Person: UYSAL, FAHRETTİN
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UYSAL
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FAHRETTİN
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Publication Two cases diagnosed with tuberosclerosis in neonatal period(Galenos Yayıncılık, 2014-12-01) Varal, İpek Güney; Köksal, Nilgün; Özkan, Hilal; Bostan, Özlem; Bağcı, Onur; Uysal, Fahrettin; Yazıcı, Zeynep; Doğan, Pelin; Varal, İpek Güney; Köksal, Nilgün; BOSTAN, ÖZLEM MEHTAP; ÖZKAN, HİLAL; Bağcı, Onur; UYSAL, FAHRETTİN; YAZICI, ZEYNEP; Doğan, Pelin; Tıp Fakültesi; Radyoloji Ana Bilim Dalı; Pediatrik Radyoloji Bilim Dalı; 0000-0001-7707-2174; 0000-0001-9308-9806; CIR-8129-2022; JGS-7600-2023; JJY-3921-2023; AAG-8558-2021; KYP-5736-2024; AAH-4421-2021; AAI-2303-2021; CNZ-3688-2022Congenital heart tumors are very rare and the most common type is the rhabdomyoma. Frequency during autopsy is between 0.027-0.08%. Moreover 51-86% of these tumors are associated with tuberosclerosis. Also hamartomas might accompany, particularly on the central nervous system and skin, kidney, liver, lung and heart. In this paper, two cases diagnosed with tuberculosis who showed rhabdomyomas in fetal echocardiography in the antenatal period and were seen to have tubers in cranial magnetic resonance (MR) postnatally, are presented.Publication A major cause of mortality and morbidity of very low birth weight infants: Patent ductus arteriosus(Galenos Yayıncılık, 2012-04-01) Aygün, Fatih; Köksal, Nilgün; Bostan, Özlem M.; Uysal, Fahrettin; Varal, İpek Güney; Doğan, Pelin; Doğan, Pelin; Varal, İpek Güney; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Köksal, Nilgün; Aygün, Fatih; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; Neonatol Bilim Dalı; 0000-0001-6519-6583; 0000-0001-7707-2174; 0000-0002-3298-066X; AAI-5981-2020; JGS-7600-2023; D-2014-2019; AAH-4421-2021; AAG-8558-2021; CNZ-3688-2022Introduction: Patent Ductus Arteriosus (PDA), a cardiac pathology commonly seen in preterm infants, has negative effects on mortality and morbidity. Persistent patency of PDA is positively correlated with respiratory distress syndrome (RDS), prolonged respiratory support, pulmonary hemorrhage, broncopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage, renal failure, neurodevelopmental impairment (cerebral palsy), retinopathy of prematurity and death. The standard treatment regimen is to close symptomatic PDA and cyclooxygenase inhibitors such as indomethacin, ibuprofen are the first choises. Our aim in this study is to report PDA rate, treatment and complications in premature infants.Materials and Methods: This study retrospectively enrolled 103 infants born < 33 gestational weeks, without any major congenital anomaly or congenital heart defects between January 2010-November 2011. Echocardiograms was performed in the first week. PDA related pulmonary hemorrhage, NEC, BPD, ROP and death were demonstrated.Results: Among of 103 infants, 45 were male and 58 were female. Seventy infants were born with cesarian section and 33 were born with normal labor. The mean gestational week was 29.7 +/- 2.2, the mean gestational week of infants with PDA was 28.8 +/- 2.3. The mean birth weight of infants was 1323 +/- 375 grams. The mean Apgar score was 7.25 +/- 1.83, the scores of infants with patent ductus arteriosus were significantly low (6.7 +/- 1.9). Echocardiography was performed on the mean of 4.8 +/- 4.4 days, PDA was determined in 48 of 103 infants (% 46). The mean of birth weight of infants with persistant PDA was 1162 +/- 351 grams, it was 1465 +/- 340 g in the closed group. The rate of pulmonary hemorrhage, NEC, BPD, ROP and death was significantly higher in infants with PDA compared with infants having ductal closure (p<0.05).Conclusion: The early closure of PDA in very low birth weight infants will reduce both mortality and early or late morbidities.Publication Arterial tortuosity syndrome: 40 new families and literature review (vol 20, pg 1236, 2017)(Nature Publishing Group, 2019-08-01) Beyens, Aude; Albuisson, Juliette; Boel, Annekatrien; Al-Essa, Mazen; Al-Manea, Waheed; Bonnet, Damien; Bostan, Ozlem; Boute, Odile; Busa, Tiffany; Canham, Nathalie; Cil, Ergun; Coucke, Paul J.; Cousin, Margot A.; Dasouki, Majed; De Backer, Julie; De Paepe, Anne; De Schepper, Sofie; De Silva, Deepthi; Devriendt, Koenraad; De Wandele, Inge; Deyle, David R.; Dietz, Harry; Dupuis-Girod, Sophie; Fontenot, Eudice; Fischer-Zirnsak, Bjoern; Gezdirici, Alper; Ghoumid, Jamal; Giuliano, Fabienne; Baena, Neus; Haider, Mohammed Z.; Hardin, Joshua S.; Jeunemaitre, Xavier; Klee, Eric W.; Kornak, Uwe; Landecho, Manuel F.; Legrand, Anne; Loeys, Bart; Lyonnet, Stanislas; Michael, Helen; Moceri, Pamela; Mohammed, Shehla; Muino-Mosquera, Laura; Nampoothiri, Sheela; Pichler, Karin; Prescott, Katrina; Rajeb, Anna; Ramos-Arroyo, Maria; Rossi, Massimiliano; Salih, Mustafa; Seidahmed, Mohammed Z.; Schaefer, Elise; Steichen-Gersdorf, Elisabeth; Temel, Şehime; Uysal, Fahrettin; Vanhomwegen, Marine; Van Laer, Lut; Van Maldergem, Lionel; Warner, David; Willaert, Andy; Collins, Tom R., II; Taylor, Andrea; Davis, Elaine C.; Zarate, Yuri; Callewaert, Bert; TEMEL, ŞEHİME GÜLSÜN; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Tıp Fakültesi; Histoloji ve Embriyoloji Ana Bilim Dalı; AAG-8558-2021; AAG-9324-2021; AAG-8385-2021; AAH-4421-2021Publication A novel technique of pulmonary artery banding by means of radiofrequency ablation: An experimental study in rabbits(Bayçınar Tıbbi Yayıncılık, 2022-07-01) Uysal, Fahrettin; Akça, Tuğberk; Genç, Abdüsselam; Küpeli, Zehra Avcı; Özfırat, Erencan; Canatan, Uygur; Uysal, Berfin; Sığnak, Işık Şenkaya; UYSAL, FAHRETTİN; AKÇA, TUĞBERK; GENÇ, ABDÜSSELAM; KÜPELİ, ZEHRA AVCI; ÖZFIRAT, ERENCAN; CANATAN, UYGUR; ŞENKAYA SIĞNAK, IŞIK; 0000-0002-2747-974X; AAH-4421-2021; AEX-4557-2022; CQK-7120-2022; FHA-3247-2022; JHY-2022-2023; CJU-7194-2022; GPN-0680-2022Background: The aim of this study was to evaluate the efficacy and feasibility of a novel method of narrowing pulmonary arteries with catheter angiography using radiofrequency energy in rabbits. Methods: A total of nine New Zealand white rabbits weighing 3.0 to 4.2 kg each were utilized in this experimental study. After the location of pulmonary artery was confirmed by echocardiography and angiography, radiofrequency energy was applied by starting with 5 W energy for the first time and increasing by 5 W, if there was no rupture to a maximum of 20 W. Multiple applications of radiofrequency energy with different durations were performed at different levels of the pulmonary artery. Eight weeks later, surviving rabbits were sacrificed. The pulmonary arteries were removed for histological investigation. Results: Five rabbits remained alive after the experiment. There was a significant correlation between radiofrequency power and the degree of vessel thickness change in the pulmonary artery. The endothelial integrity of the tunica intima was impaired in all groups and the diameter of vessel was thickened by an average of 3.5 times. Conclusion: The narrowing of the pulmonary artery using radiofrequency energy was successfully performed in a small sample size of experimental animals in this study.Publication The prevalence of post-COVID-19 hypertension in children(Sage Publications Inc, 2022-04-24) Uysal, Berfin; Akça, Tuğberk; Akaci, Okan; Uysal, Fahrettin; AKÇA, TUĞBERK; UYSAL, FAHRETTİN; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; Pediartrik Kardiyoloji Bilim Dalı; 0000-0002-2747-974X; AAH-4421-2021; AEX-4557-2022Coronavirus disease 2019 (COVID-19) is the greatest pandemic in a century. In this study, children with mild COVID-19 infections were evaluated at least 8 weeks after the polymerase chain reaction (PCR) test positivity, and the frequency of hypertension (HT) in these children was investigated. These results were compared to those of the control group, which consisted of 32 healthy children in the same age range as the trial group but who did not have COVID-19. This prospective multicenter study was conducted including children aged 10 to 18 years. There were 16 patients (16%) who had elevated systolic blood pressure, while 11 patients (11%) had stage-1 HT and 1 patient (1%) had stage-2 HT. It was revealed that children with COVID-19 had significantly higher systolic and diastolic blood pressures than normal healthy children. The findings of this study contribute toward increasing the understanding of the sequelae of mild COVID-19 in pediatric patients.Publication Complete atrioventricular block as a complication of varicella infection in a child: Recovery with a single dose of intravenous immunoglobulin therapy(Sage Publications, 2016-06-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Çetin, Benhur; Uysal, Berfin; Güney, Begüm; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Çetin, Benhur; Güney, Begüm; ÇİL, ERGÜN; Tıp Fakültesi; 0000-0001-7707-2174; 0000-0002-8470-4907; 0000-0003-3516-0082; AAH-3865-2021; AAG-8558-2021; AAG-9324-2021; AAH-4421-2021; H-2691-2017Publication The role of external loop recorders in arrhythmia-related symptoms in children: A single center experience(Springer, 2021-08-13) Akça, Tuğberk; Uysal, Fahrettin; Bostan, Özlem Mehtap; Genç, Abdusselam; Türkmen, Hasan; AKÇA, TUĞBERK; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; GENÇ, ABDÜSSELAM; TÜRKMEN, HASAN; Tıp Fakültesi; Çocuk Kardiyoloji Bölümü; 0000-0001-7707-2174; 0000-0002-2747-974X; AEX-4557-2022; AAH-4421-2021; AAG-8558-2021; CQK-7120-2022; JKC-8556-2023In this study, we report our experience with the use of external loop recorders (ELRs), in terms of diagnostic efficiency according to symptoms and symptom-rhythm correlation in pediatric patients. We evaluated ELRs applied to 178 patients between April 2017 and November 2020 at our center. The mean age of 172 patients included in the study was 13.6 +/- 3.8 years, and 69.8% were female. ELR indications were palpitations in 98 (56.9%) cases, chest pain and palpitations in 43 (25%) cases, presyncope/syncope in 28 (16.2%) cases, and pacemaker/ implantable cardioverter-defibrillator (ICD) problems in 3 (0.2%) cases. ELR recording times were 14.2 +/- 9.7 days on average, ranging from 2 to 67 days. While the symptom-rhythm correlation was 29.1% in total, when the indications were evaluated one by one, this correlation was found to be 30.2% in palpitations, 34.7% in chest pain and palpitations, and 10.7% in presyncope/syncope. The total diagnostic efficiency was 68.1%. In the follow-up of ELR cases, a total of 139 (80.8%) patients received clinical follow-up without medication, 15 (8.8%) patients received medical treatment, and 18 (10.4%) patients underwent EPS. The cardiac ELR system is useful in detecting underlying arrhythmias. Demonstrating sinus tachycardia at the time of the symptom may be seen as negative finding, but while experiencing symptoms, it is diagnostically valuable and may help avoid further investigation with costly and invasive diagnostic procedures. For diagnostic efficiency and cost effectiveness, the optimal recording time is 2 weeks, but it should be extended to 4 weeks in cases such as of presyncope/syncope that cannot be explained with a 2-week ELR use.Publication The frequency of asymptomatic urinary system abnormalities in children detected with cineurography imaging during angiocardiography(Cambridge Univ Press, 2019-02-01) Oral, Orçun; Toprak, Muhammet Hamza Hata; Uysal, Fahrettin; Bostan, Özlem Mehtap; Çil, Ergün; Toprak, Muhammet Hamza Hata; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Bursa Uludağ Üniversitesi; 0000-0001-7707-2174; 0000-0003-3516-0082; AAG-9324-2021; AAH-4421-2021; AAG-8558-2021; AAH-3865-2021; ECM-4447-2022Introduction: Diagnostic and interventional catheter angiography of the heart is frequently used in paediatric cardiology. It is also possible to detect urinary system anomalies with cineurography images that may be obtained during angiocardiography. In this study, the aim was to determine the frequency, distribution, and properties of urinary system anomalies accompanying heart diseases, and to find out the effectiveness of cineurographic images in detecting the urinary system anomalies. Methods: The cineurographic images of 2022 children who had undergone angiocardiography between 1995 and 2015 were retrospectively examined. Results: Urinary system anomalies were detected in 261 of the 2022 cases (12.9%). Of these 261 cases, 148 were males (56.7%), whereas 113 were females (43.3%). Among the heart diseases, the group most accompanied by urinary system anomalies was the non-cyanotic left-to-right shunted heart diseases, which was detected in 120 (39.1%) patients. Pelvicalyceal ectasia was the most common urinary system anomaly encountered and was detected in 89 patients (34.1%). Of the urinary system anomalies cases, 94 detected by cineurography were determined to be clinically severe. When the effectiveness of the cineurography was evaluated using the ultrasonography records of the patients, it was found to have 63.8% accuracy. Conclusion: Many of the patients with CHDs concomitantly have urinary system anomalies. It is possible to determine asymptomatic urinary system anomalies using cineurographic imaging during angiocardiography. This may lead to earlier treatments and improved prognosis for the patients, thus making it possible to prevent potential future problems.Publication Effects of levetiracetam treatment on autonomic nervous system functions in pediatric epilepsy patients(Wiley, 2023-01-01) Direk, Meltem Çobanoğulları; Epcacan, Serdar; Özdemir, Asena Ayca; Okuyaz, Çetin; Uysal, Fahrettin; UYSAL, FAHRETTİN; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; AAH-4421-2021Background: This study investigated the effects of levetiracetam (LEV) treatment on cardiac rhythm and heart rate variability.Methods: The study included two groups of patients diagnosed with non-lesional epilepsy who had not yet been treated and who presented to the outpatient pediatric neurology clinic at Van Training and Research Hospital, Van, Turkey, between 2019 and 2020. The heart rate variability (HRV) of 47 patients in the first group, before and at the 3rd month of treatment, and intravenous (IV) LEV loading in 13 patients in the second group was evaluated by Holter electrocardiography (ECG).Results: It was determined that the values of triangular index, standard deviation of the RR intervals over a 24-hour period (SDNN), standard deviation of all 5-minute mean RR intervals (SDANN), mean of standard deviations of all normal RR intervals (SDNNI), the percentage of RR intervals with >50-millisecond variation (PNN50), and the square root of mean squared differences of successive RR intervals (RMSSD). HRV of 47 patients under LEV treatment significantly increased in the 3rd month of treatment compared to baseline (p < 0.05). No difference was found in HRV between the intravenous loading and the control group (p > 0.05).Conclusions: Our study suggests that the sympathovagal balance before treatment in the patient group is in favor of the sympathetic nervous system and that the sympathovagal imbalance improves after treatment. Our results show that LEV monotherapy and loading have no negative effect on HRV and potential cardiac arrhythmia risk in children with epilepsy.Publication A rare and fatal cause of hypertrophic cardiomyopathy: Danon disease(Cambridge Univ Press, 2023-01-05) Türkmen, Hasan; TÜRKMEN, HASAN; Uysal, Fahrettin; UYSAL, FAHRETTİN; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Tıp Fakültesi; Pediatri Ana Bilim Dalı; 0000-0001-7707-2174Danon disease is a rare and fatal disease caused by a mutation in the lysosome-associated membrane protein 2 gene. Impaired intracellular autophagy causes lysosomal vacuoles to accumulate mainly in myocardial and skeletal muscle cells, leading to hypertrophic cardiomyopathy, skeletal myopathy, and varying degrees of intellectual disability. Two distinct childhood presentations of Danon disease are described in this report.