additionally there are weighty disturbances in objective and subjective sleep parameters. Our findings were revealed that all the components of quality of life decreased significantly in these patients. Furthermore, our study showed that deep sleep duration was related with physical activity and emphasized the importance of sleep evaluation in MS patients.Publication Headaches associated with seizure: A prospective comparative cohort study(Turkish Neuropsychiatry Assoc-Turk Noropsikiyatri Dernegi, 2021-03-01) Haki, Cemile; Akdoğan, Özlem; Bora, İbrahim; BORA, İBRAHİM HAKKI; Tıp Fakültesi; Nöroloji Ana Bilim Dalı; ENI-7759-2022Introduction: The purpose of the present study is to examine the frequency of headaches based on their relationship with seizures in epileptic patients as well as types of these headaches, and their clinical characteristics. Methods: 100 patients with epilepsy (60 female, 40 male), who applied to the epilepsy outpatient clinic of Faculty of Medicine of Uludag University, were included in the study after accepting their consent forms. Patients with symptomatic epilepsy, secondary headaches and mental retardation were excluded from the study. Patients with epilepsy were divided into two groups as the patients with or without headaches associated with seizure. In addition, according to their temporal relationships with seizures, headaches were grouped as preictal, ictal and postictal headaches and the characteristics of headaches associated with seizure were examined and the patients with and without headache associated with seizure were compared in terms of their demographic and clinical features. Results: In this study, the prevalence of headache associated with seizure was found as 42%. Headaches associated with seizure were more frequent in the postictal period and they were mostly characterized as migraine-like headache. According to the seizure periods, 22 (52.3%) of the patients experienced pain during every seizure period. It was determined that preictal headache was frequently migraine-like compared to postictal headache and this headache was more frequently accompanied by aura.Conclusion: Headache and epilepsy are the most frequent paroxysmal neurological conditions. However, because the symptoms of epilepsy are more remarkable, and its clinical presentation has a more dramatic picture, additional neurological conditions may be overlooked. Since both epilepsy and headache symptoms decrease the quality of life, it is important to treat both conditions. Examination of the correlation between these two situations can guide the physicians for selecting the treatment type, as well as helping them to improve the quality of life.Publication The role of obstructive sleep apnea syndrome as a cause of stroke(Galenos Publ House, 2015-09-01) SARIDAŞ, FURKAN; BİCAN DEMİR, AYLİN; Demir, Aylin Bican; Zarifoğlu, Mehmet; ZARİFOĞLU, MEHMET; Bora, İbrahim; BORA, İBRAHİM HAKKI; 0000-0001-5945-2317; 0000-0001-6739-8605; JCE-6657-2023; HSB-2700-2023; V-7170-2017Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep disorder. Stroke is the second leading cause of death and the third leading cause of disability in the world. OSAS and stroke has common risk factors, are associated with each other and are both reported to play an important role in the etiology of each other. OSAS and stroke association was identified in our two cases in whom sleep-related respiratory problems were encountered before stroke. We would like to draw attention to the importance of OSAS being among the risk factors in the etiopathogenesis of stroke.Publication Assessment of the quality of life scores of operated and unoperated patients with temporal and extra temporal lobe epilepsy and their relatives-caregivers(Kare Publ, 2018-01-01) BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; Atasayar, Gülfer; Demiralay, Ahmet; Uzabacı, Ender; UZABACI, ENDER; Tıp Fakültesi; Nöroloji Ana Bilim Dalı; 0000-0001-6739-8605; 0000-0002-9634-0055; JPL-5273-2023; JCE-6657-2023; V-7170-2017Objectives: We investigated how seizure syndromes and treatment methods correlated with the quality of life and social functioning of patients with epilepsy and their relatives-caregivers.Methods: A total of 203 patients with epilepsy and their relatives-caregivers were divided into four groups. The patients were administered the following assessments: Quality of Life in Epilepsy Inventory and the Social Functioning Scale. The patients and their relatives-caregivers were administered the Hamilton Depression and Anxiety Rating Scale. The Kruskal-Wallis Test and Mann-Whitney U Test were used for statistical analysis.Results: When the quality of life and social functioning subscales were evaluated, the patient group with resistant temporal lobe epilepsy (TLE) had the lowest scores, while the highest scores occurred in the TLE group that had undergone surgical intervention and had entered remission with medical treatment. For both patients and their relatives-caregivers, the anxiety and depression scores were the highest in the resistant TLE group and the lowest in the surgical and remission group.Conclusion: Control of seizures was the most important variable affecting the quality of life of patients with epilepsy and their relativescaregivers. Treatment plans for epilepsy patients should encompass the quality of life considerations, including measures to increase social functioning such as assessments of comorbid psychiatric conditions like anxiety and depression.Publication Electro-clinical analysis of ictal kissing automatism(Wiley, 2015-02-01) Taşkıran, E.; Carpraz, I.; Bilir, E.; Bican, Aylin; Bora, İbrahim; Chassoux, F.; Aydoğdu, I.; Özkara, C.; BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; Uludağ Üniversitesi; CEN-7664-2022; ENI-7759-2022Publication Preliminary experience from the turkey epilepsy pregnancy registry(Wiley, 2015-02-01) Güveli, B. Tekin; Bican, Aylin; Güler, S. Keskin; Bora, İbrahim; Gürses, C.; Türkiye Epilepsi Gebelik Kayıt Defteri; BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; Bursa Uludağ Üniversitesi; CEN-7664-2022; ENI-7759-2022Publication Birth outcomes in pregnant women with epilepsy: A nationwide multicenter study from Turkiye(Wiley, 2023-07-14) Peköz, Mehmet Taylan; Aslan-Kara, Kezban; Tekin, Betül; Gürses, Candan; Yeni, Seher Naz; Bozdemir, Hacer; Keskin-Güler, Selda; Ataklı, Dilek; Gül, Günay; Eren, Fulya; Sarı, Hüseyin; Gül, Zeynep Bastuğ; Ceyhan-Dirican, Ayten; Genç, Fatma; Biçer-Gömceli, Yasemin; Özkara, Ciğdem; Delil, Şakir; Atalar, Arife Çimen; Bebek, Nerses; Baykan, Betül; Bican-Demir, Aylin; Mısırlı Cemile Handan; Tutkavul, Kemal; Velioğlu, Sibel K. K.; Ilhan-Algın, Demet; Erdinç, Oğuz; Saygı, Serap; Tezer-Filik, Irsel; Apaydın-Doğan, Ebru; Akyol, Ali; Kamışlı, Özden; Yalçın, A. Destina; Çakmak, Gönül; Ersoy, Alevtina; Üstün-Özek, Sibel; Halaç, Gülistan; Kutlu, Gülnihal; Tantik-Pak, Aygül; Yücel, Sevinç P. P.; Bora, İbrahim; BORA, İBRAHİM HAKKI; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; ENC-9727-2022; ENI-7759-2022ObjectiveThe present study was aimed at investigating the effects of anti-seizure medications (ASMs), patient demographic characteristics, and the seizure type and frequency on the development of congenital malformations (CMs) in the infants of pregnant women with epilepsy (PWWE).MethodsPWWE followed up at the neurology outpatient clinic of 21 centers between 2014 and 2019 were included in this prospective study. The follow-up of PWWE was conducted using structured, general pregnant follow-up forms prepared by the Pregnancy and Epilepsy Study Committee. The newborns were examined by a neonatologist after delivery and at 1 and 3 months postpartum.ResultsOf the infants of 759 PWWE, 7.2% had CMs, with 5.6% having major CMs. Polytherapy, monotherapy, and no medications were received by 168 (22.1%), 548 (72.2 %), and 43 (5.7 %) patients, respectively. CMs were detected at an incidence of 2.3% in infants of PWWE who did not receive medication, 5.7% in infants of PWWE who received monotherapy, and 13.7% in infants of PWWE who received polytherapy. The risk of malformation was 2.31-fold (95% confidence interval (CI): 1.48-4.61, p < .001) higher in infants of PWWE who received polytherapy. Levetiracetam was the most frequently used seizure medication as monotherapy, with the highest incidence of CMs occurring with valproic acid (VPA) use (8.5%) and the lowest with lamotrigine use (2.1%). The incidence of CMs was 5% at a carbamazepine dose <700 mg, 10% at a carbamazepine dose & GE;700 mg, 5.5% at a VPA dose <750 mg, and 14.8% at a VPA dose =750 mg. Thus the risk of malformation increased 2.33 times (p = .041) in infants of PWWE receiving high-dose ASMs.SignificanceBirth outcomes of PWWE receiving and not receiving ASMs were evaluated. The risk of CMs occurrence was higher, particularly in infants of PWWE using VPA and receiving polytherapy. The incidence of CMs was found to be lower in infants of PWWE receiving lamotrigine.