Person: ÖZ ATALAY, FATMA
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ÖZ ATALAY
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FATMA
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Publication Omental micrometastasis in endometrial cancer(Karger, 2019-01-01) Bayrak, Mehmet; Yılmaz, Alpay; Yılmaz, Fatih; İlhan, Olcay; Atalay, Fatma Öz; Ozan, Hakan; Bayrak, Mehmet; Yılmaz, Fatih; İlhan, Olcay; ÖZ ATALAY, FATMA; OZAN, HAKAN; Tıp Fakültesi; Cerrahi Patoloji Kliniği; 0000-0002-9910-8032; 0000-0002-5820-3754; DUU-5336-2022; C-5252-2015; CXA-2700-2022; JHC-4482-2023; DKZ-4159-2022Introduction: Although there are several reports on omentum metastasis, limited studies have evaluated omental micrometastases, particularly isolated microscopic metastases in endometrial cancer (EC). We performed this study to assess the frequency of omental micrometastasis in EC, especially when the omentum is the only site of extrauterine spread. Methods: A retrospective study was conducted to assess cases of EC with an omental sample during primary surgical treatment for EC at the Gynecological Oncology Unit, Uludag University Hospital, Bursa, Turkey, between January 2005 and May 2018. Results: In total, 435 patients fulfilled the inclusion criteria, which comprised a complete surgical staging. The prevalence of omental metastases was 5.3% (n = 23), regardless of the subtype or clinical stage. Omental micrometastasis was detected in four cases (17.4%). In half of these patients, the omentum was the only site of disease outside the uterus, with an estimated 0.46% of isolated omental involvement. The grade of the endometrioid tumor was found to be statistically correlated with omental metastases (p = 0.01). There was a significant correlation between omental metastasis and positive peritoneal cytology, as well as adnexal involvement (p = 0.001 and p = 0.03, respectively). Conclusion: We recommend omentectomy routinely in serous EC. In addition, we suggest selective omentectomy in patients with EC who have concomitant adnexal involvement or grade 3 tumors.Publication Effects of combination therapy with captopril and angiotensin ii on the viability of random-pattern skin flaps in diabetic rat model(Wolters Kluwer Medknow Publications, 2016-12-01) Atalay, Fatma Öz; ÖZ ATALAY, FATMA; Vuruşkan, Berna Aytaç; AYTAÇ VURUŞKAN, BERNA; Akın, Selçuk; AKIN, SELÇUK; Aygören, Binevs Heja; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0002-7188-6115; AAH-9746-2021Objective: Diabetes mellitus leads to tissue damage by erythrocyte aggregation and an endothelial dysfunction-mediated disturbance in vascularization. These mechanisms facilitate the formation of skin wounds. As skin flaps are often used in the treatment of diabetic wounds, enhancing the blood supply and lowering blood glucose levels have emerged as important factors to increase the success of treatment using skin flaps. Therefore, in this study, the effectiveness of captopril and angiotensin II treatments were investigated to determine if they increased blood flow to skin flaps to protect their viability in an experimental diabetic rat model.Material and Methods: The experiment was conducted using 45 rats. Nine constituted the sham group, whereas diabetes was induced in 36 of them by an intraperitoneal injection of streptozotocin. Skin flaps (3x8 cm in diameter) were prepared, separated, and consequently reimplanted with staplers to their original place at the dorsum of the rats. Diabetic rats were treated with saline (n=9), angiotensin II (n=9), captopril (n=9), captopril+angiotensin II (n=9) during the postoperative period. Flap viability was assessed by clinical and histopathological findings.Results: The percentage of flap viability in diabetic rats was found to be significantly higher in the captopril+angiotensin II group than in the captopril group and was lowest in the angiotensin II group. Additionally, both individual and combined use of captopril and angiotensin II were found to increase the intensity of blood vessels compared to the administration of saline alone in diabetic rats.Conclusion: Our study showed that the use of captopril and angiotensin II could increase the viability of skin flaps in diabetic rats.Publication Clear cell carcinoma of the endometrium: Evaluation of eight cases(Springer, 2019-09-01) Özsen, M.; Atalay, Fatma Öz; Çakır, Y.; ÖZ ATALAY, FATMA; Tıp Fakültesi; JHC-4482-2023Publication Primary myeloid sarcoma of ovary: A case report and review of the literature(Federation Turkish Pathology Soc, 2021-09-01) Akyol, Sevda; Öz Atalay, Fatma; ÖZ ATALAY, FATMA; Tıp FakültesiMyeloid sarcoma (granulocytic sarcoma or chloroma) is a tumor formed by myeloid precursor cells in any localization other than the bone marrow. It can occur without underlying acute myeloid leukemia (AML) or other myeloid neoplasms. Herein, we present a forty-two-year-old female patient who underwent surgery because of a left adnexal mass. Microscopic examination of the specimen revealed cord-like arrangement of the tumor cells with a diffuse growth of small blue cells effacing the ovarian stroma. Adult granulosa cell tumor was in the differential given the scanty cytoplasm of the tumor and in fact was the diagnosis of the referring institution. Further microscopic evaluation with immunohistochemical analysis at our institution revised the diagnosis to myeloid sarcoma. Myeloid sarcoma is a difficult tumor to diagnose due to its rarity, especially in the absence of a history of leukemia, and correct tissue diagnosis is essential for its treatment.Publication What should we do to optimise outcome in twin pregnancy complicated with placenta percreta? A case report(BMC, 2015-11-05) Atalay, Mehmet Aral; Atalay, Fatma Öz; Demir, Bilge Çetinkaya; Atalay, Mehmet Aral; ÖZ ATALAY, FATMA; ÇETİNKAYA DEMİR, BİLGE; Tıp Fakültesi; Cerrahi Patoloji Ana Bilim Dalı; 0000-0002-9685-956X; 0000-0001-6845-9991; AAH-9834-2021; A-8779-2013; JHC-4482-2023Background: Patients with morbidly adherent placenta (MAP) are under risk of massive bleeding. It readily necessitates very complicated surgery and massive blood transfusion, and even leads to mortality. Cesarean hysterectomy (CH) is the procedure that is acknowledged worldwide, since it helps to minimize complications.Case presentation: A patient with dichorionic twin pregnancy underwent to cesarean section (CS) due to preliminary diagnosis of placenta percreta at her 35th week of pregnancy. Both of the placentas were left in situ. The patient admitted with signs of infection. Emergency total abdominal hysterectomy was performed 7 weeks after CS. In the course of hysterectomy, 3 units of erythrocyte suspension and 2 units of fresh frozen plasma were transferred, whereas none was required during CS.Conclusion: Abandoning placenta in situ seems to be a logical alternative to the CH in patients with placenta percreta in order to minimize complications related to massive blood transfusion and surgical technique. However, it appears to increase maternal morbidity due to maternal infection in twin pregnancy.Publication The impact of ki-67 index, squamous differentiation, and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2021-01-01) Ocak, Birol; Atalay, Fatma Oz; Sahin, Ahmet Bilgehan; Ozsen, Mine; Dakiki, Bahar; Ture, Seray; Mesohorli, Merve; Odman, Hikmet Utku; Tanriverdi, Ozgur; Ocakoglu, Gokhan; Bayrak, Mehmet; Ozan, Hakan; Demiroz, Candan; Sali, Seda; Orhan, Sibel Oyucu; Deligönül, Adem; Çubukcu, Erdem; Evrensel, Turkkan; Ocak, Birol; OCAK, BİROL; Sahin, Ahmet Bilgehan; ŞAHİN, AHMET BİLGEHAN; Atalay, Fatma Oz; ÖZ ATALAY, FATMA; Ozsen, Mine; ÖZŞEN, MİNE; Dakiki, Bahar; DAKİKİ KORUCU, BAHAR; Ture, Seray; TÜRE AYDIN, SERAY; Mesohorli, Merve; Odman, Hikmet Utku; Ocakoglu, Gokhan; OCAKOĞLU, GÖKHAN; Bayrak, Mehmet; Ozan, Hakan; OZAN, HAKAN; Demiroz, Candan; DEMİRÖZ ABAKAY, CANDAN; Sali, Seda; SALİ, SEDA; Orhan, Sibel Oyucu; OYUCU ORHAN, SİBEL; Deligonul, Adem; DELİGÖNÜL, ADEM; Cubukcu, Erdem; ÇUBUKÇU, ERDEM; Evrensel, Turkkan; EVRENSEL, TÜRKKAN; Tıp Fakültesi; Onkoloji Ana Bilim Dalı; 0000-0001-7537-1699; 0000-0002-7188-6115; 0000-0002-7846-0870; 0000-0002-5771-7649; 0000-0001-9255-2475; 0000-0002-1114-6051; 0000-0003-1600-333X; AEC-2238-2022; ABA-2897-2021; AAH-5180-2021; AAM-4927-2020; AAJ-8314-2021Endometrial endometrioid carcinoma (EEC) represents approximately 75-80% of endometrial carcinoma cases. Three hundred and thirty-six patients with EEC followed-up in the authors' medical center between 2010 and 2018 were included in our study. Two hundred and seventy-two low and intermediate EEC patients were identified using the European Society for Medical Oncology criteria and confirmed by histopathological examination. Recurrence was reported in 17 of these patients. The study group consisted of patients with relapse. A control group of 51 patients was formed at a ratio of 3:1 according to age, stage, and grade, similar to that in the study group. Of the 17 patients with recurrent disease, 13 patients (76.5%) were Stage 1A, and 4 patients (23.5%) were Stage 1B. No significant difference was found in age, stage, and grade between the case and control groups (p > 0.05). Body mass index, parity, tumor size, lower uterine segment involvement, squamous differentiation (SqD), and Ki-67 index with p<0.25 in the univariate logistic regression analysis were included in the multivariate analysis. Ki-67 was statistically significant in multivariate analysis (p = 0.018); however, there was no statistical significance in SqD and other parameters. Our data suggest that the Ki-67 index rather than SqD needs to be assessed for recurrence in patients with low- and intermediate-risk EEC.Publication Why do some patients with stage 1a and 1b endometrial endometrioid carcinoma experience recurrence? A retrospective study in search of prognostic factors(Via Medica, 2022-01-01) Tanrıverdi, Özgür; Ocak, Birol; OCAK, BİROL; Şahin, Ahmet Bilgehan; ŞAHİN, AHMET BİLGEHAN; Atalay, Fatma Oz; ÖZ ATALAY, FATMA; Özsen, Mine; ÖZŞEN, MİNE; Dakiki, Bahar; DAKİKİ KORUCU, BAHAR; Türe, Seray; TÜRE AYDIN, SERAY; SALİ, SEDA; Bayrak, Mehmet; OZAN, HAKAN; DEMİRÖZ ABAKAY, CANDAN; Deligönül, Adem; DELİGÖNÜL, ADEM; Evrensel, Turkkan; ÇUBUKÇU, ERDEM; EVRENSEL, TÜRKKAN; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0001-7537-1699; 0000-0002-7846-0870; 0000-0002-5771-7649; 0000-0001-9255-2475; 0000-0001-8407-0169; ABA-2897-2021; AEC-2238-2022; AAM-4927-2020Objectives: Endometrial endometrioid carcinoma (EEC) is the most encountered subtype of endometrial cancer (EC). Our study aimed to investigate the factors affecting recurrence in patients with stage 1A and 1B EEC. Material and methods: Our study included 284 patients diagnosed with the International Federation of Gynecology and Obstetrics stage 1A/1B EEC in our center from 2010 to 2018. The clinicopathological characteristics of the patients were obtained retrospectively from their electronic files. Results: The median age of the patients was 60 years (range 31-89). The median follow-up time of the patients was 63.6 months (range 3.3-185.6). Twenty-two (7.74%) patients relapsed during follow-up. Among the relapsed patients, 59.1% were at stage 1A EEC, and 40.9% were at stage 1B. In our study, the one-, three-, and five-year recurrence-free survival (RFS) rates were 98.9%, 95.4%, and 92.9%, respectively. In the multivariate analysis, grade and tumor size were found to be independent parameters of RFS in all stage 1 EEC patients. Furthermore, the Ki-67 index was found to affect RFS in stage 1A EEC patients, and tumor grade affected RFS in stage 1B EEC patients. In the time-dependent receiver operating characteristic curve analysis, the statistically significant cut-off values were determined for tumor size and Ki-67 index in stage 1 EEC patients. Conclusions: Stage 1 EEC patients in the higher risk group in terms of tumor size, Ki-67, and grade should be closely monitored for recurrence. Defining the prognostic factors for recurrence in stage 1 EEC patients may lead to changes in follow-up algorithms.Publication Histopathological changes of neoadjuvant chemoradiation and relation with the pre-treatment tumor stage in rectal carcinoma(Gazi Univ, Fac Med, 2017-01-01) Özgün, Gonca; ÖZ ATALAY, FATMA; Ugraş, Nesrin; UĞRAŞ, NESRİN; Yerci, Ömer; YERCİ, ÖMER; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0002-7188-6115; AAH-2716-2021Objective: Neoadjuvant chemoradiotherapy has considered one of the standard treatment modalities for locally advanced rectal cancers. Chemoradiotherapy has a variety of different effects and responses on tumor, tumor bed and peritumoral tissues. The purpose of the present study was to evaluate the stromal responses in tumor bed between the different treatment modalities and different clinical T stages.Methods: Fifty-seven consecutive patients with median age of 62.4 years were treated for rectal adenocarcinoma between January 2005 and July 2012 in Uludag University Medical Faculty. Twenty-three of the patients were treated with neoadjuvant chemoradiation therapy and following surgery, 34 patients treated with surgery only.Results: When we compared the stromal responses in the tumor bed between the two different treatment modalities, the amount of fibrosis and intensity of inflammatory cell infiltration were found considerably marked. The existence of calcification, hemosiderin-laden macrophages and mucin lakes were found also significant marked. There was no difference found in between the patients with different clinical stages which were received neoadjuvant CRT.Conclusion: The stromal response in the tumor bed increases with the neoadjuvant chemoradiotherapy but the excess of the response doesn't have any relation with the clinical T stage.Publication Igg4-related disease of the ovary(Türk Patoloji Derneği, 2021-01-01) Akyol, Sevda; Öz Atalay, Fatma; Hasdemir, Seçil; Yerci, Ömer; AKYOL, SEVDA; ÖZ ATALAY, FATMA; HASDEMİR, SEÇİL; YERCİ, ÖMER; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0003-1769-7484; 0000-0002-3107-207X; 0000-0002-1275-7743; 0000-0001-7118-5258; CBY-0641-2022; FUC-3875-2022; GBY-7549-2022; EIS-5114-2022Immunoglobulin G4-related disease is characterized by dense fibrosis, obliterative phlebitis, and lymphoplasmacytic infiltration that contains abundant IgG4 positive plasma cells. It causes tumefactive lesions in the involved organs and is most commonly seen in the salivary glands, pancreas, and retroperitoneum. Ovarian involvement has been reported in only two cases. In our case, a 58-year-old female patient presented with abdominal distention and pain. Pelvic computed tomography revealed a soft tissue lesion compatible with the omental cake, several intraabdominal implants, and bilateral adnexal fullness. A laparotomy was performed under suspicion of peritoneal carcinomatosis secondary to bilateral adnexal mass. In the histopathologic examination, abundant lymphoplasmacytic infiltration and dense fibrosis were observed in both ovaries and the peritoneum. In the areas of greatest density, the density of IgG4-positive plasma cells was found to range from 40 to 50 per high-power field. The patient was accepted as suffering from probable IgG4-related disease because of the bilateral involvement of the ovaries and the histopathological findings. In conclusion, we present this case to draw attention to the fact that IgG4-related disease can also be seen in the ovary.Publication Primary central nervous system lymphoma: Diffuse large b-cell lymphoma(Turkish Neurological Soc, 2019-01-01) Ali, Asuman; Haki, Cemile; Yalçın, Ramazan; Atalay, Fatma Öz; ÖZ ATALAY, FATMA; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0002-7188-6115; GLR-2585-2022