Person: GÜLLÜLÜ, MUSTAFA
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GÜLLÜLÜ
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MUSTAFA
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Publication Screening for fabry disease in patients who underwent renal biopsy and identification of a novel mutation(Aves, 2021-04-01) Oruç, Ayşegül; Yıldız, Abdulmecit; Akgür, Suat; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Yavuz, Mahmut; Dilek, Kamil; Güllülü, Mustafa; ORUÇ, AYŞEGÜL; YILDIZ, ABDULMECİT; AKGÜR, SUAT; Aydın, Mehmet Fethullah; ERSOY, ALPARSLAN; YAVUZ, MAHMUT; DİLEK, KAMİL; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-0342-9692; 0000-0002-5665-7402; AAJ-8220-2020; AAH-4002-2021; HIG-9032-2022; EJA-1761-2022; CPX-5894-2022; EHM-7377-2022; EUF-5229-2022; JGS-9425-2023Background: The X-linked Fabry disease (FD) with lysosomal storage of globotriaosylceramide (Gb3) due to alpha-galactosidase deficiency contributes to nephropathy consisting of proteinuria and renal failure eventually. Early initiation of the enzyme replacement therapy promises favorable renal outcomes. With the importance of early diagnosis, we screened FD among proteinuric patients in whom biopsy findings revealed Fabry nephropathy.Methods: Patients with light microscopic biopsy findings of vacuolated cells, focal and/or segmental glomerular sclerosis, tubular atrophy, and interstitial fibrosis were not associated with particular etiology, the presence of acro-paresthesia, angiokeratomas, and cornea verticillata, stroke history younger than 50 years, family history of renal failure with no cardiovascular risk factors were screened. Fifty-three of 308 consecutive adult patients (45.34 +/- 15.23 years old, 60.1% male) who underwent renal biopsy because of proteinuria were enrolled in the study. Screening for FD was performed by assessing alpha-Gal A activity in dried blood spots (DBS) for males and by genetic testing for females.Results: Fifty-three patients (39.94 +/- 11.97 years, 69.8% male) who underwent renal biopsy were screened. Laboratory findings revealed mean serum creatinine of 1.44 +/- 1.06 mg/dL, mean estimated glomerular filtration rate of 78.31 +/- 39.89 mL/min/1.73 m(2), and mean proteinuria of 4.32 +/- 3 g/day, whereas the females genetic screening was negative. Two of 37 males had low enzyme activity (<0.1 micmol/L/h) and confirmed FD by genetic analysis in whom one had a novel mutation of GLA gene (c.(1047G>A) p.(Trp349*)).Conclusion: It is worth noting that FD screening in patients with proteinuria, in whom vacuolated cells, mesangial expansion, glomerulosclerosis, interstitial fibrosis, and tubular atrophy of unknown etiology, are present in the renal biopsy either with or without a family history of kidney disease.Publication Correlation between arterial stiffness and inflammatory markers in autosomal dominant polycystic kidney disease patients with preserved renal function(Springer, 2015-07-01) Gül, Cuma Bülent; Yıldız, Abdülmecit; Ersoy, Alparslan; Kahvecioğlu, Serdar; Asiltaş, Burak; Yıldırım, Fatih; Ermurat, Selime; Sağ, Saim; Oruç, Ayşegül; Güllülü, Sumeyye; Güllülü, Mustafa; YILDIZ, ABDULMECİT; ERSOY, ALPARSLAN; Asıltaş, Burak; YILDIRIM, FATİH; Ermurat, Selime; Sağ, Saim; ORUÇ, AYŞEGÜL; GÜLLÜLÜ, NAZMİYE SÜMEYYE; GÜLLÜLÜ, MUSTAFA; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0003-2467-9356; 0000-0002-0342-9692; 0000-0002-3090-1585; 0000-0001-8404-8252; HIG-9032-2022; AAH-5054-2021; JCN-7114-2023; AAH-4002-2021; ABE-4424-2022; AAW-9185-2020; EKV-7386-2022; EXG-3181-2022; CTG-8811-2022To evaluate the association between arterial stiffness and inflammatory markers including C-reactive protein (CRP), pentraxin 3 (PTX3) and neutrophil-to-lymphocyte ratio (NLR) in autosomal dominant polycystic kidney disease (ADPKD) patients with preserved renal function.A total of 52 ADPKD patients [mean (SD) age 38.2 (12.8) years, 69.2 % were females] with preserved renal function and 25 healthy volunteers [mean (SD) age 35.5 (6.5) years, 48.0 % were females] were included. Data on patient characteristics, blood biochemistry, inflammatory markers [PTX3 (pg/mL), CRP (mg/dL) and NLR] and arterial stiffness [large artery elasticity index (LAEI) (mL/mmHg x 10) and small artery elasticity index (SAEI) (mL/mmHg x 100)] were recorded in patient and control groups. Correlation between inflammatory markers and arterial stiffness parameters was analysed in patients.Overall, 42.3 % of ADPKD patients were hypertensive and 44.4 % were receiving renin-angiotensin-aldosterone system (RAAS) blockade therapy. Median levels for PTX3 [442.0 (20.0-4140.0) pg/mL vs. 220.5 (14.7-393.0) pg/mL, p < 0.001] and SAEI [4.90 (1.60-11.80) mL/mmHg x 100 vs. 6.45 (2.80-15.70) mL/mmHg x 10, p = 0.013] were significantly higher in ADPKD patients than in controls. PTX3 and CRP were not correlated with arterial elasticity, while NLR was significantly correlated with LAEI negatively (Rho = -0.278, p = 0.042).In conclusion, our findings revealed increased PTX3 levels and reduced SAEI in patients as compared with controls, while no correlation between inflammatory markers studied and the small artery elasticity.Publication Association of morning blood pressure surge (mbps) with left ventricular hypertrophy in autosomal dominant polycystic kidney disease (ADPKD): Across sectional study(Oxford Univ Press, 2016-05-01) Sağ, Saim; Yıldız, Abdulmecit; Ersoy, Alparslan; Ocakoğlu, Gökhan; Oruç, Ayşegül; Güngören, Fatih; Ayar, Yavuz; Gül, Cuma Bülent; Güllülü, Sümeyye; Güllülü, Mustafa; Sağ, Saim; YILDIZ, ABDULMECİT; ERSOY, ALPARSLAN; OCAKOĞLU, GÖKHAN; ORUÇ, AYŞEGÜL; Güngören, Fatih; Ayar, Yavuz; GÜL, CUMA BÜLENT; GÜLLÜLÜ, NAZMİYE SÜMEYYE; GÜLLÜLÜ, MUSTAFA; Uludağ Üniversitesi/Tıp Fakültesi/Kardioloji Bölümü; 0000-0002-1114-6051; 0000-0002-0342-9692; 0000-0003-4607-9220; 0000-0003-2467-9356; AAH-5180-2021; AGF-0767-2022; AAW-9185-2020; AAH-5054-2021; O-9948-2015; AAA-3163-2021; HLG-6346-2023; AAH-4002-2021; A-7063-2018; GSE-0029-2022; HIG-9032-2022; JGR-6552-2023; CTG-8811-2022Publication Lower gastrointestinal tract hemorrhage due to ectopic pancreatic tissue in a renal transplant recipient: : A case report(Elsevier, 2002-06-01) Ersoy, Alpaslan; Yavuz, M; Tokyay, R; Yerci, Ömer; Kıyıcı, Murat; Usta, M; Güllülü, Mustafa; Dilek, Kamil; Oktay, B; Yurtkuran, Merih; ERSOY, ALPARSLAN; Yavuz, M; Tokyay, R; YERCİ, ÖMER; KIYICI, MURAT; Usta, M; GÜLLÜLÜ, MUSTAFA; DİLEK, KAMİL; Oktay, B; Yurtkuran, M.; Uludağ Tıp Fakültesi/Tıp Fakültesi/Nefroloji Bölümü; Uludağ Tıp Fakültesi/Tıp Fakültesi/Patoloji Bölümü; Uludağ Tıp Fakültesi/Tıp Fakültesi/Gastroenteroloji Bölümü; Uludağ Tıp Fakültesi/Tıp Fakültesi/Üroloji Bölümü; 0000-0002-3208-6211; AAH-5054-2021; AAI-4213-2021; IHY-2104-2023; DZX-1258-2022; EIS-5114-2022; GGE-6952-2022; JGS-9425-2023; EUU-1912-2022; FRV-0139-2022; EGT-2006-2022Publication Focal segmental glomerulosclerosis: A single center experience(Galenos Yayıncılık, 2016-09-01) Ayar, Yavuz; Ersoy, Alparslan; Yıldız, Abdülmecit; Oruç, Ayşegül; Can, Fatma Ezgi; Ocakoğlu, Gökhan; Güllülü, Mustafa; Demirayak, Dilay; Bayrakçı, İsmail; Düger, Hakan; Ocak, Tuğba; Korkut, Bayram; Şahin, Ahmet Bilgehan; Akan, Mustafa; Eylemer, Eda; Ayar, Yavuz; ERSOY, ALPARSLAN; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; Can, Fatma Ezgi; OCAKOĞLU, GÖKHAN; GÜLLÜLÜ, MUSTAFA; Demirayak, Dilay; Bayrakçı, İsmail; Düger, Hakan; OCAK, TUĞBA; Korkut, Bayram; ŞAHİN, AHMET BİLGEHAN; Akan, Mustafa; Eylemer, Eda; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-0342-9692; 0000-0002-1114-6051; 0000-0001-5926-6813; 0000-0001-5478-3192; 0000-0002-7846-0870; 0000-0002-9252-8341; 0000-0002-0710-0923; 0000-0002-1953-7735; AGF-0767-2022; AAH-5054-2021; HIG-9032-2022; AAH-4002-2021; JSL-7718-2023; HLG-6346-2023; JGS-9425-2023; EQO-1344-2022; JLB-1564-2023; IZP-9361-2023; FPM-3131-2022; FFH-4157-2022; AAM-4927-2020; KUI-8062-2024; COF-1782-2022Aim: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerulonephritis (GNP) worldwide. Despite treatment, it may progress to end-stage renal disease. In the present study, we compared clinical and histopathological data on FSGS with primary and secondary GNP retrospectively.Methods: We retrospectively analyzed data on clinical and laboratory findings, treatment response, and risk factors associated with mortality in patients, who had been diagnosed with FSGS and other GNP via renal biopsy between January 2009 and December 2014. The average follow-up time was 22 (8-76) months.Results: FSGS and primary GNP were more frequently seen in males than in females (55.9% vs. 65.3%, p=0.033). Nephrotic syndrome was more common in patients with FSGS (41.2%) and primary GNP (57.7%), while chronic renal disease was more frequent in patients with secondary GNP (35%). In FSGS, the complete remission rate was 54.4%. 63.2% of patients had continued to receive treatment. According to the biopsy findings, interstitial inflammation and fibrosis were observed in 100% and 98.5% of patients with FSGS, respectively (p=0.010 and p<0.001, respectively). Serum albumin level was found to be increased and proteinuria, total cholesterol, triglyceride, and LDL levels to be decreased after treatment (p<0.001). Serum creatinine levels and type of GNP (secondary GNP) were detected to be 1.48 and 8.14 fold increased in mortality analysis, respectively.Conclusion: Renal biopsy is the gold standard for the diagnosis of glomerular diseases. Renal function at the time of diagnosis, follow-up and appropriate immunosuppressive therapy have effects on mortality and clinical progress in FSGS as is the case in all GNPs.Publication Demographic and clinical characteristics of primary glomerular diseases in Turkey(Springer, 2014-12-01) Öztürk, Savaş; Sumnu, Abdullah; Seyahi, Nurhan; Sipahioglu, Murat; Artan, Serra; Bicik, Zerrin; Kutlay, Sim; Keles, Mustafa; Oygar, Deren; Odabas, Ali Riza; Kayatas, Mansur; Dursun, Belda; Sayarlioglu, Hayriye; Trablus, Sinan; Taymez, Dilek Guven; Özdemir, Ali Abbas; Sahin, Gulizar Manga; Altun, Bulent; Azak, Alper; Altıntepe, Lutfullah; Suleymanlar, Gultekin; Koc, Mehmet; Selcuk, Yilmaz; Kazancıoğlu, Rumeyza; Erkoç, Reha; Gursu, Meltem; Küçük, Mehmet; Akçaoglu, Selma Alagöz; Yıldız, Abdulmecid; Ünal, Aydın; Akarsu, Özger; Ates, Kenan; Cankaya, Erdem; Türkmen, Aydın; Güllülü, Mustafa; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.The aim of our study was to delineate the demographic and clinical properties of primary glomerular diseases of adult population in our country in the light of global knowledge.All over the country, a total of 25 centers entered data between May 2009 and July 2012 to the database created by 'Glomerulonephritis Study Group' of Turkish Society of Nephrology. Demographic and clinical characteristics, specific diagnoses of glomerular diseases and biopsy findings recorded to the database were analyzed.Among the 1,274 patients, who had renal biopsy within the defined time period, 55 % were male and 45 % were female. The mean age was 40.8 +/- A 14.6 years. The most frequent indication for biopsy was nephrotic syndrome (57.8 %), followed by nephritic syndrome including rapidly progressive glomerulonephritis (16.6 %) and asymptomatic urinary abnormalities (10.8 %). The most frequent primary glomerular disease was membranous nephropathy (28.8 %), followed by focal segmental glomerulosclerosis (19.3 %) and IgA nephropathy (17.2 %).The presented study displayed important data about the epidemiology of primary glomerular diseases among adults in our country. The predominance of membranous nephropathy in contrast to other countries, in which the most frequent etiology is IgA nephropathy, seems to be due to differences in the indications for renal biopsy.Publication The evaluation of amyloidosis cases with renal involvement: A single-center experience(Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2015-01-01) Ayar, Yavuz; Ersoy, Alparslan; Yıldız, Abdülmecit; Işıktas Sayılar, Emel; Çelikçi, Sedat; Arslan, İsmail; Öksüz, Mustafa Ferhat; Güllülü, Mustafa; Ayar, Yavuz; ERSOY, ALPARSLAN; Işıktas Sayılar, Emel; Çelikçi, Sedat; Arslan, İsmail; Öksüz, Mustafa Ferhat; GÜLLÜLÜ, MUSTAFA; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bilim Dalı.; 0000-0003-4607-9220; 0000-0002-1539-9216; AGF-0767-2022; AAH-5054-2021; FAZ-9764-2022; JIF-8775-2023; JML-0742-2023; KQP-2558-2024; JGS-9425-2023OBJECTIVE: Amyloidosis is a chronic disease associated with proteinuria and can progress to renal failure. The diagnosis and treatment of the underlying cause is therefore important. In this study at a university hospital, the diagnosis of amyloidosis patients with renal biopsies was evaluated retrospectively.MATERIAL and METHODS: 69 (42 males, 27 females, mean age: 51.7 +/- 14.8 years) patients were diagnosed with amyloidosis with renal biopsy. Indications for biopsy was nephrotic syndrome in 42 patients (60.9%), nephritic syndrome in 27 (39.1%) and renal dysfunction with proteinuria in 31 (44.9%).RESULTS: The most common causes of secondary amyloidosis were Familial Mediterranean Fever in 17 of the 62 patients, chronic inflammatory diseases in 17 patients and chronic infection in 13 patients. No cause was determined in 12 patients. Multiple myeloma was present in 5 patients with primary amyloidosis. At the time of diagnosis with amyloidosis, 19 patients were stage 1, 15 stage 2, 5 stage 3A, 12 stage 3B, 10 stage 4 and 8 stage 5. The baseline hemoglobin, serum albumin, creatinine, sodium, potassium, calcium, phosphorus, AST, ALT, PTH, SAA, CRP levels, average daily urinary protein excretion and baseline GFR values were not significantly different in primary and secondary amyloidosis patients. The treatment was medical in 62.3% of the patients, dialysis in 31.9% and renal transplantation in 5.8%.CONCLUSION: The reliability of renal biopsy in the diagnosis of amyloidosis is high. However, genetic studies for the diagnosis of idiopathic cases and special histological staining methods should be considered.Publication Ki-67 proliferation index in renal biopsy samples of patients with systemic lupus erythematosus(Clinical, 2015-05-01) Dalkılıç, Ediz; Pehlivan, Yavuz; Ermurat, Selime; Coşkun, Belkıs Nihan; Tufan, Ayşe Nur; Öksüz, Mustafa Ferhat; Yerci, Ömer; Güllülü, Mustafa; DALKILIÇ, HÜSEYİN EDİZ; PEHLİVAN, YAVUZ; Ermurat, Selime; COŞKUN, BELKIS NİHAN; Tufan, Ayşe Nur; Öksüz, Mustafa Ferhat; YERCİ, ÖMER; GÜLLÜLÜ, MUSTAFA; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Patholoji Bölümü; AAG-8227-2021; AAG-7155-2021; ABE-4424-2022; CMF-4757-2022; GHE-4236-2022; JXF-7598-2024; GKD-6344-2022; CTG-8811-2022Publication A family with IgA nephropathy and hereditary lymphoedema praecox(Wiley, 2002-05-01) Usta, M; Dilek, Kamil; Ersoy, Ahmet; Alper, E; Özbek, Serhat; Özdemir, Bülent; Filiz, G; Yavuz, M; Güllülü, Mustafa; Yurtkuran, Merih; Usta, M; DİLEK, KAMİL; Ersoy, Ahmet; Alper, E; ÖZBEK, SERHAT; ÖZDEMİR, BÜLENT; Filiz, G; Yavuz, M; GÜLLÜLÜ, MUSTAFA; Yurtkuran, Merih; Uludağ Üniversitesi Tıp Fakültesi/Nefroloji Bölümü; Uludağ Üniversitesi Tıp Fakültesi/Nükleer Tıp Bölümü; Uludağ Üniversitesi Tıp Fakültesi/Plastik ve Rekonstrüktif Cerrahi; Uludağ Üniversitesi Tıp Fakültesi/Patoloji Anabilim Dallarından; 0000-0003-3427-8337; 0009-0001-9179-9107; HYD-3798-2023; CNY-9323-2022; GXG-1656-2022; CCY-8570-2022; FTG-3544-2022; JHE-3353-2023; EVQ-8652-2022; HJG-9929-2022; JGS-9425-2023; GLB-5791-2022Immunoglobulin A (IgA) nephropathy is the most common primary glomerulonephritis worldwide. The pathogenesis is still unknown and treatment has not yet been established. Rarely it can be associated with other disorders. Its association with hereditary lymphoedema is not reported before. We report four patients, a 60-year-old father, his two sons and his daughter, with hereditary lymphoedema. The family had nine members and in four of them lymphoedema was evident. The other members had neither lymphoedema nor IgA nephropathy. This is the first report of IgA nephropathy in association with hereditary lymphoedema.Publication Morning blood pressure surge in early autosomal dominant polycystic kidney disease and its relation with left ventricular hypertrophy(Oxford Univ Press, 2018-05-01) Yıldız, Abdulmecit; Sağ, Saim; Gül, Cuma; Can, Fatma; Oruç, Aysegül; Aydın, Mehmet; Bedir, Ömer; Akgür, Suat; Ayar, Yavuz; Güllülü, Sürneyye; Güllülü, Mustafa; Ersoy, Alparslan; YILDIZ, ABDULMECİT; Can, Fatma; ORUÇ, AYŞEGÜL; AYDIN, MEHMET AKİF; Bedir, Ömer; AKGÜR, SUAT; Ayar, Yavuz; GÜLLÜLÜ, NAZMİYE SÜMEYYE; GÜLLÜLÜ, MUSTAFA; ERSOY, ALPARSLAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Bölümü; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Bölümü; 0000-0003-2467-9356; 0000-0002-0342-9692; 0000-0002-5665-7402; 0000-0003-4607-9220; 0000-0002-5665-7402; AGF-0767-2022; GSE-0029-2022; AAH-5054-2021; AAH-4002-2021; O-9948-2015; HIG-9032-2022; IBQ-9926-2023; AAJ-8220-2020; IVE-3975-2023; EJA-1761-2022; EWD-8403-2022; JGS-9425-2023
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