Person: SAVCI, VAHİDE
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Publication Cytidine 5′-diphosphocholine differentially affects hemostatic parameters in diverse conditions in rats: An investigation via thromboelastography(Lippincott Williams & Wilkins, 2015-04-01) Çam, Betül; Sağdilek, Engin; Yıldırım, Nalan; Savcı, Vahide; Çam, Betül; SAĞDİLEK, ENGİN; Yıldırım, Nalan; SAVCI, VAHİDE; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0001-8696-4035; KHD-9454-2024; AAH-4397-2021; CGO-3719-2022; GIK-1812-2022Cytidine 5'-diphosphocholine (CDP-choline) has several physiological and pharmacological effects on various bodily functions, including hemostasis. This study determined the impact of CDP-choline on hemostasis in a trauma-hemorrhage (T-H) model in rats or under in vitro conditions or after chronic treatment via thromboelastography. Trauma-hemorrhage resuscitation was induced, and either saline (1 mL/kg) or CDP-choline (50 mg/kg) was injected intravenously just prior to resuscitation in the T-H group and at the same time point in the sham-control group. The effects of CDP-choline on thromboelastogram parameters, coagulation markers, and platelet aggregation were investigated under in vitro conditions (1.5 mM, 30- or 3-min incubation in blood or plasma) and after chronic use (50 mg/kg, i.p., 10 days). Acute CDP-choline treatment was shown to decrease the initial and maximum clot formation time, accelerate clotting rapidity, reduce the lysis percentage, and increase the coagulation index in the T-H resuscitation group, whereas the same treatment in the sham-control rats did not alter any of the thromboelastogram parameters. However, the incubation of whole blood with CDP-choline prolonged the initial and maximum clot formation time, and CDP-choline treatment significantly decreased the slopes of the disaggregation and aggregation curves when platelets were stimulated with ADP and collagen, respectively. Interestingly, the chronic use of this drug did not influence any of these hemostatic parameters. These data implicate that acute but not chronic CDP-choline administration may differentially alter the hemostatic parameters under diverse conditions. The drug may produce a hypercoagulable state in activated situations but cause opposite effects under normal in vitro conditions.Publication Central injection of CDP-choline suppresses serum ghrelin levels while increasing serum leptin levels in rats(Elsevier, 2015-07-06) Kıyıcı, Sinem; Başaran, Nesrin Filiz; Çavun, Sinan; Savcı, Vahide; Kıyıcı, Sinem; Başaran, Nesrin Filiz; ÇAVUN, SİNAN; SAVCI, VAHİDE; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0002-0076-6554; AAC-9702-2019; KHD-9454-2024; FGL-7924-2022; GBK-8383-2022In this study we aimed to test central administration of CDP-choline on serum ghrelin, leptin, glucose and corticosterone levels in rats.lntracerebroventricular (i.c.v.) 0.5,1.0 and 2.0 mu mol CDP-choline and saline were administered to male Wistar-Albino rats. For the measurement of serum leptin and ghrelin levels, blood samples were obtained baseline and at 5, 15, 30, 60 and 120 min following i.c.v., CDP-choline injection. Equimolar doses of i.c.v. choline (1.0 mu mol) and cytidine (1.0 mu mol) were administered and measurements were repeated throughout the second round of the experiment. Atropine (10 mu g) and mecamylamine (50 mu g) were injected intracerebroventricularly prior to CDP-choline and measurements repeated in the third round of the experiment. After 1 mu mol CDP-choline injection, serum ghrelin levels were suppressed significantly at 60 min (P=0.025), whereas serum leptin levels were increased at 60 and 120 min (P=0.012 and P=0.017 respectively). CDP-choline injections also induced a close- and time-dependent increase in serum glucose and corticosterone levels. The effect of choline on serum leptin and ghrelin levels was similar with CDPcholine while no effect was seen with cytidine. Suppression of serum ghrelin levels was eliminated through mecamylamine pretreatment while a rise in leptin was prevented by both atropine and mecamylamine pretreatments.In conclusion; centrally injected CDP-choline suppressed serum ghrelin levels while increasing serum leptin levels. The observed effects following receptor antagonist treatment suggest that nicotinic receptors play a role in suppression of serum ghrelin levels,whereas nicotinic and muscarinic receptors both play a part in the increase of serum leptin levels. (C) 2015 Elsevier B.V. All rights reserved.Publication Central histaminergic system mediates prostaglandin cascade induced cardiovascular effects(Federation Amer, 2013-04-01) Yalçın, Murat; Altınbaş, Burçin; Topuz, Bora Burak; Yılmaz, Mustafa Sertaç; Savcı, Vahide; Aydın, Sami; YALÇIN, MURAT; Altınbaş, Burçin; Topuz, Bora Burak; YILMAZ, MUSTAFA SERTAÇ; SAVCI, VAHİDE; Aydın, Sami; Fen Edebiyat Fakültesi; Fizik Bölümü; 0000-0002-5600-8162; 0000-0001-9496-1475; AAG-6956-2021; IYS-2646-2023; KHD-9454-2024; AAH-1571-2021; EBJ-3864-2022; CCT-7508-2022Publication The effect of centrally and peripherally injected cdp-choline on plasma nesfatin-1 level in rats(Ankara Univ Press, 2019-01-01) Usta, Hikmet Ayşin; Güvenç, Gökçen; Savcı, Vahide; SAVCI, VAHİDE; Yalçın, Murat; YALÇIN, MURAT; Tıp Fakültesi; Farmakoloji Ana Bilim Dalı; 0000-0002-1413-3651; 0000-0002-5600-8162; KHD-9454-2024; AAG-6956-2021; AAR-6815-2021Nesfatin-1 has a role in appetite control and energy balance. The activity of the cholinergic system also is able to affect feeding behavior. Moreover, the central cholinergic system interacts with central nesfatinergic systems. The main goal of the study was to determine the effect of intracerebroventricular (icv) and intravenous (iv) administrated CDP-choline (0.5 ve 1 mu mol; icv ve 250 mg / kg; iv) on levels of plasma nesfatin-1 in the homogeneous number of male and female fasted and the satiated Wistar albino rats. The polyethylene cannula was inserted into the carotid artery and jugular vein of the rats anesthetized with sevoflurane (2-4%/100% O-2) to collect blood samples and to make iv injection, respectively. For icy treatment, the lateral ventricle of rats was cannulated with guide cannula. The basal levels of plasma nesfatin- I in the satiated rats were higher than those observed in the fasted animals. While 0.5 and 1 mu mol dose of icy and/or 250 mg/kg dose of iv injected CDP-choline increased the level of plasma nesfatin-1 in the satiated rats, plasma nesfatin-1 level of the fasted animals decreased after the same dose and route of CDP-choline injection. The current findings show that CDP-choline can influence the level of plasma nesfatin-1 in the rats. The effect of the drug was different according to the food intake of the rats. These data might suggest a potential role in CDP-choline on plasma nesfatin-1 concentration.Publication CDP-choline protects against sepsis-induced acute tissue injury in rats(Federation Amer, 2013-04-01) Yılmaz, Mustafa Sertaç; Sevim, Çiğdem; Altınbaş, Burçin; Özyiğit, Musa Özgür; Savcı, Vahide; Yalçın, Murat; YILMAZ, MUSTAFA SERTAÇ; Sevim, Çiğdem; Altınbaş, Burçin; ÖZYİĞİT, MUSA ÖZGÜR; SAVCI, VAHİDE; YALÇIN, MURAT; Veteriner Fakültesi; Fizyoloji Bölümü; 0000-0001-9496-1475; 0000-0002-5600-8162; 0000-0002-9534-736X; 0000-0002-0575-3090; AAG-6956-2021; IYS-2646-2023; AAH-2873-2021; AAH-1571-2021; AAR-6478-2021; KHD-9454-2024; JED-7015-2023