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BOSTAN, ÖZLEM MEHTAP

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BOSTAN

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ÖZLEM MEHTAP

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  • Publication
    Qt dispersion in epileptic children and effect of antiepileptic drugs on QT dispersion
    (Erciyes Üniversitesi Tıp Fakültesi, 2010-09-01) Şentürk, Ebru Tayfun; Semizel, Evren; Bostan, Özlem Mehtap; Okan, Mehmet; Çil, Ergün; TAYFUN ŞENTÜRK, EBRU; Semizel, Evren; BOSTAN, ÖZLEM MEHTAP; OKAN, MEHMET SAİT; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Nörolojisi Anabilim Dalı.; 0000-0001-7707-2174; 0000-0003-3516-0082; JMN-6038-2023; DQX-9595-2022; AAG-8558-2021; IMZ-1723-2023; AAG-9324-2021
    Purpose: Sudden death in epileptic patients may due to epilepsia or drug induced arrhythmia. The aim of this study is to identify changes of QT dispersion, as a predictive marker for arrhythmias, in children treated with antiepileptic drugs.Material and Methods: Ninety children treated with antiepileptic drugs and 30 healthy children as controls were involved in the study. Standard 12-lead surface electrocardiograms (ECG) of the study groups were evaluated before antiepileptic drug therapy and after 3 months. ECG of the control group was also reviewed at the beginning of the study and after 3 months. QT, JT and RR intervals were measured in both groups. The corrected QT (QTc) and JT (JTc) intervals were determined and QTc and JTc dispersions were measured.Results: QTc and JTc dispersion were found to be 85.8+/-16.5 ms and 79.8+/-15.6 ms respectively in patients group before the therapy and 43.3+/-8.2 ms and 40.8+/-5.6 ms in control group at the beginning (p<0.05). Even QTc dispersion were found to be significantly decreased after 3 months of therapy (80.5+/-12.9 ms), it was still significantly higher than the QTc dispersion in control group after 3 months.Conclusion: Determination of QTcd and JTcd values may be useful to predict the risk of sudden death in epileptic patients.
  • Publication
    Treatment of infective endocarditis with recombinant tissue plasminogen activator
    (Wiley-liss, 2008-01-01) Güneş, Adalet Meral; MERAL GÜNEŞ, ADALET; Baytan, Birol; Semizel, Evren; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/ Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0001-7707-2174; 0000-0002-9375-2855; AAG-8558-2021
    Infective endocarditis (IE) caused by microbial infection is virtually always fatal if untreated. High-dose and long-term antibiotic treatment is required to eradicate microorganisms. If increased risk of embolic events, persistent infection, and progressive cardiac failure are present, surgery is indicated. However, surgery can carry an increased risk of mortality and morbidity in critically ill children of whom other treatment options Such as administering, a thromholytic agent; recombinant tissue plasminogen activator (r-tPA) could be an alternative choice. Here, we report a 14-year-old male with Down syndrome and acute myeloblastic leukemia, diagnosed with IE characterized by two large vegetations on aortic and mitral valves, who was successfully treated with r-tPA.
  • Publication
    The frequency of asymptomatic urinary system abnormalities in children detected with cineurography imaging during angiocardiography
    (Cambridge Univ Press, 2019-02-01) Oral, Orçun; Toprak, Muhammet Hamza Hata; Uysal, Fahrettin; Bostan, Özlem Mehtap; Çil, Ergün; Toprak, Muhammet Hamza Hata; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Bursa Uludağ Üniversitesi; 0000-0001-7707-2174; 0000-0003-3516-0082; AAG-9324-2021; AAH-4421-2021; AAG-8558-2021; AAH-3865-2021; ECM-4447-2022
    Introduction: Diagnostic and interventional catheter angiography of the heart is frequently used in paediatric cardiology. It is also possible to detect urinary system anomalies with cineurography images that may be obtained during angiocardiography. In this study, the aim was to determine the frequency, distribution, and properties of urinary system anomalies accompanying heart diseases, and to find out the effectiveness of cineurographic images in detecting the urinary system anomalies. Methods: The cineurographic images of 2022 children who had undergone angiocardiography between 1995 and 2015 were retrospectively examined. Results: Urinary system anomalies were detected in 261 of the 2022 cases (12.9%). Of these 261 cases, 148 were males (56.7%), whereas 113 were females (43.3%). Among the heart diseases, the group most accompanied by urinary system anomalies was the non-cyanotic left-to-right shunted heart diseases, which was detected in 120 (39.1%) patients. Pelvicalyceal ectasia was the most common urinary system anomaly encountered and was detected in 89 patients (34.1%). Of the urinary system anomalies cases, 94 detected by cineurography were determined to be clinically severe. When the effectiveness of the cineurography was evaluated using the ultrasonography records of the patients, it was found to have 63.8% accuracy. Conclusion: Many of the patients with CHDs concomitantly have urinary system anomalies. It is possible to determine asymptomatic urinary system anomalies using cineurographic imaging during angiocardiography. This may lead to earlier treatments and improved prognosis for the patients, thus making it possible to prevent potential future problems.
  • Publication
    A rare and fatal cause of hypertrophic cardiomyopathy: Danon disease
    (Cambridge Univ Press, 2023-01-05) Türkmen, Hasan; TÜRKMEN, HASAN; Uysal, Fahrettin; UYSAL, FAHRETTİN; Bostan, Özlem Mehtap; BOSTAN, ÖZLEM MEHTAP; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 0000-0001-7707-2174
    Danon disease is a rare and fatal disease caused by a mutation in the lysosome-associated membrane protein 2 gene. Impaired intracellular autophagy causes lysosomal vacuoles to accumulate mainly in myocardial and skeletal muscle cells, leading to hypertrophic cardiomyopathy, skeletal myopathy, and varying degrees of intellectual disability. Two distinct childhood presentations of Danon disease are described in this report.
  • Publication
    The role of external loop recorders in arrhythmia-related symptoms in children: A single center experience
    (Springer, 2021-08-13) Akça, Tuğberk; Uysal, Fahrettin; Bostan, Özlem Mehtap; Genç, Abdusselam; Türkmen, Hasan; AKÇA, TUĞBERK; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; GENÇ, ABDÜSSELAM; TÜRKMEN, HASAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Bölümü; 0000-0001-7707-2174; 0000-0002-2747-974X; AEX-4557-2022; AAH-4421-2021; AAG-8558-2021; CQK-7120-2022; JKC-8556-2023
    In this study, we report our experience with the use of external loop recorders (ELRs), in terms of diagnostic efficiency according to symptoms and symptom-rhythm correlation in pediatric patients. We evaluated ELRs applied to 178 patients between April 2017 and November 2020 at our center. The mean age of 172 patients included in the study was 13.6 +/- 3.8 years, and 69.8% were female. ELR indications were palpitations in 98 (56.9%) cases, chest pain and palpitations in 43 (25%) cases, presyncope/syncope in 28 (16.2%) cases, and pacemaker/ implantable cardioverter-defibrillator (ICD) problems in 3 (0.2%) cases. ELR recording times were 14.2 +/- 9.7 days on average, ranging from 2 to 67 days. While the symptom-rhythm correlation was 29.1% in total, when the indications were evaluated one by one, this correlation was found to be 30.2% in palpitations, 34.7% in chest pain and palpitations, and 10.7% in presyncope/syncope. The total diagnostic efficiency was 68.1%. In the follow-up of ELR cases, a total of 139 (80.8%) patients received clinical follow-up without medication, 15 (8.8%) patients received medical treatment, and 18 (10.4%) patients underwent EPS. The cardiac ELR system is useful in detecting underlying arrhythmias. Demonstrating sinus tachycardia at the time of the symptom may be seen as negative finding, but while experiencing symptoms, it is diagnostically valuable and may help avoid further investigation with costly and invasive diagnostic procedures. For diagnostic efficiency and cost effectiveness, the optimal recording time is 2 weeks, but it should be extended to 4 weeks in cases such as of presyncope/syncope that cannot be explained with a 2-week ELR use.
  • Publication
    A rare anomaly: Recurrent congenital aorto-azygos fistula after two procedure of transcatheter occlusion
    (Springer, 2015-10-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı; 0000-0001-7707-2174; 0000-0003-3516-0082; AAH-3865-2021; AAH-4421-2021; AAG-9324-2021; AAG-8558-2021
  • Publication
    Two cases diagnosed with tuberosclerosis in neonatal period
    (Galenos Yayıncılık, 2014-12-01) Varal, İpek Güney; Köksal, Nilgün; Özkan, Hilal; Bostan, Özlem; Bağcı, Onur; Uysal, Fahrettin; Yazıcı, Zeynep; Doğan, Pelin; Varal, İpek Güney; Köksal, Nilgün; BOSTAN, ÖZLEM MEHTAP; ÖZKAN, HİLAL; Bağcı, Onur; UYSAL, FAHRETTİN; YAZICI, ZEYNEP; Doğan, Pelin; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Neonatoloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Pediatrik Kardiyoloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı/Pediatrik Radyoloji Bilim Dalı.; 0000-0001-7707-2174; 0000-0001-9308-9806; CIR-8129-2022; JGS-7600-2023; JJY-3921-2023; AAG-8558-2021; KYP-5736-2024; AAH-4421-2021; AAI-2303-2021; CNZ-3688-2022
    Congenital heart tumors are very rare and the most common type is the rhabdomyoma. Frequency during autopsy is between 0.027-0.08%. Moreover 51-86% of these tumors are associated with tuberosclerosis. Also hamartomas might accompany, particularly on the central nervous system and skin, kidney, liver, lung and heart. In this paper, two cases diagnosed with tuberculosis who showed rhabdomyomas in fetal echocardiography in the antenatal period and were seen to have tubers in cranial magnetic resonance (MR) postnatally, are presented.
  • Publication
    Arterial tortuosity syndrome: 40 new families and literature review (vol 20, pg 1236, 2017)
    (Nature Publishing Group, 2019-08-01) Beyens, Aude; Albuisson, Juliette; Boel, Annekatrien; Al-Essa, Mazen; Al-Manea, Waheed; Bonnet, Damien; Bostan, Ozlem; Boute, Odile; Busa, Tiffany; Canham, Nathalie; Cil, Ergun; Coucke, Paul J.; Cousin, Margot A.; Dasouki, Majed; De Backer, Julie; De Paepe, Anne; De Schepper, Sofie; De Silva, Deepthi; Devriendt, Koenraad; De Wandele, Inge; Deyle, David R.; Dietz, Harry; Dupuis-Girod, Sophie; Fontenot, Eudice; Fischer-Zirnsak, Bjoern; Gezdirici, Alper; Ghoumid, Jamal; Giuliano, Fabienne; Baena, Neus; Haider, Mohammed Z.; Hardin, Joshua S.; Jeunemaitre, Xavier; Klee, Eric W.; Kornak, Uwe; Landecho, Manuel F.; Legrand, Anne; Loeys, Bart; Lyonnet, Stanislas; Michael, Helen; Moceri, Pamela; Mohammed, Shehla; Muino-Mosquera, Laura; Nampoothiri, Sheela; Pichler, Karin; Prescott, Katrina; Rajeb, Anna; Ramos-Arroyo, Maria; Rossi, Massimiliano; Salih, Mustafa; Seidahmed, Mohammed Z.; Schaefer, Elise; Steichen-Gersdorf, Elisabeth; Temel, Şehime; Uysal, Fahrettin; Vanhomwegen, Marine; Van Laer, Lut; Van Maldergem, Lionel; Warner, David; Willaert, Andy; Collins, Tom R., II; Taylor, Andrea; Davis, Elaine C.; Zarate, Yuri; Callewaert, Bert; TEMEL, ŞEHİME GÜLSÜN; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; ÇİL, ERGÜN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Kardiyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; AAG-8558-2021; AAG-9324-2021; AAG-8385-2021; AAH-4421-2021
  • Publication
    Complete atrioventricular block as a complication of varicella infection in a child: Recovery with a single dose of intravenous immunoglobulin therapy
    (Sage Publications, 2016-06-01) Uysal, Fahrettin; Bostan, Özlem Mehtap; Çetin, Benhur; Uysal, Berfin; Güney, Begüm; Çil, Ergün; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Çetin, Benhur; Güney, Begüm; ÇİL, ERGÜN; Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0001-7707-2174; 0000-0002-8470-4907; 0000-0003-3516-0082; AAH-3865-2021; AAG-8558-2021; AAG-9324-2021; AAH-4421-2021; H-2691-2017
  • Publication
    A major cause of mortality and morbidity of very low birth weight infants: Patent ductus arteriosus
    (Galenos Yayıncılık, 2012-04-01) Aygün, Fatih; Köksal, Nilgün; Bostan, Özlem M.; Uysal, Fahrettin; Varal, İpek Güney; Doğan, Pelin; Doğan, Pelin; Varal, İpek Güney; UYSAL, FAHRETTİN; BOSTAN, ÖZLEM MEHTAP; Köksal, Nilgün; Aygün, Fatih; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Neonatol Bilim Dalı.; 0000-0001-6519-6583; 0000-0001-7707-2174; 0000-0002-3298-066X; AAI-5981-2020; JGS-7600-2023; D-2014-2019; AAH-4421-2021; AAG-8558-2021; CNZ-3688-2022
    Introduction: Patent Ductus Arteriosus (PDA), a cardiac pathology commonly seen in preterm infants, has negative effects on mortality and morbidity. Persistent patency of PDA is positively correlated with respiratory distress syndrome (RDS), prolonged respiratory support, pulmonary hemorrhage, broncopulmonary dysplasia (BPD), necrotizing enterocolitis (NEC), intraventricular hemorrhage, renal failure, neurodevelopmental impairment (cerebral palsy), retinopathy of prematurity and death. The standard treatment regimen is to close symptomatic PDA and cyclooxygenase inhibitors such as indomethacin, ibuprofen are the first choises. Our aim in this study is to report PDA rate, treatment and complications in premature infants.Materials and Methods: This study retrospectively enrolled 103 infants born < 33 gestational weeks, without any major congenital anomaly or congenital heart defects between January 2010-November 2011. Echocardiograms was performed in the first week. PDA related pulmonary hemorrhage, NEC, BPD, ROP and death were demonstrated.Results: Among of 103 infants, 45 were male and 58 were female. Seventy infants were born with cesarian section and 33 were born with normal labor. The mean gestational week was 29.7 +/- 2.2, the mean gestational week of infants with PDA was 28.8 +/- 2.3. The mean birth weight of infants was 1323 +/- 375 grams. The mean Apgar score was 7.25 +/- 1.83, the scores of infants with patent ductus arteriosus were significantly low (6.7 +/- 1.9). Echocardiography was performed on the mean of 4.8 +/- 4.4 days, PDA was determined in 48 of 103 infants (% 46). The mean of birth weight of infants with persistant PDA was 1162 +/- 351 grams, it was 1465 +/- 340 g in the closed group. The rate of pulmonary hemorrhage, NEC, BPD, ROP and death was significantly higher in infants with PDA compared with infants having ductal closure (p<0.05).Conclusion: The early closure of PDA in very low birth weight infants will reduce both mortality and early or late morbidities.