Person: ÖZYENER, FADIL
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ÖZYENER
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FADIL
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Publication Respiratory system response to exercise(Wiley, 2023-12-01) Özyener, Fadıl; ÖZYENER, FADIL; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Fizik Bölümü; JXG-6506-2024Publication Comparison of peak expiratory flow (PEF), vital capacity (VC) and FEV1/FVC values of healthy people considering their exercise status(Wiley, 2016-09-01) Demirel, Sadettin; Özyener, Fadıl; DEMİREL, SADETTİN; ÖZYENER, FADIL; Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.; AAH-3460-2021; AAH-1641-2021Publication Vascular functional effect mechanisms of elabela in rat thoracic aorta(Elsevier Science Inc, 2022-08-01) Şahintürk, Serdar; ŞAHİNTÜRK, SERDAR; ÖZYENER, FADIL; Demirel, Sadettin; İŞBİL, NACİYE; DEMİREL, SADETTİN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.; AAH-3460-2021; AAH-1641-2021; ACQ-9887-2022Background: Elabela is a recently discovered peptide hormone. The present study aims to investigate the vasorelaxant effect mechanisms of elabela in the rat thoracic aorta.Methods: The vascular rings obtained from the thoracic aortas of the male Wistar albino rats were placed in the isolated tissue bath system. Resting tension was set to 1 gram. After the equilibration period, the vessel rings were contracted with phenylephrine or potassium chloride. Once a stable contraction was achieved, elabela-32 was applied cumulatively (10(-9)-10(-6) molar) to the vascular rings. The experimental protocol was repeated in the presence of specific signaling pathway inhibitors or potassium channel blockers to determine the effect mechanisms of elabela.Results: Elabela showed a significant vasorelaxant effect in a concentration-dependent manner (P < 0.001). The vasorelaxant effect level of elabela was significantly reduced by the apelin receptor antagonist F13A, cyclooxygenase inhibitor indomethacin, adenosine monophosphate-activated protein kinase inhibitor dorsomorphin, protein kinase C inhibitor bisindolmaleimide, large-conductance calcium-activated potassium channel blocker iberiotoxin, and intermediate-conductance calcium-activated potassium channel blocker TRAM-34 (P < 0.001). However, the vasorelaxant effect level of elabela was not significantly affected by the endothelial nitric oxide synthase inhibitor nitro-L-arginine methyl ester and mitogen-activated protein kinase inhibitor U0126.Conclusions: Elabela exhibits a prominent vasodilator effect in rat thoracic aorta. Apelin receptor, prostanoids, adenosine monophosphate-activated protein kinase, protein kinase C, and calcium-activated potassium channels are involved in the vasorelaxant effect mechanisms of elabela.Publication Potassium channels contributes to apelin-induced vasodilation in rat thoracic aorta(Bentham Science Publ Ltd, 2022-01-01) ŞAHİNTÜRK, SERDAR; İŞBİL, NACİYE; DEMİREL, SADETTİN; ÖZYENER, FADIL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.; AAH-1641-2021; AAH-3460-2021; ACQ-9887-2022Background: Apelin is a newly discovered peptide hormone and originally discovered endogenous apelin receptor ligand. Objective: In this study, we aimed to investigate the possible roles of potassium channel subtypes in the vasorelaxant effect mechanisms of apelin. Methods: The vascular rings obtained from the thoracic aortas of the male Wistar Albino rats were placed into the isolated tissue bath system. The resting tension was set to 2 g. After the equilibration period, the aortic rings were precontracted with 10-5 M phenylephrine (PHE) or 45 mM KCl. Pyroglutamyl-apelin-13 ([Pyr1]apelin-13), which is the dominant apelin isoform in the human cardiovascular tissues and human plasma, was applied cumulatively (10(-10)-10(-6) M) to the aortic rings in the plateau phase. The experimental protocol was repeated in the presence of specific K+ channel subtype blockers to determine the role of K(+)channels in the vasorelaxant effect mechanisms of apelin. Results: [Pyr1]apelin-13 induced a concentration-dependent vasorelaxation (p < 0.001). The maximum relaxation level was approximately 52%, according to PHE-induced contraction. Tetraethylammonium, iberiotoxin, 4-Aminopyridine, glyburide, anandamide, and BaCl2 statistically significantly decreased the vasorelaxant effect level of [Pyr1]apelin-13 (p < 0.001). However, apamin didn't statistically significantly change the vasorelaxant effect level of [Pyr1]apelin-13. Conclusion: In conclusion, our findings suggest that BKCa, IKCa, Kv, K-ATP, Kir, and K-2P channels are involved in the vasorelaxant effect mechanisms of apelin in the rat thoracic aorta.Publication Parenchymal and vascular physiolopathology in COPD(Wiley, 2019-12-01) Özyener, Fadıl; ÖZYENER, FADIL; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Fizik Bölümü; AAH-1641-2021Publication [Pyr1]apelin-13 relaxes the rat thoracic aorta via APJ, NO, AMPK, and potassium channels(Aepress Sro, 2021-01-01) Şahintürk, Serdar; Demirel, Sadettin; Özyener, Fadıl; İşbil, Naciye; ŞAHİNTÜRK, SERDAR; DEMİREL, SADETTİN; ÖZYENER, FADIL; İŞBİL, NACİYE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı; 0000-0002-7612-0055; 0000-0002-3629-5344; 0000-0002-4606-6596; AAH-3460-2021; ACQ-9887-2022; AAH-1641-2021; FBW-7104-2022In this study, the effect and effect mechanisms of [Pyr1]apelin-13, the dominant apelin isoform in the human cardiovascular tissues and human plasma, on vascular contractility were investigated. The vascular rings obtained from the thoracic aortas of the male Wistar Albino rats were placed in the isolated tissue bath system. After the equilibration period, [Pyr1]apelin-13 (10(-9) to 10(-6) M) was applied cumulatively to the aortic rings pre-contracted with phenylephrine in the plateau phase. The protocol was repeated in the presence of specific signaling pathway inhibitors (F13A, L-NAME, dorsomorphin, TEA, U0126, or indomethacin) to determine the effect mechanisms of [Pyr1]apelin-13. [Pyr1]apelin-13 induced a dose-dependent relaxation in the pre-contracted aortic rings. APJ, eNOS, AMPK, and potassium channel inhibition statistically significantly decreased the vasodilator effect of [Pyr1]apelin-13. MAPK and COX inhibition didn't statistically significantly changed the vasodilator effect of [Pyr1]apelin-13. In conclusion, [Pyr1]apelin-13 relaxes the rat thoracic aorta via APJ, NO, AMPK, and potassium channels.Publication Irisin relaxes rat trachea via KV channels, KATP channels, and BKCa channels(Bentham Science Publ Ltd, 2022-01-01) DEMİREL, SADETTİN; Demirel, Sadettin; ÖZYENER, FADIL; Özyener, Fadıl; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.; AAH-1641-2021; AAH-3460-2021Background: This study aimed to investigate the effects of irisin on rat tracheal smooth muscle contraction-relaxation responses and the roles of voltage-gated potassium (K-V) channels, ATP-sensitive potassium (K-ATP) channels, and large-conductance calcium-activated potassium (BKCa) channels in these effects. Methods: Isometric contraction and relaxation responses of tracheal segments were measured using the tissue bath method. Submaximal contractions were induced by ACh (10(-5) M) or KCl (60 mM), and then concentration-response curves of irisin (10(-9) to 10(-6) M) were obtained. For the temporal control, a double-distilled water group was formed. ACh and irisin were added to the baths after tracheal segments were incubated with 4-AP (K-V channel blocker), glibenclamide (K-ATP channel blocker), TEA, and iberiotoxin (BKCa channel blockers) to assess the role of K+ channels. In addition, a vehicle group was performed for the solvent dimethyl sulfoxide (DMSO). Results: Irisin exhibited the relaxant effects in tracheal segments precontracted with both ACh and KCl at concentrations of 10(-8)-10(-6) M (p<0.05). Besides, incubations of 4-AP, glibenclamide, TEA, and iberiotoxin significantly inhibited the irisin-mediated relaxation (p<0.05), whereas DMSO incubation did not modulate irisin responses (p>0.05). Conclusion: In conclusion, the first physiological results on the relaxant effects of irisin in rat trachea were obtained. Our findings demonstrated that irisin mediates concentration-dependent relaxation in rat tracheas. Moreover, the present study reported for the first time that irisin-induced bronchorelaxation is associated with the activity of the K+ channels.Publication [pyr1] apelin-13 exerts vasorelaxant effect in the rat thoracic aorta via APJ, NO, AMPK, and potassium channels(Wiley, 2022-02-01) Şahintürk, Serdar; Demirel, Sadettin; Özyener, Fadıl; İşbil, Naciye; ŞAHİNTÜRK, SERDAR; DEMİREL, SADETTİN; ÖZYENER, FADIL; İŞBİL, NACİYE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.; ACQ-9887-2022; AAH-3460-2021; AAH-1641-2021; FBW-7104-2022Publication Irisin dilates the rat thoracic aorta via pkc, mek1/2 signaling pathway, kv channels, skca channels, and bkca channels(Wiley, 2022-02-01) Demirel, Sadettin; Şahintürk, Serdar; ŞAHİNTÜRK, SERDAR; İşbil, Naciye; İŞBİL, NACİYE; Özyener, Fadil; ÖZYENER, FADIL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.; AAH-1641-2021; AAH-3460-2021; ACQ-9887-2022Publication Investigation of respiratory physiopathology by determination of pulmonary gas exchange and ventilation dynamics in chronic lung diseases(European Respiratory Soc Journals Ltd, 2023-09-09) Coşkun, Necmiye Funda; Özyener, Fadıl; Dilektaşlı, Aslı Görek; Ediger, Dane; COŞKUN, NECMİYE FUNDA; ÖZYENER, FADIL; GÖREK DİLEKTAŞLI, ASLI; EDİGER, DANE; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Fizyoloji Anabilim Dalı.; 0000-0001-7099-9647; 0000-0002-2954-4293; AAE-9142-2019; JWT-1047-2024; JXG-6506-2024; DTT-7416-2022