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İNCİ ÖZBAĞCI, DUYGU

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İNCİ ÖZBAĞCI

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2019 - 201912020 - 20231
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    New copper(ii) complexes containing tryptophan based schiff bases as promising antiproliferative agents on breast cancer cells
    (Elsevier, 2023-12-28) Zorlu, Yunus; Arı, Ferda; ARI, FERDA; Gültekin, Büşra; Özbağcı, Duygu Inci; İNCİ ÖZBAĞCI, DUYGU; Aydın, İpek; İPEK, AYDIN; Aydın, Rahmiye; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Biyoloji Bölümü; 0000-0002-0443-1129; 0000-0002-0483-9642; 0000-0003-4944-0181; 0000-0002-6729-7908; 0000-0003-2811-1872; G-2201-2019; IUO-8513-2023; AAG-7012-2021
    Three new copper(II) complexes, [Cu(5-ClSal-Trp)(H2O)2] (1), [Cu(5-ClSal-Trp)(phen)] & sdot;C2H5OH (2) and [Cu (3,5-ClSal-Trp)(phen)] (3) (5-ClSal-Trp: Schiff base derived from 5-chlorosalicylaldehyde and L-tryptophan, 3,5-ClSal-Trp: Schiff base derived from 3,5-dichlorosalicylaldehyde and L-tryptophan, phen: 1,10-phenanthroline), have been synthesized and characterized by electronic absorption spectroscopy, CHN analysis, FTIR, ESI-MS and XRD techniques. Interaction of the complexes 1-3 with biomolecules {calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)} has been investigated by electronic absorption and fluorescence spectroscopy. The results show that the complexes 1-3 can bind to CT-DNA via a moderate intercalation mode. Moreover, the fluorescence quenching mechanism between the complexes 1-3 and BSA is a static quenching process. Radical scavenging activity studies reveal that the complexes 1-3 show a moderate activity. Antiproliferative effects of the complexes 1-3 on both breast cancer cells (MCF-7 and MDA-MB-231) and healthy breast epithelial cells (MCF-10A) were also investigated using the Sulforhodamine B (SRB) viability assay. The results demonstrated that the complexes 1-3 exhibited a more pronounced cytotoxic effect on cancer cells compared to normal breast epithelial cells. Among the complexes, the best cytotoxic activity was obtained for the complex 3 against both human breast cancer cell lines. Further analysis indicated that the complex 3 induced apoptosis, as evidenced by fluorescent staining, positive Annexin-V-FITC staining, and the involvement of caspase. Subsequent to the administration of the complex 3, an evaluation of intracellular reactive oxygen species (ROS) generation was conducted through the utilization of dihydroethidium (DHE) fluorescent staining.
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    Publication
    Structures, hydrolysis, stabilities of palladium(II) complexes containing biologically active ligands and species distribution in aqueous solution
    (Elsevier, 2019-04-13) İnci, Duygu; Aydın, Rahmiye; İNCİ ÖZBAĞCI, DUYGU; AYDIN, RAHMİYE; Fen Edebiyat Fakültesi; Kimya Bölümü; 0000-0002-0483-9642; 0000-0003-4944-0181; G-2201-2019; AAH-8936-2021
    [PdACl(2)](n-1)H2O complexes {A: 1,10-phenanthroline (phen), 4-methyl-phenanthroline (4-mphen), 5-methyl-1,10-phenanthroline (5-mphen), 4,7-dimethyl-1,10-phenanthroline (dmphen), 3,4,7,8-tetramethyl-1,10-phenanthroline (tmphen)} were synthesized and characterized by CHN elemental analysis, ATR-FT-MIR and ATR-FT-FIR, H-1 NMR and C-13 NMR spectral measurements. n is the number of crystal water molecules in the complexes. The n value for the complexes [Pd(phen)Cl-2], [Pd(4-mphen)Cl-2] and [Pd(5-mphen)Cl-2] is 1; for the complex [Pd(tmphen)Cl-2]H2O is 2; for the complex [Pd(dmphen)Cl-2]2H(2)O is 3. [PdACl(2)](n-1)H2O complexes were converted into aqua complexes derived from 1,10-phenanthroline, [PdA(H2O)(2)](2+), and investigated [PdAB](+) mixed ligand complexes formed between [PdA(H2O)(2)](2+) complexes and amino acids {B: glycine (gly) and tyrosine (tyr)}. Protonation constants of the gly and tyr, the acid dissociation constants of the coordinated water molecules in [PdA(H2O)(2)](2+) complexes and the stepwise stability constant of the [PdAB](+) mixed ligand complexes were determined in aqueous 0.1 M KNO3 ionic media at 298.15 K by potentiometric methods. The protonation constants of ligands, the acid dissociation constants of aqua complexes and the stepwise stability constants of mixed ligand complexes were calculated from the potentiometric data using the "BEST" software package. The concentration distribution of the various species formed in aqueous solution was obtained using the "SPE" software package under the experimental conditions described. The order of stepwise stability of the mixed ligand complexes in terms of the gly and tyr was [Pd(tmphen)(gly/tyr)](+) > [Pd(dmphen)(gly/tyr)](+) > [Pd(4-mphen)(gly/tyr)](+) > [Pd(phen) (gly/tyr)](+) > [Pd(5-mphen)(gly/tyr)](+). This study could contribute to a better understanding of the behavior of the palladium(II) complexes in biological systems.