Person: KARACA, ESRA
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KARACA
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ESRA
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Publication Evaluation of Nigella sativa oil loaded electrospun polyurethane nanofibrous mat as wound dressing(Taylor, 2021-06-02) Aras, Cansu; Özer, Elif Tümay; Göktalay, Gökhan; Saat, Gülbahar; Karaca, Esra; ARAS GÜL, CANSU; TÜMAY ÖZER, ELİF; GÖKTALAY, GÖKHAN; KARACA, ESRA; Bursa Uludağ Üniversitesi/Mühendislik Fakültesi/Tekstil Bölümü; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı; 0000-0003-1777-3977; AAI-3137-2021; AAS-8480-2020; EKA-8835-2022; AAI-3137-2021; JKY-1522-2023; DPL-6507-2022Electrospun nanofibers have a natural wound healing effect due to their similarity to the extracellular matrix (ECM). Nigella sativa oil, which has therapeutic properties, is used for a wide variety of applications in traditional medicine. The aim of this study was to investigate the release characteristic and wound healing performance of Nigella sativa oil (NSO) loaded polyurethane (PU) electrospun nanofibrous mats in wound dressing applications. In addition, the antibacterial activity and cytotoxicity of the electrospun mats were studied. Analyses using a scanning electron microscope (SEM) showed that PU/NSO nanofibrous mat with an average fiber diameter of 416 +/- 66 nm were successfully fabricated. NSO was released at a maximum ratio of 30% from the electrospun mat, and the Korsmeyer-Peppas model was identified as best for determining the release mechanism. Significant antibacterial activity was observed against Staphylococcus aureus (90.26%) and Escherichia coli (95.75%). The developed PU/NSO nanofibrous mat increased the cell viability more than 100% in human umbilical vein endothelial cell line (HUVEC) cell line. The NSO loaded PU nanofibrous mat significantly promoted the wound healing process on a rat wound model, and its wound closure reached approximately 85% compared to the control groups on the 9(th) day (p < 0.01). The results indicated PU/NSO nanofibrous mat is a suitable candidate for a wound dressing.Publication In vitro evaluation of electrospun polysaccharide based nanofibrous mats as surgical adhesion barriers(Ege Univ, 2020-01-01) Şafak, Şerife; Vatan, Özgür; VATAN, ÖZGÜR; Cinkılıç, Nilufer; ÇİNKILIÇ, NİLÜFER; Karaca, Esra; KARACA, ESRA; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Tekstil Anabilim Dalı.; 0000-0002-7687-3284; 0000-0002-3595-6286; 0000-0003-1777-3977; AAH-5296-2021; O-7508-2015; AAS-8480-2020; ISV-0209-2023Post-operative adhesions are one of the most important problems faced by patients and surgeons. In this study, nanofibrous mats were produced as novel surgical adhesion barrier from polysaccharide-based polymers, hyaluronic acid, carboxymethyl cellulose and sodium alginate, via electrospinning. The produced nanofibrous mats were crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide. Furthermore, the morphology, in vitro degradation, cytotoxicity and cell adherence potentials of the nanofibrous mats aimed to be used as adhesion barriers were evaluated and compared with a commercial adhesion barrier. Results of the in vitro experiment showed that the nanofibrous mats have maintained their physical structures during the critical period for adhesion formation, and had non-adherent cell feature and non-cytotoxic nature required for an ideal adhesion barrier.Publication Effects of fiber cross-sectional shapes on tensile and tearing properties of polyester woven fabrics(Ege Üniversitesi, 2015-10-01) Karaca, Esra; Ömeroğlu, Sunay; Becerir, Behçet; KARACA, ESRA; ÖMEROĞLU, SUNAY; BECERİR, BEHÇET; Uludağ Üniversitesi/Mühendislik Fakültesi/Tekstil Mühendisliği Bölümü.; 0000-0003-1777-3977; 0000-0002-2655-2773; AAH-1445-2021; AAM-7071-2020; AAS-8480-2020Breaking load and elongation, and tearing load properties of two type fabrics (plain and twill) woven from polyester fibers having round, hollow round, trilobal and hollow trilobal cross-sectional shapes were investigated. The fabrics produced from full fibers had higher breaking elongation and tearing load values but generally lower breaking load values than the fabrics produced from hollow fibers. The highest breaking load value was obtained in twill fabric woven from filaments having hollow round cross-sectional shape, while the highest tearing load value was obtained in twill fabric woven from filaments having round cross-sectional shape. The fabrics constituting filaments with round cross-sectional shapes had the highest breaking elongation values It was concluded that the effect of fiber cross-sectional shape on breaking strength and on tearing strength differed from each other.