Person: SARAYDAROĞLU, ÖZLEM
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SARAYDAROĞLU
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ÖZLEM
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Publication C-kit (CD117) expression in patients with small cell lung cancer(Galenos Yayıncılık, 2015-03-01) Gözkaman, Ayşe; Okuturlar, Yıldız; Kanat, Özkan; Günald, Meral; Serin, Sibel Ocak; Saraydaroğlu, Özlem; Kumbasar, A. Baki; Evrensel, Türkkan; Gözkaman, Ayşe; Okuturlar, Yıldız; Kanat, Özkan; Serin, Sibel Ocak; SARAYDAROĞLU, ÖZLEM; EVRENSEL, TÜRKKAN; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Onkoloji Bilim Dalı.; ludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Z-1463-2018; AAJ-1027-2021; X-3647-2018; AAH-9701-2021; JRQ-2583-2023; JRU-4028-2023; DQW-9819-2022Aim: The tyrosine-kinase receptor c-kit and its ligand stem cell factor (SCF) are coexpressed in many small cell lung cancer (SCLC) cell lines. The aim of this study was to search the role of CD117 (c-kit) overexpression as a prognostic marker in SCLC.Methods: Demographic and clinical data of patients with SCLC was registered. C-kit overexpression was evaluated using immunohistochemistry performed in paraffin-embedded specimens. Immunostaining data of 87 patients were correlated with survival and other relevant clinical parameters.Results: The mean age of the patients was 57.1 +/- 9.9 years. Thirty-nine patients (44.8%) had limited disease and 48 patients (55.2%) had extensive disease. C-kit (+) expression was observed in 24.1% of 87 patients. The mean survival time for c-kit (+) patients was 10.2 (CI=5.7-14.7) months as compared with the c-kit (-) population in whom the survival was 14.7 (CI=10.7-18.6) months. The difference in survival time between c-kit (+) and (-) patients was not statistically significant (p=0.264).Conclusion: New prognostic markers and more effective treatment regimens are needed for SCLC. Our findings may provide an insight to future clinical trials searching c-kit inhibitors in SCLC.Publication The effects of tumour thickness and size on cervical lymph node metastasis in tongue cancer(Derman Medical Publ, 2015-02-01) Demir, Uygar Levent; Akça, Mehmet Ege; Saraydaroğlu, Özlem; DEMİR, UYGAR LEVENT; Akça, Mehmet Ege; SARAYDAROĞLU, ÖZLEM; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı. 2Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAO-2435-2020; AAH-9701-2021; CNQ-7672-2022Aim: To evaluate the association between cervical lymph node metastasis and histopathological parameters related with tumour in oral tongue cancer patients. Material and Method: Thirty-six patients who underwent glossectomy combined with either unilateral or bilateral neck dissection with the diagnosis of anterior 2/3 tongue cancer were enrolled in the study. Data regarding tumour size, tumour thickness, perineural invasion, degree of differentiation, pathological cervical lymph node and extracapsular spread were retrieved from patients' files. Subsequently, we analyzed the association between these parameters and nodal metastasis. Results: There were 16 (44.4%) patients with nodal metastasis. There was no significance between tumour size (T) and nodal metastasis (p=0.702). Pathological lymph node incidence increased in accordance with tumour thickness. The percentage of lymph node metastasis was 20% in patients with tumor thickness <= 5mm and it was found 27.2% in those with thickness >5mm and <= 10mm. We showed that if the tumour thickness was > 10mm, <= 20mm or >20mm then the incidence of metastasis found higher as 58.3% and 62.5% respectively. However, we did not find a cut-off value for tumour thickness. There was no significance between perineural invasion and nodal metastasis (p=0.478). Discussion: Tongue cancer shows high risk of cervical lymph node metastasis even at early stages. We suggest to perform neck dissection in all patients who have high risk of occult metastasis inrelation with poor prognosis.Publication Differences between atypical parathyroid tumors and parathyroid adenomas in patients with primary hyperparathyroidism(Springer India, 2023-09-29) Aydemir, Ensar; AYDOĞAN ÜNSAL, YASEMİN; ÖZ GÜL, ÖZEN; AYDEMİR, ENSAR; ATEŞ, COŞKUN; Ateş, Coşkun; CANDER, SONER; Cander, Soner; Saraydaroğlu, Özlem; SARAYDAROĞLU, ÖZLEM; Ersoy, Canan; ERSOY, CANAN; Ertürk, Erdinc; ERTÜRK, ERDİNÇ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0003-4300-2965; 0000-0003-4565-9848; 0000-0002-1332-4165; AAJ-6536-2021; AAB-6671-2022; AAA-7171-2022Atypical parathyroid tumor is a rare disease that can be challenging to distinguish from parathyroid adenoma. Atypical parathyroid tumor shows some laboratory and histopathological features with parathyroid cancer. This study attempts to compare clinical, laboratory, radiologic, and histopathological characteristics in atypical parathyroid tumor and parathyroid adenoma. This was a retrospective study based on the database of eighty-two subjects who underwent surgery for primary hyperparathyroidism at a tertiary referral center between 2010 and 2021. Forty-one patients with atypical parathyroid tumor were matched by age and gender to controls with parathyroid adenoma. Clinical, laboratory, radiologic, and characteristics were obtained from the hospital database. Forty-five (54.8%) of primary hyperparathyroidism patients were symptomatic, 36 (90%) had nephrolithiasis, 6 (15%) had fracture, and 3 (7.5%) had hypercalcemic crisis. Atypical parathyroid tumor patients present with significantly increased serum calcium, parathormone, and alkaline phosphatase levels (P < .001, all). No significant difference was observed in the results of bone mineral density, T-scores, and Z-scores. The size of adenoma was significantly greater in the atypical parathyroid tumor group (24 (8.8-70) mm vs. 12 (3.8-32) mm, P = 0.005). Our study revealed that increased preoperative serum calcium, parathormone, alkaline phosphatase concentrations, and parathyroid adenoma size on ultrasound may have predicted the atypical parathyroid tumor.Publication An unusual case of adult-onset multi-systemic langerhans cell histiocytosis with perianal and incident thyroid involvement(Bioscientifica Ltd, 2017-02-01) Gül, Özen Öz; Şişman, Pınar; Cander, Soner; Gözden, Erdem; Kurt, Meral; Saraydaroğlu, Özlem; Kırdak, Turkay; Ersoy, Canan; Ertürk, Erdinç; ÖZ GÜL, ÖZEN; Şişman, Pınar; KURT, MERAL; CANDER, SONER; Gözden, Erdem; SARAYDAROĞLU, ÖZLEM; Kırdak, Turkay; ERSOY, CANAN; ERTÜRK, ERDİNÇ; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.; AAI-1005-2021; DUS-9872-2022; HUR-0563-2023; EWL-5375-2022; AAA-3961-2020; AAH-9701-2021; CZX-7145-2022; AAH-8861-2021; AAJ-6536-2021Langerhans cell histiocytosis (LCH) is a rare sporadic disease characterized by histiocytic neoplastic infiltration of various organ systems and a wide spectrum of clinical manifestations, ranging from benign and self-limiting to lethal. Herein, we report a rare case of adult-onset multi-systemic LCH in a 36-year-old male patient with an initial perianal presentation and incidental finding of subsequent thyroid gland involvement in the follow-up period. The patient with a history of perianal LCH treated with surgical excision and local radiotherapy was referred to our Endocrinology Department upon detection of hypermetabolic nodular lesions in the left lateral lobe of thyroid gland on positron emission tomography-computed tomography (PET/CT)scan in the nineth month of follow-up. Current evaluation revealed euthyroid status, a hypoechoic solid lesion of 13 x 9 mm in size with irregular borders in the left thyroid lobe on thyroid USG and cytologic assessment of thyroid nodule. The patient was diagnosed with suspected, oncocytic lesion, Hashimoto thyroiditis or LCH. The patient underwent total thyroidectomy and pathological assessment confirmed the diagnosis of Langerhans cell histiocytosis. Assessments in the sixth month of postoperative follow-up revealed euthyroid status with no thyroid tissue remnants or pathological lymph node on thyroid USG. In view of the multifocal lesions indicating multi-system disease, a systemic chemotherapy protocol with combination of prednisone (PRED) and vinblastine (VBL) has been planned by the hematology department.Publication A close look at our cases with parathyroidectomy: 11 years of experience(Edizioni Minerva Medica, 2022-06-01) Saraydaroğlu, Özlem; SARAYDAROĞLU, ÖZLEM; ÖZŞEN, MİNE; Kirdak, Turkay; Narter, Selin; NARTER, SELİN; Ertürk, Erdinç; ERTÜRK, ERDİNÇ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı.; 0000-0002-5771-7649; AAJ-6536-2021BACKGROUND: Hyperparathyroidism is caused by parathyroid adenoma, hyperplasia or carcinoma. Parathyroid ade-nomas are the most common cause of parathyroid disease (85-88%) while atypical parathyroid adenomas and carcinomas are the least frequently seen parathyroid neoplasms which cause diagnostic difficulty. This series aims to identifiy lesions of parathyroidectomy specimens in our center and draw attention to borderline cases in between parathyroid adenoma and carcinoma.METHODS: The study included 638 parathyroidectomy materials diagnosed in our center between the years 2005 and 2016 and examined retrospectively, and all were included in the study.RESULTS: In all the 638 parathyroidectomy cases evaluated, 427 were diagnosed with adenoma, 117 with hyperplasia, 54 with normal parathyroid tissue, 32 with parathyroid neoplasm with uncertain malignant potential, 7 with parathyroid carcinoma and 1 with normal thyroid tissue.CONCLUSIONS: Parathyroid neoplasm with uncertain malignant potential defines cases with suspicious histopathological features of carcinoma but doesn't meet the criteria for parathyroid carcinoma. In our series, these cases are identified as atypical parathyroid adenoma. We present clinical and morphological features of our parathyroidectomy cases in an 11-year period and aim to raise concern about borderline cases in between adenoma and carcinoma. We think that such tumors, similar to the thyroid neoplasm classification, should be defined as parathyroid neoplasms with uncertain malignant potential and should be followed closely.Publication P53 expression in patients with nasopharyngeal cancer(Elsevier Ireland Ltd, 2008-09-01) DEMİRÖZ ABAKAY, CANDAN; Özkan, L.; Saraydaroglu, Özlem; SARAYDAROĞLU, ÖZLEM; Yerci, Ömer; YERCİ, ÖMER; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAH-3847-2021; AAH-9701-2021Publication Macropenis in a toddler(Sage Publications Inc, 2023-03-15) Demiral, Meliha; Çelik, Fatih; Saraydaroğlu, Özlem; Sığ, Özlem Öz; Eren, Erdal; ÇELİK, FATİH; SARAYDAROĞLU, ÖZLEM; EREN, ERDAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Cerrahisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Endokrinolojisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-1684-1053; JPK-3909-2023; JKN-9078-2023; DPZ-1981-2022Publication Role of the neck dissection in early-stage lower lip cancers(Wolters Kluwer Medknow Publications, 2023-09-01) İNAN, HAKKI CANER; İnan, Caner; Yanaşma, H. O.; ÖZTÜRK YANAŞMA, HALİDE; Saraydaroğlu, O.; SARAYDAROĞLU, ÖZLEM; Aslier, Mustafa; ASLIER, MUSTAFA; Şahin, İ.; Basut, O.; BASUT, OĞUZ İBRAHİM; Kasapoğlu, F.; Özmen, A. O.; Demir, U. L.; Coşkun, H.; KASAPOĞLU, FİKRET; ÖZMEN, ÖMER AFŞIN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0001-6254-372X; O-2907-2018Background: In early-stage lip cancer, spread to cervical lymph nodes is extremely rare. Elective neck treatment options include suprahyoid or supraomohyoid neck dissection, sentinel lymph node biopsy, or close follow-up. Aim: In this study, our aim was to investigate the effect of elective surgery on survival in patients operated for early-stage lip cancer. Methods: Patients who underwent surgical treatment for lower lip squamous cell carcinoma between 2005 and 2020 were retrospectively analyzed. Age, gender, neck dissection status (yes/no), clinical and pathological T stage of the tumor, grade, and perineural invasion were recorded and 3-year and 5-year overall (OS) and disease-free survival (DFS) rates were estimated. Results: Thirty patients were included: 20 patients had pT1 and 10 patients had pT2 tumors. Neck dissection was performed in 13 patients. The 5-year OS rate was 90.9% and 87.8% with and without dissection, respectively. Neck dissection did not appear to affect OS (P = 0.534) in these patients. The 5-year DFS rate was 96.4% in the overall group, while it was 91.7% and 100% in patients who did or did not undergo neck dissection, respectively (P = 0.756). Discussion: Patients with or without neck dissection did not differ significantly in terms of OS and DFS. Watchful waiting with regular ultrasound imaging of the neck in patients with T1 and T2 lip tumors may be an appropriate therapeutic option.Publication Cd56 and smooth muscle actin immunoreactivity in basal cell carcinomas: Are they indicators of differentiation or do they hold a diagnostic use?(Wiley, 2022-09-21) Yirmibeş, Selin; Adım, Şaduman Balaban; BALABAN ADIM, ŞADUMAN; Saraydaroğlu, Özlem; SARAYDAROĞLU, ÖZLEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.Background Basal cell carcinoma (BCC) is the most common cutaneous malignancy and may show various differentiations. The possible pluripotent stem cell lineage of BCCs, whose origins are controversial today, is thought to be the main reason for the different morphologies. The aim of the study is to evaluate the expression of some neuroendocrine and smooth muscle markers of differentiation in BCCs and investigate the relationship between histopathologic subtypes and recurrence. Methods A total of 128 cases diagnosed as BCC in our center were included. Immunohistochemical studies of CD56, synaptophysin, chromogranin-A, smooth muscle actin (SMA), desmin, caldesmon, and Ki67 were applied. Results CD56, chromogranin-A, and synaptophysin immunoreactivity were detected in 77.3%, 13.3%, and 0.8% of the cases, respectively. 78.1% showed SMA positivity while no tumor expressed desmin or caldesmon. A correlation between histopathologic recurrence risk groups and CD56 expression was found (p < 0.05). Conclusions CD56 and SMA immunoreactivity is present in the majority of BCCs. However, the available findings do not support neuroendocrine or smooth muscle differentiation. CD56 antigen can be used for prognostic purposes in detecting high recurrence risk tumors. After the investigation of the expression rates of these two antigens in different cutaneous tumors, it may be appropriate to use them for diagnostic purposes in BCCs.Publication A rare hepatic tumor; hepatic epithelioid hemangioendothelioma(Derman Medical Publ, 2013-08-01) Akyıldız, Elif Ülker; Adım, Şaduman Balaban; Saraydaroğlu, Özlem; Kaya, Ekrem; Savcı, Gürsel; AKYILDIZ, ELİF ÜLKER; BALABAN ADIM, ŞADUMAN; SARAYDAROĞLU, ÖZLEM; KAYA, EKREM; SAVCI, GÜRSEL; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; AAH-5481-2021; AAG-7319-2021; CBA-9252-2022; EMN-0789-2022; DOQ-8725-2022Primary sarcomas of the liver account for about 1% of all liver tumors. Two basic histological forms of these sarcomas are hepatic epithelioid hemangioendothelioma and angiosarcoma. Epithelioid hemangioendothelioma is a tumor of vascular origin that involves soft tissues and organs. Primary epithelioid hemangioendothelioma of the liver was first described by Ishak in 1984 and has an incidence of 1/100,000. We present a 68-year-old female case referred to the pathology department with an initial diagnosis of cholangiocellular carcinoma and diagnosed with primary hepatic epithelioid hemangioendothelioma with review of the literature.