Person: ABAY, MERVE
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Publication Clinical significance of risk-reducing salpingo-oophorectomy in patients with BRCA1/2 mutation(Elsevier, 2023-10) Abay, Merve; Özgen, Levent; Yalçın, Yakup; Özerkan, Kemal; ABAY, MERVE; ÖZGEN, LEVENT; YALÇIN, YAKUP; ÖZERKAN, KEMAL; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0003-0070-2646; CAK-3842-2022; JFT-0660-2023; HQP-3191-2023; AAH-9791-2021Objective: Serous tubal intraepithelial carcinoma (STIC) is a precursor lesion which is located in the distal fallopian tube and causes high grade serous ovarian carcinoma (HGSOC). The incidence of STIC for women underwent risk reducing salpingo-oophorectomy for BRCA mutation varies from 0.6 to 7% and its clinical outcomes are still unclear. The aim of this study was to demonstrate the incidence of STIC and HGSOC in BRCA1/2 mutation carriers after risk reducing salpingo-oophorectomy (RRSO) and the clinical outcomes of these patients. Material and methods: We retrospectively reviewed the records of 48 BRCA1 and/or 2 mutation carriers who underwent prophylactic salpingo-oophorectomy with or without hysterectomy at the Department of Obstetrics and Gynecology, Bursa Uludag University between January 2000 and January 2022. Inclusion criteria: BRCA 1 and/or 2 mutation carriers diagnosed by genetic testing, asymptomatic patients with no abnormal findings on pelvic examination. Exclusion criteria: patients with no abnormal findings on pelvic examination and a presence of a personal history of ovarian, fallopian tube or peritoneal cancer. Results: A total of 48 BRCA 1 and/or 2 mutation carriers underwent RRSO. STIC was diagnosed in 1 (2,0%) patient and restaging surgery was not performed. Primary peritoneal carcinoma (PPC) did not develop during the 20 months follow-up period. One (2.0%) patient was diagnosed with occult ovarian cancer. Restaging surgery was performed and chemotherapy treatments were given after surgery. A pelvic recurrence developed 25 months after the occult cancer diagnosis in the follow up period. One (2.0%) patient with normal histopathological findings after RRSO was diagnosed with peritoneal cancer 57 months after the operation. Conclusion: The risk of PPC continues after RRSO. Therefore, close follow-up procedure is very important for early diagnosis and effective treatment of patients with PPC after RRSO.Publication Impact of uterine adenomyosis on survival outcome of patients with non-endometrioid endometrial cancer(Bmj Publishing Group, 2023-09-01) Özgen, Levent; ÖZGEN, LEVENT; Yalçın, Yakup; YALÇIN, YAKUP; Özerkan, Kemal; ÖZERKAN, KEMAL; Abay, Merve; ABAY, MERVE; Tıp Fakültesi; Cerrahi Tıp Bilimleri Ana Bilim DalıPublication Early effect of pelvic organ prolapse surgery on female sexual functions(Bayrakol Medical Publisher, 2023-06-01) Abay, Merve; Özgen, Levent; Özgen, Gülten; Aydın, Derya Sivri; Göksedef, Behiye Pınar; ABAY, MERVE; ÖZGEN, LEVENT; Özgen, Gülten; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0002-7283-0930; JFT-0660-2023; HDL-9272-2022; CAK-3842-2022Aim: In this study, we aimed to detect changes in sexual functions before and after surgery in women who underwent pelvic reconstruction for pelvic organ prolapse and urinary incontinence. Material and Methods: This prospective cross-sectional study included 60 patients who underwent anterior and posterior vaginal repair due to cysto-rectocele and/or uterine prolapse. One day before and three months after the operation, FSFI scoring was performed. Patients were divided into 3 groups according to age: 30-40 years old (Group 1), 41-49 years old (Group 2) and 50-59 years old (Group 3). Results: There was no significant difference in the total FSFI score of the patients after the operation (p = 0.072). There was a statistically significant increase in sexual desire and arousal scores (p = 0.011 and p = 0.049, respectively) but there was no statistically significant difference in the other subscale scores. There was a statistically significant difference in the sexual desire and arousal scores of Group 1 and the sexual desire score of Group 3 patients (p = 0.028, 0.046 and 0.017, respectively). There was a decrease in the total FSFI score and sexual desire, lubrication, orgasm, satisfaction subscale scores after the operation but this decrease was not statistically significant. Discussion: There was no change in the total FSFI score in the 3rd month after pelvic organ prolapse operation, but there was a statistically significant increase in sexual desire and arousal scores. We believe that this increase may be due to the changing body image and sexual self-confidence of the patients in the postoperative period.