Person: AYDIN, RAHMİYE
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AYDIN
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RAHMİYE
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Publication Equilibria studies on nickel(II) complexes with 1,10-phenanthroline derivatives and some amino acids in aqueous solution(Springer, 2021-01-02) İnci, Duygu; Aydın, Rahmiye; AYDIN, RAHMİYE; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü; 0000-0002-0483-9642; AAH-8936-2021In recent years, an increase in the biological applications of metal complexes of biologically active ligands has been observed due to their key role in clinical treatments. A potentiometric titration technique has been used to determine the protonation constants of biologically active ligands {glycine (gly), leucine (leu), methionine (met), phenylalanine (phe), tryptophan (trp), asparagine (asn), glutamine (gln), 1,10-phenanthroline (phen), 4-methyl-phenanthroline (4-mphen), 5-methyl-phenanthroline (5-mphen), 3,4,7,8-tetramethyl-1,10-phenanthroline (3,4,7,8-tmphen), 5-nitro-phenanthroline (5-nphen)} and the stability constants of their (1:1) and (1:1:1) complexes with Ni(II) ion (I = 0.100 mol center dot L-1 KCl and T = 298.15 K). The protonation constants of the biologically active ligands and the stability constants of the (1:1) and (1:1:1) complexes of Ni(II) with the biologically active ligands have been computed by using the BEST program. Moreover, the SPE program has been used to determine the distribution of the species that occurred in the aqueous solution medium. The relative stabilities of the (1:1:1) Ni(II) complexes are compared with those of the corresponding (1:1) Ni(II) complexes in terms of Delta log(10)K values. The effect of phenanthroline substituents (4-methyl, 5-methyl, 3,4,7,8-tetramethyl, 5-nitro) on the nature of the Ni(II) complexes is evaluated.Publication Noo-type tridentate schiff base ligand and its one-dimensional cu(ii) coordination polymer: Synthesis, crystal structure, biomacromolecular interactions and radical scavenging activities(Elsevier, 2021-01-01) İnci, Duygu; Aydın, Rahmiye; Zorlu, Yunus; AYDIN, RAHMİYE; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü; AAH-8936-2021N-salicylidene-2-amino5-chlorobenzoic acid, (H2L), NOO-type tridentate Schiff base and its one-dimensional Cu (II) coordination polymer, [Cu-2(H2L)(2)(MeOH)(n), have been synthesized and characterized by CHN analysis, FTIR, (HNMR)-H-1, C-13 NMR, ESI-MS and XRD techniques. Interaction of the H2L Schiff base ligand and its the Cu(II) coordination polymer with biomacramolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy. The experimental outcomes indicate that the H2L Schiff base ligand and its the Cu(II) coordination polymer bind to CT-DNA by means of a moderate intercalation mode. Furthermore, the fluorescence quenching mechanism between the H2L Schiff base ligand and its the Cu(II) coordination polymer and BSA is a static quenching process. Radical scavenging activity of the H2L Schiff base ligand and its the Cu(II) coordination polymer was determined in terms of IC50, using the DPPH and H2O2 method. In biomacromolecules interaction and radical activity studies, the Cu(II) coordination polymer was found to give better results than free the H2L Schiff base ligand.Publication Neocuproine copper(ii) complexes with bioactive ligands in aqueous solution(Maik Nauka/interperiodica/Springer, 2020-12-01) Inci, Duygu; Aydın, Rahmiye; AYDIN, RAHMİYE; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/ Kimya Bölümü.; 0000-0003-4944-0181; AAH-8936-2021A potentiometric titration technique has been used to determine protonation constants of neocuproine {(neo): 2,9-dimethyl-1,10-phenanthroline} and bioactive ligands {(N,O-donor chelator, N,O): glycine (gly), leucine (leu), methionine (met), phenylalanine (phe), tyrosine (tyr), tryptophan (trp), asparagines (asn), glutamine (gln), aspartic acid (asp), glutamic acid (glu)} and their binary and ternary stability constants with copper(II) ion were determined at the constant ionic strength 0.1 M KCl and at 298.15 K. The protonation constants of neo and bioactive ligands and their stability constants of the binary and ternary copper(II) complexes were computed from the potentiometric titration data using BEST program. Furthermore, SPE program was used to determine the distribution of the species formed in solution medium. The stability of the ternary copper(II) complexes are compared with those of the corresponding the stability of the binary copper(II) complexes with regard to Delta logK values.Publication Biomacromolecular interactions and radical scavenging activities of one-dimensional (1D) copper(II) glycinate coordination polymer(Springer, 2021-05-18) İnci, Duygu; Aydın, Rahmiye; Zorlu, Yunus; AYDIN, RAHMİYE; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü; 0000-0003-4944-0181; AAH-8936-2021One-dimensional (1D) copper(II) glycinate coordination polymer {[Cu(gly)(2)(H2O)](n); (gly: glycine)} has been synthesized and characterized by CHN analysis, ESI-MS, FTIR and single-crystal X-ray diffraction techniques. Interaction of the complex with biomacromolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy methods. The experimental outcomes indicate that the complex binds to CT-DNA by means of a moderate intercalation mode. Furthermore, the fluorescence quenching mechanism between the complex and BSA is a static quenching process. The Stern-Volmer constants, binding constants, binding sites and the corresponding thermodynamic parameters (Delta G, Delta H, Delta S) of BSA + the complex systems were determined at different temperatures. The binding distance between the complex and BSA was calculated according to Forster non-radiation energy transfer theory (FRET). The effect of the complex on the conformation of BSA was also examined using synchronous, two-dimensional (2D) and three-dimensional (3D) fluorescence spectroscopy. Radical scavenging activity of the complex was determined in terms of IC50, using the DPPH and H2O2 method. In biomacromolecules interactions and radical activity studies, the complex was found to give good results.Publication Cu(ii) complex with auxin (3-indoleacetic acid) and an aromatic planar ligand: Synthesis, crystal structure, biomolecular interactions and radical scavenging activity(Springer, 2021-04-30) İnci, Duygu; Aydın, Rahmiye; Zorlu, Yunus; AYDIN, RAHMİYE; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü; AAH-8936-2021A novel water soluble ternary copper(ii) complex,-[Cu-2(phen)(2)(3-IAA)(2)(H2O)](ClO4)(2)center dot H2O-(phen: 1,10-phenanthroline, 3-IAA: 3-indoleacetic acid), has been synthesized and characterized by elemental CHN analysis, ESI-TOF, FTIR and single-crystal X-ray diffraction techniques. Interaction of the complex with calf thymus DNA (CT-DNA) has been investigated by absorption spectral titration, ethidium bromide (EB) and Hoechst 33258 displacement assay. The interactions between the complex and bovine serum albumin (BSA) were investigated by electronic absorption and fluorescence spectroscopy methods. The experimental results indicate that the fluorescence quenching mechanism between the complex and BSA is a static quenching process. The Stern-Volmer constants, binding constants, binding sites and the corresponding thermodynamic parameters (Delta G, Delta H, Delta S) of BSA + complex systems were determined at different temperatures. The binding distance between the complex and BSA was calculated according to Forster non-radiation energy transfer theory (FRET). The effect of the complex on the conformation of BSA was also examined using synchronous, two dimensional (2D) and three dimensional (3D) fluorescence spectroscopy. Furthermore, the oxygen radical scavenging activity of the complex was determined in terms of IC50, using the DPPH and H2O2 method, to show that it particularly enables electron loss from radical species. This study highlights the importance of indole and moieties in the development of antioxidant agents.