Person:
SÖYÜT, HAKAN

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

OrgUnit Logo
Organizational Unit

Job Title

Last Name

SÖYÜT

First Name

HAKAN

Name

Filters

2021 - 20222
Reset filters

Settings

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Investigation of inhibition of busulfan (Chemotherapeutic Drug) on human serum paraoxonase-1 (PON1)
    (Asian Network Scientific Information-ansinet, 2021-01-01) Söyüt, Hakan; SÖYÜT, HAKAN; Bursa Uludağ Üniversitesi/Eğitim Fakültesi/İlköğretim Bölümü; AAE-6795-2019
    Background and Objective: Paraoxonase 1 (PON1) is an antiatherogenic lactonase. It plays the role of an antioxidant enzyme by protecting HDLs from oxidative stress and also has important roles such as protection of Low-Density Lipoprotein (LDL) against oxidation and detoxification of highly toxic substances. Lowering the levels of this enzyme is a major risk in patients with cardiovascular disease. This study, it was aimed to investigate the in vitro effect of busulfan which is widely used in chemotherapy, on the human paraoxonase-1 enzyme. Materials and Methods: This study identifies interactions between the enzyme and busulfan, which is widely used in cancer chemotherapy. Paraoxonase activity measurement was used to determine the chemotherapeutic drug constants. Results: This study found that busulfan exhibited very potent inhibitory properties for human serum PON1 with an IC50 value of 77 mu M and an average K-i value of 42.83 mu M. Busulfan showed competitive inhibition. Conclusion: The use of busulfan, which has a very strong inhibition, in chemotherapeutic treatment can be very dangerous.
  • No Thumbnail Available
    Publication
    Facile one-pot synthesis of water-soluble conjugated polymers derived from 7-amino-4-hydroxy-2-naphthalenesulfonic acid: Synthesis and photoluminesence properties
    (Elsevier, 2022-04-21) Kaya, İsmet; Akyüz, Burçin; Kolcu, Feyza; Söyüt, Hakan; SÖYÜT, HAKAN; Bursa Uludağ Üniversitesi/Eğitim Fakültesi/Temel Eğitim Bölümü.; AAE-6795-2019
    Schiff base polymers or poly(imine)s are a conjugate polymers group. Due to their high thermal stability, conjugated polymers (CPs) are widely used in the production of electronic equipment such as accumulators, solar cells, rechargeable cells, conductive coating, photo-receptors, ion exchangers, photo-diodes, sensors, electrochromic devices, and light emitting diodes. That's why the synthesis of new conjugated polymers is essential in technological applications. The Schiff base compound was synthesized through the condensation reaction between 7-amino-4-hydroxy-2-naphthalene sulphonic acid and 4-hydroxybenzaldehyde, and the substance obtained was transformed into a polyimine in an alkali medium by the addition of H2O2 (35% aqueous solution) as an oxidant. In addition, a polynaphtol derivative was obtained in an alkali medium from 7-amino-4-hydroxy-2naphthalene sulphonic acid with the participation of H2O2 (35% aqueous solution) used as the oxidant. The structures of the synthesized compounds were approved using NMR and FT-IR techniques. Solvatochromism was observed as a bathochromic shift for the polymers, particularly in H2O2 (35% aqueous solution). Bicolored fluorescent light emission intensities of the poly-naphtol derivative were 786 a.u. and 394 a.u when excitation took place at 355 and 440 nm, respectively, with had the emission QY of 8.6% for 410 nm of PL emission in DMF. The synthesized polymers, which had lower optical and electrochemical band gaps than their regarding monomers, could be evaluated as semi-conductors. Mw values of polymers varied between 6365 Da and 8900 Da, and their PDI values were found to be between 1.148 and 1.166.