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KARESİOĞLU, EMİNE

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KARESİOĞLU

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    Serum pNF-H levels in the first six hours after experimental mild traumatic brain injury in rats
    (Verduci Publisher, 2022-01-01) Karesioğlu, E.; Çıkrıklar, H. I.; Durak, V. A.; Aydın, B.; Ardıç, A.; Armağan, E.; KARESİOĞLU, EMİNE; ÇIKRIKLAR, HALİL İBRAHİM; DURAK, VAHİDE ASLIHAN; AYDİN, BİRNUR; Ardıç, Aslıgül; Armağan, Ersin; Tıp Fakültesi; Acil Tıp Bölümü; 0000-0003-0836-7862; 0000-0002-8193-474X; HEI-9103-2022; AAH-8714-2021; AAE-9483-2021; ADT-6417-2022; EKH-5913-2022; CBW-8706-2022
    OBJECTIVE: Mild traumatic brain injury (mTBI) cases with a normal CT scanning account for the vast majority of all TBI patients. The aim of this study was to investigate the course of serum Phosphorylated Neurofilament Heavy Chain (pNF-H) levels in the first six hours after trauma in rats in experimental mTBI.MATERIALS AND METHODS: In this experi-mental animal study, 32 female Sprague-Dawley rats were enrolled equally (n=8) into 3 experimen-tal groups and 1 control group. In experimental groups, animals were exposed to a mTBI with a free fall of 50-gram metal disc from a height of 80 cm. We compared serum pNF-H levels at the 2nd, 4th, and 6th hours after traumatic brain injury in the experimental groups with the control group.RESULTS: Serum pNF-H levels at the 2nd and 4th hours after traumatic brain injury were sta-tistically significantly higher than the control group. Serum pNF-H levels gradually decreased at the 4th and 6th hours compared to the 2nd hour and decreased to a similar level to the control group at the 6th hour after injury.CONCLUSIONS: A high serum pNF-H value, could be used in the diagnosis and management of mTBI patients.