Person: CANITEZ, YAKUP
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CANITEZ
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YAKUP
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Publication The use of cyclosporine a in the treatment of toxic epidermal necrolysis; case report and review of literature(Galenos Yayincilik, 2014-08-01) Canıtez, Yakup; CANITEZ, YAKUP; Çekiç, Şükrü; ÇEKİÇ, ŞÜKRÜ; Sapan, Nihat; SAPAN, NİHAT; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0002-9574-1842; L-1933-2017Toxic epidermal necrolysis (TEN) is a serious and life-threatening acute mucocutaneous disease that is often triggered by drugs, can affect skin, eyes, mucous membranes and multiple organs.While an eleven-year-old female patient with epilepsy had been using valproic acid for three years, lamotrigine was added to the treatment one month ago. The patient was admitted complaints such as fever, malaise, sores in the mouth, eye redness, watering of eyes, rashes and many bullous lesions in the skin that had started just 2 days earlier. On the physical examination, whose overall situation was bad, that were common maculopapular rash, purpuric macules on the whole body, atypical target-like skin lesions, and many bullae that affected more than 30% of the body in different stages and whose largest one was 6-10 cm in diameter were detected. There were ulcerated lesions in the oral mucosa and keratitis, blepharitis and conjunctival hyperemia in both eyes. The patient was diagnosed with TEN through the existing findings. The lamotrigine treatment was discontinued; the supportive treatment, methylprednisolone, intravenous immunoglobulin, necessary care for skin and eye lesions and the necessary topical treatment were applied. As no improvement was observed in clinical picture and skin lesions in the follow-up period, cyclosporine A was added to the treatment. Significant improvement was observed in the clinical picture and skin lesions of the patient who responded well to the treatment of cyclosporine A.The basis of the treatment of TEN is composed of discontinuation of the suspicious drug and the supportive therapy. The immunosuppressive agents such as systemic corticosteroids and IVIG therapy may be used in the treatment of TEN. Cyclosporine can positively contribute to the treatment in cases who are resistant to treatment and with a severe TEN condition. There is a need for in-depth studies to investigate the place and impact of cyclosporine in the treatment of TEN.Publication Evaluation of the cases with non-cystic fibrosis bronchiectasis(Galenos Yayıncılık, 2018-01-01) Korkmaz, Serpil; Canıtez, Yakup; Çekiç, Şükrü; Efe, Hülya Poyraz; Ocakoğlu, Gökhan; Sapan, Nihat; Korkmaz, Serpil; CANITEZ, YAKUP; ÇEKİÇ, ŞÜKRÜ; Efe, Hülya Poyraz; OCAKOĞLU, GÖKHAN; SAPAN, NİHAT; Tıp Fakültesi; Çocuk Alerji Ana Bilim Dalı; 0000-0002-9574-1842; 0000-0002-1114-6051; HLG-6346-2023; L-1933-2017; CJQ-2060-2022; CPN-6371-2022; FFE-8839-2022; FUI-8766-2022INTRODUCTION: Bronchiectasis is a chronic inflammatory disease characterized by a permanent dilation of the bronchial wall. We aimed to evaluate pediatric cases diagnosed with non-cystic fibrosis bronchiectasis.METHODS: A total of 98 cases who were diagnosed with non-cystic fibrosis bronchiectasis and were being followed-up between January 2010 and January 2015 at our clinic were included. Clinical, laboratory and radiological evaluations were recorded from patients electronic files.RESULTS: Female to male ratio of the cases was 1.3 (56/42). The median age of the cases was 12.2 years (1-18), the median age of diagnosis was 6 years (1-17 years), and the median duration of follow-up was 38 months (3-140 months).The most common symptom of the cases was cough (n: 91, 93%) followed by sputum expectoration (n: 56, 57%). In the pulmonary function tests performed during the initial phase of diagnosis; restrictive pattern was seen in 29.1% (n = 21) of patients and obstructive pattern was seen in 23.2% (n = 17). Furthermore, in last control visit, restrictive pattern was seen in 17.3% (n=9) of them and obstructive pattern was seen in 44.2% (n = 23). The most frequent etiological cause was infectious diseases (n: 41, 42%). Bronchiectasis was seen most commonly in the left lower lobe of the lung (n: 52, 53%), followed by the right lower lobe (n=32, 33.7%).DISCUSSION and CONCLUSION: Bronchiectasis is still a major health problem in developing countries and causes irreversible damage to the lung when untreated. Postinfectious lung diseases are one of the most important causes of bronchiectasis in children. Early diagnosis improves treatment success.Publication Omalizumab treatment in childhood chronic urticaria(Wiley, 2018-08-01) Çekiç, Şükrü; Karali, Yasin; Canıtez, Yakup; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; KARALI, YASİN; CANITEZ, YAKUP; SAPAN, NİHAT; Tıp Fakültesi; Pediatri ve Alerji Bölümü; 0000-0002-9574-1842; L-1933-2017; FFS-1974-2022; CJQ-2060-2022; FUI-8766-2022Publication A comprehensive assessment of long-term complications in patients with stevens-johnson syndrome and toxic epidermal necrolysis(Karger, 2023-07-26) Çekiç, Sükrü; Canıtez, Yakup; Yüksel, Hale; Gündüz, Gamze Ucan; Karalı, Zühal; Yalçınbayır, Özgür; Vural, Pınar; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; CANITEZ, YAKUP; Yüksel, Hale; UÇAN GÜNDÜZ, GAMZE; KARALI, ZUHAL; VURAL, AYŞE PINAR; YALÇINBAYIR, ÖZGÜR; SAPAN, NİHAT; Tıp Fakültesi; Çocuk Alerjisi Ana Bilim Dalı; 0000-0002-9574-1842; 0009-0002-4004-449X; 0000-0002-5458-1686; 0000-0002-7311-5277; 0000-0001-8929-679X; L-1933-2017; AAH-1789-2021; IZZ-9492-2023; AAH-6661-2021; CZC-9168-2022; IYJ-9408-2023; GIK-1690-2022; FUI-8766-2022Introduction: Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome are rare severe hypersensitivity reactions that lead to epithelial sloughing. Studies investigating the chronic multisystem effects of these syndromes and assessing patients in terms of quality of life (QOL), depression, and anxiety in the pediatric population are limited. In this study, we aimed to investigate the long-term effects of these diseases from a multisystem perspective. Method: Sixteen pediatric patients diagnosed with SJS, TEN, and SJS/TEN overlap syndrome were evaluated between September 2020 and March 2021. Physical and eye examinations were performed. To evaluate QOL and psychological status, Children's Dermatology Life Quality Index (CDLQI), Screen for Child Anxiety-Related Emotional Disorders (SCARED), and Children's Depression Inventory (CDI) were conducted. The patients' general characteristics, symptoms, and examination findings at their first admission were retrospectively obtained from the hospital's electronic records. Results: Nineteen percent of the patients were female (n = 3). There were 7 patients (44%) with the diagnosis of SJS, 5 patients (31%) with TEN, and 4 patients (25%) with SJS/TEN overlap. The median follow-up time of the subjects was 6.5 years. The most common sequelae in the chronic period were skin changes (n = 13, 81%). Hyperpigmentation was the most common skin change (n = 9, 56%). In the last evaluation, 9 cases had eye involvement. In two cases, eye examination was normal in the acute phase, while ocular involvement was present in the chronic period. In 4 (50%) patients, there was height and/or weight percentile loss. Three patients' SCARED scores and 2 patients' CDI scores were high. According to the CDLQI survey, SJS, TEN, or SJS/TEN overlap syndrome had a small to moderate effect on the QOL in the 43% (n = 6) of the patients. The ANA values of 3 patients (60%) were positive at the follow-up and negative at the first admission. Conclusion: SJS, TEN, and SJS/TEN overlap syndrome may cause sequelae even after a long time of the onset of the disease. Patients' QOL and psychological status can be affected negatively. Ocular symptoms may develop in the follow-up, even without involvement in the acute period. Patients with SJS, TEN, and SJS/TEN overlap syndrome should be followed up in the chronic period and approached multidisciplinary.Publication Investigation of blattella germanica sensitivity in atopic children(Bursa Uludağ Üniversitesi, 2021-12-01) Canitez, Yakup; Çiçek, Fatih; CANITEZ, YAKUP; ÇİÇEK, FATİH; Tıp Fakültesi; Çocuk Alerji Bilim Dalı; AAH-1789-2021; JKI-5906-2023Introduction: Cockroach sensitivity plays an important role in the pathogenesis of childhood asthma and allergic respiratory diseases. It was aimed to investigate the incidence of Blattella germanica (German cockroach) sensitivity in atopic children in Bursa and its surroundings and possible risk factors that may be associated with the presence of Blattella germanica sensitivity.Materials and Methods: 1382 children aged 0-12 years, who were followed up with a diagnosis of any allergic disease and defined as atopic by detecting sensitivity to at least one allergen in skin prick tests with inhalant allergens, were included in the study. The data of the cases (skin prick test results with inhalant allergens, serum total IgE levels and total eosinophil counts, allergic disease diagnoses, et al. characteristics) were evaluated retrospectively.Results: The overall sensitivity rate to Blattella germanica was found to be 2.7% (n=38) in atopic cases (n=1382) in the study group. Blattella germanica sensitivity was found in 3.6% of asthmatics, 3% of allergic rhinitis and 4.9% of patients with asthma and allergic rhinitis. Asthma prevalence (69.4%) in those with Blattella germanica sensitivity was significantly higher than those without Blattella germanica sensitivity (49.2%) (p=0.017). Blattella germanica monosensitization was not detected in any of the patients. It was observed that sensitivity to mite allergens was the highest among all inhalant allergen groups (57.7%), and grass pollen (28.5%) was the second rank. Blattella germanica sensitivity rates were found to be 2% in the 0-3 age group, 2.2% in the 4-7 age group, and 4.1% in the 8-12 age group (p=0.129). It was observed that the presence of canine sensitization was negatively correlated with Blattella germanica sensitivity.Conclusions: In this study, which was conducted for the first time in a large population of atopic children in the Bursa region, the incidence of Blattella germanica sensitivity was found to be 2.7% in the entire study population, while it was found to be higher (4.1%) in the 8-12 age group. In addition, Blattella germanica sensitivity is seen at a higher rate (4.9%) in the coexistence of asthma and allergic rhinitis.Publication Evaluation of school age asthmatic cases with childhood asthma control test(Galenos Yayincilik, 2017-12-01) ÇEKİÇ, ŞÜKRÜ; SAPAN, NİHAT; CANITEZ, YAKUP; Demirbaş, Başak Ceylan; Tıp Fakültesi; Çocuk sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0002-9574-1842; L-1933-2017Introduction: Asthma is the most common chronic disease in children. It is known that seasonal changes affect the number of asthma attacks and the condition of the disease under control as well. We evaluated children aged 6-11 years of age who had been diagnosed with asthma using the childhood asthma control test (C-ACT) to determine the factors affecting the control of asthma.Methods: One hundred and three follow-up cases diagnosed with asthma between the ages of 6-11 were included. All cases were asked to fill in the C-ACT and the asthmatic questionnaire that we had prepared to evaluate the patients.Results: It was determined that the 47.5% of the cases (n=49) were under control according to the results of the C-ACT. The number of annual attacks in the group under control (median=2/year, minimum=0/year, maximum=10/year) was significantly less than for the uncontrolled cases (median=3.5/year, minimum=0/year, maximum=10/year) (p=0.005). We determined that 14.3% (n=7) of the families of the group under control and 38.9% (n=21) of the families of the uncontrolled cases had a history of eczema (p=0.005). The hospital admission rates of the group under control were found to be 30.6% (n=15) in September, 32.7% (n=16) in October, 30.6% (n=15) in November, and 6.10% (n=3) in December, and the rates for the uncontrolled cases were 5.6% (n=3) in September, 25.9% (n=14) in October, 33.3% (n=18) in November, and 35.2% (n=19) in December. We detected that the uncontrolled cases were admitted more frequently than the ones under control in December (p=0.001).Discussion and Conclusion: C-ACT is a practical application that helps physicians with the follow-up of patients. We have determined in our study that a significant percentage of the asthmatics are uncontrolled cases. We estimated that the increase of complaints in December in patients with asthma may be related to regional climatic changes as well as environmental conditions.Publication The evaluation of gastroesophageal reflux disease with esophageal pH monitorization in children(Galenos Yayıncılık, 2009-12-01) Erdemir, Gülin; Özgür, Taner; Canitez, Yakup; Kayık, Bülent; Özboyacı, Ali; Özkan, Tanju B.; Erdemir, Gülin; ÖZGÜR, TANER; CANITEZ, YAKUP; Kayık, Bülent; Özboyacı, Ali; Özkan, Tanju B.; Tıp Fakültesi; Çocuk Sağlığı Hastalıkları Ana Bilim Dalı; Çocuk Alerji Bilim Dalı; AAG-8381-2021; ETR-2252-2022; CJQ-2060-2022; CYG-7798-2022; JLB-3549-2023Introduction: Gastroesophageal reflux disease is named when gastroesophageal reflux becomes symptomatic, influences the life comfort, and results in morbidity. In this study, we aimed to evaluate the patients admitted with GER-associated symptoms with demographic characteristics, 24-hour esophageal pH monitorization results, and responses to different treatment protocols.Materials and Method: The data of patients who admitted to Uludag University Pediatrics Outpatient Clinic between January 2008 and September 2009 with GERD-associated symptoms and underwent esophageal pH monitorization was collected retrospectively. The associations between initial symptoms, 24-hour esophageal pH monitorization results, presence of accompanying disease, sociocultural conditions, and therapy responses were evaluated.Results: Ninety-two patients (37 female, 55 male) were included and mean age was 4.42 +/- 4.33 (1 mo-18 years). The frequency of cough, vomiting and abdominal pain at admission were 49.5%, 47.3% and 22% respectively. Esophageal pH monitorization diagnosed GERD in 21 patients (22.8%). The frequency of symptoms in GERD patients who diagnosed with esophageal pH monitorization was; cough (n: 15, 33.4%), vomiting (n: 11, 25.6%), and abdominal pain (n: 5, 22.3%). Among all complaints, cough was found to be significantly associated with GERD (p=0.041). Accompanying neurological disease was present in 13.1% (n: 12), immunodeficiency 13.1% (n: 12) and bronchial reactivity 13.1% (n: 12). Therapy success was achieved in 57.7% of patients. Therapy response were similar with different therapy protocols (proton pump inhibitor+prokinetic+sucralfate, proton pump inhibitor+prokinetic, H2 receptor blocker+sucralfate, proton pump inhibitor+sucralfate, H2 receptor blocker+prokinetic, monotherapy with proton pump inhibitor or H2 receptor blocker) (p=0.068).Conclusion: GERD is a common childhood disease. Currently, diagnosis and treatment of GERD in children is still controversial. The results of our study revealed no association with therapy success and different treatment regimens, sociocultural status or accompanying disease. The complaint of cough was found to be significantly in association with GERD.Publication Evaluation of the patients diagnosed with stevens johnson syndrome and toxic epidermal necrolysis: A single center experience(Aves, 2016-09-01) Çekiç, Şükrü; Canıtez, Yakup; Sapan, Nihat; ÇEKİÇ, ŞÜKRÜ; CANITEZ, YAKUP; SAPAN, NİHAT; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı,; Çocuk Alerji Bilim Dalı; 0000-0002-9574-1842; 0000-0001-8929-679X; AAH-1789-2021; L-1933-2017Aim: Stevens Johnson syndrome and toxic epidermal necrolysis are severe acute mucocutaneous diseases. In this study, we evaluated the clinical aspects of Steven Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap patients who admitted to our clinics in the last five years.Material and Methods: Eleven patients diagnosed as Stevens-Johnson syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome/toxic epidermal necrolysis overlap in Department of Pediatric Allergy in Uludag University School of Medicine were included in this study. Clinical findings, laboratory tests and response to treatments were evaluated via electronic files.Results: Two of the patients had Stevens-Johnson syndrome, four had Stevens-Johnson syndrome/toxic epidermal necrolysis overlap, and five had toxic epidermal necrolysis. The median period for drug usage was 10 days (2-44 days). Herpes simpleks virus IgM antibody was detected two patients. The median healing time was 38 days 26-94 days). Maculopapular eruptions and oral mucositis were seen in all patients. Vesicul or bullae, epidermal detachment and ocular involvement in 10 of patients. Wound care, H1 antihistamine and methyl prednisolon were used in all patients, intravenous immunoglobulin were used in 7 patients and cyclosporine in 1 patient. Sequel lesions developed in 2 of the patients and there was no death.Conclusion: Anticonvulsants, antibiotics and non steroid anti-inflammatory drugs play a major role in the etiology of Stevens-Johnson syndrome and toxic epidermal necrolysis. Anticonvulsants are associated with severe disease. The patients with proper wound care and treatment with immunosuppressive drugs can be recovered without or with minimal sequelae.Publication The prevalence of reactions related to insect (hymenoptera) stings in children(Galenos Yayınevi, 2020-12-10) Canıtez, Yakup; Sapan, Nihat; CANITEZ, YAKUP; SAPAN, NİHAT; Tıp Fakültesi; Çocuk Alerji Ana Bilim Dalı; 0000-0001-8929-679X; 0000-0002-7601-8392; CJQ-2060-2022; FUI-8766-2022INTRODUCTION: There has a few number of studies in children that looked for the prevalence of reactions caused by insect (hymenoptera) stings. This study was planned with the aim of investigating the prevalence of systemic, large local and local reactions due to hymenoptera stings in the general population in children.MATERIALS and METHODS: In this study, four different schools in Bursa city center and its villages were selected for research by random sampling method. A total of 3243 children in the 6-15 age group were evaluated using the questionnaire method in the study.RESULTS: Of the children, 1714 (52.9%) were boys and 1529 (47.1%) were girls. The mean age was 9.80.0,04 years. The number of children who were stung at least once in their lifetime was 1992 (61.4%), and the number of children who were stung in the last 12 months was 711 (21.9%). The frequency of reactions due to hymenoptera stings in the study population (lifetime prevalences), systemic reaction in 9 children (0.3%), large local reaction in 19 children (0.6%), local reaction in 1964 children (60.5%) were found. There were higher numbers of lifetime hymenoptera sting and rates of systemic or large local reactions in boys compared to girls (p<0,001, p<0,05, p<0,01 respectively).CONCLUSIONS: In our region, children between the ages of 6-15 frequently encounter hymenoptera stings. Since reactions due to hymenoptera stings occur at certain rates, it would be appropriate to consider these data in terms of defining possible reactions and approach.Publication The evaluation of local and systemic reactions to subcutaneous house dust mite allergen immunotherapy(Galenos Publ House, 2022-06-15) Canitez, Yakup; CANITEZ, YAKUP; Karali, Zuhal; KARALI, ZUHAL; ÇEKİÇ, ŞÜKRÜ; SAPAN, NİHAT; Şadırvan, Yağmur Hazal; ŞADIRVAN OĞUZKAYA, YAĞMUR HAZAL; Tıp Fakültesi; Pediatri Ana Bilim Dalı; L-1933-2017Objective: Allergen -specific immunotherapy is an effective treatment method that enables the development of immunotolerance against allergens in allergic rhinitis, asthma, and venom allergy. This study investigated the local and systemic reactions during subcutaneous house dust mite allergen immunotherapy. Methods: Injection -related local and systemic reactions of 45 patients who received subcutaneous mite immunotherapy were evaluated retrospectively. Results: Forty-five children, 15 (33.3%) females and 30 (66.4%) male were included in the study. A total of 582 injections were administered. A local reaction was observed in 23 (3.94%) of all injections and the systemic reaction was observed in only 1 (0.17%) injection. Sixteen (37.7%) of the children had local reactions during the immunotherapy process and 1 (2.2%) had a systemic reaction. Conclusion: Although subcutaneous mite immunotherapy is a safe treatment, it should only be applied in centers with appropriate emergency equipment and trained healthcare professionals due to possible systemic reactions.
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