Browsing by Author "Yavuz, Dilek Gogas"
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Publication Identifying clinical characteristics of hypoparathyroidism in Turkey: HIPOPARATURK-NET study(Springer, 2022-02) Değertekin, Ceyla Konca; Yavuz, Dilek Gogas; Pekkolay, Zafer; Saygılı, Emre; Uğur, Kader; Koca, Arzu Or; Ünübol, Mustafa; Topaloğlu, Ömercan; Aydoğan, Berna İmge; Kutbay, Nilüfer Özdemir; Hekimsoy, Zeliha; Yılmaz, Nusret; Balcı, Mustafa Kemal; Tanrıkulu, Seher; Ünsal, Yasemin Aydoğan; Ersoy, Canan; Omma, Tülay; Keskin, Müge; Yalçın, Mehmet Muhittin; Yetkin, İlhan; Soylu, Hikmet; Karaköse, Melia; Yılmaz, Merve; Karakılıç, Ersen; Pişkinpaşa, Hamide; Batman, Adnan; Akbaba, Gülhan; Elbuken, Gülşah; Bahadir, Cigdem Tura; Kılınç, Faruk; Bilginer, Muhammet Cüneyt; İyidir, Özlem Turhan; Cantürk, Zeynep; Yılmaz, Banu Aktaş; Sayıner, Zeynel Abidin; Eroğlu, Mustafa; ERSOY, CANAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı; AAH-8861-2021Hypoparathyroidism is an orphan disease with ill-defined epidemiology that is subject to geographic variability. We conducted this study to assess the demographics, etiologic distribution, treatment patterns and complication frequency of patients with chronic hypoparathyroidism in Turkey. This is a retrospective, cross-sectional database study, with collaboration of 30 endocrinology centers located in 20 cities across seven geographical regions of Turkey. A total of 830 adults (mean age 49.6 +/- 13.5 years; female 81.2%) with hypoparathyroidism (mean duration 9.7 +/- 9.0 years) were included in the final analysis. Hypoparathyroidism was predominantly surgery-induced (n = 686, 82.6%). The insulting surgeries was carried out mostly due to benign causes in postsurgical group (SG) (n = 504, 73.5%) while patients in nonsurgical group (NSG) was most frequently classified as idiopathic (n = 103, 71.5%). The treatment was highly dependent on calcium salts (n = 771, 92.9%), calcitriol (n = 786, 94.7%) and to a lower extent cholecalciferol use (n = 635, 76.5%) while the rate of parathyroid hormone (n = 2, 0.2%) use was low. Serum calcium levels were most frequently kept in the normal range (sCa 8.5-10.5 mg/dL, n = 383, 46.1%) which might be higher than desired for this patient group. NSG had a lower mean plasma PTH concentration (6.42 +/- 5.53 vs. 9.09 +/- 7.08 ng/l, p < 0.0001), higher daily intake of elementary calcium (2038 +/- 1214 vs. 1846 +/- 1355 mg/day, p = 0.0193) and calcitriol (0.78 +/- 0.39 vs. 0.69 +/- 0.38 mcg/day, p = 0.0057), a higher rate of chronic renal disease (9.7% vs. 3.6%, p = 0.0017), epilepsy (6.3% vs. 1.6%, p = 0.0009), intracranial calcifications (11.8% vs. 7.3%, p < 0.0001) and cataracts (22.2% vs. 13.7%, p = 0.0096) compared to SG. In conclusion, postsurgical hypoparathyroidism is the dominant etiology of hypoparathyroidism in Turkey while the nonsurgical patients have a higher disease burden with greater need for medications and increased risk of complications than the postsurgical patients.Item Vitamin D receptor gene BsmI, FokI, ApaI, TaqI polymorphisms and bone mineral density in a group of Turkish type 1 diabetic patients(Springer, 2011-12) Yavuz, Dilek Gogas; Keskin, Lezan; Sert, Murat; Yazıcı, Dilek; Şahin, İbrahim; Yüksel, Meral; Deyneli, Oğuzhan; Aydın, Hasan; Akalın, Sema; Kıyıcı, Sinem; Tuncel, Ercan; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Diyabet ve Metabolizma Anabilim Dalı.; 12753880400; 7006929833Previous studies have suggested an influence of vitamin D receptor alleles on bone metabolism and on susceptibility to type 1 diabetes mellitus in different ethnic populations. We aimed to investigate the distribution of vitamin D receptor (VDR) alleles in relation to biochemical bone turnover parameters and bone densitometry measurements in a group of Turkish type 1 diabetic patients. One hundred and seventeen patients (M/F 57/60, 27.6 +/- A 7.3 y duration of diabetes 8.1 +/- A 6.3 y) and 134 healthy controls (M/F 61/73, 26.2 +/- A 5.3 y) were included in the study. Bone mineral density (BMD) was evaluated by dual-energy X-ray absorptiometry (DEXA). The vitamin D receptor gene (VDR) polymorphisms FokI, Bsm1, Apa1, and Taq1 were examined using a PCR-based restriction analysis. Serum levels of calcium, phosphor osteocalcin, intact parathyroid hormone, and C telopeptide were measured. Vitamin D receptor Bsm1 Fok1, Apa1, and Taq1 genotype distributions were not different between patient with diabetes and control groups. BMD was 0.77 +/- A 0.2 g/cm(2) vs. 0.97 +/- A 0.2 g/cm(2) (P = 0.0001) for the femur, 1.0 +/- A 0.1 g/cm(2) vs. 1.13 +/- A 0.1 g/cm(2) (P = 0.001) for type 1 diabetic patients and controls. Bone turnover markers were significantly lower in type 1 diabetic group. BMD measurements and bone metabolic markers were not different between the genotypes in either the patient with diabetes or the controls. The VDR gene polymorphisms, Bsm1, Fok 1, Apa1, and Taq1 showed no influence on bone metabolism in our group of type 1 diabetic patients.