1988 Cilt 7 Sayı 1-2-3

Permanent URI for this collectionhttps://hdl.handle.net/11452/31984

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    Nitrat ve nitrit'in immunosuppresif olarak etkiledikleri farelerde bazı biyolojik değişiklikler üzerinde araştırmalar II. bazı doku ve organlarda gözlenen histopatolojik değişiklikler
    (Uludağ Üniversitesi, 1988) Kahraman, Mustafa; Ertürk, Erdoğan; Özkula, Mihriban; Sönmez, Gürsel; Veteriner Fakültesi; Mikrobiyoloji Ana Bilim Dalı
    Eighty Swiss mice divided into 4 equal groupı as follow: Group I Negative controls (nonvaccinated with Newcastle Disease vaccine and did not receive any additional treatment); Group. Il was consisted of 20 mice that received ND vaccine only; Group III had 20 mice that were ND vaccinated and drunk nitrite water (0.4 gr/lt) and the last group IV, had equal number of mice that were immunostimulated with ND vaccination and was additionally treated with nitrate in their drinking water (0.4 gr./lt) for a period of 26 weeks. Three mice randomly selected from each group were used to obtain blood samples and histopathological evaluations by the termination. The respective HI tilers for groups were 2-², 2-⁶, 2-⁵ and 2-⁴.The second group (vaccinated controls) being highest and followed by the third and the fourth groups showed moderate severe to lymphoid hyperplasia in thymus, peripheral lymph nodes and payer patches observed by light microscopy. In some cases, as the result of this severe lymphoid response, some mononuclear cell infiltrations into kidney, liver and even into the lungs were detected. The strength of hyperplasia and resulting infiltrations were in agreement with the immunosuppressive potential of nitrate and nitrite administered in drinking water.