Person: KESKİN, ABDULKADİR
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KESKİN
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ABDULKADİR
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Publication Distributions of CYP19, ERα and PGR allele frequencies between fertile and subfertile Holstein-Friesian heifers(Kafkas Üniversitesi, 2015-11-01) Keskin, Abdulkadir; Öner, Yasemin; Yılmazbaş-Mecitoğlu, Gülnaz; Güner, Barış; Karakaya, Ebru; Elmacı, Cengiz; Gümen, Ahmet; KESKİN, ABDULKADİR; ÖNER, YASEMİN; MECİTOĞLU, GÜLNAZ; Güner, Barış; Karakaya, Ebru; ELMACI, CENGİZ; GÜMEN, AHMET; Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; Uludağ Üniversitesi/Ziraat Fakültesi/Hayvan Bilimleri Biyometri ve Genetik Bölümü.; 0000-0002-2904-8986; 0000-0003-2817-3221; 0000-0001-6414-6752; 0000-0003-4837-1858; 0000-0003-4819-0221; 0000-0002-3607-4365; V-7882-2019; AIF-3815-2022; ABB-3181-2020; AAH-3831-2021; AAH-1406-2021; AAG-4440-2019; AGY-3496-2022; ABG-2047-2020The aim of this study was to investigate the gene and genotype distributions of some mutations in the aromatase cytochrome P450 (CYP19), estrogen receptor alpha (ER alpha), and progesterone receptor (PGR) genes in fertile and subfertile Holstein-Friesian heifers using the PCR-RFLP method and comparing the distributions between groups. A total of 106 heifers were included the study, and the heifers that became pregnant after the first artificial insemination (n=51) were used as a fertile group. Heifers (n=55) with equal and more than 3 AIs were accepted as a subfertile heifers. Blood samples from all of the heifers were obtained for DNA isolation. While two alleles and three genotypes were found at the PGR and ER alpha loci, two alleles and two genotypes were detected at the CYP19 locus. The A allele and AA genotype, G allele and GG genotype, and C allele and CT genotype were found to be predominant in CYP19, ER alpha and PGR, respectively. According to the chi-square test (chi(2)), two of the groups investigated were in Hardy-Weinberg equilibrium for all gene loci. There were no differences detected in allele or genotype frequencies between the fertile and subfertile heifers.Publication Butaphosphan and cyanocobalamin treatment of pregnant ewes: Metabolic effects and potential prophylactic effect for pregnancy toxaemia(Elsevier, 2015-04-01) Temizel, Ethem Mutlu; Batmaz, Hasan; Keskin, Abdülkadir; Orman, Abdülkadir; Gençoğlu, Hıdır; Çatık, Serkan; Topal, Onur; TEMİZEL, ETHEM MUTLU; BATMAZ, HASAN; KESKİN, ABDULKADİR; ORMAN, ABDÜLKADİR; GENÇOĞLU, HIDIR; Çatık, Serkan; TOPAL, ONUR; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı; 0000-0001-9138-4422; 0000-0002-1933-7354; 0000-0003-1991-8957; HJZ-4775-2023; AAH-1712-2021; AAH-3831-2021; AAG-9134-2021; S-8278-2017; ECV-4083-2022; CHM-0716-2022The effect of administration of butaphosphan and cyanocobalamin on the prophylaxis of pregnancy toxaemia in ewe was investigated. Moreover, the effects of these compounds on body weight gain and biochemical metabolism of pregnant ewe was assessed. A total of 59 pregnant Kivircik crossbred ewes were used in this study. Group I (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 1-week intervals. Group II (n: 15) was administered butaphosphan and cyanocobalamin three times before delivery at 3-day intervals. Group III (n: 15) was administered 0.9% NaCl three times before delivery at 1-week intervals. Group IV (n: 14) was administered 0.9%NaCI three times before delivery at 3-day intervals. Six blood samples Were taken from each ewe four times before delivery and two times after delivery. Haematological and biochemical analyses were performed.The levels of BHB and NEFA in groups administered butaphosphan and cyanocobalamin were noticeably lower but there were no statistically significance. Elevated BHB (>0.8 mmol/L), subclinical pregnancies toxaemia were identified in 56.66% in test groups and 72.41% in control groups in all ewes and this was higher in the ewes bearing multiple pregnancies 71.42 in test groups and 82.35% in control groups. Subclinical pregnancy toxaemia in pregnant ewes with twins or triplets is lower than the levels for the control groups, despite the greater lamb counts and weights of the ewes in test groups.Based on our results, it was concluded that the butaphosphan and cyanocobalamin combination could be used as an alternative treatment for the prevention of pregnancy toxaemia. (C) 2015 Elsevier B.V. All rights reserved.Publication Comparison of the impacts of medet omidi ne/ke tamin e and medetomidine/propofol anesthesia and their reversal by atipamezole on echocardiographic values in dogs(Aves, 2022-09-01) Kibar, Murat; Aytmirzakizi, Ayperi; Öztürk, Zeynep; Keskin, Abdulkadir; KESKİN, ABDULKADİR; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji ve Doğum Anabilim Dalı.; 0000-0003-1791-1401The reaction of the cardiovascular system to anesthetics can be various and different, based on dosing, the experimental model, and agent sele-ction. A few studies have compared the effects of different anesthetic agents used for trans-thoracic echocardiography on cardiac functions in dogs; however, none of these studies examined the effects of different anesthetic regimes and their reversal by atipamezole echoc ardio graph icall y. The aim of this study was to investigate, visualize, and clarify in vivo both the short-term echocardiographic impacts of medet omidi ne-ke tamin e and medet omidi ne-pr opofo l anesthesia regimes and their reversal in dogs. Twenty sexually intact female dogs (weighing between 5.7 and 14.5 kg and 0.5-3 years of age) referred for ovariohysterectomy procedure from a local shelter at regular intervals over 3 months were included in the study. Echocardiographic measurements of the two-dimensional guided M-mode echocardiography were conducted with the dogs positioned in right lateral recumbence. Both groups showed declines in interventricu-lar septum percent, left ventricular diameter percent, and left ventricular ejection fraction after anesthesia induction (baseline vs. T1, all, p < .05); nevertheless, the reduction and starting pattern of interventricular septum percent, left ventricular diameter percent, and left ventricular ejection fra-ction presented important intergroup distinction. The echocardiographic values were affected significantly after anesthesia with medet omidine- ketamin e and medet omidi ne-pr opofo l; atipamezole can be useful for return to baseline values quickly and safely in dogs after abdominal sur-gery such as ovariohysterectomy.Publication Mammary hyperplasia in a pregnant queen(Australian Small Animal Veterinary Assoc, 2008-06-01) Keskin, Abdulkadir; Yılmazbaş, Gülnaz; Şimşek, Gözde; Seyrek-İntas, Kamil; KESKİN, ABDULKADİR; Yılmazbaş, Gülnaz; Şimşek, Gözde; Seyrek-İntas, Kamil; Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji Anabilim Dalı.; 0000-0003-2817-3221; AAH-7292-2019; AAH-3831-2021; AAG-4440-2019; DRG-7451-2022Mammary hyperplasia producing severe swelling and ulceration of the mammary glands occurred during late gestation in a 10-month-old queen. Inguinal and caudal abdominal mammary glands and the left cranial abdominal mammary gland were asymmetrically and diffusely enlarged. Mammary gland skin was ulcerative and necrotic, and milk was leaking from the affected areas. To prevent mastitis the queen received topical antibacterial and anti-inflammatory drugs and systemic antibacterial and antiprolactin drugs. At the end of the first week following parturition, the majority of the mammary glands had regressed significantly with complete regression 14 days later.