2022 Cilt 3 Sayı 1

Permanent URI for this collectionhttps://hdl.handle.net/11452/28036

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    Investigation of size exclusion chromatography (SEC) column performance for detection of microplastics in aquatic environment
    (Bursa Uludağ Üniversitesi, 2022-06-08) Kuruca, Büşra; İzgi, Belgin; Bursa Uludağ Üniversitesi/Fen Bilimleri Enstitüsü/Kimya Bölümü.; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.; 0000-0002-9177-6992; 0000-0002-1074-3612
    Microplastics have become a problem of the modern era with the increasing use of plastics. However, the effects of microplastics on living beings are not known exactly. As stated in the booklet "Microplastics in Drinking Water" published by the World Health Organization (WHO) in 2019, there is no standard method for the detection of microplastics. Although there are various analysis methods for the determination of microplastics in the literature, some deficiencies are observed. In this study, it is aimed to analyze the microplastics in aquatic environment without using organic solvents, especially in accordance with green chemistry. In this context, Size Exclusion Chromatography was used and the performance of four different Ultra- hydrogel columns suitable for aqueous mobile phases was tested. Polyethylene glycol (PEG) standards with different molecular masses were used during this performance test. As a result of the study, the theoretical plate numbers of Ultra- hydrogel 250 Å, Ultra-hydrogel 500 Å, and Ultra-hydrogel 1000 Å columns were calculated as 256, 713, and 342, respectively, and the regression coefficients (R²) were calculated as >0.97. The theoretical plate number of Ultra- hydrogel 2000 Å column was not calculated because of lower regression coefficient.
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    Roles of plant and fungal lectins in cancer diagnosis and treatment: A scoping review
    (Bursa Uludağ Üniversitesi, 2022-03-01) Kasapoğlu, Taner; Dere, Egemen; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; 0000-0001-5289-0242; 0000-0001-9572-1051
    Lectins are proteins that possess the carbohydrate-binding property that makes the lectins can bind and recognize carbohydrate moieties on cancer cells. Lectins trigger various cell death forms such as apoptosis, autophagy, and necrosis in various cancer cell lines. These abilities of lectins are making the lectins a potential and convenient tool for cancer treatment and diagnosis. According to carbohydrate specificities and affinities, sequence similarities, the number of carbohydrate-binding domains, etc., lectins are classified into many groups. Therefore, the different lectins in each other have distinct affinities in various cancer cell lines. The researches and reviews of the potential use in cancer treatment and diagnosis of plant and fungal lectins have been aimed to document in this review.