Person: BODUR, MUHİTTİN
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BODUR
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MUHİTTİN
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Publication Neuro-behcet is a rare disease but should be considered in all kinds of neurological findings, even in childhood(Clinical & Exper Rheumatology, 2022-08-01) Toker, Rabia Tütüncü; Bodur, Muhittin; Demir, Aylin Bican; Okan, Mehmet Sait; TÜTÜNCÜ TOKER, RABİA; BODUR, MUHİTTİN; BİCAN DEMİR, AYLİN; OKAN, MEHMET SAİT; Tıp Fakültesi; Nöroloji Ana Bilim Dalı; Çocuk Nörolojisi Bilim Dalı; 0000-0002-3129-334X; 0000-0002-2588-8195; 0000-0001-6739-8605; 0000-0002-9303-5768; IZP-6290-2023; JAN-9435-2023; KHB-9765-2024; DKC-6496-2022Objective: Behfet's disease (BD) is a vasculitis characterised by eye, musculoskeletal, neurological and gastrointestinal involvement, in addition to recurrent oral ulcers. Neuro-Behvet is the term used to define the nervous system involvement in BD and is very rarely seen in childhood. This study aims to show that neuro-Behret can manifest a clinical course involving all kinds of neurologic findings in the paediatric population.MethodsThe Clinic of Paediatric Neurology at Uludag University provides tertiary treatment for children up to eighteen years of age in Bursa, Turkey. Five patients who were clinically diagnosed with Neuro-Beket in the last 5 years were included in the study. Results: Seizure, myopathy, transverse myelitis, polyneuropathy, venous thrombosis and facial nerve paralysis were respectively seen in the patients. ConclusionNeuro-Behfet is rare in children, but it is important to know that it can cause various neurological findings, and also systemic findings should be taken into consideration in the diagnosis of neurological diseases. Studies on the neurological involvement of BD in children are inadequate. We believe that paediatric neurologists should be more aware of the neuro-Behfet condition.Publication Etiologies of convulsive status epilepticus in children(Galenos Yayınevi, 2023-08-01) Toker, Rabia Tütüncü; Bodur, Muhittin; Okan, Mehmet Sait; TÜTÜNCÜ TOKER, RABİA; BODUR, MUHİTTİN; OKAN, MEHMET SAİT; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; Çocuk Nörolojisi Bilim Dalı; 0000-0002-3129-334X; 0000-0002-2588-8195; 0000-0002-9303-5768; IZP-6290-2023; JAN-9435-2023; DKC-6496-2022Introduction: Convulsive status epilepticus (CSE) is one of the neurologic emergencies of childhood with varying degrees of impaired consciousness and motor symptoms. The aim of this study was to try to define the etiology of patients with CSE.Materials and Methods: Children aged 1 month to 18 years with CSE were included in the study. The demographic characteristics of the patients, seizure type, seizure etiology, epilepsy history, drugs used, and complications were recorded.Results: One hundred forty-five patients who were diagnosed as having were included in the study, 60.7% of whom were male. The seizure type was focal onset in 55.9% of the patients. According to the etiology of CSE, the most common group was found as unknown group (48%), and 72.9% of those had a history of epilepsy. Febrile (17%) and central nervous system infections (8.3%) were found to be the most common in acute etiology, respectively. Pulmonary complications developed most frequently. The mortality rate was 0.7%.Conclusion: The "unknown etiology" is found as the most common etiology of CSE in children. Febrile seizure and central nervous system infections are common in acute etiologies.Publication Multiple sclerosis in childhood: Single center experience(Bursa Uludağ Üniversitesi, 2021-08-01) Bodur, Muhittin; Toker, Rabia Tütüncü; Okan, Mehmet Sait; BODUR, MUHİTTİN; TÜTÜNCÜ TOKER, RABİA; OKAN, MEHMET SAİT; Tip Fak; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; Çocuk Noroloji Bilim Dalı; 0000-0002-2588-8195; 0000-0002-3129-334X; 0000-0002-9303-5768; AAH-2684-2021; IZP-6290-2023; JAN-9435-2023Introduction: In this study, clinical and demographic features of childhood multiple sclerosis(MS) diagnosed in a single center for 10 years are presented.Materials and Methods: In this study files of 2.3 patients with multiple sclerosis who were admitted to Department of Pediatric Neurology between January 2006 and January 2016 were investigated retrospectively. The data of 19 cases were evaluated since 3 cases were excluded due to lack of attending the control visits for more than 2 years and 1 case died in a traffic accident. Gender, current age, family history of MS, onset ages of symptoms, age at diagnosis, duration of disease follow-up, initial symptoms, magnetic resonance(MR) findings, cerebrospinal fluid(CSF) oligoclonal band positivity, visual evoked potential(VEP), somatosensory evoked potential(SEP) findings, treatments and a number of attacks were evaluated.Results: Of the 19 patients diagnosed with multiple sclerosis, 13 were female (68.4%), 6 were male (31.5%), and the female/male ratio was 2.16. The mean age of onset of symptoms was 1409 years. The mean age of diagnosis was 15.2 years, and the mean follow-up period was 2.17 years. Family history was positive in 3 patients (15.7%). When the initial symptoms of our patients were examined, motor, sensory and brainstem findings were present in 11(57.8%), 9 (47.3%) and 7 cases (36.8%), respectively. Two patients (10.5%) presented with cerebellar findings and 6 patients (31.5%) with visual impairment. The oligoclonal band of CSF was found to be positive in 17 (89.4%) of the cases.Conclusions: In this study, gender, age, family history, age at onset of symptoms, initial symptoms, MR findings, CSF findings, VEP, SEP findings, treatments used, and the number of episodes were evaluated. Multicenter, prospective, and longitudinal studies with larger study populations are needed to understand multiple sclerosis onset in the pediatric period.Publication A case report; mumps acute cerebellitis presented as hydrocephalus and brainstem compression(Elsevier, 2015-10-15) Uzun, Meltem; Cufalı, Yelda; Kiristioğlu, Feride; Bodur, Muhittin; BODUR, MUHİTTİN; Tıp Fakültesi; Çocuk Nörolojisi Bölümü; 0000-0002-2588-8195; JAN-9435-2023; AAH-2684-2021Publication Evaluation of patients admitted to pediatric emergency outpatient clinic with non-traumatic neurological complaint(Bursa Uludag Univ, 2020-12-01) Toker, Rabia Tutuncu; TÜTÜNCÜ TOKER, RABİA; Bodur, Muhittin; BODUR, MUHİTTİN; Özmen, Abdullah Hakan; ÖZMEN, ABDULLAH HAKAN; Okan, Mehmet Sait; OKAN, MEHMET SAİT; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0002-3129-334X; 0000-0002-2588-8195; 0000-0002-9303-5768; JAN-9435-2023; AAH-2684-2021; AAE-2163-2022; IZP-6290-2023; AAF-8981-2020INTRODUCTION: Pediatric Emergency Outpatient Clinic are the units where treated the entire range of emergent and urgent medical conditions. Patients present with a wide range of complaints. Determining the general distribution, frequency and density of Pediatric Emergency Outpatient Clinic applications is of great importance in order to make appropriate future plans. In this study, it was aimed to evaluate the clinical features of patients presenting with non-traumatic neurological complaints.MATERIALS and METHODS: The files of the patients who applied to the Pediatric Emergency Outpatient Clinic within one year were evaluated retrospectively. Patients with a known neurological disease who presented to the Pediatric Emergency Outpatient clinic with non neurological complaints, those in the neonatal and trauma patients were not included in the study.RESULTS: It was found that the main complaint of 628 of the patients who applied to the Pediatric Emergency Outpatient Clinic within a year was neurological symptoms. % 50,3 of the patients were found as girls and %49,7 as boys. Seizure was the most common neurological complaint. It was found that %83,1 of the patients who presented with seizures for the first time presented with a febrile seizures and %16,9 with febrile seizures. Status epilepticus rate was found to be %4,5 in patients presenting with seizuresCONCLUSIONS: Seizure was the most common non-traumatic neurological presentation to Pediatric Emergency Outpatient Clinic. We believe that updating knowledge and skills on emergency approach to seizures in Pediatric Emergency Outpatient Clinic will increase the quality of healthcare services to be provided.Publication Pediatric-onset chronic inflammatory demyelinating polyneuropathy: A multicenter study(Elsevier Science Inc, 2023-05-26) Uzan, Gamze Sarıkaya; Vural, Atay; Yüksel, Deniz; Aksoy, Erhan; Öztoprak, Ülkühan; Canpolat, Mehmet; Öztürk, Selcan; Yıldırım, Çelebi; Güleç, Ayten; Per, Hüseyin; Gümüş, Hakan; Okuyaz, Çetin; Direk, Meltem Çobanoğulları; Kosmür, Mustafa; Ünalp, Aycan; Yılmaz, Ünsal; Bektas, Ömer; Teber, Serap; Aliyeva, Nargiz; Dündar, Nihal Olgaç; Gençpınar, Pınar; Gürkaş, Esra; Yılmaz, Sanem Keskin; Kanmaz, Seda; Tekgtil, Hasan; Aksoy, Ayşe; Tuncer, Gökcen Öz; Arslan, Elif Acar; Tosun, Ayşe; Kızılırmak, Ali Burak; Yousefi, Mohammadreza; Ünay, Bülent; Kurul, Semra Hiz; Yis, Uluç; Ayanoğlu, Müge; Bodur, Muhittin; BODUR, MUHİTTİN; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0002-2588-8195; JAN-9435-2023; EKU-8347-2022Background: To evaluate the clinical features, demographic features, and treatment modalities of pediatric-onset chronic inflammatory demyelinating polyneuropathy (CIDP) in Turkey. Methods: The clinical data of patients between January 2010 and December 2021 were reviewed retrospectively. The patients were evaluated according to the Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society Guideline on the management of CIDP (2021). In addition, patients with typical CIDP were divided into two groups according to the first-line treatment modalities (group 1: IVIg only, group 2: IVIg + steroid). The patients were further divided into two separate groups based on their magnetic resonance imaging (MRI) characteristics. Results: A total of 43 patients, 22 (51.2%) males and 21 (48.8%) females, were included in the study. There was a significant difference between pretreatment and post-treatment modified Rankin scale (mRS) scores (P < 0.05) of all patients. First-line treatments include intravenous immunoglobulin (IVIg) (n = 19, 4 4.2%), IVIg + steroids (n = 20, 46.5%), steroids (n = 1, 2.3%), IVIg + steroids + plasmapheresis (n = 1, 2.3%), and IVIg + plasmapheresis (n = 1, 2.3%). Alternative agent therapy consisted of azathioprine (n = 5), rituximab (n = 1), and azathioprine + mycophenolate mofetil + methotrexate (n = 1). There was no difference between the pretreatment and post-treatment mRS scores of groups 1 and 2 (P > 0.05); however, a significant decrease was found in the mRS scores of both groups with treatment (P < 0.05). The patients with abnormal MRI had significantly higher pretreatment mRS scores compared with the group with normal MRI (P < 0.05). Conclusions: This multicenter study demonstrated that first-line immunotherapy modalities (IVIg vs IVIg + steroids) had equal efficacy for the treatment of patients with CIDP. We also determined that MRI features might be associated with profound clinical features, but did not affect treatment response.Publication A rare case of juvenile amyotrophic lateral sclerosis(Türk Pediatri Dergisi, 2021-05-01) Bodur, Muhittin; Toker, Rabia Tütüncü; Başak, Ayşe Nazlı; Okan, Mehmet Sait; BODUR, MUHİTTİN; TÜTÜNCÜ TOKER, RABİA; OKAN, MEHMET SAİT; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; Çocuk Nörolojisi Ana Bilim Dalı; 0000-0002-2588-8195; 0000-0002-3129-334X; 0000-0002-9303-5768; JAN-9435-2023; AAH-2684-2021; IZP-6290-2023; DKC-6496-2022Background. Amyotrophic lateral sclerosis (ALS) is a chronic motor neuron disease characterised by progressive weakness in striated muscles resulting from the destruction of neuronal cells. The term juvenile ALS (JALS) is used for patients whose symptoms start before 25 years of age. JALS may be sporadic or familial.Case. Here, we present a sporadic case of JALS because of its rarity in children. The heterozygous p.Pro525Leu (c.1574C>T) variation was identified in the fused in sarcoma (FUS) gene.Conclusion. The p.Pro525Leu mutation in the FUS gene has been detected in patients with ALS, characterised by early onset and a severely progressive course.Publication Evaluation of tuberculin skin test results of one year(Aves Yayincilik, Ibrahim Kara, 2011-12-01) Bozdemir, Şefika Elmas; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Çelebi, Solmaz; ÇELEBİ, SOLMAZ; Hacimustafaoglu, Mustafa; Çakır, Deniz; Aygün, Deniz; Bodur, Muhittin; BODUR, MUHİTTİN; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0003-4646-660X; 0000-0002-7056-0615; 0000-0002-2588-8195; JAN-9435-2023; AAC-9239-2021; AAH-2684-2021; GQP-2135-2022Objective: We aimed to determine reasons for Tuberculin Skin Test (TST) application, positive TST frequency and the factors influencing positivity in children in the Uludag University Medical Faculty Pediatric Infectious Disease Outpatient Clinic.Materials and Methods: In the Outpatient Clinic, TST was applied to 503 children between January 1st-December 31th. The reasons for the TST application, TST positivity and factors influencing positivity were evaluated. 5 TU of Purified Protein Derivative (PPD) was given, and the test was evaluated after 72 hours by measuring the diameter of enduration. Ages, genders, BCG scarring, contact with tuberculosis disease and diagnosis were recorded.Results: Of the patients, 52.9% were boys with a mean age 7.71 +/- 4.7 years (1 month-18 years). Diagnoses of patients were, frequent infection in 30.8%, prolonged cough in 24.3%, asthma/bronchial hyperreactivity (BHR) in 11.1%, recurrent pneumonia in 8.2%, close contact with tuberculosis in 6.5%, peripheral lymphadenopathy in 5.4%, tuberculosis disease in 2.4%, immunodeficiency in 2.6%, bronchiectasis in 1.6%. Most frequent cases of TST positive patients (73.5%) were in the tuberculosis close contact group. TST positivity was 55.7% in the prolonged cough group, 30.9% in the frequent infection group, 33.9% in the asthma/BHR group, 19.5% in the recurrent pneumonia group, 29.6% in the lymphadenopathy group, 38.4% in the immunodeficiency group and 50% in the bronchiectasis group. 40.7% of patients had TST>15 mm, 26.4% TST=10-14 mm and 30.7% TST<10mm in induration. TST positivity rate increased with BCG scarring number (p<0.001) and older age (p<0.001). Of the patients 91.5% had BCG scarring, while 75.1% had 1 scarring, 16.4% had 2 scarrings.Chest PA graphy of all patients with positive TST were evaluated and 92.4% were normal, 3.1 % revealed pneumonia, 1.3% atelectasis and 1.2% revealed hiler lymphadenopathy. Of the patients evaluated with Thoracic CT (7.9%), 40% were normal, 22.5% revealed pneumonia, 22.5% bronchiectasis and 15% hilar/subcarinal lymphadenopathy. 40% of patients were given prophylaxis, 3.3% were given antituberculosis treatment.Conclusion: As the study group consisted of children of different ages with risk factors for tuberculosis disease from different sociocultural environments, more studies evaluating TST results are needed.Publication Reliability of CT angiography scoring systems used for brain death and the effect of cranial interventions on the results(Elsevier Science, 2021-04-19) Özpar, Rıfat; Tonkaz, Mehmet; Girgin, Nermin Kelebek; Bodur, Muhittin; Dinç, Yasemin; Kocaeli, Hasan; Hakyemez, Bahattin; ÖZPAR, RİFAT; TONKAZ, MEHMET; KELEBEK GİRGİN, NERMİN; BODUR, MUHİTTİN; DİNÇ, YASEMİN; KOCAELİ, HASAN; HAKYEMEZ, BAHATTİN; Tıp Fakültesi; Radyoloji Ana Bilim Dalı; 0000-0001-6649-9287; 0000-0002-5882-1632; 0000-0002-2588-8195; 0000-0002-3425-0740; IUQ-6999-2023; JAN-9435-2023; AAH-5062-2021; AAH-2684-2021; DZJ-5260-2022; DTU-3148-2022; FDK-3229-2022; AAI-2318-2021Objective: To assess vascular opacifications, the efficiency, and interobserver agreement (IOA) of five different computed tomography angiography (CTA) brain death (BD) scoring systems in patients with and without cranial interventions, for determining alternative findings correctly supporting BD diagnosis by CTA even in cranial intervention presence. Methods: 45 patients clinically identified with BD and evaluated with CTA were included. IOA of five different scoring systems used for CTA BD diagnosis, the effect of intracranial interventions on scoring systems, and vascular opacification were evaluated. Results: IOA was almost perfect (Kappa = 0.843-0.911, p < 0.05) and substantial (Kappa = 0.771-0.776, p < 0.05) in all scoring systems. Significant relationships were observed between craniectomy presence and middle cerebral artery M4 segment and internal cerebral vein (ICV) opacification. No opacification was observed in straight sinus (SS) by observers in any of the craniectomized patients. Conclusion: IOA of CTA scoring systems is adequate. But a significant degree of false-negative results is observed due to ICV filling in craniectomy cases. Opacification presence in SS can give an idea of BD in these cases.Publication Facial colliculus syndrome due to a Herpes simplex virus infection following Herpes labialis(Turkish J Pediatrics, 2021-07-01) Bodur, Muhittin; Toker, Rabia Tütüncü; Özmen, Abdullah Hakan; Okan, Mehmet Sait; BODUR, MUHİTTİN; TÜTÜNCÜ TOKER, RABİA; ÖZMEN, ABDULLAH HAKAN; OKAN, MEHMET SAİT; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; Çocuk Nörolojisi Bilim Dalı; 0000-0002-2588-8195; 0000-0002-3129-334X; 0000-0002-9303-5768; IZP-6290-2023; AAF-8981-2020; AAH-2684-2021; AAE-2163-2022; JAN-9435-2023; DKC-6496-2022Background. The facial colliculus is an elevated area that is formed by fibers from the motor nucleus of the 7'th cranial nerve as they loop over the abducens nucleus. Clinical signs and symptoms of facial colliculus lesions occur primarily due to injury to the abducens nerve nucleus, the facial nerve fibers around the abducens nucleus, paramedian pontine reticular formation, and the medial longitudinal fasciculus. The etiology of facial colliculus lesions varies by age. While tumors, demyelinating lesions, and viral infections can be involved in young individuals' etiology, vascular ischemia is a common causative factor in older people. Case. In this paper, we present a case of facial colliculus syndrome due to its rare occurrence in a young patient; who developed the signs and symptoms after a herpes infection. Conclusion. Facial colliculus syndrome is rare and the treatment is based on etiology.