Person: SAĞDİLEK, ENGİN
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SAĞDİLEK
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ENGİN
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Publication Cytidine 5′-diphosphocholine differentially affects hemostatic parameters in diverse conditions in rats: An investigation via thromboelastography(Lippincott Williams & Wilkins, 2015-04-01) Çam, Betül; Sağdilek, Engin; Yıldırım, Nalan; Savcı, Vahide; Çam, Betül; SAĞDİLEK, ENGİN; Yıldırım, Nalan; SAVCI, VAHİDE; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0001-8696-4035; KHD-9454-2024; AAH-4397-2021; CGO-3719-2022; GIK-1812-2022Cytidine 5'-diphosphocholine (CDP-choline) has several physiological and pharmacological effects on various bodily functions, including hemostasis. This study determined the impact of CDP-choline on hemostasis in a trauma-hemorrhage (T-H) model in rats or under in vitro conditions or after chronic treatment via thromboelastography. Trauma-hemorrhage resuscitation was induced, and either saline (1 mL/kg) or CDP-choline (50 mg/kg) was injected intravenously just prior to resuscitation in the T-H group and at the same time point in the sham-control group. The effects of CDP-choline on thromboelastogram parameters, coagulation markers, and platelet aggregation were investigated under in vitro conditions (1.5 mM, 30- or 3-min incubation in blood or plasma) and after chronic use (50 mg/kg, i.p., 10 days). Acute CDP-choline treatment was shown to decrease the initial and maximum clot formation time, accelerate clotting rapidity, reduce the lysis percentage, and increase the coagulation index in the T-H resuscitation group, whereas the same treatment in the sham-control rats did not alter any of the thromboelastogram parameters. However, the incubation of whole blood with CDP-choline prolonged the initial and maximum clot formation time, and CDP-choline treatment significantly decreased the slopes of the disaggregation and aggregation curves when platelets were stimulated with ADP and collagen, respectively. Interestingly, the chronic use of this drug did not influence any of these hemostatic parameters. These data implicate that acute but not chronic CDP-choline administration may differentially alter the hemostatic parameters under diverse conditions. The drug may produce a hypercoagulable state in activated situations but cause opposite effects under normal in vitro conditions.Publication The effect of exosomes released from apheresis plateletconcentrates under the impact of gamma irradiation and storage time upon platelet aggregation and hemostasis(Simtipro Srl, 2023-05-01) Bal, Salih Haldun; Sağdilek, Engin; Karacay, Mehmet; Kızmaz, Muhammed A.; Kumaş, Levent T.; Can, Fatma E.; Yıldırım, Muzaffer; Canavar-Yıldırım, Tuğçe; Kosay-Gülkaya, Deniz; Yöyen-Ermiş, Diğdem; Budak, Ferah; Heper, Yasemin; Gürsel, İhsan; Oral, Haluk B.; BAL, SALİH HALDUN; SAĞDİLEK, ENGİN; Karaçay, Mehmet; Kizmaz, Muhammed A.; Kumaş, Levent T.; Can, Fatma E.; Kosay-Gülkaya, Deniz; YÖYEN ERMİŞ, DİĞDEM; BUDAK, FERAH; HEPER, YASEMİN; ORAL, HALUK BARBAROS; Tıp Fakültesi; Dr. Raşit Durusoy Kan Bankası; 0000-0001-7625-9148 ; 0000-0001-5871-8769 ; 0000-0001-5334-7911 ; 0000-0002-1953-7735; 0000-0002-1953-7735; HJY-9001-2023; AAH-4397-2021; JHB-7829-2023; HKN-2347-2023; FHB-1791-2022; JSL-7718-2023; HJH-5312-2023; HJH-5217-2023; IYU-6844-2023; AAH-3888-2021; IZP-9398-2023; HOK-0035-2023; K-7285-2012Background -Blood components should be gamma-irradiated (& gamma;-IR) in order to prevent transfusion-associated graft-versus-host disease. The aim of this study is to determine the effect of & Gamma;-IR and storage time on the exosomes released from apheresis platelet concentrates (aPC) and to investigate their impact on the maximum platelet aggregation (MPA) and hemostasis. Materials and methods -Eight units of aPC were included in this study. These were divided into four equal portions. Two portions were irradiated before storage while the other two were not. Thus, irradiated and non-irradiated aPC samples for storage Days 0 (D0) and 5 (D5) were obtained. Exosomes were isolated from these samples using a commercial kit and were evaluated to ascertain their parent cells by flow cytometry. For the following steps, exosomes were pooled according to their features. Pooled exosomes were then used for aggregometry and thromboelastography. Results -Platelet-derived exosome (PD-EX) levels decreased in D5 compared to D0 in NI-aPC, whereas granulocyte-derived exosome (GD-EX) levels increased. Exosome pools had no effect on MPA compared to saline groups. Exosome pools decreased the time to initial fibrin formation (R), whereas they increased the rate of clot formation (& alpha;-angle) and coagulation index (CI) compared to saline groups. Discussion -Storage time and & Gamma;-IR each have almost the opposite effects on PD-EX and GD-EX. Exosomes have no impact on MPA, but enhance the clot strength. The impact of exosomes on aPC quality and effectiveness can be ignored or considered as a positive effect.Publication Instruction-based selective action pattern (IBSAP): A novel method for talent identification in sports(Iermakov S S, 2019-01-01) Sağdilek, E.; Sahin, S. K.; SAĞDİLEK, ENGİN; Şahin, Şengül K.; Tıp Fakültesi; Sporda Antrenörlük Eğitimi Bölümü; 0000-0001-8696-4035; 0000-0002-5670-7166; AAH-4397-2021; AAI-2398-2019Purpose: Talent identification/development programs are utilized by sports federations to select or train elite athletes. In addition to the established tests that assess perceptive and motor skills, it was deemed significant that cognitive skills should be evaluated as well. The present study was undertaken to assess the utility of Instruction-Based Selective Action Pattern (IBSAP), a novel method that we developed, in estimating perceptive, motor as well as cognitive skills of athletes in order for talent identification. We also investigated the relationship between IBSAP and auditory reaction times (ARTs).Material: Forty-three students (average age: 12.6 years) participated in the study. Random/fixed-interval ARTs were recorded. IBSAP was applied using a table tennis robot that was set up to throw 30 balls in three different colors to different spots on the table with a frequency of 1 ball/s. The subjects were instructed to ignore the white balls, to touch the yellow balls, and to catch the pink balls before the first trial and their scores were calculated in two consecutive trials according to a scoring system.Results: Our results showed that motor learning, adaptation and reinforcement of the participants were significantly greater in second trial compared with the first trial and that IBSAP values were correlated with ARTs.Conclusions: We conclude that the IBSAP method reliably provides quantitative data on perception, motor as well as cognitive skills and it can be considered as a useful tool for talent identification.Publication Acute effects of different types of exercises on peripheral neurotrophic factors and cognitive functions in veteran athletes(Springernature, 2023-12-12) Birinci, Yakup Zühtü; Sağdilek, Engin; Taymur, İbrahim; Budak, Ersin; Beyaz, Aylin; Vatansever, Şerife; Pancar, Serkan; Topçu, Hüseyin; Sarandöl, Emre; Şahin, Şenay; Birinci, Yakup Zühtü; SAĞDİLEK, ENGİN; BEYAZ, AYLİN; SARANDÖL, EMRE; Topçu, Hüseyin; Şahin, Şenay; Vatansever, Şerife; Tıp Fakültesi; Antrenörlük Eğitimi Bölümü; 0000-0002-5670-7166 ; JUJ-2351-2023; AAH-4397-2021; JUJ-6778-2023; CEW-0665-2022; JUL-3582-2023; JUK-3929-2023; AEE-5817-2022PurposeDespite the clear relationship between exercise and brain health, our knowledge on the cellular and molecular mechanisms that trigger such benefits is still limited. We investigated the acute effects of aerobic running (physical exercise, PE), chess (cognitive exercise, CE), and table tennis (PE + CE) exercises on serum brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and irisin levels and cognitive functions in veteran male athletes.Methods10 table tennis athletes (TT), ten long-distance runners (LR), ten chess players (CP) between the ages of 50-65 performed 40 min of exercise sessions in their own branches while ten sedentary controls (SC) rested. Before and immediately after exercise, blood samples were obtained, and cognitive function tests [Stroop (ST), Trail Making A/B (TMT A/B), and Mental Rotation (MR), respectively] were conducted.ResultsBDNF and irisin levels increased in the TT group post-exercise (p < 0.05). TT and LR groups showed better TMT A-B, ST, and MR performances post-exercise (p < 0.05), whereas the CP group showed better TMT B and MR performances (p < 0.05). The percent change in BDNF levels in the TT group was greater than CP and SC groups (p < 0.05) whereas there were no significant differences between groups in cognitive test performances.ConclusionOur findings indicate that performing any routine exercise by veteran athletes has acute beneficial effects on cognitive functions. Table tennis is effective in elevating serum BDNF and irisin levels without additive effect in serum neurotrophic factors and cognitive test performances compared to aerobic running.Publication Investigation of the effects of SARS Cov2 spike protein S1 subunit on hemostasis by thromboelastogram(Wiley, 2023-12-01) Özer, Fatma; Gürel, Öznur; Sağdilek, Engin; Kılınç, Evren; Özer, Fatma; Gürel, Öznur; SAĞDİLEK, ENGİN; Sağlık Bilimleri Enstitüsü; Fizyoloji Bilim Dalı; JGQ-6634-2023; JZJ-2485-2024; AAH-4397-2021