Uluslararası Bilim, Teknoloji ve Tasarım Dergisi

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Browsing by BUU Author "Dere, Egemen"

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    Lactate dehydrogenase enzyme activity in some tissues of rats exposed to methyl parathion
    (Bursa Uludağ Üniversitesi, 2021-04-14) Dere, Egemen; Arı, Ferda; El Arfaoui, Aboush; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; 0000-0001-9572-1051; 0000-0002-6729-7908; 0000-0002 0057 3832
    Insecticides are of great importance in combating insects that damage agricultural products. However, the risks they pose for humans and the environment cannot be ignored. One of these frequently used insecticides is methyl parathion (MP), an organophosphate compound. In this article, the effect of methyl parathion on lactate dehydrogenase enzyme activity was investigated. Wistar rats were used in experimental studies. Small intestine, kidney, brain and liver tissues were removed 2, 4, 8, 16, 32, 64 and 72 hours after methyl parathion was injected intraperitoneally in male and female rats at a dose of 7mg/Kg. Lactate dehydrogenase enzyme activities were determined from the supernatants obtained. It is noteworthy that lactate dehydrogenase activity was significantly increased in almost all experimental periods in all tissues studied. Small increases in lactate dehydrogenase activity generally do not indicate any harm. However, significant increases can indicate many major conditions such as liver disease, circulatory failure and muscle damage. Our research results and discussion show that methyl parathion can be dangerous to human health.
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    Roles of plant and fungal lectins in cancer diagnosis and treatment: A scoping review
    (Bursa Uludağ Üniversitesi, 2022-03-01) Kasapoğlu, Taner; Dere, Egemen; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; 0000-0001-5289-0242; 0000-0001-9572-1051
    Lectins are proteins that possess the carbohydrate-binding property that makes the lectins can bind and recognize carbohydrate moieties on cancer cells. Lectins trigger various cell death forms such as apoptosis, autophagy, and necrosis in various cancer cell lines. These abilities of lectins are making the lectins a potential and convenient tool for cancer treatment and diagnosis. According to carbohydrate specificities and affinities, sequence similarities, the number of carbohydrate-binding domains, etc., lectins are classified into many groups. Therefore, the different lectins in each other have distinct affinities in various cancer cell lines. The researches and reviews of the potential use in cancer treatment and diagnosis of plant and fungal lectins have been aimed to document in this review.