Person: BOSTAN, ÖZLEM MEHTAP
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BOSTAN
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ÖZLEM MEHTAP
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Publication Two cases diagnosed with tuberosclerosis in neonatal period(Galenos Yayıncılık, 2014-12-01) Varal, İpek Güney; Köksal, Nilgün; Özkan, Hilal; Bostan, Özlem; Bağcı, Onur; Uysal, Fahrettin; Yazıcı, Zeynep; Doğan, Pelin; Varal, İpek Güney; Köksal, Nilgün; BOSTAN, ÖZLEM MEHTAP; ÖZKAN, HİLAL; Bağcı, Onur; UYSAL, FAHRETTİN; YAZICI, ZEYNEP; Doğan, Pelin; Tıp Fakültesi; Radyoloji Ana Bilim Dalı; Pediatrik Radyoloji Bilim Dalı; 0000-0001-7707-2174; 0000-0001-9308-9806; CIR-8129-2022; JGS-7600-2023; JJY-3921-2023; AAG-8558-2021; KYP-5736-2024; AAH-4421-2021; AAI-2303-2021; CNZ-3688-2022Congenital heart tumors are very rare and the most common type is the rhabdomyoma. Frequency during autopsy is between 0.027-0.08%. Moreover 51-86% of these tumors are associated with tuberosclerosis. Also hamartomas might accompany, particularly on the central nervous system and skin, kidney, liver, lung and heart. In this paper, two cases diagnosed with tuberculosis who showed rhabdomyomas in fetal echocardiography in the antenatal period and were seen to have tubers in cranial magnetic resonance (MR) postnatally, are presented.Publication Evaluation of the endocrine functions in pediatric patients with cyanotic congenital heart disease(Scientific Publishers India, 2013-01-01) Eren, Erdal; Çakır, Esra Deniz Papatya; Bostan, Özlem; Sağlam, Halil; Tarım, Ömer; EREN, ERDAL; Çakır, Esra Deniz Papatya; BOSTAN, ÖZLEM MEHTAP; SAĞLAM, HALİL; TARIM, ÖMER FARUK; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; Çocuk Endokrinolojisi Bilim Dalı; 0000-0002-1684-1053; 0000-0003-4664-7435; 0000-0001-7707-2174; 0000-0002-6598-8262; 0000-0002-5322-5508; GQO-9634-2022; AAG-8558-2021; JPK-3909-2023; C-7392-2019; GLN-8241-2022; CCU-8073-2022Our aim was to investigate effects of chronic hypoxia on endocrine function in pediatric patients with cyanotic congenital heart disease (CHD). Thirty patients with cyanotic CHD (16 boys, 14 girls), and 35 control subjects (22 boys, 13 girls) were enrolled. Age means of patients and controls were 4.37 +/- 4.51 and 4.28 +/- 4.96 years, respectively. Standard deviation scores (SDS) of height and weight were significantly lower among patients compared to controls. Mean fasting glucose levels were 75 +/- 15 mg/dL and 83 +/- 12 mg/dL among patients and controls, respectively (p=0.033). Insulin-like growth factor (IGF) 1 and its SDS were significantly lower among patients (p=0.010). There was no significant difference in ACTH and cortisol levels between groups. ACTH levels were very low in six patients. Oxygen saturation level was positively correlated with ACTH (p=0.041, r=0.439) and negatively correlated with HOMA-IR (p=0.046, r=-0.420) and insulin (p=0.017, r=-0.494). There was no difference in insulin resistance between groups. Chronic hypoxia has negative impact on growth by reducing IGF-1 along with the nutritional deficiency in children with cyanotic CHD. ACTH-adrenal axis is also affected. While cyanotic CHD has decreased serum glucose level, it had no effect on insulin level and insulin resistance. Negative correlations between oxygen saturation, and HOMA-IR, fasting insulin levels, have suggested that these patients should be monitorized for insulin resistance.Publication A major cause of mortality and morbidity of very low birth weight infants: Patent ductus arteriosus(Galenos Yayıncılık, 2012-04-01) Aygün, Fatih; Köksal, Nilgün; Bostan, Özlem M.; Uysal, Fahrettin; Varal, İpek Güney; Doğan, Pelin; Doğan, Pelin; Varal, İpek Güney; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Köksal, Nilgün; Aygün, Fatih; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; Neonatol Bilim Dalı; 0000-0001-6519-6583; 0000-0001-7707-2174; 0000-0002-3298-066X; AAI-5981-2020; JGS-7600-2023; D-2014-2019; AAH-4421-2021; AAG-8558-2021; CNZ-3688-2022Introduction: Patent Ductus Arteriosus (PDA), a cardiac pathology commonly seen in preterm infants, has negative effects on mortality and morbidity. Persistent patency of PDA is positively correlated with respiratory distress syndrome (RDS), prolonged respiratory support, pulmonary hemorrhage, broncopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage, renal failure, neurodevelopmental impairment (cerebral palsy), retinopathy of prematurity and death. The standard treatment regimen is to close symptomatic PDA and cyclooxygenase inhibitors such as indomethacin, ibuprofen are the first choises. Our aim in this study is to report PDA rate, treatment and complications in premature infants.Materials and Methods: This study retrospectively enrolled 103 infants born < 33 gestational weeks, without any major congenital anomaly or congenital heart defects between January 2010-November 2011. Echocardiograms was performed in the first week. PDA related pulmonary hemorrhage, NEC, BPD, ROP and death were demonstrated.Results: Among of 103 infants, 45 were male and 58 were female. Seventy infants were born with cesarian section and 33 were born with normal labor. The mean gestational week was 29.7 +/- 2.2, the mean gestational week of infants with PDA was 28.8 +/- 2.3. The mean birth weight of infants was 1323 +/- 375 grams. The mean Apgar score was 7.25 +/- 1.83, the scores of infants with patent ductus arteriosus were significantly low (6.7 +/- 1.9). Echocardiography was performed on the mean of 4.8 +/- 4.4 days, PDA was determined in 48 of 103 infants (% 46). The mean of birth weight of infants with persistant PDA was 1162 +/- 351 grams, it was 1465 +/- 340 g in the closed group. The rate of pulmonary hemorrhage, NEC, BPD, ROP and death was significantly higher in infants with PDA compared with infants having ductal closure (p<0.05).Conclusion: The early closure of PDA in very low birth weight infants will reduce both mortality and early or late morbidities.Publication Arterial tortuosity syndrome: 40 new families and literature review (vol 20, pg 1236, 2017)(Nature Publishing Group, 2019-08-01) Beyens, Aude; Albuisson, Juliette; Boel, Annekatrien; Al-Essa, Mazen; Al-Manea, Waheed; Bonnet, Damien; Bostan, Ozlem; Boute, Odile; Busa, Tiffany; Canham, Nathalie; Cil, Ergun; Coucke, Paul J.; Cousin, Margot A.; Dasouki, Majed; De Backer, Julie; De Paepe, Anne; De Schepper, Sofie; De Silva, Deepthi; Devriendt, Koenraad; De Wandele, Inge; Deyle, David R.; Dietz, Harry; Dupuis-Girod, Sophie; Fontenot, Eudice; Fischer-Zirnsak, Bjoern; Gezdirici, Alper; Ghoumid, Jamal; Giuliano, Fabienne; Baena, Neus; Haider, Mohammed Z.; Hardin, Joshua S.; Jeunemaitre, Xavier; Klee, Eric W.; Kornak, Uwe; Landecho, Manuel F.; Legrand, Anne; Loeys, Bart; Lyonnet, Stanislas; Michael, Helen; Moceri, Pamela; Mohammed, Shehla; Muino-Mosquera, Laura; Nampoothiri, Sheela; Pichler, Karin; Prescott, Katrina; Rajeb, Anna; Ramos-Arroyo, Maria; Rossi, Massimiliano; Salih, Mustafa; Seidahmed, Mohammed Z.; Schaefer, Elise; Steichen-Gersdorf, Elisabeth; Temel, Şehime; Uysal, Fahrettin; Vanhomwegen, Marine; Van Laer, Lut; Van Maldergem, Lionel; Warner, David; Willaert, Andy; Collins, Tom R., II; Taylor, Andrea; Davis, Elaine C.; Zarate, Yuri; Callewaert, Bert; TEMEL, ŞEHİME GÜLSÜN; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Tıp Fakültesi; Histoloji ve Embriyoloji Ana Bilim Dalı; AAG-8558-2021; AAG-9324-2021; AAG-8385-2021; AAH-4421-2021Publication Complete atrioventricular block as a complication of varicella infection in a child: Recovery with a single dose of intravenous immunoglobulin therapy(Sage Publications, 2016-06-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Çetin, Benhur; Uysal, Berfin; Güney, Begüm; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Çetin, Benhur; Güney, Begüm; ÇİL, ERGÜN; Tıp Fakültesi; 0000-0001-7707-2174; 0000-0002-8470-4907; 0000-0003-3516-0082; AAH-3865-2021; AAG-8558-2021; AAG-9324-2021; AAH-4421-2021; H-2691-2017Publication The role of external loop recorders in arrhythmia-related symptoms in children: A single center experience(Springer, 2021-08-13) Akça, Tuğberk; Uysal, Fahrettin; Bostan, Özlem Mehtap; Genç, Abdusselam; Türkmen, Hasan; AKÇA, TUĞBERK; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; GENÇ, ABDÜSSELAM; TÜRKMEN, HASAN; Tıp Fakültesi; Çocuk Kardiyoloji Bölümü; 0000-0001-7707-2174; 0000-0002-2747-974X; AEX-4557-2022; AAH-4421-2021; AAG-8558-2021; CQK-7120-2022; JKC-8556-2023In this study, we report our experience with the use of external loop recorders (ELRs), in terms of diagnostic efficiency according to symptoms and symptom-rhythm correlation in pediatric patients. We evaluated ELRs applied to 178 patients between April 2017 and November 2020 at our center. The mean age of 172 patients included in the study was 13.6 +/- 3.8 years, and 69.8% were female. ELR indications were palpitations in 98 (56.9%) cases, chest pain and palpitations in 43 (25%) cases, presyncope/syncope in 28 (16.2%) cases, and pacemaker/ implantable cardioverter-defibrillator (ICD) problems in 3 (0.2%) cases. ELR recording times were 14.2 +/- 9.7 days on average, ranging from 2 to 67 days. While the symptom-rhythm correlation was 29.1% in total, when the indications were evaluated one by one, this correlation was found to be 30.2% in palpitations, 34.7% in chest pain and palpitations, and 10.7% in presyncope/syncope. The total diagnostic efficiency was 68.1%. In the follow-up of ELR cases, a total of 139 (80.8%) patients received clinical follow-up without medication, 15 (8.8%) patients received medical treatment, and 18 (10.4%) patients underwent EPS. The cardiac ELR system is useful in detecting underlying arrhythmias. Demonstrating sinus tachycardia at the time of the symptom may be seen as negative finding, but while experiencing symptoms, it is diagnostically valuable and may help avoid further investigation with costly and invasive diagnostic procedures. For diagnostic efficiency and cost effectiveness, the optimal recording time is 2 weeks, but it should be extended to 4 weeks in cases such as of presyncope/syncope that cannot be explained with a 2-week ELR use.Publication The retrospective analysis of fetal echocardiograpy results at the uludag university hospital(Galenos Yayincilik, 2007-12-01) Kimya, Yalçın; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Alyamaç, Funda Akpınar; Özdil, Murat; Bayram, Feyza; Çelik, Nurhan; Cengiz, Candan; Tıp Fakültesi; Pediatri Ana Bilim Dalı; 0000-0003-1735-6997Objective: In this study indications, findings and results of fetal echocardiography performed in our department were evaluated.Materials and Methods: The records of fetal echocardiography findings, pregnancy and postpartum period were retrospectively evaluated in 208 patients and had fetal echocardiography who were in high risk for congenital heart diseases, in our department between May 2003-January 2007.Results: The mean age of 208 patients was 21,8 and mean gestational age 25 weeks and 3 days. The two most common indications for fetal echocardiography were congenital heart: disease in the family and suspicion of cardiac anomaly during routine ultrasonogrraphy; 88/208 (42.3%) and 43/208 (20.7%); respectively. Incidence of abnormal findings in fetal echocardiographic examination was 26.9% (56/208). While congenital heart disease ratio in patients with family history of congenital heart disease was 4.6% (4/88), it was 74.4% (32/43) in patients with suspicion of cardiac. anomaly during routine ultrasonography.Discussion: The most common request for fetal echocardiography was presence of congenital heart disease in the family. Routine prenatal ultrasonography has the most important role in detection of cardiac anomalies.Publication Treatment of infective endocarditis with recombinant tissue plasminogen activator(Wiley-liss, 2008-01-01) Güneş, Adalet Meral; MERAL GÜNEŞ, ADALET; Baytan, Birol; Semizel, Evren; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0001-7707-2174; 0000-0002-9375-2855; AAG-8558-2021Infective endocarditis (IE) caused by microbial infection is virtually always fatal if untreated. High-dose and long-term antibiotic treatment is required to eradicate microorganisms. If increased risk of embolic events, persistent infection, and progressive cardiac failure are present, surgery is indicated. However, surgery can carry an increased risk of mortality and morbidity in critically ill children of whom other treatment options Such as administering, a thromholytic agent; recombinant tissue plasminogen activator (r-tPA) could be an alternative choice. Here, we report a 14-year-old male with Down syndrome and acute myeloblastic leukemia, diagnosed with IE characterized by two large vegetations on aortic and mitral valves, who was successfully treated with r-tPA.Publication The frequency of asymptomatic urinary system abnormalities in children detected with cineurography imaging during angiocardiography(Cambridge Univ Press, 2019-02-01) Oral, Orçun; Toprak, Muhammet Hamza Hata; Uysal, Fahrettin; Bostan, Özlem Mehtap; Çil, Ergün; Toprak, Muhammet Hamza Hata; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Bursa Uludağ Üniversitesi; 0000-0001-7707-2174; 0000-0003-3516-0082; AAG-9324-2021; AAH-4421-2021; AAG-8558-2021; AAH-3865-2021; ECM-4447-2022Introduction: Diagnostic and interventional catheter angiography of the heart is frequently used in paediatric cardiology. It is also possible to detect urinary system anomalies with cineurography images that may be obtained during angiocardiography. In this study, the aim was to determine the frequency, distribution, and properties of urinary system anomalies accompanying heart diseases, and to find out the effectiveness of cineurographic images in detecting the urinary system anomalies. Methods: The cineurographic images of 2022 children who had undergone angiocardiography between 1995 and 2015 were retrospectively examined. Results: Urinary system anomalies were detected in 261 of the 2022 cases (12.9%). Of these 261 cases, 148 were males (56.7%), whereas 113 were females (43.3%). Among the heart diseases, the group most accompanied by urinary system anomalies was the non-cyanotic left-to-right shunted heart diseases, which was detected in 120 (39.1%) patients. Pelvicalyceal ectasia was the most common urinary system anomaly encountered and was detected in 89 patients (34.1%). Of the urinary system anomalies cases, 94 detected by cineurography were determined to be clinically severe. When the effectiveness of the cineurography was evaluated using the ultrasonography records of the patients, it was found to have 63.8% accuracy. Conclusion: Many of the patients with CHDs concomitantly have urinary system anomalies. It is possible to determine asymptomatic urinary system anomalies using cineurographic imaging during angiocardiography. This may lead to earlier treatments and improved prognosis for the patients, thus making it possible to prevent potential future problems.Publication A rare and fatal cause of hypertrophic cardiomyopathy: Danon disease(Cambridge Univ Press, 2023-01-05) Türkmen, Hasan; TÜRKMEN, HASAN; Uysal, Fahrettin; UYSAL, FAHRETTİN; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Tıp Fakültesi; Pediatri Ana Bilim Dalı; 0000-0001-7707-2174Danon disease is a rare and fatal disease caused by a mutation in the lysosome-associated membrane protein 2 gene. Impaired intracellular autophagy causes lysosomal vacuoles to accumulate mainly in myocardial and skeletal muscle cells, leading to hypertrophic cardiomyopathy, skeletal myopathy, and varying degrees of intellectual disability. Two distinct childhood presentations of Danon disease are described in this report.
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