Person: ÇELİK, FATİH
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ÇELİK
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FATİH
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Publication Effect of locoregional treatments in hepatocellular carcinoma: What are the pathologic/radiologic Milan Criteria?(Başkent Üniversitesi, 2023-10-01) Aksoy, Fuat; Dündar, Halit Ziya; Çelik, Fatih; Öngen, Gökhan; Nas, Ömer Fatih; Sağlam, Kutay; Gürlüler, Ercüment; Kıyıcı, Murat; Kaya, Ekrem; AKSOY, FUAT; DÜNDAR, HALİT ZİYA; ÇELİK, FATİH; ÖNGEN, GÖKHAN; NAS, ÖMER FATİH; SAĞLAM, KUTAY; GÜRLÜLER, ERCÜMENT; KIYICI, MURAT; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; 0000-0001-5808-9384; 0000-0003-2728-9521; HII-8895-2022; X-7425-2018; EWI-3634-2022; JYY-5340-2024; FQR-8472-2022; JJS-3965-2023; JSD-3843-2023; FHW-0015-2022; JSF-3184-2023Objectives: Milan criteria is the most commonly used criteria for patients with hepatocellular carcinoma awaiting liver transplant. The effects of locoregional therapy on downstaging or bridging before liver transplant on survival remain controversial. Considering that the tumor size may change with locoregional therapy and formalin fixation after explantation, we aimed to evaluate the effects of locoregional therapy on radiological and pathological Milan criteria and survival.Materials and Methods: Demographic data, etiology, preoperative alpha-fetoprotein value, Child-Pugh and Model for End-Stage Liver Disease-Na scores, status of being inside or outside of radiological Milan criteria, status of being inside or outside of Milan criteria in explant (pathological Milan criteria), and the locoregional therapy types and combinations were evaluated for their effects on inclusion in Milan criteria and survival.Results: During the study period, 396 patients underwent liver transplant at our center, with 97 because of cirrhosis and hepatocellular carcinoma. When we viewed patients according to preoperative radiologic evaluations, 67.9% were within Milan criteria and 32.1% were outside. When we viewed according to explant (pathological) evaluations, 80.7% of patients were within Milan criteria. Among 97 patients, 71 (73.2%) had locoregional therapy (22 [30.9%] for downstaging, 49 [69.0%] for bridging to transplant), and 12 patients (12.3%) were within Milan criteria on explant examination while outside of Milan criteria before LT. One-year, 3-year, and 5-year survival rates were 80.7%, 76.1%, and 71.6%, respectively. Conclusions: As a result of radiological evaluations, in patients who were outside of Milan criteria and underwent locoregional therapy, explant pathology within Milan criteria had a positive effect on survival; however, after locoregional therapy, there was no significant effect on survival in patients who were still outside of Milan criteria.Publication Macropenis in a toddler(Sage Publications Inc, 2023-03-15) Demiral, Meliha; Çelik, Fatih; Saraydaroğlu, Özlem; Sığ, Özlem Öz; Eren, Erdal; ÇELİK, FATİH; SARAYDAROĞLU, ÖZLEM; EREN, ERDAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Cerrahisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Endokrinolojisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-1684-1053; JPK-3909-2023; JKN-9078-2023; DPZ-1981-2022Publication The evaluation of central venous catheter-related complications in pediatric acute leukemia patients: Single center experience(Lippincott Williams & Wilkins, 2023-01-01) Evim, Melike Sezgin; SEZGİN EVİM, MELİKE; Yörük, Gülce; Parlak, Ayse; YÖRÜK, GÜLCE; PARLAK, AYŞE; GÜLER, SALİH; Çelik, Fatih; ÇELİK, FATİH; Çelebi, Solmaz; ÇELEBİ, SOLMAZ; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Baytan, Birol; Güneş, Adalet Meral; MERAL GÜNEŞ, ADALET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0002-1266-4897; 0000-0001-7686-2561; 0000-0002-9375-2855; 0000-0003-4646-660X; AAI-3665-2021; AAH-6766-2021Central venous catheters (CVCs) are important for maintenance of childhood leukemia treatment but CVCs may develop complications. The aim of this study was to retrospectively evaluate the CVC-related complication rate, complication types, and outcome in children with acute leukemia. Complications developing in 310 CVCs (ports n=250, Hickman catheters n=60) inserted in 262 patients were evaluated. A total of 225,296 catheter days were screened. Median (range) CVC in-dwelling time was 661.5 (1 to 2636) days. In total, 157 complications developed of which 91 (58%) were infectious complications, 35 (22.3%) were vascular, 19 (12.1%) were surgical, and 12 (7.6%) were mechanical. Hickman catheters had a higher complication rate and were more prone to mechanical complications (P<0.01) but there was no difference for other complications. A lower absolute neutrophil count at insertion was observed in children with infectious complications (P<0.01). Seventy-eight of 136 catheters (57.3%) had to be removed prematurely. The overall complication rate was 0.65 per 1000 catheter days. In multivariate analysis, relapse leukemia, Hickman catheter and low absolute neutrophil count increased complication risk by 4.00, 1.97, and 1.92 times, respectively. Five (1.9%) deaths occurred because of catheter complications. Safe use of CVCs can be improved by early detection of complications and an experienced catheter care team.Publication Evaluation of the trend of biochemical functions in the early period after cadaveric liver transplantation(Elsevier Science Inc, 2023-06-28) Aksoy, Fuat; Gürlüler, Ercüment; Çelik, Fatih; Şen, Murat; Balkan, Eyüp Anıl; Dündar, Halit Ziya; Kaya, Ekrem; AKSOY, FUAT; GÜRLÜLER, ERCÜMENT; ÇELİK, FATİH; ŞEN, MURAT; BALKAN, EYÜP ANIL; DÜNDAR, HALİT ZİYA; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; 0000-0001-5808-9384; 0000-0003-2728-9521; HII-8895-2022; X-7425-2018; AAG-7319-2021; JYY-5340-2024; JEX-7100-2023; IZR-9309-2023; EWI-3634-2022Background. Monitoring biochemical parameters to detect early complications after liver transplantation (LT) is important. Thus, we aimed to investigate parameter trends indicating liver function in patients who did not develop complications after cadaveric LT. Methods. A total of 266 cadaveric LT operations performed by a single center between 2007-2022 were included in the study. Patients with any early complications were excluded from the study. During the first 15 days, the parameters reflecting the patients' liver integrity and synthesis functions were evaluated. All parameters studied were evaluated at the same time of day and by a single laboratory. Results. Regarding synthesis functions, the coagulation parameters (prothrombin time and international normalized ratio) peaked on the first day and then decreased. Regarding tissue hypoxia, there was no significant change in lactate values. Total and direct bilirubin values also decreased after peaking on the first day. No significant change was observed in albumin, another liver synthesis value. Conclusions. Although an increase in aspartate aminotransferase, alanine aminotransferase, total and direct bilirubin, prothrombin time, and international normalized ratio, which was especially seen on the first day, is considered normal, values that do not decrease after the second day or lactate values that increase gradually should be a warning in terms of possible early complications.Publication Does liver transplant improve neurological symptoms in wilson disease? report of 24 cases(Başkent Üniversitresi, 2022-11-01) Aksoy, Fuat; Arslan, İbrahim Ethem; Özgür, Taner; Dündar, Halit Ziya; Çelik, Fatih; Demir, Aylin Bican; Özbek, Sevda Erer; Kıyıcı, Murat; Özkan, Tanju Başarır; Kaya, Ekrem; AKSOY, FUAT; Arslan, İbrahim Ethem; ÖZGÜR, TANER; DÜNDAR, HALİT ZİYA; ÇELİK, FATİH; BİCAN DEMİR, AYLİN; ERER ÖZBEK, ÇİĞDEM SEVDA; KIYICI, MURAT; Özkan, Tanju Başarır; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; 0000-0001-5808-9384; 0000-0002-9245-1241; 0000-0001-6739-8605; HII-8895-2022; ABD-3885-2020; AAG-7319-2021; FPE-9941-2022; EWI-3634-2022; JKN-9078-2023; KHB-9765-2024; DLN-1836-2022; FHW-0015-2022; JKL-3648-2023Objectives: Wilson disease is an inherited disorder that results in copper accumulation in the tissues with liver injury and failure. Orthotopic liver transplant is one of the treatments of choice for this disease. The aim of this study was to compare the neurological symptoms, before and after orthotopic liver transplant, of patients with liver cirrhosis due to Wilson disease, who represent a special group of patients with liver failure. Materials and Methods: Between 2007 and 2020, there were 24 patients with Wilson disease resistant to medical treatment who underwent deceased donor orthotopic liver transplant and were followed up for 1 year, 5 years, and 10 years for evaluation with neurological scoring systems. Patients were also evaluated for postoperative complications and survival. Results: Of the 24 patients evaluated, there were 13 (54.2%) female patients and 11 (45.8%) male patients, and the mean age was 34 years (range, 14-57 years). One of the patients died from early postoperative sepsis. After orthotopic liver transplant, disease scores returned to normal in 16 patients and improved in the remaining patients. Before transplant, all patients required help in their daily activities. After transplant, there were significant improvements in some symptoms, and the patients became more independent in their daily lives. Conclusions: Our study shows that orthotopic liver transplant provides significant improvement in neurological symptoms and quality of life in patients with Wilson disease.