Person: YILDIZ, MERAL
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YILDIZ
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MERAL
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Publication Comparison of two different evaluation methods for biofilm formation of S. epidermidis isolated from ocular surface(Assoc Research Vision Ophthalmology Inc, 2015-06-01) Budak, Berna Akova; Kıvanç, Sertaç Argün; Yıldız, Meral; Kıvanç, Merih; Güllülü, Gülay; Budak, Berna Akova; KIVANÇ, SERTAÇ ARGUN; YILDIZ, MERAL; Uludağ Üniversitesi; 0000-0003-0995-5260; AAH-1885-2021; AAH-6518-2021; ABE-3033-2020Publication The role of serial measurements of serum insulin-like growth factor 1 levels in the development of retinopathy of prematurity(Turkish Pediatrics Assoc, 2017-03-01) ÖZKAN, HİLAL; Dorum, Bayram Ali; Yılmaz, Cansu Canbolat; Köksal, Nilgün; YILDIZ, MERAL; Yıldız, Meral; Özmen, Ahmet Tuncer; ÖZMEN, AHMET TUNCER; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0002-2823-8454; AAH-1885-2021; AAG-8393-2021; A-5375-2017Aim: To determine the role of serum insulin-like growth factor-1 levels in the development of retinopathy of prematurity, which is a major cause of childhood blindness worldwide.Material and Methods: We prospectively studied newborn infants born at a postmenstrual age of < 32 weeks and birth weights < 1 500 gr, between January 1st, 2015, and December 31st, 2015. A total of 40 infants were enrolled in the study. The retinal examination time was determined in accordance with the American Academy of Pediatrics recommendations for retinopathy of prematurity screening and follow-up. Retinopathy of prematurity was classified according to the international classification of retinopathy of prematurity. Serum Insulin like growth factor 1 levels were measured serially in blood samples on the 1st, 3rd, 7th, 21st, and 28th day.Results: Among the 40 infants, 11 (27.5%) constituted the retinopathy of prematurity group and 29 comprised the non-retinopathy of prematurity group. In the retinopathy of prematurity group, the mean gestational age and birth weight was significantly lower. The demographic features of the study cohort were similar. The duration of mechanical ventilation was significantly greater in the retinopathy of prematurity group compared with the non-retinopathy of prematurity group (p=0.036). In terms of neonatal morbidities such as respiratory distress syndrome, intraventricular hemorrhage, bronchopulmonary dysplasia, patent ductus arteriosus, and necrotizing enterocolitis, no differences were detected between the groups. The mean serum insulin-like growth factor-1 levels in retinopathy of prematurity group were significantly lower than those in the non-retinopathy of prematurity group at each time point (1st, 3rd, 7th, 21st, and 28th day of postnatal life) (p=0.001).Conclusions: This study demonstrated the low serum insulin-like growth factor-1 levels was associated with retinopathy of prematurity development.Publication Discoid lupus erythematosus of the eyelid: Case report(Turkish Ophthalmological Soc, 2006-11-01) Yıldız, Meral; YILDIZ, MERAL; Yazıcı, Bülent; Filiz, Gülaydan; Yalçınkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0001-8889-1933; AAH-1885-2021; AAA-5384-2020; AAH-8924-2021Discoid lupus erythematosus is a chronic, autoimmune disease of the skin. Localized OLE involving the eyelid is seen rarely. In this report, a 28 year-old male who had a localized OLE involving the eyelid has been presented. The examination findings of the patient were a welldefined, slight elevated erythema through the right lower eyelid, scaling on the lesion and madarosis. The diagnosis was made by observing the typical histopatological changes such as hyperkeratosis, lymphoid infiltration at the dermoepidermal junction and telangiectasis in the substantia propria. The eyelid lesion totally disappeared with the treatment of 3 months-systemic hydorxychloroquine (200 mg/day). However, it recurred in the same region 14 months later. Discoid lupus did not recur after the second-systemic hydorxychloroquine treatment. Systemic lupus erythematosus did not develope in the patient followed-up for 40 months.Publication Herpes zoster ophthalmicus and lateral rectus palsy in an elderly patient(Karger, 2011-01-01) Yalçınbayır, Özgür; Yıldız, Meral; Gündüz, Gamze Ucan; Gelişken, Öner; YALÇINBAYIR, ÖZGÜR; YILDIZ, MERAL; UÇAN GÜNDÜZ, GAMZE; Gelişken, Öner; Tıp Fakültesi; Göz Hastalıkları Ana Bilim Dalı; 0000-0002-7311-5277; 0000-0002-5458-1686; HPH-3842-2023; AAH-6661-2021; KBU-8934-2024; EXE-4887-2022Acquired palsy of the lateral rectus presents with horizontal diplopia and has a broad differential. Herpes zoster ophthalmicus-(HZO) related cranial nerve palsy is a transient and self-limiting condition. Systemic antiviral treatment is administered in order to prevent sight-threatening complications. In suspected cases, zosteriform rash should be questioned. One should keep in mind that acquired esotropia in the elderly may sometimes present following HZO.Publication Anatomical and the refractive outcomes in the eyes undergoing laser photocoagulation for retinopathy of prematurity(Galenos Yayincilik, 2009-09-01) YILDIZ, MERAL; ÖZMEN, AHMET TUNCER; YALÇINBAYIR, ÖZGÜR; Yalçınbayır, Özgür; Ayvaz, Ayse Tor; Kaderli, Berkant; Avcı, Remzi; Gelişken, Öner; Tıp Fakültesi; Göz Hastalıkları Ana Bilim Dalı; 0000-0002-7311-5277; 0000-0001-9581-4856; AAH-6625-2021; IYJ-9408-2023; JAC-9459-2023Aim: This study aimed to evaluate the anatomical and the refractive outcomes in cases that underwent laser photocoagulation (LP) for retinopathy of prematurity (ROP).Materials and Method: Medical records of 38 cases that underwent LP for ROP in Uludag University Department of Ophthalmology, between 2004 and 2008, were reviewed. LP was performed in 73 eyes. Stages of ROP before and after LP were recorded. Additionally gestational age and birth weight, complications, sciascopic refractions were assessed and visual acuities were evaluated with "Teller Acuity Cards".Results: Gestational age ranged from 26 to 34 weeks, (mean 29+/-2 weeks), birth weight ranged from 850 g to 1950 g (mean 1262+/-304 g). Among all cases in the study 89%, responded with a remarkable regression of ROP with LP treatment. However, 8 eyes progressed to stage 4 and 5 despite treatment. Three eyes developed vitreous hemorrhage and 2 eyes developed preretinal hemorrhage. In the 6th month of the corrected age, spherical equivalent ranged between -8D to + 2.5D, however it ranged between -11D to + 2D in the 12th month. Hyperopia was present in 53% of all eyes and myopia was present in 25.5%. Mean visual acuity was 3.5 cpd (1.3-6.4) in the 6th month of the corrected age whereas it was 6.2 cpd (1.3-9.6) in the 12th month.Conclusion: Adequate and appropriate treatment with LP, has led to fair visual outcomes and an evident regression of ROP in all cases of the study group. Besides, hypermetropia was detected more commonly.Publication Investigation of tnf-alpha gene (g308a) and gstp1 gene (ile105val) polymorphisms in Turkish patients with retinopathy of prematurity(Tubitak Scientific & Technological Research Council Turkey, 2015-01-01) Karkucak, Mutlu; Türe, Mehmet; Yıldız, Meral; ÖZMEN, AHMET TUNCER; YILDIZ, MERAL; Gülten, Emine Tuna; Sığırlı, Deniz; SIĞIRLI, DENİZ; Özmen, Ahmet Tuncer; Yakut, Tahsin; Tıp Fakültesi; Genetik Ana Bilim Dalı; AAH-1885-2021; AAA-7472-2021Background/aim: Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor- alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism.Materials and methods: Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, the polymerase chain reaction- restriction fragment length polymorphism method was used. In statistical analysis the significance level was determined as P < 0.05.Results: When the patient and control groups were compared in terms of TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, no statistically significant difference was found (P > 0.05).Conclusion: In our study, no correlation was identified between TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms and susceptibility for development of ROP. Further studies are required with more cases of ROP patients and other gene polymorphisms that could be related.Publication Nonperforating intrascleral stabbing for sutureless 23g sclerotomy closure(Lippincott Williams & Wilkins, 2023-02-01) YALÇINBAYIR, ÖZGÜR; Gündüz, Gamze Uçan; UÇAN GÜNDÜZ, GAMZE; Nizam, Sema; NİZAM TEKCAN, SEMA; Yıldız, Meral; YILDIZ, MERAL; Tıp Fakültesi; Oftalmoloji Ana Bilim Dalı; 0000-0002-7311-5277; 0000-0002-5458-1686; IYJ-9408-2023Purpose:The need for suturing leaking sclerotomies have not been eliminated completely in transconjunctival sutureless vitrectomy (TSV). This study aims to describe a novel technique for 23-gauge (G) sclerotomy closure in TSV surgery and discuss its effectiveness. Materials and Methods:Two hundred and thirty cases of 180 patients who underwent 23G TSV with various diagnoses were included to the study. Cases with connective tissue diseases, thin sclera, and significant conjunctival and scleral scarring were excluded. Nonperforating intrascleral stabbing (NIS) was performed to leaking 23G sclerotomies (n = 650) and 27G chandeliers (n = 84). Demographics, rate of sclerotomy closure with NIS procedure, the need for suturing, and complications of the procedure were recorded. Results:The overall success of NIS was found to be 91.0% in sclerotomies. Although 9.1% of sclerotomies required sutures, 592 of the 650 sclerotomies could be closed with NIS procedure (P < 0.001). Nonperforating intrascleral stabbing procedure helped close 98.8% of leaking 27G chandeliers. An average of 1.28 0.52 NIS attempts were needed for successful sclerotomy closure. Closure of sclerotomies with the NIS technique were somewhat related to the location of the sclerotomy, history of TSV and NIS, duration of TSV, and type of endotamponade. Hypotonia and choroidal detachment were seen in one case. No additional interventions were needed to normalize intraocular pressure in any case. Subconjunctival hemorrhage happened to be the leading complication of the procedure. Conclusion:NIS procedure seems as a practical, reproducible, cost-effective, and uncomplicated approach, which significantly reduces the need to suture 23G sclerotomies. Further studies are required.Publication The effect of the linezolid and the vancomycine on biofilm production that formed on two different acrylic hydrophobic intraocular lenses(Assoc Research Vision Ophthalmology Inc, 2015-06-01) Kıvanc, Sertaç Argün; Budak, Berna Akova; Yıldız, Meral; Kıvanç, Merih; KIVANÇ, SERTAÇ ARGUN; Budak, Berna Akova; YILDIZ, MERAL; Uludağ Üniversitesi; 0000-0003-0995-5260; AAH-1885-2021; GNH-1796-2022; ABE-3033-2020; AAH-6518-2021Publication Anti-tumor necrosis factor treatment in the management of pediatric noninfectious uveitis: Infliximab versus adalimumab(Mary Ann Liebert, Inc, 2021-01-28) Uçan Gündüz, Gamze; Yalçınbayır, Özgür; Çekiç, Şükrü; Yiıdız, Meral; Kılıç, Sara Şebnem; UÇAN GÜNDÜZ, GAMZE; YALÇINBAYIR, ÖZGÜR; ÇEKİÇ, ŞÜKRÜ; YILDIZ, MERAL; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Tıp Fakültesi; Pediatrik Alerji ve Klinik İmmünoloji; 0000-0002-5458-1686; 0000-0002-7311-5277; 0000-0002-9574-1842; 0000-0001-8571-2581; AAH-1885-2021; AAH-6625-2021; AAH-6661-2021; IYJ-9408-2023; AAH-1658-2021; JAC-9459-2023; L-1933-2017Purpose: Management of uveitis displays a particular challenge in childhood. This study aims to compare the efficacy and safety of infliximab (IFX) and adalimumab (ADA) in pediatric noninfectious uveitis that were refractory to conventional immunosuppresives.Methods: This retrospective single-center study included 33 patients who were treated with anti-tumor necrosis factor (TNF) agents (16 with IFX and 17 with ADA). Patients had diverse etiologies, including juvenile idiopathic arthritis, idiopathic uveitis, and Behcet's disease. Demographic characteristics, systemic diagnosis, findings of the ophthalmological examination, control of ocular inflammation, response to treatment, and the rate of clinical remission were studied.Results: Fourteen (87.5%) patients receiving IFX and 10 (58.8%) patients receiving ADA achieved response to treatment during the follow-up (P = 0.118). The agents were discontinued with complete clinical remission in 6 (37.5%) patients receiving IFX and in 2 (11.8%) patients receiving ADA (P = 0.118). Baseline visual acuities and parameters of inflammation improved significantly in both groups after anti-TNF therapy.Conclusion: Both IFX and ADA are safe and effective for pediatric noninfectious uveitis.Publication A case of orbital metastatic neuroblastoma misdiagnosed as orbital trauma(Galenos Yayıncılık, 2008-03-01) Yıldız, Meral; Yazıcı, Bülent; Demirkaya, Metin; Sevinir, Betül; YILDIZ, MERAL; Yazıcı, Bülent; Demirkaya, Metin; SEVİNİR, BETÜL BERRİN; Tıp Fakültesi; Çocuk Hastalıkları Ana Bilim Dalı; 0000-0001-8889-1933; 0000-0002-3232-7652; HPH-3842-2023; AAA-5384-2020; LHA-1061-2024; AAH-1570-2021Neuroblastoma may manifest with symptoms due to metastasis to the orbit. This condition may be mistaken for orbital trauma. In this report, a 10 months-old patient with metastatic orbital neuroblastoma who was previously diagnosed as orbital trauma has been presented. The presenting sypmtoms were left proptosis and the appearance of racoon eyes. The diagnosis of neuroblastoma was made by typical radiological study, blood and urine findings and bone marrow aspiration biopsy. The ophthalmological findings regressed after multiple chemotherapy with multidrug and disappeared 5 months after the treatment. However, 10 months after the initiation fo the treatment, the patient was lost due to bone and lung metastasis and fulminating sepsis secondary to febrile neutropeni.