Person: AYDIN, RAHMİYE
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AYDIN
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RAHMİYE
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Publication Temperature and methyl substitution effect on copper(ii) complexes with biorelevant ligands and species distribution in aqueous solution(Taylor & Francis Ltd, 2019-06-24) İNCİ ÖZBAĞCI, DUYGU; AYDIN, RAHMİYE; Aydın, Rahmiye; Şenel, Pelin; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0003-4495-8723; 0000-0002-0483-9642; 0000-0003-4944-0181; G-2201-2019; AAH-8936-2021; AAP-5959-2020In the present work, the stability constants of copper(II) complexes with 1,10-phenanthroline (phen), its methyl derivatives [4-methyl-1,10-phenanthroline (4-mphen) and 4,7-dimethyl-1,10-phenanthroline (dmphen)] and L-tryptophan (trp) were investigated using potentiometric method in 0.1 mol.L-1 KCl aqueous ionic media at 298.15 K, 308.15 K and 318.15 K. 'BEST' software package was applied to the potentiometric data for the calculation of the protonation constants of the ligands and the stability constants of the copper(II) binary and ternary complexes. The concentration distributions of the various complex species formed in solution were also evaluated as a function of pH using the 'SPE' software package. The thermodynamic parameters, enthalpy change (Delta H degrees), entropy change (Delta S degrees) and Gibbs energy change (Delta G degrees) were determined from the stability constants using Gibbs and van't Hoff equations. The complexation of copper(II) with the ligands in this work is spontaneous, exothermic and favourable at lower temperatures.Publication Equilibria studies on nickel(II) complexes with 1,10-phenanthroline derivatives and some amino acids in aqueous solution(Springer, 2021-01-02) İnci, Duygu; Aydın, Rahmiye; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0002-0483-9642; AAH-8936-2021In recent years, an increase in the biological applications of metal complexes of biologically active ligands has been observed due to their key role in clinical treatments. A potentiometric titration technique has been used to determine the protonation constants of biologically active ligands {glycine (gly), leucine (leu), methionine (met), phenylalanine (phe), tryptophan (trp), asparagine (asn), glutamine (gln), 1,10-phenanthroline (phen), 4-methyl-phenanthroline (4-mphen), 5-methyl-phenanthroline (5-mphen), 3,4,7,8-tetramethyl-1,10-phenanthroline (3,4,7,8-tmphen), 5-nitro-phenanthroline (5-nphen)} and the stability constants of their (1:1) and (1:1:1) complexes with Ni(II) ion (I = 0.100 mol center dot L-1 KCl and T = 298.15 K). The protonation constants of the biologically active ligands and the stability constants of the (1:1) and (1:1:1) complexes of Ni(II) with the biologically active ligands have been computed by using the BEST program. Moreover, the SPE program has been used to determine the distribution of the species that occurred in the aqueous solution medium. The relative stabilities of the (1:1:1) Ni(II) complexes are compared with those of the corresponding (1:1) Ni(II) complexes in terms of Delta log(10)K values. The effect of phenanthroline substituents (4-methyl, 5-methyl, 3,4,7,8-tetramethyl, 5-nitro) on the nature of the Ni(II) complexes is evaluated.Publication Noo-type tridentate schiff base ligand and its one-dimensional cu(ii) coordination polymer: Synthesis, crystal structure, biomacromolecular interactions and radical scavenging activities(Elsevier, 2021-01-01) İnci, Duygu; Aydın, Rahmiye; Zorlu, Yunus; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Kimya Bölümü; AAH-8936-2021N-salicylidene-2-amino5-chlorobenzoic acid, (H2L), NOO-type tridentate Schiff base and its one-dimensional Cu (II) coordination polymer, [Cu-2(H2L)(2)(MeOH)(n), have been synthesized and characterized by CHN analysis, FTIR, (HNMR)-H-1, C-13 NMR, ESI-MS and XRD techniques. Interaction of the H2L Schiff base ligand and its the Cu(II) coordination polymer with biomacramolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy. The experimental outcomes indicate that the H2L Schiff base ligand and its the Cu(II) coordination polymer bind to CT-DNA by means of a moderate intercalation mode. Furthermore, the fluorescence quenching mechanism between the H2L Schiff base ligand and its the Cu(II) coordination polymer and BSA is a static quenching process. Radical scavenging activity of the H2L Schiff base ligand and its the Cu(II) coordination polymer was determined in terms of IC50, using the DPPH and H2O2 method. In biomacromolecules interaction and radical activity studies, the Cu(II) coordination polymer was found to give better results than free the H2L Schiff base ligand.Publication Biomacromolecular interactions and radical scavenging activities of one-dimensional (1D) copper(II) glycinate coordination polymer(Springer, 2021-05-18) İnci, Duygu; Aydın, Rahmiye; Zorlu, Yunus; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0003-4944-0181; AAH-8936-2021One-dimensional (1D) copper(II) glycinate coordination polymer {[Cu(gly)(2)(H2O)](n); (gly: glycine)} has been synthesized and characterized by CHN analysis, ESI-MS, FTIR and single-crystal X-ray diffraction techniques. Interaction of the complex with biomacromolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy methods. The experimental outcomes indicate that the complex binds to CT-DNA by means of a moderate intercalation mode. Furthermore, the fluorescence quenching mechanism between the complex and BSA is a static quenching process. The Stern-Volmer constants, binding constants, binding sites and the corresponding thermodynamic parameters (Delta G, Delta H, Delta S) of BSA + the complex systems were determined at different temperatures. The binding distance between the complex and BSA was calculated according to Forster non-radiation energy transfer theory (FRET). The effect of the complex on the conformation of BSA was also examined using synchronous, two-dimensional (2D) and three-dimensional (3D) fluorescence spectroscopy. Radical scavenging activity of the complex was determined in terms of IC50, using the DPPH and H2O2 method. In biomacromolecules interactions and radical activity studies, the complex was found to give good results.Publication Neocuproine copper(ii) complexes with bioactive ligands in aqueous solution(Maik Nauka/interperiodica/Springer, 2020-12-01) Inci, Duygu; Aydın, Rahmiye; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0003-4944-0181; AAH-8936-2021A potentiometric titration technique has been used to determine protonation constants of neocuproine {(neo): 2,9-dimethyl-1,10-phenanthroline} and bioactive ligands {(N,O-donor chelator, N,O): glycine (gly), leucine (leu), methionine (met), phenylalanine (phe), tyrosine (tyr), tryptophan (trp), asparagines (asn), glutamine (gln), aspartic acid (asp), glutamic acid (glu)} and their binary and ternary stability constants with copper(II) ion were determined at the constant ionic strength 0.1 M KCl and at 298.15 K. The protonation constants of neo and bioactive ligands and their stability constants of the binary and ternary copper(II) complexes were computed from the potentiometric titration data using BEST program. Furthermore, SPE program was used to determine the distribution of the species formed in solution medium. The stability of the ternary copper(II) complexes are compared with those of the corresponding the stability of the binary copper(II) complexes with regard to Delta logK values.Publication New copper(ii) complexes containing tryptophan based schiff bases as promising antiproliferative agents on breast cancer cells(Elsevier, 2023-12-28) Zorlu, Yunus; Arı, Ferda; ARI, FERDA; Gültekin, Büşra; Özbağcı, Duygu Inci; İNCİ ÖZBAĞCI, DUYGU; Aydın, İpek; İPEK, AYDIN; Aydın, Rahmiye; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Biyoloji Bölümü; 0000-0002-0443-1129; 0000-0002-0483-9642; 0000-0003-4944-0181; 0000-0002-6729-7908; 0000-0003-2811-1872; G-2201-2019; IUO-8513-2023; AAG-7012-2021Three new copper(II) complexes, [Cu(5-ClSal-Trp)(H2O)2] (1), [Cu(5-ClSal-Trp)(phen)] & sdot;C2H5OH (2) and [Cu (3,5-ClSal-Trp)(phen)] (3) (5-ClSal-Trp: Schiff base derived from 5-chlorosalicylaldehyde and L-tryptophan, 3,5-ClSal-Trp: Schiff base derived from 3,5-dichlorosalicylaldehyde and L-tryptophan, phen: 1,10-phenanthroline), have been synthesized and characterized by electronic absorption spectroscopy, CHN analysis, FTIR, ESI-MS and XRD techniques. Interaction of the complexes 1-3 with biomolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy. The results show that the complexes 1-3 can bind to CT-DNA via a moderate intercalation mode. Moreover, the fluorescence quenching mechanism between the complexes 1-3 and BSA is a static quenching process. Radical scavenging activity studies reveal that the complexes 1-3 show a moderate activity. Antiproliferative effects of the complexes 1-3 on both breast cancer cells (MCF-7 and MDA-MB-231) and healthy breast epithelial cells (MCF-10A) were also investigated using the Sulforhodamine B (SRB) viability assay. The results demonstrated that the complexes 1-3 exhibited a more pronounced cytotoxic effect on cancer cells compared to normal breast epithelial cells. Among the complexes, the best cytotoxic activity was obtained for the complex 3 against both human breast cancer cell lines. Further analysis indicated that the complex 3 induced apoptosis, as evidenced by fluorescent staining, positive Annexin-V-FITC staining, and the involvement of caspase. Subsequent to the administration of the complex 3, an evaluation of intracellular reactive oxygen species (ROS) generation was conducted through the utilization of dihydroethidium (DHE) fluorescent staining.Publication Cu(ii) complex with auxin (3-indoleacetic acid) and an aromatic planar ligand: Synthesis, crystal structure, biomolecular interactions and radical scavenging activity(Springer, 2021-04-30) İnci, Duygu; Aydın, Rahmiye; Zorlu, Yunus; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Kimya Bölümü; AAH-8936-2021A novel water soluble ternary copper(ii) complex,-[Cu-2(phen)(2)(3-IAA)(2)(H2O)](ClO4)(2)center dot H2O-(phen: 1,10-phenanthroline, 3-IAA: 3-indoleacetic acid), has been synthesized and characterized by elemental CHN analysis, ESI-TOF, FTIR and single-crystal X-ray diffraction techniques. Interaction of the complex with calf thymus DNA (CT-DNA) has been investigated by absorption spectral titration, ethidium bromide (EB) and Hoechst 33258 displacement assay. The interactions between the complex and bovine serum albumin (BSA) were investigated by electronic absorption and fluorescence spectroscopy methods. The experimental results indicate that the fluorescence quenching mechanism between the complex and BSA is a static quenching process. The Stern-Volmer constants, binding constants, binding sites and the corresponding thermodynamic parameters (Delta G, Delta H, Delta S) of BSA + complex systems were determined at different temperatures. The binding distance between the complex and BSA was calculated according to Forster non-radiation energy transfer theory (FRET). The effect of the complex on the conformation of BSA was also examined using synchronous, two dimensional (2D) and three dimensional (3D) fluorescence spectroscopy. Furthermore, the oxygen radical scavenging activity of the complex was determined in terms of IC50, using the DPPH and H2O2 method, to show that it particularly enables electron loss from radical species. This study highlights the importance of indole and moieties in the development of antioxidant agents.Publication Investigation on water soluble copper(II) mono-anionic glutamate complexes with planar aromatic ligands: Synthesis, crystal structures, biomacromolecular interactions and radical scavenging activities(Elsevier, 2021-02-05) İnci, Duygu; Aydın, Rahmiye; Zorlu, Yunus; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0003-4944-0181; AAH-8936-2021Two water soluble copper(II) mono-anionic glutamatecomplexes-[Cu(phen)(glu)(H2O)]NO3H2O (1) and [Cu(py-phen)(glu)(H2O)]NO3H2O (2) (phen: 1,10-phenanthroline, py-phen: pyrazino[2,3-f][1,10]phenanthroline, glu: glutamic acid), have been synthesized and characterized by CHN analysis, ESI-MS, FTIR and single-crystal X-ray diffraction techniques. Interaction of the complex with biomacromolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy methods. The experimental outcomes displays that the complexes 1 and 2 bind to CT-DNA by means of a moderate intercalation mode. Furthermore, the fluorescence quenching mechanism between BSA and the complexes 1 and 2 is a static quenching process. The Stern-Volmer constants, binding constants, binding sites and the corresponding thermodynamic parameters (AG, AH, AS) of BSA + the complexes 1 and 2 systems were determined at different temperatures. The binding distance between BSA and the complexes 1 and 2 was calculated according to Forster non-radiation energy transfer theory (FRET). The effect of the complexes 1 and 2 on the conformation of BSA was also examined using synchronous, two dimensional (2D) and three dimensional (3D) fluorescence spectroscopy. Radical scavenging activity of the complexes 1 and 2 was determined in terms of IC50, using the DPPH and H2O2 method. In biomacromolecules interactions and radical activity studies, the complexes 1 and 2 were found to give good results. (C) 2020 Elsevier B.V. All rights reserved.Publication Structures, hydrolysis, stabilities of palladium(II) complexes containing biologically active ligands and species distribution in aqueous solution(Elsevier, 2019-04-13) İnci, Duygu; Aydın, Rahmiye; İNCİ ÖZBAĞCI, DUYGU; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0002-0483-9642; 0000-0003-4944-0181; G-2201-2019; AAH-8936-2021[PdACl(2)](n-1)H2O complexes {A: 1,10-phenanthroline (phen), 4-methyl-phenanthroline (4-mphen), 5-methyl-1,10-phenanthroline (5-mphen), 4,7-dimethyl-1,10-phenanthroline (dmphen), 3,4,7,8-tetramethyl-1,10-phenanthroline (tmphen)} were synthesized and characterized by CHN elemental analysis, ATR-FT-MIR and ATR-FT-FIR, H-1 NMR and C-13 NMR spectral measurements. n is the number of crystal water molecules in the complexes. The n value for the complexes [Pd(phen)Cl-2], [Pd(4-mphen)Cl-2] and [Pd(5-mphen)Cl-2] is 1; for the complex [Pd(tmphen)Cl-2]H2O is 2; for the complex [Pd(dmphen)Cl-2]2H(2)O is 3. [PdACl(2)](n-1)H2O complexes were converted into aqua complexes derived from 1,10-phenanthroline, [PdA(H2O)(2)](2+), and investigated [PdAB](+) mixed ligand complexes formed between [PdA(H2O)(2)](2+) complexes and amino acids {B: glycine (gly) and tyrosine (tyr)}. Protonation constants of the gly and tyr, the acid dissociation constants of the coordinated water molecules in [PdA(H2O)(2)](2+) complexes and the stepwise stability constant of the [PdAB](+) mixed ligand complexes were determined in aqueous 0.1 M KNO3 ionic media at 298.15 K by potentiometric methods. The protonation constants of ligands, the acid dissociation constants of aqua complexes and the stepwise stability constants of mixed ligand complexes were calculated from the potentiometric data using the "BEST" software package. The concentration distribution of the various species formed in aqueous solution was obtained using the "SPE" software package under the experimental conditions described. The order of stepwise stability of the mixed ligand complexes in terms of the gly and tyr was [Pd(tmphen)(gly/tyr)](+) > [Pd(dmphen)(gly/tyr)](+) > [Pd(4-mphen)(gly/tyr)](+) > [Pd(phen) (gly/tyr)](+) > [Pd(5-mphen)(gly/tyr)](+). This study could contribute to a better understanding of the behavior of the palladium(II) complexes in biological systems.