Person: HACIMUSTAFAOĞLU, MUSTAFA KEMAL
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HACIMUSTAFAOĞLU
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MUSTAFA KEMAL
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Publication Evaluation of children with ralstonia pickkettii Bacteraemia(Aves Yayıncılık, 2023-03-01) Yeşil, Edanur; Hacımustafaoğlu, Mustafa; Çelebi, Solmaz; Özer, Arife; Kilimci, Duygu Düzcan; Eren, Hale; Özakın, Cüneyt; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; ÇELEBİ, SOLMAZ; Eren, Hale; ÖZAKIN, CÜNEYT; Tıp Fakültesi; Çocuk Enfeksiyon Hastalıkları Bilim Dalı; CTG-5805-2022; JHN-1091-2023; GQT-6881-2022; JKC-3728-2023Objective: Ralstonia pickettii is an opportunistic pathogen that is often considered to be contaminant. It can cause infection due to colonisation in infusion solutions and disinfectants. Although rare, it can lead to nosocomial outbreaks, so this agent should not be ignored. In this study, it was aimed to evaluate the growth of R. pickettii in blood cultures taken in the pediatric wards of our hospital, to analyze the outbreaks by R. pickettii and to discuss the precautions to prevent the outbreaks.Material and Methods: Patients with Ralstonia picketti in blood cultures, who were admitted in the pediatric intensive care unit (PICU; n= 46, 81%), neonatal intensive care unit (n= 7, 12%) and other pediatric wards (n= 4, 7%) between February 2014 and December 2017 were included into the study. Patient's data, the relation between the outbreaks and culture growths, and the sources and the prevention of potential outbreaks were evaluated. Recurrent growths were defined as a single episode.Results: Ralstonia pickettii detected in 57 different specimens in 38 different episodes in a total of 35 patients. Of the fifty-seven blood samples, 67% (n= 38) were peripheral blood cultures, 33% (n= 19) were catheter blood cultures and 74% of the samples lead to infection. Of the 38 ep-isodes, 63% (n= 24) were considered as infection and 37% (n= 14) was contamination. Median age of the patients were seven (0-180) months, and the major underlying comorbidity was congenital heart disease. Of 57 specimens with Raltstonia pickettii growth, 16 (28%) had only R. pickettii growth, and the remaining 41 (71%) cultured growths were poly -microbial. Among these, the most common accompanying microorganisms were Stenotrophomonas maltophilia and Burkholderia species. Of 38 episodes, 58% (n= 22) had a central venous catheter (CVC), of which 64% (n= 14) developed catheter-related bloodstream infection due to R. pickettii. Eighty-one percent of the specimens were detected in the pediatric in-tensive care unit, and the outbreak situation was examined. Twenty-three (61%) of a total of 57 growths were associated with an outbreak of health-care-associated infection in three separate periods. Ralstonia pickettii was not detected in environment scans. Antibiogram features of the growths were similar and they were thought to be of the same isolate, no molecular study was applied. Three patients died within the first 30 days after the growth.Conclusion: Our study has the largest case series reported in a pediatric population in Turkiye and the world. The mortality rate due to R. pickettii was low. Eighty-one percent of the specimens were in the pediatric inten-sive care unit and 61% was associated with the outbreak. The importance of hospital infection control measures in preventing R. pickettii and similar outbreaks were emphasized. A limited number of studies have been conducted on this subject in Turkiye, and we believe that our study will contribute to the literature.Publication Recurrent pneumonia in children(Aves Yayincilik, Ibrahim Kara, 2010-06-01) Çelebi, Solmaz; ÇELEBİ, SOLMAZ; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Albayrak, Yücehan; Bulur, Nurcan; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0003-4646-660XObjective: The aim of this study was to determine the relative frequency and describe the predisposing causes of recurrent pneumonia in children.Material and methods: We retrospectively reviewed the medical records of patients with pneumonia at Uludag University Medical Faculty, Department of Pediatrics, between January 1998 and December 2007. Recurrent pneumonia was defined as at least two episodes in a 1 year period or at least three episodes over a lifetime. Patients with recurrent pneumonia were included in this study.Results: During the study period, 1617 children were admitted to hospital with a diagnosis of pneumonia, 185 (11.4%) met the criteria for recurrent pneumonia. The mean age of patients was 16 +/- 32 months (3 months-14 years) and 61% were male. An underlying cause was identified in 143 patients (77%). Of these, the underlying cause was diagnosed prior the pneumonia in 25 patients (17%), during the first episode in 30 (21%), and during recurrence in 88 (62%). Underlying causes included congenital cardiac defects in 32 patients (17.2%), gastroesophageal reflux in 31 patients (16.7%), aspiration syndrome in 27 patients (14.5%), asthma in 16 patients (8.6%), cystic fibrosis in 12 patients (6.4%) immune disorders in 10 patients (5.4%), tuberculosis in 9 patients (4.8%) and anomalies of the chest and lung in 6 patients (3.2%). No predisposing illness could be demonstrated in 42 patients (33%).Conclusion: Recurrent pneumonia occurred in 11.4% of all children hospitalized for pneumonia. The underlying cause was identified in 77% of the children. The most common causes were congenital cardiac defects, gastroesophageal reflux and aspiration syndrome.Publication Evaluation of methicillin resistant staphylococcus aureus infection in children(Galenos Yayincilik, 2019-01-01) Yeşil, Edanur; ÇELEBİ, SOLMAZ; YEŞİL, EDANUR; Çelebi, Solmaz; Özer, Arife; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0002-8926-9959; 0000-0003-4646-660X; GSO-3630-2022BACKGROUND: This study was conducted to investigate cases of methicillin-resistant Staphylococcus aureus (MRSA) infections and also to draw attention to community-acquired MRSA in patients hospitalized at our Pediatric Clinics.METHODS: The patients who had meaningful S. aureus growth in the cultures taken from the patients who were hospitalized in Uludag University Medical Faculty Children's Health and Diseases Clinics between October 2012-February 2017 were included in the study. SPSS 17.0 program was used for statistical analysis.RESULTS: A total of 31 S. aureus infections were detected during this period. Seventeen (54.8%) of the cases with S. aureus infection were health care related. Methicillin-resistant S. aureus was present in 12 (70.5%) of the healthcare-acquired staphylococcal infections. Methicillin-resistant S. aureus was detected in 12 (85.7%) of 14 community-acquired staphylococcal infections. Eighty-three percent (n=10) of community-acquired MRSA infections were male and their mean age was 67.6 +/- 77.8 months (median 26, range 1-204). Sixty-seven percent (n=8) of healthcare-acquired MRSA (HAMRSA) were male and their mean age was 106.7 +/- 81.3 months (median 108, range 0-222). Most of the community-acquired MRSA patients were diagnosed with soft tissue infection. In the HA-MRSA cases, bacteraemia was the most common infection. Sixty-nine percent of the soft tissue infections originated from CA-MRSA, 73% of the other infections originating from HA-MRSA (p=0.041). MRSA associated mortality was not detected in the cases.CONCLUSIONS: Methicillin-resistant S. aureus (85.7%) was found to be high in community-acquired staphylococcal infections in our study. Most of the community-acquired MRSA was detected in patients with soft tissue infections, followed by septicemia. Bacteraemia was the most frequent healthcare-acquired MRSA infection.Publication Evaluation of children cases admitted for tick bite in uludag university medicine of faculty(Aves Yayincilik, Ibrahim Kara, 2010-12-01) ÇELEBİ, SOLMAZ; Çelebi, Solmaz; KILIÇ, UĞUR; Aydın, Levent; AYDIN, LEVENT; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Çelik, Uğur; Çakır, Deniz; Emir, Begüm Runa; Çetin, Meryem; Tıp Fakültesi; Parazitoloji Bilim Dalı; 0000-0003-4646-660X; 0000-0002-7056-0615; GQP-2135-2022Objective: Crimean-Congo hemorrhagic fever (CCHF) virus causes a severe disease in humans, with a mortality of up to 30%. The geographical environment of our country is suitable for ticks. The aim of this study was to evaluate the clinical, and laboratory characteristics of children admitted for tick bites and determine the species of tick removed from the children.Material and Methods: Between April 2009 and September 2009, a total of 104 cases who had tick bites were included in the study. Detailed demographic, laboratory and clinical data were prospectively collected for each patient using a standardized questionnaire.Results: During the study period, a total of 104 children were admitted for tick bite. The mean age of patients was 7.3 +/- 4.4 years (1-18 years) and 71% were female. Most of the children (58%) were living in the rural region of Bursa. Of the 104 reported tick bites, most were nymphs of Rhipicephalus spp (42.3%) and larvae of Rhipicephalus spp (22.1%). Larvae of Ixodes spp (8.6%), nymphs of Ixodes spp. (6.7%), nymphs of Hyalomma spp. (4.8%) and adults of H. marginatum (2.7%) and R. sanguineus (10.5%) were also recorded. The records of H. aegyptium (0.9%) and R. turanicus (0.9%) were unremarkable. Clinical findings were normal on admission and follow up. The levels of liver enzymes, creatinine phosphokinase, lactate dehydrogenase, bleeding markers and complete blood count were normal. No CCHF infection was detected among the children admitted for tick bite.Conclusion: Tick bites and CCHF are important public health problems and it is crucial to publish information on tick bite prevention, which would play an important role in reducing the incidence of direct parasitic contact and the occurrence of transmittable diseases.Publication Nature and duration of protective antibodies developed after COVİD-19 infection(Aves Yayıncılık, 2021-03-01) Turan, Cansu; Hacımustafaoğlu, Mustafa; TURAN, CANSU; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Tıp Fakültesi; Çocuk Sağlık ve Hastalıklar Ana Bilim Dalı; Çocuk Enfeksiyon Hastalıkları Bilim Dalı; 0000-0003-3146-6391; 0000-0003-4646-660X; IVB-4013-2023; CTG-5805-2022Publication Comparison of c-reactive protein, procalcitonin and serum amyloid-a levels in diagnosis of bacterial infection in children(Aves Yayincilik, Ibrahim Kara, 2013-12-01) Çelebi, Solmaz; ÇELEBİ, SOLMAZ; ÖZAKIN, CÜNEYT; Bulur, Nurcan; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Özakın, Cüneyt; Çakır, Deniz; Bozdemir, Şefika Elmas; Çetin, Benhur Şirvan; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0003-4646-660X; 0000-0002-7056-0615; 0000-0002-8470-4907; GQP-2135-2022; AAG-8392-2021; H-2691-2017Objective: The aim of the study was to compare C-reactive protein (CRP), procalcitonin (PCT) and serum amyloid A (SAA) levels in children with bacterial infection.Material and Methods: In this prospective study, 120 pediatric patients who were hospitalized with bacterial infection in the Uludag University Medical Faculty Pediatric Clinic between June 2009 and June 2011 were included. Patients were evaluated in 5 groups as sepsis, pneumonia, meningitis, pyelonephritis and other infection groups. Before initiating the antimicrobial therapy, blood samples for whole blood count, blood culture, CRP, PCT and SAA were obtained from children with bacterial infection. This procedure was repeated three times at 48 h, 7 and 10 days. Whole blood count was performed using an automated counter, Cell Dyn 3700 (Abbott Diagnostics Division, Santa Clara, CA, USA). CRP and SAA were determined by an immunonephelometric method using BN II device (Dade Behring Marburg GMBH, Marburg, Germany). PCT was measured by EnzymeLinked Fluorescent Assay (VIDAS PCT; Brahm Diagnostica GMBH, Lyon, France).Results: Of the patients, 66 (55%) were male and 54 (45%) were female. The median age was 37.5 months (1-209). PCT levels of the sepsis group was significantly higher than those of the pneumonia and other infection groups (respectively, p=0.001, p=0.003). SAA levels were higher in the meningitis group than those of the pneumonia group (p=0.007). When patients were divided into two groups as invasive bacterial infection group and localised bacterial infection group; PCT levels were found significantly higher in the invasive bacterial infection group than those of the localised bacterial infection group. Also, percentage change of PCT at the 48th hour, 7 and 10 days was determined as significantly higher in the invasive bacterial infection group than that of the localised bacterial infection group.Conclusion: In this study, PCT seems to be a more valuable parameter in diagnosing invasive bacterial infections.Publication X-ray-evaluation(Aves Yayincilik, Ibrahim Kara, 2008-03-01) Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Çelebi, Solmaz; ÇELEBİ, SOLMAZ; Yazıcı, Zeynep; YAZICI, ZEYNEP; Tıp Fakültesi; Radyoloji Ana Bilim Dalı; 0000-0003-4646-660X; AAI-2303-2021Publication Clinical clues(Aves Yayincilik, Ibrahim Kara, 2012-09-01) Gurpinar, Arif; GÜRPINAR, ARİF NURİ; Yazici, Zeynep; YAZICI, ZEYNEP; Celebi, Solmaz; ÇELEBİ, SOLMAZ; Hacimustafaoglu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Tıp Fakültesi; Çocuk Cerrahi Ana Bilim Dalı; 0000-0003-4646-660X; AAI-2303-2021Publication Risk factors and clinical outcomes of infections caused by acinetobacter spp. in children: Results of a 5 year study(Aves Yayincilik, Ibrahim Kara, 2010-03-01) Çelebi, Solmaz; ÇELEBİ, SOLMAZ; Hacımustafaoğlu, Mustafa; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Yüce, Necla; Karalı, Zuhal; KARALI, ZUHAL; Gül, Yahya; Çakır, Deniz; Gedikoğlu, Suna; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0003-4646-660X; 0000-0002-7056-0615; GQP-2135-2022Objective: The number of infections caused by microorganisms of the genus Acinetobacter has increased in recent years. The aim of this study was to evaluate the risk factors and clinical outcomes associated with multidrug resistant (MDR) Acinetobacter infections in children and to define the predisposing factors associated with Acinetobacter spp. infection related mortality.Material and Method: We conducted a case-control study between January 1, 2004 and December 31, 2008 at the Uludag University Pediatric Clinic. Multidrug resistance was defined as resistance to all antibiotics apart from colistin. All patients with MDR Acinetobacter spp. infections were compared to patients with non-MDR Acinetobacter spp. infections. Risk factors analyzed included prior antibiotic use, underlying diseases, invasive medical devices, and other demographic characteristics.Results: Acinetobacter spp. infections were diagnosed in 95 of the 8879 patients hospitalized in our center between January 1, 2004 and December 31, 2008 (overall incidence, 10.6 per 1,000 admissions). The mean age of patients was 62.1+ 61.2 months (15 days-18 years) and 56% were male. The prevalence of MDR isolates among Acinetobacter spp. was found to be 33.6%. In this study, risk factors for MDR Acinetobacter spp. infections included prolonged hospitalization and prolonged exposure to broad-spectrum antibiotics (p< 0.05). The mortality rate of Acinetobacter spp. infection was found to be 26.3%. Predisposing factors associated with mortality were pediatric intensive care unit stay, male gender, ventilator associated pneumonia, presence of immunodeficiency or renal disease, presence of mechanical ventilation and MDR Acinetobacter spp. infections (p< 0.05).Conclusion: In this study, the prevalence of multidrugresistant isolates among Acinetobacter spp. was 33.6 %. The mortality (50%) for patients in the MDR group was significantly higher than the mortality for patients in the non-MDR group (11%) (p< 0.05).Publication X-ray-evaluation(Aves Yayincilik, Ibrahim Kara, 2011-09-01) Hacımustafaoglu, Mustafa; ÇELEBİ, SOLMAZ; HACIMUSTAFAOĞLU, MUSTAFA KEMAL; Çelebi, Solmaz; YAZICI, ZEYNEP; Yazıcı, Zeynep; Tıp Fakültesi; Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı; 0000-0003-4646-660X; AAI-2303-2021